Abstract Background After ventriculoperitoneal shunt surgery for idiopathic normal pressure hydrocephalus (iNPH) with adjustable gravitational valves, a certain proportion of patients develop secondary clinical worsening after initial improvement of clinical symptoms. The aim of this study was to analyze this group of patients with secondary deterioration and to evaluate the performed shunt management. ...
Wed Mar 04, 2020 02:00
Abstract Background Cooperation in public health and in oncology in particular, is currently a major issue for the island of Martinique, given its geopolitical position in the Caribbean region. The region of Martinique shares certain public health problems with other countries of the Caribbean, notably in terms of diagnostic and therapeutic management of patients with cancer. We present here a roadmap of cooperation priorities and...
Wed Mar 04, 2020 02:00
Zusammenfassung Ernährung bleibt ein Thema bis zum Lebensende – für Patienten und Angehörige. Dies gilt insbesondere für Palliativpatienten mit einem fortgeschrittenen Kopf-Hals-Karzinom. Zu den lokalen Problemen durch Erkrankung und Therapie kommen die sozialen Aspekte wie Isolation, nachlassende Kraft und sich verkleinernder Aktionsradius. Eine effektive Ernährungsberatung und -therapie ist notwendig, um Lebensqualität und Selbstversorgung so lange wie möglich zu erhalten. Aus...
Wed Mar 04, 2020 02:00
Zusammenfassung Hintergrund Wegen stetig schwindender Präsenz Studierender wurde an der Univ.-HNO-Klinik Freiburg im Wintersemester (WS) 2017/18 ein neuartiges Blended-Learning-Vorlesungsformat gestartet: die HNO-3-D-Reihe. Um komplexe HNO-Themen (z. B. Mittelohr) verständlicher, ansprechender und klinisch relevanter zu präsentieren, kooperierten die klinischen Fachgebiete HNO-Heilkunde und Radiologie mit dem vorklinischen Fachgebiet...
Wed Mar 04, 2020 02:00
Zusammenfassung Hintergrund Im Jahr 2015 hat die European Laryngological Society (ELS) ein Konsensuspapier publiziert, in dem ein neues Klassifikationssystem für laryngotracheale Stenosen (LTS) präsentiert wurde. In einer retrospektiven Analyse werden die Zuverlässigkeit und die prognostische Aussagekraft in Bezug auf das Ergebnis einer Atemwegsrekonstruktion in einer pädiatrischen Population untersucht. ...
Wed Mar 04, 2020 02:00
Zusammenfassung Malformationen des Ohrs stellen eine der häufigsten Fehlbildungen im Kindesalter dar. Diese unterteilen sich in Dysplasien der Ohrmuschel, Fehlanlagen des äußeren Gehörgangs und Fehlbildungen des Mittel- und Innenohrs. Letztere treten glücklicherweise relativ selten auf. Am häufigsten treten klinisch isolierte geringgradige Dysplasien der Ohrmuschel (Otabtosis, „cup ear“) in Erscheinung. Höhergradige Fehlbildungen der Ohrmuschel (Mikrotie II–III°) sind oft syndromgebunden...
Wed Mar 04, 2020 02:00
Zusammenfassung Hintergrund Als Ansatzpunkt zur Entwicklung konkreter Optimierungsvorschläge für das HNO-ärztliche Weiterbildungssystem wurde zunächst die Ausbildungssituation an deutschen HNO-Kliniken analysiert, um existierende Schwachstellen der Weiterbildung identifizieren zu können. Methodik HNO-Weiterbildungsassistenten an deutschen HNO-Kliniken...
Wed Mar 04, 2020 02:00
Abstract Objective and design This study aimed to investigate the anti-pulmonary inflammation effect of emodin on Wistar rats with lipopolysaccharide (LPS)-induced acute lung injury (ALI) and RAW264.7 cells through the mammalian target of rapamycin (mTOR)/hypoxia-inducible factor-1α (HIF-1α)/vascular endothelial growth factor (VEGF) signaling pathway. Subjects ...
Wed Mar 04, 2020 02:00
Abstract Mammalian Na+/H+ exchanger type I isoform (NHE1) is a ubiquitously expressed membrane protein that regulates intracellular pH (pHi) by removing one intracellular proton in exchange for one extracellular sodium ion. Abnormal activity of the protein occurs in cardiovascular disease and breast cancer. The purpose of this study is to examine the role of negatively charged amino acids of extracellular loop 3 (EL3) in the activity of the NHE protein. We mutated glutamic acid...
Wed Mar 04, 2020 02:00
Abstract Amyloid beta is a major constituent of the plaques found in the brains of patients suffering from Alzheimer’s disease (AD). A growing body of research work suggests that neuroinflammation plays important roles in the development of AD. Thus, considerable efforts are directed towards identification of compounds that can reduce or inhibit neuroinflammation. Here, we show that sinomenine, a compound present in a Chinese medicinal plant, Sinomenium acutum, inhibits oligomeric...
Wed Mar 04, 2020 02:00
Abstract Background Hepatic metastasis develops in ~ 50% of uveal melanoma (UM) patients with no effective treatments. Although GNAQ/GNA11 mutations are believed to confer pathogenesis of UM, the underlying mechanism of liver metastasis remains poorly understood. Given that profound epigenetic evolution may occur in the long journey of circulating tumor cells (CTCs) to distant organs, we hypothesized that EZH2 endowed tumor cells...
Wed Mar 04, 2020 02:00
Abstract Background Long noncoding RNAs (lncRNAs) are emerging as critical regulatory elements and play fundamental roles in the biology of various cancers. However, we are still lack of knowledge about their expression patterns and functions in human colorectal cancer (CRC). Methods Differentially expressed lncRNAs in CRC were identified...
Wed Mar 04, 2020 02:00
Zusammenfassung Hintergrund In den letzten Jahren verringerte sich die frühgeburtliche Morbidität und Mortalität über Ländergrenzen hinweg deutlich. Allen Untersuchungen gemeinsam ist aber eine höhere Betroffenheit und Sterblichkeit von Jungen gegenüber Mädchen, insbesondere bei der nekrotisierenden Enterokolitis. Fragestellung Besteht in Deutschland auf...
Wed Mar 04, 2020 02:00
Abstract Exploring the neurochemical continuum between frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) with respect to monoamines and kynurenines in cerebrospinal fluid (CSF) and serum, may be useful to identify possible new research/therapeutic targets. Hence, we analysed monoamines and kynurenines in CSF and serum derived from patients with FTD (n = 39), ALS (n = 23), FTD-ALS (n = 4) and age-matched control subjects (n = 26), using reversed-phase ultra-high...
Wed Mar 04, 2020 02:00
Abstract Reductions in the activities of mitochondrial electron transport chain (ETC) enzymes have been implicated in the pathogenesis of numerous chronic neurodegenerative disorders. Maintenance of the mitochondrial membrane potential (Δψm) is a primary function of these enzyme complexes, and is essential for ATP production and neuronal survival. We examined the effects of inhibition of mitochondrial ETC complexes I, II/III, III and IV activities by titrations of respective inhibitors...
Wed Mar 04, 2020 02:00
Abstract Purpose The management of residual or persistent intracranial aneurysms after flow-diversion therapy is not well defined in the literature. In this multicentric study, we report clinical and angiographic outcomes of 11 patients that underwent retreatment for 12 aneurysms initially treated with flow-diverter stents. Methods The median patient age...
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Abstract Applying health behaviour change models, such as the theory of planned behaviour (TPB), to help-seeking for mental health problems can address the deficit in health care utilisation. However, previous studies largely focused on help-seeking intentions and not behaviour, which might be problematic due to the intention-behaviour gap. Hence, TPB and help-seeking were examined in a German community sample with current untreated depressive symptoms: 188 adults (Mage = 50.34;...
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Abstract Sexual minority youth (SMY) report more substance use and experience more physical and sexual dating violence victimization than heterosexual youth; however, few studies have explored the relationship between substance use and disparities in teen dating violence and victimization (TDVV) using national-level estimates, and examined if these relationships vary by sexual minority subgroups. Data from the nationally representative 2015 and 2017 national Youth Risk Behavior...
Wed Mar 04, 2020 13:10
Abstract Individuals’ financial well-being has been recognised as an important concern to reach individuals’ general well-being and societal welfare. In this context, understanding how individuals can ensure a good state of financial well-being is a critical question. However, previous studies have not paid enough attention to underlying the mechanisms by which individuals achieve financial well-being. The purpose of this paper is to explore the influence of attitude to money on...
Wed Mar 04, 2020 02:00
Abstract China is undergoing a campaign which is called “The Targeted Poverty Alleviation Policy” to eradicate extreme poverty from rural China until 2020. Though poverty in rural China has been studied intensively in different objective dimensions, little attention has been paid to poverty line settings and subjective poverty, which are hinged to the policy effects. In order to fill in the research gap, this study employs a nationally representative survey of rural households...
Wed Mar 04, 2020 02:00
Zusammenfassung Gestörter Schlaf und schlafbezogene Atmungsstörungen (SBAS) können mit einer erheblichen Einschränkung der Lebensqualität und mit einer erhöhten Morbidität einhergehen. Die moderne Diagnostik von SBAS beinhaltet weiterhin die Standardmethoden mit Polygrafie und Polysomnografie für eine Nacht. Aufgrund der hohen Nacht-zu-Nacht-Variabilität des Schweregrades von SBAS gewinnen Methoden, die über einen längeren Zeitraum SBAS erfassen (z. B. Herzschrittmachersysteme),...
Wed Mar 04, 2020 02:00
Abstract Background Caudate lobectomy via laparoscopic surgery has rarely been described. This multicenter, propensity score-matched study was performed to assess the safety and efficacy of laparoscopic caudate lobectomy (LCL). Methods A multicenter retrospective study was performed including all patients who underwent LCL and open caudate lobectomy...
Wed Mar 04, 2020 02:00
Abstract Medicine co-administration with food or drink vehicles is a common administration practice in paediatrics. The aims of this review were (i) to describe the current recommended strategies for co-administration of paediatric medicines with food and drinks (vehicles); (ii) to compare current administration recommendations from different countries; and (iii) to obtain a global perspective on the rationale behind the choice of recommended vehicle, in the context of the physicochemical...
Wed Mar 04, 2020 02:00
Abstract Background The efficacy and safety of opicapone, a once-daily catechol-O-methyltransferase inhibitor, have been established in two large randomized, placebo-controlled, multinational pivotal trials. Still, clinical evidence from routine practice is needed to complement the data from the pivotal trials. Methods OPTIPARK (NCT02847442)...
Wed Mar 04, 2020 02:00
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