Abstract Purpose Primary closure is often inadequate for large congenital diaphragmatic hernia (CDH) and necessitates repair by prosthetic patch or autologous muscle flap. Our aim was to evaluate outcomes of open patch versus flap repair, specifically diaphragmatic reherniation. Methods A retrospective review (IRB #2017-6361) was performed on all CDH...
02:00
Abstract Pre-eclampsia (PE) is a disorder of pregnancy characterized by proteinuria and high blood pressure, affecting 2–8% of pregnancies worldwide. Previous studies have shown that PE is closely associated with trophoblast cell dysfunction. Here, we investigated the role of tissue factor pathway inhibitor-2 (TFPI-2) in regulating the biological processes of trophoblast cells. The TFPI-2 levels in plasma samples and placental tissues were tested by ELISA, immunohistochemistry,...
02:00
Abstract Aberrant expression of miR-1256 has been reported to be closely associated with the development and progression of tumors, including colon cancer and lung cancer. However, study of its expression pattern and functional role in papillary thyroid cancer (PTC) is rare. Using quantitative real time PCR analysis, we found miR-1256 was significantly down-regulated in PTC tissues and cell lines. The correlation of miR-1256 expression with clinicopathological features was statistically...
02:00
Reproducible quantification of IgG uptake at endogenous and overexpressed FcRn levels at pH 7.4: Comparison of a wild type IgG and a stronger FcRn binding variant. J Immunol Methods. 2020 Feb 28;:112767 Authors: Zhang J, Vernes JM, Wen X, Oh E, Scales SJ, Meng YG Abstract IgG antibodies have been used to treat many diseases including cancer. IgG antibody-drug conjugates (ADCs) deliver cytotoxic drugs to target cells for cell elimination, but they have dose limiting toxicity...
Fri Feb 28, 2020 00:00
Authors: do Vale INPC, Saliba JW, Fonseca GSF, Peruhype-Magalhães V, de Araújo FF, Pascoal-Xavier MA, Teixeira-Carvalho A, Campos FMF, Andrade MC, Lula JF, Reis AB, Lemos EM, de Carvalho SFG, Oliveira E, Martins-Filho OA Abstract The performance of distinct serological tests (rK39-ICT, IFAT, DAT-LPC, FC-Simplex IgG1) was assessed and a laboratorial algorithm was proposed for accurate diagnosis of VL. DAT-LPC and FC-Simplex IgG1 showed outstanding accuracy (AUC = 0.93) to identify VL patients....
Fri Feb 28, 2020 00:00
The current COVID-19 coronavirus outbreak is changing how people are greeting and bidding farewell to each other.
08:50
Conclusions: Microwave ablation for colorectal liver metastases avoids extensive liver resection while ensuring therapeutic efficacy; the operation is safe, feasible, and reproducible. PMID: 32117483 [PubMed] (Source: Videosurgery and Other Miniinvasive Techniques)
Tue Mar 03, 2020 20:09
Conclusions: The "enjoyable space" approach is an option to achieve D2 + CME, and its safety and feasibility over conventional method are confirmed with lower intraoperative blood loss and more harvested LNs. PMID: 32117487 [PubMed] (Source: Videosurgery and Other Miniinvasive Techniques)
Tue Mar 03, 2020 20:09
Conclusions: Transanal total mesorectal excision is a promising yet technically demanding procedure and requires at least 40 cases to complete the learning curve. More data are needed to introduce it as a standard procedure for low rectal cancer treatment. PMID: 32117484 [PubMed] (Source: Videosurgery and Other Miniinvasive Techniques)
Tue Mar 03, 2020 20:09
Conclusions: The combined technique is both feasible and safe. Performing the most difficult maneuver, removal of the prostate, in the first stage appears to be more comfortable for the operator. The timing of the PLND stage in the combined technique and the number of removed LNs do not differ from the standard lenticular access. PMID: 32117504 [PubMed] (Source: Videosurgery and Other Miniinvasive Techniques)
Tue Mar 03, 2020 20:09
Conclusions: Robotic surgery was found to be feasible and safe for obese patients with endometrial cancer. Its widespread application needs a larger sample with longer follow-up. PMID: 32117501 [PubMed] (Source: Videosurgery and Other Miniinvasive Techniques)
Tue Mar 03, 2020 20:09
Publication date: Available online 3 March 2020Source: Revista Española de Medicina Nuclear e Imagen Molecular (English Edition)Author(s): Seval Erhamamcı, Sait Sager, Sertac Asa, Lebriz Uslu, Elife Akgun, Kerim Sonmezoglu (Source: Revista Espanola de Medicina Nuclear e Imagen Molecular)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Tue Mar 03, 2020 20:08
Authors: Liu Z, Frank M, Yu X, Yu H, Tran-Cong NM, Gao Y, Proksch P Abstract Marine-derived fungi play an important role in the search for structurally unique secondary metabolites, some of which show promising pharmacological activities that make them useful leads for drug discovery. Marine natural product research in China in general has made enormous progress in the last two decades as described in this chapter on fungal metabolites. This contribution covers 613 new natural products...
Tue Mar 03, 2020 19:56
Conclusion: No significant correlation was found between the expression of EGFR protein inOSCCs and ESCCs. High expression of EGFR was observed in ESCCs with Stages II, III. (Source: Dental Research Journal)
Tue Mar 03, 2020 09:00
Conclusion: High expression of VEGF and COX ‑2 in malignant tumors compared to PA suggested therole of both markers in malignant transformation. The significant correlation of VEGF expression withCOX ‑2 may represent the role of COX‑2 in tumor angiogenesis by modulating VEGF production. (Source: Dental Research Journal)
Tue Mar 03, 2020 09:00
In the original publication of this manuscript [1], Fig. 2 contains incorrect labels and feedback loops. The revised version of Fig. 2 is shown below. (Source: Journal of Experimental and Clinical Cancer Research)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Tue Mar 03, 2020 01:00
Osteosarcoma is the most common primary malignant bone tumor in children and adolescents and has also been associated with a high degree of malignancy and enhanced metastatic capacity. Curcumin (CUR) is well k... (Source: BMC Complementary and Alternative Medicine)
Tue Mar 03, 2020 01:00
Oncogene, Published online: 03 March 2020; doi:10.1038/s41388-020-1239-yAlterations of T-cell-mediated immunity in acute myeloid leukemia (Source: Oncogene)
Tue Mar 03, 2020 00:00
Authors: Mattei Bouvier-Labit Barets Macagno Chocry Chibon Morando Rochwerger Duffaud Olschwang Salas Jiguet-Jiglaire Soft tissue sarcoma (STS) are rare and aggressive tumours. Their classification includes numerous histological subtypes of frequent poor prognosis. Liposarcomas (LPS) are the most frequent type among them, and the aggressiveness and deep localization of dedifferentiated LPS are linked to high levels of recurrence. Current treatments...
Tue Mar 03, 2020 00:00
AbstractIntravascular papillary endothelial hyperplasia (IPEH) or Masson ’s tumour is a rare benign lesion of vascular origin commonly found on the head, neck, and upper extremities. Excessive proliferation of endothelial cells in vascular malformations or normal blood vessels is considered to be the aetiology and is generally a non-neoplastic reactive process. Typical ly, IPEHs cause no symptoms and present as slowly growing soft-tissue masses. Plastic surgeon should be aware of this rare entity,...
Tue Mar 03, 2020 00:00
This study highlights the importance of PI3K/Akt in ovarian tumor progression and chemoresistance and the potential application of AZD compounds, especially AZD8835 and AZD5363, as therapeutic agents for the treatment of ovarian cancer. (Source: Frontiers in Pharmacology)
Tue Mar 03, 2020 00:00
ConclusionThere is an urgent need to improve RUM through improved educational and other activities among European countries, with countries learning from each other. This will involve addressing current challenges and we will be following this up. (Source: Frontiers in Pharmacology)
Tue Mar 03, 2020 00:00
Cancer drugs for solid tumors approved by the EMA since 2014: an overview of pivotal clinical trials
ConclusionsThe rule of 2 well-controlled trials was complied with in just over 50% of the authorized drugs, and even when there was only 1 pivotal trial supporting the authorization, the trial itself may not have been necessarily well-controlled; the authorization was revoked for a drug because the trial did not confirm the benefits expected from confirmatory trials; while for 2 drugs, the evidence of efficacy yielded by the trials was not considered exhaustive. Considering that sometimes clinical...
Tue Mar 03, 2020 00:00
Conclusions Our study suggest that the severity of pneumonitis after durvalumab is unrelated to V20 or any of the clinical factors assessed in this study. (Source: Investigational New Drugs)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Tue Mar 03, 2020 00:00
AbstractPurpose of ReviewThis review aims to understand how Australia compares internationally in the practice of teledermatology for the diagnosis and management of skin cancer, and in the process, ascertain the robustness of the evidence for teledermatology, as well as identify its limitations and current difficulties for its adoption in Australia.Recent FindingsDiagnostic and treatment concordance, time to detection and action, as well as expected cost in Australia were comparable with international...
Tue Mar 03, 2020 00:00
AbstractPurpose of ReviewCancer treatment –related cardiotoxicity (CTRC) represents a significant cause of morbidity and mortality worldwide. The purpose of our review is to summarize the epidemiology, natural history, and pathophysiology of cardiotoxicity-related to cancer treatment. We also summarize appropriate screening, surveillance, and management of CTRC. While cardiotoxicity is characteristically associated with anthracyclines, HER2-B antagonists, and radiation therapy (XRT), there is growing...
Tue Mar 03, 2020 00:00
In this study we thoroughly investigated the impact of different temperatures (37–42 °C), and the sequence of and time interval (0 up to 4 h) between ionizing radiation and hyperthermia on HPV16+: SiHa, Caski; HPV18+: HeLa, C4I; and HPV−: C33A, HT3 cervical cancer cell lines. Our results demonstrate that a short time interval between treatments caused more unrepaired DNA damages and more cell kill, especially at higher temperatures. Although hyperthermia before ionizing radiation may result in slightly...
Tue Mar 03, 2020 00:00
In conclusion, the MCT1-dependent import of lactate supplies “reverse Warburg “PDAC cells with an efficient driver of metabostemness. This condition may essentially contribute to malignant traits including therapy resistance. (Source: Cancers)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Tue Mar 03, 2020 00:00
CONCLUSIONS: Spinal metastases from GI primary cancers have high rates of LF with SRS at a lower dose. This study found that SRS dose is a significant predictor of failure and that prescribed SFED ≥ 20 Gy10 (biological equivalent dose ≥ 60 Gy10) is associated with superior local control. PMID: 32114530 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery.Spine)
Tue Mar 03, 2020 18:54
Publication date: Available online 2 March 2020Source: The Annals of Thoracic SurgeryAuthor(s): Mouhammad Kanj, Roula Moucadie, Moussa Abi Ghanem, Ziad Mansour (Source: The Annals of Thoracic Surgery)
Tue Mar 03, 2020 17:38
Publication date: Available online 2 March 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchAuthor(s): Faisal Thayyullathil, Anees Rahman Cheratta, Siraj Pallichankandy, Karthikeyan Subburayan, Saeed Tariq, Vivek M. Rangnekar, Sehamuddin Galadari (Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research)
Tue Mar 03, 2020 14:36
Publication date: Available online 2 March 2020Source: Saudi Journal of Biological SciencesAuthor(s): Sawsan Babiker, Omaima Nasir, Alaa Marzogi, Mohammad Bogari, Tahani Alghamdi (Source: Saudi Journal of Biological Sciences)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Tue Mar 03, 2020 14:03
Publication date: Available online 3 March 2020Source: Life SciencesAuthor(s): Elahe Tahmasebi, Milad Alikhani, Alireza Yazdanian, Mohsen Yazdanian, Hamid Tebyanian, Alexander Seifalian (Source: Life Sciences)
Tue Mar 03, 2020 14:02
Authors: Scerrati A, Mongardi L, Visani J, Lofrese G, Cavallo MA, Fiorentino A, De Bonis P Abstract Introduction: Meningiomas represent the most common primary intracranial tumors. Today, surgical resection, followed by radiotherapy when indicated, is still the treatment of choice. In recent years, distinct oncogenic pathways have been identified, laying the foundations of new personalized targeted therapies.Areas covered: The aim of this study was to highlight the effects, complications,...
Tue Mar 03, 2020 14:01
Authors: Jakola AS, Sagberg LM, Gulati S, Solheim O Abstract Introduction: Diffuse glioma is a challenging neurosurgical entity. Although surgery does not provide a cure, it may greatly influence survival, brain function, and quality of life. Surgical treatment is by nature highly personalized and outcome prediction is very complex. To engage and succeed in this balancing act it is important to make best use of the information available to the neurosurgeon.Areas covered: This narrative...
Tue Mar 03, 2020 14:01
CONCLUSIONS: This meta-analysis demonstrated that fan therapy may be an effective intervention for dyspnea at rest in patients with terminal cancer. PMID: 32114788 [PubMed - in process] (Source: The American Journal of Hospice and Palliative Care)
Tue Mar 03, 2020 13:32
Exploring the 'cold/hot' properties of traditional Chinese medicine by cell temperature measurement.
Discussion and conclusions: The changes in cellular temperature are speculated to be caused by the alteration of intracellular calcium influx mediated by TRPV4. In addition, the 'cold/hot' properties of compounds in TCM can be classified by using cellular temperature detection. PMID: 32114881 [PubMed - in process] (Source: Pharmaceutical Biology)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in...
Tue Mar 03, 2020 13:25
Authors: Zakeri-Milani P, Shirani A, Nokhodchi A, Mussa Farkhani S, Mohammadi S, Shahbazi Mojarrad J, Mahmoudian M, Gholikhani T, Farshbaf M, Valizadeh H Abstract The low cellular uptake of Methotrexate (MTX), a commonly used anticancer drug, is a big challenge for efficient cancer therapy. Self-assembled peptide nanoparticles (SAPNs) are one of the major classes of peptide vectors that have gained much of attention towards novel drug delivery systems. In the present study, different sequences...
Tue Mar 03, 2020 13:23
Authors: Hradska K, Kascak M, Hajek R, Jelinek T Abstract Introduction: One of the hallmarks of cancerogenesis is the ability of tumor cells to evade the immune system. They can achieve it by abusing inhibitory immune checkpoint pathways, which, under normal circumstances, maintain peripheral tolerance during infection. Immune checkpoint inhibitors, especially anti-PD-1/PD-L1 monoclonal antibodies, currently represent a widely discussed treatment option not only in solid oncology, but in...
Tue Mar 03, 2020 13:19
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