Τρίτη 3 Μαρτίου 2020


Giving radiologists a voice: a review of podcasts in radiology
Abstract Objectives Podcasts are audio recordings distributed via the Internet. We review the availability of podcasts on the topic of radiology. Methods A search for podcasts relating to radiology was performed using search engines and free public websites that either hosted or distributed podcasts. Only English language podcast series were...
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Assessment of early damage of endometrium after artificial abortion by shear wave elastography
Abstract Objectives This study aimed to investigate the application of shear wave elastography (SWE) in the early damage detection through assessing the endometrial elasticity after artificial abortion. Methods A total of nulliparous women (20–30 years) who received ultrasonography in our hospital were recruited between January 2017 and December...
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Spectacular rediscovery of the original prints of radiographs Roentgen sent to Lorentz in 1896
Abstract Background Ninety years after the Dutch theoretical physicist H.A. Lorentz died, detailed investigation of his scientific heritage yielded the set of nine original prints of radiographs that W.C. Roentgen made during his experiments and had sent him, among half a dozen other scientists, on January 1st, 1896. Main text Through communications...
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Tue Mar 03, 2020 02:00
Implementation of the Clinically Oriented Reasoning Evaluation: Impact on the European Diploma in Radiology (EDiR) exam
Abstract The aim of the study is to perform an analysis of the results that have been compiled in the nine years that the examination has existed.
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Tue Mar 03, 2020 02:00
ASO Author Reflections: Minimally Invasive Surgery for Gastric Cancer—Has the Future Arrived?
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Tue Mar 03, 2020 02:00
Clinical and radiation dose-volume factors related to pneumonitis after treatment with radiation and durvalumab in locally advanced non-small cell lung cancer
Summary Introduction Durvalumab has been shown to confer a survival benefit after definitive chemoradiotherapy in the patients with locally advanced non-small cell lung cancer, but no studies have attempted to identify risk factors for pneumonitis after durvalumab therapy. The purpose of this study was to investigate associations between clinical and radiation dose-volume factors, and the severity of pneumonitis. Methods We retrospectively assessed the cases of 30 patients who...
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Tue Mar 03, 2020 02:00
Phase 1 study of the protein deubiquitinase inhibitor VLX1570 in patients with relapsed and/or refractory multiple myeloma
Summary This phase 1 study sought to characterize the safety, tolerability, and pharmacokinetic behavior of VLX1570, a small molecule inhibitor of the deubiquitinases (DUBs) that remove sterically bulky ubiquitin chains from proteins during processing in the19S regulatory subunit of the proteasome, in patients with relapsed and refractory multiple myeloma (MM). Fourteen patients were treated with escalating doses of VLX1570 ranging from 0.05 to 1.2 mg/kg as a brief intravenous...
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Tue Mar 03, 2020 02:00
Bioreduction of Cr(VI) by Indigenously Isolated Bacterial Strains from Stream Sediment Contaminated with Tannery Waste
Abstract The potential of indigenously isolated bacteria from the Estância Velha stream to reduce Cr(VI) was evaluated and also the chromium contamination over the past ten years was verified in one of the most important industrial centers of Brazil, the “Brazilian Capital of Tanneries,” Estância Velha municipality in the Rio Grande do Sul State, South Brazil. Samples were collected from the Estância Velha stream at the source (P1), as well as at upstream (P2) and downstream (P3)...
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Tue Mar 03, 2020 02:00
Purification and Biochemical Characterization of Alkalophilic Cellulase from the Symbiotic Bacillus subtilis BC1 of the Leopard Moth, Zeuzera pyrina (L.) (Lepidoptera: Cossidae)
Abstract In the current study, an extracellular cellulase belonging to symbiotic Bacillus subtilis Bc1 of the leopard moth is purified and characterized. The molecular mass of enzyme was 47.8 kDa using SDS-PAGE. The purified enzyme had optimum activity in temperature and pH around 60 °C and 8, respectively. The purified cellulase was introduced as a stable enzyme in a wide variety of temperature (20–80 °C) and pH (4–10) and remained active to more than 74% at 80 °C for 1 h. Moreover,...
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Tue Mar 03, 2020 02:00
Antioxidative and Radioprotective Properties of Glycosylated Flavonoid, Xanthorhamnin from Radio-Resistant Bacterium Bacillus indicus Strain TMC-6
Abstract A radio-resistant bacterium labeled as strain TMC-6 was isolated from Thal desert, Pakistan and identified through 16S rRNA gene sequencing as Bacillus indicus strain TMC-6 (MN721293). The isolate was found to be resistant to UV radiation dose of 6.780 × 103 J/m2 and showed 50% survivability to mitomycin C (6 μg/ml) and H2O2 (30 mM). The bacterium showed yellowish orange coloration when grown on tryptone yeast glucose (TGY) medium. The cellular metabolite was extracted...
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Tue Mar 03, 2020 02:00
Abdominal wall sonography: a pictorial review
Abstract The anterior abdominal wall, which is composed of three layers (skin and adipose tissues; the myofascial layer; and the deep layer, consisting of the transversalis fascia, preperitoneal fat, and the parietal peritoneum), has many functions: containment, support and protection for the intraperitoneal contents, and involvement in movement and breathing. While hernias are often encountered and well reviewed in the literature, the other abdominal wall pathologies are less...
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Tue Mar 03, 2020 02:00
DCEP and bendamustine/prednisone as salvage therapy for quad- and penta-refractory multiple myeloma
Abstract Multiple myeloma (MM) almost invariably progresses through novel therapies. Patients with quad-refractory MM (refractory to bortezomib, carfilzomib, lenalidomide, and pomalidomide) and penta-refractory MM (additional refractoriness to daratumumab) have few treatment options. Two chemotherapy regimens, bendamustine/prednisone (BP) and dexamethasone, cyclophosphamide, etoposide, and cisplatin (DCEP), are often used in quad- and penta-refractory MM, but there are limited...
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Histological and magnified endoscopic evaluation of villous atrophy in gastrointestinal graft-versus-host disease
Abstract Aim: To measure histological villous atrophy and to clarify the diagnostic accuracy of endoscopic villous atrophy in gastrointestinal graft-versus-host disease. Methods: Data for patients who underwent upper and/or lower endoscopic examinations after hematopoietic stem cell transplantation were retrospectively collected. In study 1, group A included 56 patients in whom GI-GVHD was histologically confirmed and group B included 60 patients in whom GI-GVHD was not histologically...
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ALK detection in lung cancer: identification of atypical and cryptic ALK rearrangements using an optimal algorithm
Abstract Purpose IHC, FISH, and NGS are common methods of ALK evaluation in NSCLC. The purpose of this study was to investigate whether ALK false positives or false negatives occurred more often in daily routines. An approach to identify ALK fusion was then proposed. Materials and methods We analyzed 1815 cases of NSCLC, including 83 (4.6%) ALK IHC positives....
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Tue Mar 03, 2020 02:00
Study on industrial selection of counterpart cooperation between Jilin province and Zhejiang province in China from the perspective of low carbon
Abstract Counterpart cooperation is a major innovative measure in China’s strategy for revitalizing north-eastern China. While promoting economic progress, regional counterpart cooperation should also focus on low-carbon economy and sustainable development. Under the background of China’s proposed innovative cooperation strategy, using a multi-regional input-output (MRIO) model and structural decomposition analysis (SDA), this study takes Jilin province and its counterpart Zhejiang...
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Leakage of CO 2 from geological storage and its impacts on fresh soil–water systems: a review
Abstract Leakage of CO2 from the geological storage is a serious issue for the sustainability of the receiving fresh soil–water systems. Subsurface water quality issues are no longer related to one type of pollution in many regions around the globe. Thus, an effort has been made to review studies performed to investigate supercritical CO2 (scCO2) and CO2 enrich brine migration and it's leakage from geological storage formations. Further, the study also reviewed it's impacts on...
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Tue Mar 03, 2020 02:00
Role of phosphate concentration in control for phosphate removal and recovery by layered double hydroxides
Abstract Phosphorus removal from wastewater has become urgent because of eutrophication control. Phosphate concentration in control for phosphate removal and recovery by Mg–Fe oxide has been investigated. The results show that the adsorption capacity of phosphate by Mg–Fe oxide calcined at 450 °C was 28.3 mg/g, and it was kept at wide optimal adsorption pH ranges (4–10). The coexisting ions had influenced phosphate adsorption process and the order is CO32− > SO42− > NO3− > Cl−,...
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Tue Mar 03, 2020 02:00
When male seahorses take the female contraceptive pill ...
Abstract 17α-ethinylestradiol (EE2), the female contraceptive pill, has been detected in mediterranean coasts where seahorse populations, Hippocampus guttulatus, live. Low environmental concentrations have the potential to disrupt growth but also endocrine metabolism, and this imbalance is all the more critical in early life stage. To investigate the impact of EE2 in reared seahorses, we exposed aged 2 months and sexually undifferentiated seahorses to an environmental concentration...
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Tue Mar 03, 2020 02:00
Removal of propranolol hydrochloride by batch biosorption using remaining biomass of alginate extraction from Sargassum filipendula algae
Abstract Propranolol hydrochloride is a popular anti-hypertensive and pollutant of emerging concern because of potential ecological risks to aquatic environment. In this study, biosorption is presented as an advanced approach for propranolol uptake from aqueous media. The remaining biomass of alginate extraction from brown seaweed (RSF) was tested as biosorbent owing to its key binding sites, namely carboxyl and hydroxyl functional groups. The high 93% removal efficiency achieved...
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Tue Mar 03, 2020 02:00
Sub-type source profiles of fine particles for fugitive dust and accumulative health risks of heavy metals: a case study in a fast-developing city of China
Abstract Sub-type source profiles for atmospheric fine particle (PM2.5) were still scare in China, which limited the accurate source identification of it. Fugitive dust (including road dust, soil dust, resuspended dust, and construction dust, etc.) was one type of the most important contributors to PM2.5 and its associated toxic metals held potential threaten to human health. The chemical compositions, sources, and health risks of sub-type fugitive dust deserved an investigation...
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Tue Mar 03, 2020 02:00
Study of spectral characteristics of black carbon from biomass burning and source apportionment over Agartala in the northeastern India
Abstract We have studied the black carbon (BC) mass concentrations, contributions from Fossil Fuels (FF), and Biomass burning (BB) to total BC mass concentrations using a 7-wavelength Aethalometer (Model, AE-31; Make, Magee Scientific, USA) at a rural continental location in the northeastern India. We have taken the continuous measurements of BC from January 2011 to December 2017 (excluding the year 2016 due to nonavailability of data). The annual mean BC concentration at 880 nm...
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Tue Mar 03, 2020 02:00
Microporous intermittent aeration vertical flow constructed wetlands for eutrophic water improvement
Abstract To enhance eutrophic water improvement effect, three parallel lab-scale oxidation pond-vertical subsurface flow constructed wetland-stable pond combined systems with different microporous intermittent aeration positions were constructed. The purification effect of each system was determined, and the contribution rate of each part of the system was also calculated. The characters of bacterial community under different aeration positions were also analyzed. Microporous intermittent...
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Tue Mar 03, 2020 02:00
Study on environmental pollution loss measurement method of waste gas emits in Nanjing MV Industrial Park
Abstract In order to realize the effective measurement of environmental pollution loss (EPL) caused by waste gas emits from energy consumption in industrial parks, it is built a shadow price model of waste gas emits in this study on the basis of literature review and status analysis. The measurement model is applied to Nanjing MV Industrial Park by using relevant statistical data. It is found that the total environmental pollution loss of waste gas emits from energy consumption...
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Tue Mar 03, 2020 02:00
One academic year laboratory and student breathing zone formaldehyde level, measured by gas-piston hand pump at gross anatomy laboratory, Siriraj Hospital, Thailand
Abstract This study used a formaldehyde detector tube with a gas-piston hand pump to assess ceiling levels of student breathing zone and gross laboratory environment across the 2018 academic year. The room dimension was 28.6 × 55.48 × 5.5 m. It contained 90 cadavers, each placed on a hinged cover table. We measured before and during nine body region dissections. There was a significant difference (p < 0.01) between student exposure and laboratory environment levels. The highest...
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Tue Mar 03, 2020 02:00
Radiochemotherapie des Analkarzinoms
Zusammenfassung Hintergrund Das Analkarzinom ist in 70–90 % der Fälle mit einer Infektion durch Hochrisikostämme des humanen Papillomavirus (HPV) assoziiert. In den letzten Jahrzehnten wurde ein Anstieg der Inzidenz beobachtet. Die definitive Radiochemotherapie (RCT) mit 5‑Fluorouracil und Mitomycin C stellt die Standardbehandlung für lokalisierte Erkrankungen dar. Allerdings sprechen etwa 30 % der Patienten mit lokal fortgeschrittenen...
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Tue Mar 03, 2020 02:00
Das proximale Ösophaguskarzinom – eine Domäne der Radiochemotherapie
Zusammenfassung Das proximale, zervikal lokalisierte Ösophaguskarzinom stellt innerhalb der Plattenepithelkarzinome der Speiseröhre eine relativ seltene Untergruppe mit besonders schlechter Prognose dar. Es erfolgte die Auswertung der entsprechenden Literatur. Eine operative Versorgung erfordert regelhaft eine Mitentfernung von Larynx und Hypopharynx und kommt bei hohen perioperativen Komplikationsraten und schlechter resultierender Lebensqualität nur in Ausnahmefällen zum Einsatz....
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Tue Mar 03, 2020 02:00
Clinical evaluation of reconstruction and acquisition time for pediatric 18 F-FDG brain PET using digital PET/CT
Abstract Background 18F-2-fluoro-2-deoxyglucose (FDG) positron emission tomography (PET) plays an important role in the diagnosis, evaluation and treatment of childhood epilepsy. The selection of appropriate acquisition and reconstruction parameters, however, can be challenging with the introduction of advanced hardware and software functionalities. Objective ...
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Tue Mar 03, 2020 02:00
Funktionelle Ergebnisse nach Rekonstruktion des weichen Gaumens bei Patienten mit Oropharynxkarzinom
Zusammenfassung Hintergrund Die operative Therapie von Karzinomen des Oropharynx mir Beteiligung des weichen Gaumens kann Einschränkungen in Bezug auf die Schluck‑, Stimm- und Sprechkompetenz hervorrufen. Die Rekonstruktion der resezierten Strukturen kann dazu beitragen, die Funktionalität posttherapeutisch wiederherzustellen. Ziel der Arbeit Ziel der durchgeführten...
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Tue Mar 03, 2020 02:00
Optimization and Evaluation of the Thermosensitive In Situ and Adhesive Gel for Rectal Delivery of Budesonide
Abstract Budesonide is a glucocorticoid for the treatment of ulcerative colitis (UC). The current study aims to develop a thermosensitive in situ and adhesive gel for rectal delivery of budesonide. HPMC K4M was selected as the adhesive agent based on the adhesive force and the effect on gel performance. The formulation of gel was optimized by using the central composite design-response surface methodology (CCD-RSM); a mathematical model was successfully developed to predict...
Latest Results for AAPS PharmSciTech
Tue Mar 03, 2020 02:00
Simulation of the Pharmacokinetics of Oseltamivir and Its Active Metabolite in Normal Populations and Patients with Hepatic Cirrhosis Using Physiologically Based Pharmacokinetic Modeling
Abstract Oseltamivir is a neuraminidase inhibitor widely used to treat and prevent influenza A and B infections, although its safety and pharmacokinetics have not been evaluated in patients with severe hepatic impairment. A physiologically based pharmacokinetic (PBPK) model of the prodrug oseltamivir and its active metabolite, oseltamivir carboxylate (OC), was established and validated to simulate their disposition in adults and predict the exposure in patients with Child-Pugh...
Latest Results for AAPS PharmSciTech
Tue Mar 03, 2020 02:00

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