| British Journal of Dermatology Early View
Online Version of Record before inclusion in an issue
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Image Correspondence
Image Gallery: Acrodermatitis enteropathica: recurrent flares in adulthood
Version of Record online: 01 August 2019
General Dermatology
Scabies polymerase chain reaction with standardized dry swab sampling: an easy tool for cluster diagnosis of human scabies
Version of Record online: 01 August 2019
What's already known about this topic?
What does this study add?
Respond to this article
- Scabies diagnosis requires expertise.
- Scabies polymerase chain reaction (PCR) is specific but has poor sensitivity.
- Poor sensitivity is the consequence of the low efficiency of sampling methods.
What does this study add?
- This PCR‐based diagnostic method based on nontraumatic standardized skin sampling is not expert‐dependent and is reproducible.
- This diagnostic method may be relevant as a non‐expert sentinel diagnosis tool in large clusters where a scabies outbreak is suspected.
Respond to this article
Critically Appraised Research Paper
Suicidality and risk of suicidality in psoriasis: a critical appraisal of two systematic reviews and meta‐analyses
Version of Record online: 01 August 2019
Clinical Trials
The conventional protocol vs. a protocol including illumination with a fabric‐based biophotonic device (the Phosistos protocol) in photodynamic therapy for actinic keratosis: a randomized, controlled, noninferiority clinical study
Version of Record online: 01 August 2019
What's already known about this topic?
What does this study add?
- Topical photodynamic therapy using methyl aminolaevulinate is effective for treating actinic keratosis.
- In Europe, the conventional protocol involves illumination with a red‐light lamp. Unfortunately, pain is often experienced by patients undergoing this protocol.
- An alternative protocol that uses daylight illumination has recently been shown to be as effective as the conventional protocol while being nearly painless. However, this alternative protocol can be conducted only in suitable weather conditions.
What does this study add?
- The Phosistos protocol is demonstrated to be as effective as the conventional protocol, nearly as painless as the daylight protocols and suitable year round for treatment of actinic keratosis.
Open AccessCommentary
How reliable are scoring systems for hidradenitis suppurativa?
Version of Record online: 28 July 2019
Open AccessTranslational Research
Tumour‐cell‐derived complement components C1r and C1s promote growth of cutaneous squamous cell carcinoma
Version of Record online: 28 July 2019
What's already known about this topic?
What does this study add?
What is the translational message?
- The incidences of actinic keratosis, cutaneous squamous cell carcinoma (cSCC) in situ and invasive cSCC are increasing globally.
- Few specific biomarkers for progression of cSCC have been identified, and no biological markers are in clinical use to predict the aggressiveness of actinic keratosis, cSCC in situ and invasive cSCC.
What does this study add?
- Our results provide novel evidence for the role of complement classical pathway components C1r and C1s in the progression of cSCC.
What is the translational message?
- Our results identify complement classical pathway components C1r and C1s as biomarkers and putative therapeutic targets in cSCC.
Open AccessQualitative and Outcomes Research
‘It's like the bad guy in a movie who just doesn't die’: a qualitative exploration of young people's adaptation to eczema and implications for self‐care
Version of Record online: 28 July 2019
What's already known about this topic?
What does this study add?
What are the clinical implications of this work?
Respond to this article
- There is a common perception that people ‘grow out of’ eczema, but for many people eczema follows a lifelong episodic course.
- Qualitative work has shown that parents can find that being told their child will grow out of eczema is dismissive, and that they have difficulty with messages about ‘control not cure’ of eczema.
- It is unclear how young people perceive their eczema and the implications of this perception for their adaptation and self‐care.
What does this study add?
- The message that many people ‘grow out of’ eczema has a potentially detrimental effect for young people where the condition persists.
- This has implications for young people's perceptions of their eczema, their learning to self‐care and how they adapt to living with eczema and eczema treatments.
What are the clinical implications of this work?
- Clinicians need to promote awareness among young people that eczema is a long‐term episodic condition in order to engage them with effective self‐care.
- Young people transitioning to self‐care need evidence‐based information that is specific and relatable to them.
Respond to this article
Review Articles
Changing our microbiome: probiotics in dermatology
Version of Record online: 28 July 2019
What's already known about this topic?
What does this study add?
- The microbiome plays a role in human health and disease pathogenesis.
- Probiotics can manipulate the host microbiome and may confer health benefits for patients.
- Research to date has already begun to explore the utility of oral and topical probiotics for certain dermatological diseases.
What does this study add?
- This review presents basic science and clinical trial data to support the role of the gut and skin microbiome in dermatology.
- Current data are reviewed on the use of probiotics in the prevention and treatment of skin diseases, including atopic dermatitis, acne vulgaris, psoriasis, seborrhoeic dermatitis, chronic wounds and cutaneous neoplasms.
- Future probiotic interventions are proposed.
Research Letters
Inter‐rater and intrarater agreement and reliability in clinical staging of hidradenitis suppurativa/acne inversa
Version of Record online: 28 July 2019
Research Letters
Periodic worsening, or flare, in hidradenitis suppurativa: the perspective of people with hidradenitis
Version of Record online: 28 July 2019
Open AccessCase Report: Clinical and Diagnostic
Recessive mosaicism in ABCA12 causes blaschkoid congenital ichthyosiform erythroderma
Version of Record online: 28 July 2019
What's already know about this topic?
What does this study add?
- Specific mutations in the ABCA12 lipid transporter are known to cause different phenotypes like harlequin ichthyosis, congenital ichthyosiform erythroderma and lamellar ichthyosis.
- In mosaicism, two or more cell populations that are genetically different arise postzygotically in the developing embryo.
- In the skin, mosaicism can present itself in different patterns of affected skin, often caused by a dominant genetic mutation.
What does this study add?
- We report a unique patient with blaschkoid congenital ichthyosiform erythroderma due to biallelic mutations, one inherited germline missense mutation and the other a postzygotic frameshift mutation in the ABCA12 gene.
- This study describes the diagnostic approach and applied research that can be used if one encounters a similar diagnostic dilemma with manifestations suspected for genetic mosaicism.
- We propose the term ‘recessive mosaicism’ for this kind of mosaic presentation of an autosomal recessive genodermatosis.
Commentary
Genotype–phenotype correlation in inherited hidradenitis suppurativa: one step forward, one step back
Version of Record online: 28 July 2019
Open AccessCommentary
Predicting treatment success with biologics in psoriasis
Version of Record online: 28 July 2019
Commentaries
Cross‐cultural adaptations of health‐related quality of life measures
Version of Record online: 28 July 2019
Review Articles
A narrative review of the definition of ‘flare’ in hidradenitis suppurativa
Version of Record online: 28 July 2019
What's already known about this topic?
What does this study add?
- Hidradenitis suppurativa (HS) is a chronic, relapsing inflammatory skin condition.
- The ability to assess flares is important to people who have HS; however, it is unclear how this is defined.
- HS flare is one of the core outcomes in the core outcome set for HS clinical trials; however, it is unclear how this should be assessed.
What does this study add?
- This literature review reveals the paucity of measurable definitions associated with the use of the term ‘flare’ in the HS literature.
- It also highlights the variation and lack of a validated and reliable measure of HS flare.
General Dermatology
Characteristics associated with significantly worse quality of life in mycosis fungoides/Sézary syndrome from the Prospective Cutaneous Lymphoma International Prognostic Index (PROCLIPI) study
Version of Record online: 28 July 2019
What's already known about this topic?
What does this study add?
- Cross‐sectional studies of mixed populations of known and newly diagnosed patients with mycosis fungoides (MF)/Sézary syndrome (SS) have shown significant impairment in health‐related quality of life (HRQoL).
- Previous studies on assessing gender‐specific differences in HRQoL in MF/SS are conflicting.
- More advanced‐stage disease and pruritus is associated with poorer HRQoL in patients with MF/SS.
What does this study add?
- This is the first prospective study to investigate HRQoL in a homogenous group of newly diagnosed patients with MF/SS.
- In patients newly diagnosed with MF/SS, HRQoL is worse in women and in those with alopecia and confluent erythema.
- MF/SS diagnosis has a multidimensional impact on patient HRQoL, including a large burden of cutaneous symptoms, as well as a negative impact on emotional well‐being.
Surgical Dermatology
Efficacy and clinical significance of omitting blue dye injection during sentinel lymph node biopsy before Mohs micrographic surgery for malignant melanoma of the lower extremities
Version of Record online: 28 July 2019
What's already known about this topic?
What does this study add?
- Sentinel lymph node biopsy (SLNB) is usually performed using a triple technique including lymphoscintigraphy, which involves the injection of a radiolabelled tracer, blue dye injection, and radioisotope detection using a gamma probe.
- Blue dye injection may cause pathological misinterpretation and obscure clinical margins.
What does this study add?
- Omitting the dye does not decrease diagnostic accuracy and is particularly advantageous for Mohs micrographic surgery (MMS) in melanomas with clinically indistinct tumour borders.
- SLNB without blue dye injection is feasible in MMS for melanoma.
Commentary
Are swabs an appropriate way to sample for skin microbiome research?
Version of Record online: 28 July 2019
General Dermatology
Standardization of dermoscopic terminology and basic dermoscopic parameters to evaluate in general dermatology (non‐neoplastic dermatoses): an expert consensus on behalf of the International Dermoscopy Society
Version of Record online: 28 July 2019
What's already known about this topic?
What does this study add?
- Over the last few years, several papers have been published attempting to describe the dermoscopic features of non‐neoplastic dermatoses, yet there is poor consistency in the terminology among different studies.
What does this study add?
- The present expert consensus provides a set of standardized basic dermoscopic parameters to follow when evaluating inflammatory, infiltrative and infectious dermatoses.
- This consensus should enhance the reproducibility and comparability of existing and future research findings and uniformly expand the universal knowledge on dermoscopy in general dermatology.
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