Τετάρτη, 21 Αυγούστου 2019


Plasma metabolites Xanthine, 4-Pyridoxate, and d-glutamic acid as novel potential biomarkers for pulmonary tuberculosis
ConclusionThe results suggested that Xanthine, 4-Pyridoxate, and d-glutamic acid may serve as potential biomarkers for pulmonary TB. The present study provides experimental basis for developing potential biomarkers of pulmonary TB. (Source: Clinica Chimica Acta)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
MedWorm Cancer & Oncology Research
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Ceramide synthases in cancer therapy and chemoresistance
Publication date: Available online 20 August 2019Source: Progress in Lipid ResearchAuthor(s): Sebastian Brachtendorf, Khadija El-Hindi, Sabine GröschAbstractDrug resistance is one major reason for failure of cancer therapy. In the past 10 years, evidence emerged showing that ceramides of specific chain length, generated by six different ceramide synthases (CerS), are deregulated in different cancer types thereby influencing chemosensitivity. In this review we sum up the cellular mechanisms regulated...
MedWorm Cancer & Oncology Research
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SOX18 Affects Cell Viability, Migration, Invasiveness, and Apoptosis in Hepatocellular Carcinoma (HCC) Cells by Participating in Epithelial-to-Mesenchymal Transition (EMT) Progression and Adenosine Monophosphate Activated Protein Kinase (AMPK)/Mammalian Target of Rapamycin (mTOR).
CONCLUSIONS SOX18 downregulation in HCC cells suppressed cell viability and metastasis, induced cell apoptosis and hindered the occurrence and progression of tumor cells by participating in the EMT process and regulating the autophagy signaling pathway AMPK/mTOR. PMID: 31427562 [PubMed - in process] (Source: Medical Science Monitor)
MedWorm Cancer & Oncology Research
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Quercetin facilitates cell death and chemosensitivity through RAGE/PI3K/AKT/mTOR axis in human pancreatic cancer cells
In conclusion, the results demonstrated that the molecular mechanisms of quercetin in regulating apoptosis and autophagy-related pathways and increasing GEM chemosensitivity in pancreatic cancer cells involved inhibition of RAGE expression.Graphical abstractThis diagram illustrated that quercetin treatment effectively attenuated RAGE expression to facilitate autophagy, apoptosis, and GEM chemosensitivity in MIA Paca-2 and MIA Paca-2 GEMR cells. (Source: Journal of Food and Drug Analysis)
MedWorm Cancer & Oncology Research
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Combination of solid-phase extraction with microextraction techniques followed by HPLC for simultaneous determination of 2-methylimidazole and 4-methylimidazole in beverages
Publication date: Available online 19 August 2019Source: Food ChemistryAuthor(s): Chunjian Wu, Li Wang, He Li, Shujuan YuAbstractA sensitive analytical method for the monitoring 2-methylimidazole and 4-methylimidazole (2-MI and 4-MI) is desirable due to their carcinogenic property. Here, we propose a highly sensitive method basing on the combination of solid-phase extraction and dispersive liquid-liquid microextraction techniques followed by high-performance liquid chromatography to simultaneously...
MedWorm Cancer & Oncology Research
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Investigation of hot spot region in XIAP inhibitor binding site by fragment molecular orbital method
Publication date: Available online 21 August 2019Source: Computational and Structural Biotechnology JournalAuthor(s): Hocheol Lim, Xuemei Jin, Jongwan Kim, Sungbo Hwang, Ki Beom Shin, Jiwon Choi, Kyoung Tai NoAbstractX-linked inhibitor of apoptosis protein (XIAP) is an important regulator of cancer cell survival whose BIR3 domain (XIAP-BIR3) recognizes the Smac N-terminal tetrapeptide sequence (AVPI), making it an attractive protein-protein interaction (PPI) target for cancer therapies. We used the...
MedWorm Cancer & Oncology Research
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Phenolic acids: Natural versatile molecules with promising therapeutic applications
Publication date: Available online 20 August 2019Source: Biotechnology ReportsAuthor(s): Naresh Kumar, Nidhi GoelAbstractPlant phenolics are considered to be a vital human dietary component and exhibit a tremendous antioxidant activity as well as other health benefits. Epidemiology evidence indicates that a diet rich in antioxidant fruits and vegetables significantly reduces the risk of many oxidative stress related diseases viz. cancers, diabetes and cardiovascular. The number and position of hydroxyl...
MedWorm Cancer & Oncology Research
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Long noncoding RNA LINC00958 promotes the oral squamous cell carcinoma by sponging miR-185-5p/YWHAZ
Publication date: Available online 20 August 2019Source: Life SciencesAuthor(s): Zongsheng Wang, Xuemei Zhu, Pengfei Dong, Jun CaiAbstractAimIncreasing evidence has indicated the essential roles of long noncoding RNA (lncRNA) in the oral squamous cell carcinoma (OSCC). However, there are still numerous uncertain mechanisms for the pathophysiological process of OSCC. In this work, we tried to identify the biological function and potential mechanism of lncRNA LINC00958 in the OSCC.Main methodsThe expressions...
MedWorm Cancer & Oncology Research
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Bulbine frutescens phytochemical inhibits notch signaling pathway and induces apoptosis in triple negative and luminal breast cancer cells
In conclusion, B. frutescens phytochemicals have cell cycle arrest, ROS production, apoptosis induction, and mitochondria membrane potential disruption efficacy in breast cancer cells. B. frutescens phytochemicals have the ability to downregulate the notch signaling pathway in triple-negative and luminal breast cancer cells. (Source: Life Sciences)
MedWorm Cancer & Oncology Research
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Corrigendum to “Plumbagin induces paraptosis in cancer cells by disrupting the sulfhydryl homeostasis and proteasomal function” [Chem. Biol. Interact. 310 (2019) 108733]
Publication date: Available online 20 August 2019Source: Chemico-Biological InteractionsAuthor(s): Anupama Binoy, Divya Nedungadi, Neeraj Katiyar, Chinchu Bose, Sahadev Shankarappa, Bipin G. Nair, Nandita Mishra (Source: Chemico Biological Interactions)
MedWorm Cancer & Oncology Research
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Tailor-made porous polymer and silica monolithic designs as probe anchoring templates for the solid-state naked eye sensing and preconcentration of hexavalent chromium
We present a facile approach towards the fabrication of solid state optical sensors for the naked-eye sensing of carcinogenic Cr6+ ions, using porous polymer and silica monoliths, as probe anchoring templates. The monoliths proffer superior structural properties of high surface area and capacious pore size for the uniform and voluminous probe anchoring. The surface morphology and structural features of the monoliths are analyzed using various surface and structural characterization techniques. The...
MedWorm Cancer & Oncology Research
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Exposure to high levels of PM2.5 and PM10 in the metropolis of Tehran and the associated health risks during 2016–2017
This study provides the daily, seasonal and annual variations and the related human health risk assessment from exposure to PM2.5 and PM10 in the ambient air of Tehran from January 2016 to December 2017. The hourly PM2.5 and PM10 data of ten selected air quality monitoring stations was acquired from Tehran air quality control center. The results showed that, annual mean concentrations of PM2.5 and PM10 in the selected stations varied from 22.6 to 39.5 μg/m3 and from 62.5 to 104.3 μg/m3, respectively....
MedWorm Cancer & Oncology Research
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Synthesis, photophysics, and photochemistry of ball-type phthalocyanines
In this study, four novel ball-type Pc compounds were synthesized with 1,2-benzenediol as a substituent, including one non-metal complex (H4Pc2) and three metal-containing complexes (Mg2Pc2, Co2Pc2, and Zn2Pc2). The structures of the synthesized compounds were characterized using common spectroscopic methods. Quantum yields for fluorescence (ΦF), triplet state (ΦT), singlet oxygen (ΦΔ), and photodegradation (Φd) were measured except Co2Pc2 in dimethylsulfoxide. All the three compounds exhibited low...
MedWorm Cancer & Oncology Research
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In vitro Assessment of the Cytotoxicity of Gallium(III) Complexes with Isoniazid-Derived Hydrazones: Effects on Clonogenic Survival of HCT-116 Cells
Publication date: Available online 16 August 2019Source: Inorganica Chimica ActaAuthor(s): Gisele dos S.S. Firmino, Stephanie C. André, Zandora Hastenreiter, Vanessa Karen Campos, Mostafa A.L. Abdel-Salam, Elaine M. de Souza-Fagundes, Josane A. LessaAbstractCancer cells have high iron demand to mediate their rapid proliferation. Aiming to obtain cytotoxic compounds with potential iron metabolism disturbance in malignant cells, [Ga(HAPIH)(APIH)](NO3)2⋅2H2O (1) and [Ga(HPAmIH)(PAmIH)](NO3)2⋅2H2O (2)...
MedWorm Cancer & Oncology Research
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Low-dimensional compounds containing bioactive ligands. Part XI: Synthesis, structures, spectra, in vitro anti-tumor and antimicrobial activities of 3d metal complexes with 8-hydroxyquinoline-5-sulfonic acid
Publication date: Available online 9 August 2019Source: Inorganica Chimica ActaAuthor(s): Veronika Kuchárová, Juraj Kuchár, Milan Zaric, Petar Canovic, Nebojsa Arsenijevic, Vladislav Volarevic, Maja Misirkic, Vladimir Trajkovic, Ivana D. Radojević, Ljiljana R. Čomić, Marek Matik, Ivan PotočňákAbstractFive 3d metal [M(H2O)2(SQ)]n complexes, where M is Mn (1), Co (2), Ni (3), Zn (4) and Cu (5), and SQ is the dianion of 8-hydroxyquinoline-5-sulfonic acid have been prepared and characterized by IR spectroscopy...
MedWorm Cancer & Oncology Research
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Capture of Circulating Tumor Cells by Hydrogel-Nanofiber Substrate
Publication date: August 2019Source: Chinese Journal of Analytical Chemistry, Volume 47, Issue 8Author(s): Zhi-Li WANG, Pi DING, Tian GAO, Chang-Chong CHEN, Yi CAO, Na SUN, Ren-Jun PEIAbstractThe method for detection of circulating tumor cells (CTCs) is considered as a promising cancer liquid biopsy technique. However, due to the rarity and heterogeneity, it is still a challenging task to capture CTC with high purity and viability from blood for the following enumeration and molecular analysis. Herein,...
MedWorm Cancer & Oncology Research
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A Novel Genistein Electrochemical Sensor Based on Molecularly Imprinted Polycarbazole/Carboxylated Multiwalled Carbon Nanotubes Nanocomposite
Publication date: August 2019Source: Chinese Journal of Analytical Chemistry, Volume 47, Issue 8Author(s): Li-Ting NIU, Gen-Gen LI, Hai-Feng LI, Fan CUI, Jing ZHANG, Ying HUANG, Kai CHEN, Jian-Fu ZHANG, Wen-Fei LI, Wei-Lu LIUAbstractGenistein is an important isoflavone that has been widely used to prevent blood disease and cancer. In this work, a novel genistein electrochemical sensor was developed based on the composite of molecularly imprinted polymer (MIP) and carboxylated multiwalled carbon nanotubes...
MedWorm Cancer & Oncology Research
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A synergistic cancer immunotherapy nano-system for preventing tumor growth
Publication date: 15 January 2020Source: Chemical Engineering Journal, Volume 380Author(s): Yingying Zhang, Hongbin Chen, Hanjie Wang, Tiange Wang, Huizhuo Pan, Wanying Ji, Jin ChangAbstractImmunotherapy has become a promising therapy in cancer treatment. Both photothermal therapy (PTT) and genotoxic chemotherapy can trigger immune responses. On this subject, a synergistic cancer immunotherapy nano-system was developed for treating primary and distant tumors. This long-time, synergistic therapeutic...
MedWorm Cancer & Oncology Research
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Synthesis, characterization and biological evaluation of cationic organoruthenium(II) fluorene complexes: influence of the nature of the counteranion
In this study, thein vitro antiproliferative activity and thein vivo toxicity of ruthenium arene complexes bearing fluorene bidentate ligands was assessed in human breast cancer cells and on the development of zebrafish embryos, respectively. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Dalton Trans. latest articles)
MedWorm Cancer & Oncology Research
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A quadrupole ion trap mass spectrometer for dry microparticle analysis
Analyst, 2019, Advance Article DOI: 10.1039/C9AN01431D, PaperAbdil Özdemir, Jung-Lee Lin, Mustafa Gülfen, Chun-Jen Hsiao, Chung-Hsuan Chen In this work, we report a new design of a charge detection quadrupole ion trap mass spectrometer (QIT-MS) for the analysis of micro-sized dry inorganic and bioparticles including red blood cells (RBCs) and different sizes of MCF-7 breast cancer cells. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this...
MedWorm Cancer & Oncology Research
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Anesthetic toxic isoflurane and health risk assessment in the operation room in Abadan, Iran during 2018
ConclusionAccording Result this study the average concentration of isoflurane and the health risk assessment in Valiasr and Shahid Beheshti teaching hospital operating room during 2018 because of flaw in the ventilation system was significantly higher than standard. (Source: Clinical Epidemiology and Global Health)
MedWorm Cancer & Oncology Research
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Acinic cell carcinoma of the parotid gland: A diagnostic dilemma on cytology.
We report cytomorphological features of two uncommon variants of acinic cell carcinoma. The first case was an eleven-year-old female with a nodular mass in parotid and the FNA smears demonstrated a lymphoepithelial lesion composed of epithelial tumour cells with features of acinar cells in a lymphoid background. The second case was a 62-year-old male with a large parotid mass. The FNA smears revealed presence of extracellular, acellular amyloid-like material with tumour cells arranged in follicles....
MedWorm Cancer & Oncology Research
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A comparison study of HER2 protein overexpression and its gene status in breast cancer.
CONCLUSION: ISH study should be done in all IHC-equivocal cases (2+) to select patient for targeted therapy. Gene amplification must also be confirmed in IHC-positive cases (3+) to prevent from giving non-effective treatment with possible adverse effects to patient with non-amplified HER2 gene. PMID: 31427548 [PubMed - in process] (Source: Malaysian Journal of Pathology)
MedWorm Cancer & Oncology Research
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Nasopharyngeal undifferentiated carcinoma with sarcomatoid features: Pitfalls in the immunohistochemistry.
We present a case of an undifferentiated subtype of non-keratinizing squamous cell carcinoma (NK-SCC) with sarcomatoid features in the nasopharynx in a 69-year-old man who was difficult to diagnose due to spindle-shaped malignant cells. He was admitted because of a right nasal obstruction and right headache, and imaging revealed a heterogeneously enhanced irregularly shaped mass at the nasopharynx. Histopathologically, the tumour was partially organised, and the tumour cells were epithelioid or spindle-shaped....
MedWorm Cancer & Oncology Research
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Intraductal Carcinoma of Salivary Gland Originating from an Intraparotid Lymph Node: A Case Report.
We present the second case of IDC originating from an intraparotid lymph node (LN) with a more detailed description of the histogenesis, immunohistochemistry (IHC) and updated molecular information. CASE REPORT: An 87-year-old male had a tumour nodule over the left parotid tail for about 20 years. Physical examinations revealed a 4.5 cm soft, non-tender and fixed mass. After the left parotidectomy, pathology confirmed the diagnosis of IDC arising within an intraparotid lymph node. The cystic...
MedWorm Cancer & Oncology Research
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Ulcerated bleeding palisaded encapsulated neuroma of the tongue.
This article describes a case of a 41-year-old male, a chronic smoker with an actively bleeding, ulcerated, solitary, firm lesion on the lateral border of the tongue which had bled thrice before. A differential diagnosis of pyogenic granuloma, haemangioma, fibroma, nerve sheath tumour, salivary gland tumour and malignancy was made and surgically excised. Histopathology of the excised specimen revealed a well-circumscribed lesion with spindle-shaped cells arranged in interlacing fascicles and with...
MedWorm Cancer & Oncology Research
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Extranodal NK/T-cell lymphoma mimicking Crohn's colitis.
We report a case of a 46-year-old Chinese male who presented with six months history of abdominal pain, weight loss and rectal bleeding. Diagnostic colonoscopy revealed multiple aphthous ulcers within the ileo-caecal region and distal transverse colon, separated by normal mucosa, mimicking skip lesions of Crohn's colitis. Computer topography (CT) scan of the abdomen showed multiple circumferential thickenings involving predominantly the right colon. A clinical diagnosis of colonic Crohn's disease...
MedWorm Cancer & Oncology Research
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Screening for microsatellite instability in colorectal carcinoma: Practical utility of immunohistochemistry and PCR with fragment analysis in a diagnostic histopathology setting.
Authors: Cheah PL, Li J, Looi LM, Koh CC, Lau TP, Chang SW, Teoh KH, Mun KS, Nazarina AR Abstract Since 2014, the National Comprehensive Cancer Network (NCCN) has recommended that colorectal carcinoma (CRC) be universally tested for high microsatellite instability (MSI-H) which is present in 15% of such cancers. Fidelity of resultant microsatellites during DNA replication is contingent upon an intact mismatch repair (MMR) system and lack of fidelity can result in tumourigenesis. Prior to...
MedWorm Cancer & Oncology Research
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Androgen receptor expression in triple negative breast carcinoma and its association with the clinicopathological parameters.
CONCLUSION: AR is expressed in about one-third of TNBC and loss of AR immunoexpression does not predict adverse clinical outcomes. Larger cohorts for better characterisation of the role of AR immunoexpression in TNBC are warranted. PMID: 31427547 [PubMed - in process] (Source: Malaysian Journal of Pathology)
MedWorm Cancer & Oncology Research
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Penile strangulation intentionally using a rubber band to prevent the development of penile cancer
Publication date: Available online 20 August 2019Source: Urology Case ReportsAuthor(s): Takahiro Yoshida, Daisuke Watanabe, Tadaaki Minowa, Akemi Yamashita, Kunihisa Miura, Akio MizushimaAbstractPenile strangulation is a disease which causes circulatory failure in the distal part of the penis by the penis strangulated by foreign substances, and it is a rare emergency disease in urology. Most of the motives are for pranks, sexual intercourses and treatments of incontinence. We herein report the clinical...
MedWorm Cancer & Oncology Research
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Re: Jonas Hugosson, Monique J. Roobol, Marianne Månsson, et al. A 16-yr Follow-up of the European Randomized Study of Screening for Prostate Cancer. Eur Urol 2019;76:43–51: Mortality in the Age Group ≥70 yr and the Case of Italy
Publication date: Available online 20 August 2019Source: European UrologyAuthor(s): Alberto Donzelli, Gianluca Castelluzzo, Giulia Giudicatti (Source: European Urology)
MedWorm Cancer & Oncology Research
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European Association of Urology Guidelines on Non-muscle-invasive Bladder Cancer (TaT1 and Carcinoma In Situ) - 2019 Update
ConclusionsThese abridged EAU guidelines present updated information on the diagnosis and treatment of NMIBC for incorporation into clinical practice.Patient summaryThe European Association of Urology Non–muscle-invasive Bladder Cancer (NMIBC) Panel has released an updated version of their guidelines, which contains information on classification, risk factors, diagnosis, prognostic factors, and treatment of NMIBC. The recommendations are based on the current literature (until the end of 2018), with...
MedWorm Cancer & Oncology Research
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Reply to Gregory J. Nason, Michael A.S. Jewett, and Robert J. Hamilton’s Letter to the Editor re: Adam C. Calaway, Lawrence H. Einhorn, Timothy A. Masterson, Richard S. Foster, Clint Cary. Adverse Surgical Outcomes Associated with Robotic Retroperitoneal Lymph Node Dissection Among Patients with Testicular Cancer. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2019.05.031: Adverse Surgical Outcomes Associated with Robotic Retroperitoneal Lymph Node Dissection Among Patients with Testicular Cancer
Publication date: Available online 20 August 2019Source: European UrologyAuthor(s): Adam C. Calaway, Lawrence H. Einhorn, Timothy A. Masterson, Richard S. Foster, Clint Cary (Source: European Urology)
MedWorm Cancer & Oncology Research
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Docetaxel Versus Surveillance After Radical Radiotherapy for Intermediate- or High-risk Prostate Cancer—Results from the Prospective, Randomised, Open-label Phase III SPCG-13 Trial
ConclusionsAdjuvant docetaxel without prednisone did not improve BDFS after radical RT with ADT for intermediate- or high-risk PCa.Patient summaryWe compared six cycles of adjuvant docetaxel given after radical external radiotherapy plus androgen deprivation therapy to surveillance in intermediate- and high-risk localised prostate cancer. We found no overall benefit in this setting. (Source: European Urology)
MedWorm Cancer & Oncology Research
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The Case | An 82-year-old male with worsening kidney function
An 82-year-old male, with a history of bowel cancer with partial colectomy, gastroesophageal reflux disease, remote partial gastrectomy for peptic ulcer disease, and no documented prior kidney disease, presents with several months of fatigue and subacute decline in kidney function. He had no history of diabetes, hypertension, kidney stones, or prior urinary tract infections. He denied use of nonsteroidal anti-inflammatory agents, herbal medications, and recent antibiotics. There was no family history...
MedWorm Cancer & Oncology Research
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"Oncol Lett"[ta]; +133 new citations
133 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Oncol Lett"[ta] These pubmed results were generated on 2019/08/21PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: Oncology Letters)
MedWorm Cancer & Oncology Research
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Renal cancer
Publication date: Available online 21 August 2019Source: Surgery (Oxford)Author(s): Gideon Blecher, Kara McDermott, Benjamin ChallacombeAbstractRenal carcinoma is a reasonably common cancer in the UK. Fortunately, its diagnosis is nowadays much earlier due to the increased utilization of radiological imaging. While surveillance is an option, particularly in older/comorbid patients, nephron-sparing surgery remains the gold standard treatment for small renal masses. Laparoscopic, robotic or open partial...
MedWorm Cancer & Oncology Research
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Finding carcinoid tumor before bariatric surgery. Is preoperative endoscopy necessary? Case report
DISCUSSIONThe routine use of upper GI endoscopy in preoperative evaluation of bariatric surgery patients still remains controversialCONCLUSİONUpper GI endoscopy is very important in determining various gastric pathologies and determining the most appropriate surgical method before bariatric surgery. (Source: International Journal of Surgery Case Reports)
MedWorm Cancer & Oncology Research
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Long-term survival with stable disease after multidisciplinary treatment for synchronous liver metastases from gastric cancer: a case report
ConclusionWe report a rare case of patient with synchronous liver metastases from gastric cancer who experienced stable disease for 7 years and 3 months following multidisciplinary modalities. Future trials are required to prospectively investigate the established regimen of multidisciplinary treatment. (Source: International Journal of Surgery Case Reports)
MedWorm Cancer & Oncology Research
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