ConclusionWe report a rare case of patient with synchronous liver metastases from gastric cancer who experienced stable disease for 7 years and 3 months following multidisciplinary modalities. Future trials are required to prospectively investigate the established regimen of multidisciplinary treatment. (Source: International Journal of Surgery Case Reports)
5h
CONCLUSIONUsing 3D-MDCT, we could accurately divide A4 + 5 and safely perform the surgery. (Source: International Journal of Surgery Case Reports)
5h
DiscussionUp to now, only 105 cases of occurring renal SFT have been reported. SFTs are usually asymptomatic when they have a small size, that’s why the diagnosis is often delayed. Blood tests do not have any diagnostic value. Imaging features are not specific for the diagnosis of SFT which are diagnosed as renal cell carcinoma and treated as such. Typical immunohistochemical characteristic is a high positivity for CD34. As SFT has a malignant potential, careful follow-up is mandatory,searching for...
5h
ConclusionIn conclusion we report three rare cases of mediastinal malignant triton tumor treated with radical surgical resection and post-operative radiotherapy, one patient developed lung metastasis, and two had late local recurrence. The malignant triton tumor is a lethal neoplasm which carries very poor prognosis particularly when they occur in the mediastinum because it’s very difficult to obtain wider tumor free margin due to the nature of location site (Source: International Journal of Surgery...
5h
ConclusionAppendiceal mucinous neoplasm should be considered as a differential diagnosis of pelvic mass in women. For patients who do not require fertility-sparing surgery, excision and frozen section of the bilateral ovaries and appendix regardless of the appearance of the appendix might improve the diagnosis. For older patients with peritoneal dissemination, appropriate cytoreductive surgery is recommended to reduce the clinical impact of misdiagnosis. (Source: European Journal of Surgical Oncology...
5h
Publication date: Available online 20 August 2019Source: European Journal of Surgical OncologyAuthor(s): Ashok R. Shaha, R. Michael Tuttle (Source: European Journal of Surgical Oncology (EJSO))
5h
CONCLUSIONS: Patients undergoing surgery for PCL have high rates of margin positivity and high short-term mortality. Chemotherapy improves survival, but <50% receive it. These data suggest the opportunity for improvement of care in patients with PCL. PMID: 31187517 [PubMed - indexed for MEDLINE] (Source: Ann Oncol)
7h
ConclusionThe shrinkage pattern of HER2-positive tumors after targeted therapy may be associated with pCR. There was no association between IER and pCR. Future studies evaluating the correlation of shrinkage patterns to texture radiomics are of interest. (Source: Academic Radiology)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
7h
Authors: Rutledge BP, Desai P, Liu S, Luo J, Nassir R, Lihong Q, Arun M, Abdel-Rasoul M, Simon MS Abstract The anticarcinogenic effect of statins may reduce the metastatic potential of cancer cells leading to 'stage migration', with users more likely diagnosed with early rather than late stage cancer. The association between prior statin use and colorectal cancer (CRC) stage at diagnosis in the Women's Health Initiative (WHI) was investigated. The study population included 132,322 post-menopausal...
7h
Publication date: Available online 20 August 2019Source: The Journal of Molecular DiagnosticsAuthor(s): Amy Oreskovic, Norman D. Brault, Nuttada Panpradist, James J. Lai, Barry R. LutzUrine cell-free DNA (cfDNA) is a valuable noninvasive biomarker for detecting cancer mutation, diagnosing infectious disease (eg, tuberculosis), monitoring organ transplantation, and prenatal screening. Conventional silica DNA extraction does not efficiently capture urine cfDNA, which is dilute (ng/mL) and highly fragmented...
7h
We describe our evaluation, validation, and implementation of this system for routine testing of BRAF, EGFR, KRAS, and NRAS using formalin-fixed, paraffin-embedded cancer samples. All four Idylla test systems showed excellent concordance with reference methods. The analytical sensitivity ranged from 94.66% to 100%, depending on the cartridge, and specificity was 100%. A few discordant results were noted and further investigated: KRAS Q61L was misclassified as Q61H; KRAS Q61R was not identified; there...
7h
Publication date: Available online 20 August 2019Source: Pathology - Research and PracticeAuthor(s): Chengyan Wang, Xiaoling Zhou, Luping Ma, Yanhua Zhuang, Yuanfeng Wei, Lu Zhang, Shan Jin, Weihua Liang, Xihua Shen, Changtao Li, Yinghong Wang, Lijuan PangAbstractGalectin-3 has an important function in the development of tumors. The purpose of this meta-analysis was to explore the relationships between the expression of galectin-3 on clinicopathological features and prognosis of colorectal cancer...
7h
This study assessed the inter-observer agreement of histological grading in a series of ILBC and LN.54 cases (36x ILBC, 18x LN) were evaluated by 17 observers. 3978 classification calls on various histological features, including nuclear grade, proliferative activity (Ki67 immunohistochemistry, categorical scoring), histological grade and pleomorphism were obtained. Pairwise Cohen’s kappa values were calculated and compared between various features and different observer subsets with variable histomorphological...
7h
Abstract: Studies on the genomic aberrations in melanocytic neoplasms have shown a complex genomic landscape. In nevi and melanomas, a MAP-kinase pathway activation was generally found, produced by different chromosomal aberrations, including BRAF, NRAS, HRAS, GNAQ, GNA11, BAP1, CTNNB1, MAP2K1, PRKAR1A, and NF1 mutations, and ALK, ROS1, NTRK1, RET, MET, BRAF, NTRK3, and PRKCA fusions. Melanomas also showed a variable number of additional mutations ablating tumor-suppression mechanisms and activating...
7h
No abstract available (Source: The American Journal of Dermatopathology)
7h
Abstract: Synovial sarcoma (SS) is a high-grade soft-tissue sarcoma occurring predominantly in older children and young adults. Only approximately 7% occur in the head and neck region, with SS representing less than 0.1% of all head and neck cancers. Orbital location is exceedingly rare with only 8 cases reported so far in the literature. It is noted for its propensity for late local recurrences and metastases. Histologically, SS is monophasic, biphasic, or poorly differentiated and harbors a specific...
7h
No abstract available (Source: The American Journal of Dermatopathology)
7h
No abstract available (Source: The American Journal of Dermatopathology)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
7h
We present the first case of this phenomenon in a man. A gray-haired, 80-year-old man presented to dermatology clinic with a 3-cm lock of black hair on his vertex scalp that developed over 1 year. Punch biopsies showed an increase in junctional dendritic melanocytes with rare pagetoid cells and extension along the follicular outer root sheath epithelium and interfollicular epidermis, associated with prominent dendritic melanocytic hyperplasia and pigment-containing melanocytes within the hair bulbs....
7h
Authors: Löser C, Rütten A, Dippel E Abstract Cylindromas are rare tumors of adnexal structures in adults. They are predominantly found on the scalp and face. More impressive than incidentally diagnosed solitary cylindromas are multiple tumors in patients with familial Brooke-Spiegler syndrome. If many large cylindromas appear on the head, they are termed turban tumor. Sudden growth or ulceration should raise suspicion for malignant transformation. PMID: 31428801 [PubMed - as supplied...
7h
We report the case of 78-year-old woman suffering from SCIS of the left cheek, presenting as an erythematous skin lesion. The histological examination revealed intraepidermal and intraadnexal population of atypical cells with foamy cytoplasm and with immunohistochemical adipophilin-, cytokeratin-7- and EMA-positivity in the tumor cells. PMID: 31420711 [PubMed - as supplied by publisher] (Source: Der Hautarzt: Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete)
7h
In this study, we investigated the expression of different systemic and mucosal T-cell subsets during the course of azoxymethane (AOM)/dextran sulphate sodium (DSS)-induced colitis and colitis-associated CRC. In addition, we examined the expression of PD-1 and its ligands PD-L1 and PD-L2 as well as other molecular targets related to T-cell exhaustion. We found a significant increase in PD-1 expression on all examined mucosal T-cell subsets of the colon and the ileum, which correlated with disease...
7h
In this study, we used large-scale electronic health records data from multiple linked UK databases to address these evidence gaps.MethodsFor this population-based cohort study, we used linked primary care, hospital, and cancer registry data from the UK Clinical Practice Research Datalink to identify cohorts of survivors of the 20 most common cancers who were 18 years or older and alive 12 months after diagnosis and controls without history of cancer, matched for age, sex, and general practice. We...
10h
Publication date: Available online 20 August 2019Source: The LancetAuthor(s): Anne H Blaes, Chetan Shenoy (Source: The Lancet)
10h
Publication date: Available online 20 August 2019Source: Journal of the Formosan Medical AssociationAuthor(s): Dong-Yi Chen, Wen-Kuan Huang, Victor Chien-Chia Wu, Wen-Cheng Chang, Jen-Shi Chen, Cheng-Keng Chuang, Pao-Hsien ChuImmune checkpoint inhibitors (ICIs) are a novel treatment option for cancer therapy, which help direct the immune system to recognize and target cancer cells. ICIs have been shown to provide significant mortality benefits for cancer patients, but they are also associated with...
10h
Authors: Tsoukalas N, Mosa E, Tsapakidis K, Kamposioras K, Tolia M PMID: 31423856 [PubMed - as supplied by publisher] (Source: Journal of Investigative Surgery)
10h
Conclusion: Uncovered and covered stent insertion are both safe means of effectively treating patients with malignant SVCO, but covered stents achieve better patency for long-term periods than uncovered stents. PMID: 31430213 [PubMed - as supplied by publisher] (Source: Minimally Invasive Therapy and Allied Technologies)
10h
CONCLUSION The incidence of MDD increased in the period immediately after thyroidectomy and remained high for 1-2 years. This study highlights the importance of relatively long-term regular psychiatric assessments in patients who undergo partial or total thyroidectomy. PMID: 31422760 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
11h
Publication date: Available online 20 August 2019Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Yu Fan, Xuyu Gu, Zhenjun Gao (Source: Clinics and Research in Hepatology and Gastroenterology)
11h
Authors: Jayakumar A, Bothwell ALM Abstract Myeloid-derived suppressor cells (MDSCs) are immature suppressive cells found in tumors and immunological niches. In this article, we highlight the ability of MDSCs to promote IL-17-producing T cells (Th17) and regulatory T cells in addition to suppressing cytotoxic T cells in different tumor models. These interactions between MDSCs and T cells support tumor growth because IL-17 is tumorigenic in many cancer types and regulatory T cells suppress...
11h
(Source: Digestive Diseases and Sciences)
11h
ConclusionsSDC exhibits some specific CT features, and multiphase CECT imaging is useful in the differential diagnosis of salivary gland malignancies. (Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology)
11h
ConclusionBased on the results of the meta-analysis, MRI may be the first choice for the differential diagnosis of benign and malignant salivary gland tumors for its relatively high diagnostic value. PET/CT tends to have greater accuracy than CT. Ultrasonography and RTE may help achieve better diagnostic outcomes if they are used in conjunction. (Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology)
11h
ConclusionsCOX-1, COX-2, and CD147 appear to be independently regulated in OSCC, potentially representing 2 therapeutic targets for future investigation. COX-1 expression in OSCC deserves further study because it may be an important determinant of PGE2 secretion from OSCC cells. (Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology)
11h
Publication date: September 2019Source: Trends in Endocrinology & Metabolism, Volume 30, Issue 9Author(s): Zhiyong ChengAutophagy controls cellular remodeling and quality control. Dysregulated autophagy has been implicated in several human diseases including obesity, diabetes, cardiovascular disease, neurodegenerative diseases, and cancer. Current evidence has revealed that FoxO (forkhead box class O) transcription factors have a multifaceted role in autophagy regulation and dysregulation. Nuclear...
11h
ConclusionsThis work provides novel insights into the mechanistic underpinnings of metformin's therapeutic benefits and potential as an agent to reduce the lipotoxicity associated with hypermetabolism and adipose browning.Graphical abstract (Source: Molecular Metabolism)
11h
Publication date: Available online 20 August 2019Source: Pharmacological ResearchAuthor(s): Hong-Yuan Lu, Yu-Xin Zu, Xiao-Wen Jiang, Xiao-Tong Sun, Tian-Yi Liu, Ruo-Lan Li, Qiong Wu, Ying-Shi Zhang, Qing-Chun ZhaoAbstractAcquired drug-resistant non-small cell lung cancer (NSCLC) has strong proliferation ability and is prone to epithelial-mesenchymal transition (EMT) and subsequent metastasis. Notch pathway mediates cell survival and EMT and is involved in the induction of multidrug resistance (MDR)....
11h
ConclusionsAs an important traditional Chinese medicine, modern pharmacological studies have demonstrated that S. alopecuroides has prominent bioactivities, especially on gynecological inflammation and hepatitis B, and anticancer activities. These activities provide prospects for novel drug development for cancer and some chronic diseases. Nevertheless, the comprehensive evaluation, quality control, understanding of the multitarget network pharmacology, long-term in vivo toxicity, and clinical efficacy...
11h
In conclusion, our study suggested that GAS5 silencing repressed the malignant progression of AS at least partly through upregulation of miR-135a. Targeting GAS5 might be a promising treatment strategy for AS management. (Source: Biomedicine and Pharmacotherapy)
11h
Introduction: Dermatomyositis (DM) is an idiopathic inflammatory myopathy that presents with proximal muscle weakness accompanied by a characteristic rash. The relationship between DM and malignancy is well established in the literature, with malignancy identified in approximately 25% of cases of DM. The most commonly associated malignancies are ovarian, lung, gastric, pancreatic and bladder adenocarcinomas. The presence of transcriptional intermediary factor 1- γ (TIF1-γ) autoantibodies in patients...
11h
We report the estimation of the percentage of stroma (POS) using digital pathology in a large population-ascertained cohort of primary melanomas. Consent was obtained from participants in the Leeds Melanoma Cohort Study to access and sample tumor FFPE blocks. H&E-stained slides were digitally scanned and blocks were sampled for gene expression studies using a tissue microarray needle; this yielded a core of tissue from which RNA was extracted and assayed using Illumina WGDASL. (Source: Journal...
11h
Introduction: Spitzoid melanocytic tumors (SMTs) range from benign, borderline, to malignant neoplasms: Spitz nevus (SN), atypical Spitz tumor (AST), and Spitzoid melanoma (SM), respectively. While certain histologic and molecular features appear to predict prognosis, significant ambiguity about their biological behavior remains. Herein, we describe the clinical, histologic, and molecular features of Spitzoid neoplasms seen at our large-volume academic practice and examine the impact of secondary...
11h
Background: According to the World Health Organization, between 2 and 3 million nonmelanoma skin cancers occur each year and the incidence is continuously increasing. The current gold standard and first line of treatment is surgical excision. Nevertheless, some patients are not good candidates for surgery. Elderly patients with multiple nonmelanoma skin cancers are often not candidates for surgical excision, especially on the lower legs where wound healing may be impaired. Here we present a case...
11h
Background: A significant proportion of advanced basal cell carcinomas (BCCs) are incompletely treated with current therapies. As BCCs have particularly high mutational burdens and can express programmed death ligand (PDL)-1, we performed a proof-of-concept study of the PD-1 inhibitor, pembrolizumab, for advanced BCCs. (Source: Journal of the American Academy of Dermatology)
11h
Importance: Melanoma is a highly aggressive cancer with extremely poor late stage survival. Those with a previous melanoma diagnosis have a 9-fold increased risk for developing a second primary melanoma compared with the general population. Yet, guidelines for dermatologic follow-up full body skin examinations (FBSEs) after diagnosis of stage I melanoma are ill-defined and vary widely. (Source: Journal of the American Academy of Dermatology)
11h
Introduction: Endocrine therapies (ETs) are associated with alopecia (EIA) in 15-25% of patients. There are no approved therapies for EIA. The purpose of this review is to provide dermatologists and oncologists with a foundation for the practical understanding of 5 α-reductase inhibitors and spironolactone for breast cancer patients and survivors with alopecia attributed to ETs, including the effect of these treatments on sex hormone levels, any reported drug interactions, and any risk of malignancy....
11h
Background: Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare, clinically aggressive hematologic malignancy that was classified as a subgroup of acute myeloblastic leukemia by the WHO in 2008. It has a poor prognosis with median survival of 12-16 months and no standardized therapeutic guidelines. It is characterized by leukemic dissemination and high incidence of skin involvement. Cutaneous lesions typically present as solitary or multiple purpuric erythematous plaques, nodules, or tumors....
11h
A 73-year-old Caucasian male with a history of multiple nonmelanoma skin cancers presented to dermatology for evaluation of a growth on the left scalp. He endorsed that the lesion had been present for many years but was slowly growing larger and thicker and had recently bled spontaneously and become intermittently painful. The lesion had been evaluated several times over a span of 3 years and was previously thought to most likely represent a verrucous seborrheic keratosis. The patient was otherwise...
11h
Introduction: The incidence of both melanoma and nonmelanoma skin cancer is increasing at an alarming rate, particularly for minority populations. Outcomes are often worse in these populations due to delayed detection and treatment, attributed to barriers such as decreased understanding about skin cancers and limited access to dermatological care from lack of insurance. Uninsured patients make up a smaller fraction of dermatology practices than would be predicted by their prevalence in the population....
11h
Background: Transplant recipients are known to have an increased risk of squamous cell carcinoma (SCC), with literature reporting a 65 to 200-fold higher risk of SCC than the general population. They are also prone to developing opportunistic infections including nontuberculous mycobacterial (NTM) infections. However there is paucity of data on dual pathology of both SCC and NTM infection occurring concurrently in a single lesion. (Source: Journal of the American Academy of Dermatology)
11h
Background: Mohs micrographic surgery is a specialized surgical technique using staged excisions and standard margins to treat cutaneous malignancies in difficult to treat or high-risk locations. Defect closure can be performed primarily by the Mohs surgeon or after referral to another surgical subspecialist. (Source: Journal of the American Academy of Dermatology)
11h
For tumors amenable to definitive surgical management, meticulous margin control is of utmost importance to prevent recurrence. A cornerstone in the treatment of cutaneous malignancies, Mohs micrographic surgery (MMS) may be impractical for the treatment of large tumors due to logistical challenges arising from complexities of the tumor (ie, size/location), time to process tissue, local anesthesia limitations, and patient tolerability. In contrast, en bloc resection inherently precludes tissue conservation,...
11h
Background: The incidence of melanoma and nonmelanoma skin cancer has been increasing in all age groups including children and adolescents. Prior studies in the pediatric population have shown low rates of sun protection behaviors and only modest improvement over the past several decades. (Source: Journal of the American Academy of Dermatology)
11h
Background: Ultraviolet radiation (UVR) is a major risk factor in the development of skin cancer. Sunscreens are designed to block and/or absorb UVR, but are often used incorrectly by the public possibly due to lack of knowledge regarding sunscreen terminology, proper use, and overall benefits. Lifeguards in particular are at an increased risk for excessive UVR exposure, thus it is crucial they have a high level of sunscreen knowledge. Previous studies have examined patterns of sunscreen use, sun...
11h
Proper photoprotective practices are critical for skin cancer prevention. A significant proportion of data on these practices is yielded from intake forms distributed during free skin cancer screenings. However, it is possible that the knowledge, perceptions, and practices of populations who seek free screenings may differ from the general public. We sought to examine these differences by surveying pedestrians in a major city and attendees of a skin cancer screening. An IRB approved 9 question survey...
11h
In this study we evaluated the posttreatment radiation toxicity course associated with HDR-BT. (Source: Journal of the American Academy of Dermatology)
11h
This study aimed to compare the quality of life (QoL) of patients with BCC against that of patients with relapse-free MM. (Source: Journal of the American Academy of Dermatology)
11h
Background: The ears are chronically exposed to the sun and exhibit a heightened risk for skin cancer. However, the morphology of pigmented ear lesions has been scarcely studied. We sought to describe the clinical and dermoscopic features of benign pigmented ear lesions. (Source: Journal of the American Academy of Dermatology)
11h
Background: Merkel cell carcinoma (MCC) is an aggressive neuroendocrine tumor, usually arising on the head and neck (Source: Journal of the American Academy of Dermatology)
11h
We report the combined clinical experience of cemiplimab in advanced CSCC in both studies (NCT02383212 and NCT02760498). (Source: Journal of the American Academy of Dermatology)
11h
We examined the clinical impact of sonidegib 200 mg muscle-related AEs based on 42 m data from BOLT, the randomized, double-blind, multicenter, registration Phase 2 study of sonidegib for the treatment of locally advanced (laBCC) or metastatic BCC (mBCC; NCT01327053). (Source: Journal of the American Academy of Dermatology)
11h
Clinically significant incidental teledermatology findings in patients with a history of skin cancer
In the store-and-forward teledermatology model, patients are referred by primary care providers and receive high quality imaging of their skin complaint. In this process, skin surrounding the lesion is imaged as a byproduct. Little data exists regarding the prevalence of incidental lesions found by the consultant dermatologist beyond the reason for consult captured during the teledermatology process. We sought to evaluate incidental lesions as well as factors associated with higher likelihood of...
11h
Introduction: Porokeratosis ptychotropica (PP) is a rare variant of porokoretosis, which is distinctive based on its clinical presentation of pruritic, verrucous papules and plaques that often form a “butterfly” configuration. They are most commonly located on the perinatal cleft with extension to the buttocks. Thus far, few cases have been reported in the literature. Similar to other variants of porokeratosis, it is histologically distinguished by the presence of cornoid lamellae. Proper di agnosis...
11h
Background: Symptoms of posttraumatic stress disorder (PTSD) have been observed in patients with life-threatening health conditions, ranging from cancer to asthma. Autoimmune blistering diseases (AIBD) are chronic, relapsing diseases that significantly impair quality of life in affected patients. Growing evidence has indicated a high degree of psychological distress associated with AIBD. Indeed, even during disease remission, many patients with AIBD can experience nonspecific symptoms similar that...
11h
Background: Complementary and alternative medicine (CAM) is widely used by cancer patients, but data is scarce for skin cancer. It has been reported that ∼20% of NMSC patients and 40-50% of melanoma patients have used CAM. (Source: Journal of the American Academy of Dermatology)
11h
Introduction: Malignant melanoma is life-threatening neoplasm of melanocytes, diagnosed via pathology. Pathology elements previously linked to predicted outcome include lesion depth, mitotic index and a presence or absence of ulceration. Tanning bed exposure is one of the primary risk factors for melanoma development. To our knowledge, this is the first study comparing pathology elements of tanning bed users and nonusers. (Source: Journal of the American Academy of Dermatology)
11h
We report the use of dilute intralesional 5-FU 10.0 mg/mL and 16.7 mg/mL in a series of 51 NMSC lesions at a single institution. Historical billing data and manual chart review were used to identify all patients who received intralesional 5-FU at Dartmouth-Hitchcock Medical Center from July 1, 2008 to July 1, 2018 for cutaneous squamous cell carcinoma (cSCC), basal cell carcinoma (BCC), or keratoacanthoma (KA). (Source: Journal of the American Academy of Dermatology)
11h
We report a case of EDHM in a patient with hematoproliferative disorders. (Source: Journal of the American Academy of Dermatology)
11h
Introduction: Despite having an incidence of approximately 1600 cases per year in the United States, the dermoscopic features of Merkel cell carcinoma (MCC) have not been clearly described. There is no standard nomenclature to describe MCC and no study specifically examining how use of polarized (PD) versus nonpolarized dermoscopy (NPD) impacts which dermoscopic features of MCC are visualized. Considering that PD and NPD each evaluate different depths of structures, the authors performed a systematic...
11h
Background: Novel noninvasive technologies augment information available to a clinician to enhance diagnosis. Electrical impedance spectroscopy (EIS) is a highly sensitive technology used before biopsy to differentiate equivocal lesions through differences in electrical resistance of benign versus malignant cells. A recent study of an FDA-approved EIS device supported this device ’s impact on clinical management among dermatology residents. The device provides an EIS score which increases with increasing...
11h
Elderly patients often have comorbidities, which may contribute to a poor prognosis upon hospitalization. Comorbidities and hospital-related complications in elderly malignant melanoma patients were evaluated. A retrospective analysis was performed for malignant melanoma patient cases found in the National Inpatient Sample (NIS) database from 2003 to 2012. Differences in hospital complications and comorbidities were assessed between elderly ( ≥65 years) and nonelderly patients. Of the 7351 adult...
11h
The objective of this study was to examine the incidence, treatment, overall survival (OS), and disease-specific survival of patients with cutaneous adenosquamous carcinoma. (Source: Journal of the American Academy of Dermatology)
11h
Background: Immune checkpoint inhibitors (ICI) such as anti-programmed death protein 1 (anti-PD-1) antibodies produce durable responses in a subset of cancer patients. ICI can produce immune-related adverse events (irAEs). Among the earliest and most common irAEs are skin toxicities. Several studies have associated the development of irAEs with increased treatment efficacy, though it remains unclear whether steroid treatment for irAEs interferes with the antitumor effects of ICI. We sought to evaluate...
11h
Institute and Comprehensive Center for Inflammation Medicine, University of L übeck, Lübeck Germany; Jeffrey J. Crowley, Bakersfield Dermatology and Skin Cancer Medical Group, Bakersfield, CA; Caitriona Ryan, Charles’ Institute of Dermatology, University College Dublin, Ireland; James G. Krueger, Laboratory for Investigative Dermatology, The Rockefeller University, New Yo rk, NY; Tsen-Fang Tsai, Department of Dermatology, National Taiwan University Hospital, National Taiwan University College of...
11h
Background: Shared medical appointments (SMAs) enhance adherence to medical recommendations. Despite their documented advantages in other specialties, SMAs have rarely appeared in the dermatology literature. Topical 5-fluorouracil (5-FU) for actinic keratosis (AKs), which relies on patient behavior for effectiveness, presents a therapeutic challenge that could benefit from the group clinic format. (Source: Journal of the American Academy of Dermatology)MedWorm Message: Have you tried our new medical...
11h
Introduction: Sweet syndrome (SS) is a rare syndrome presenting with painful, erythematous plaques or nodules and fevers. Subtypes of SS include malignancy-associated SS, commonly linked to acute myelogenous leukemia (AML), and medication-associated SS, associated with granulocyte colony-stimulating factor (G-CSF). (Source: Journal of the American Academy of Dermatology)
11h
Background: Malignancy is a potential safety concern for all immunosuppressive biologics. Guselkumab (GUS), a monoclonal antibody targeting interleukin 23, is approved for psoriasis. VOYAGE 1& 2 are randomized, double-blinded, placebo (PBO)/active comparator-controlled trials comparing GUS with PBO and adalimumab (ADA) in which patients (pts) with a history of malignancy with no evidence of recurrence for more than 5 years before screening were allowed to participate. (Source: Journal of the...
11h
Introduction: Ex vivo confocal microscopy (CM) is a scanner laser microscope capable of visualizing freshly excised tissues in real-time with cellular resolution without ulterior sample processing. Depending on the laser wavelength, either reflectance (RCM) or fluorescence (FCM) can be collected from the tissue, obtaining thin digital images. It has been demonstrated that ex vivo CM is useful and reliable for fast evaluation of tumour margins during Mohs micrographic surgery (MMS). The use of dyes...
11h
Surgery, Doylestown, PA (Source: Journal of the American Academy of Dermatology)
11h
Background: Although closely related, the treatment and prognosis varies greatly between actinic keratosis (AK), keratoacanthoma (KA), and squamous cell carcinoma (SCC); therefore, an accurate diagnosis is essential. Immunohistochemistry (IHC) has been explored as a possible means to differentiate between AK, KA, and SCC. (Source: Journal of the American Academy of Dermatology)
11h
This study assessed follow-up care of uninsured patients with a history of malignant melanoma in order to improve and ensure the highest quality long-term care. Demographics and chronic disease diagnoses were extracted from 4,804 patients managed at eight free-clinics from the Tampa Bay Area during 2016. (Source: Journal of the American Academy of Dermatology)
11h
Introduction: High frequency ultrasound is becoming a common tool in dermatology ´s office. Several studies support this technique for demarking surgical edges before removal nonmelanoma skin cancer, classifying basal cell carcinomas in high risk vs low risk, and showing infiltrative components after incisional biopsy of superficial basal cell carcinomas. Only few studies descr ibe the sonographic findings of skin lymphomas and its applications in the clinical practice. We expose ultrasound features...
11h
Background: Skin cancers are the most common cancers in patients who have received a solid organ transplant. The risk of developing skin cancer is significantly increased in solid organ transplant recipients (SOTRs) compared with the general population, likely due to their highly immunosuppressive drug regimens. Because of this increase in skin cancer risk, it is extremely important for SOTRs to receive regular and thorough dermatologic monitoring (Source: Journal of the American Academy of Dermatology)MedWorm...
11h
Merkel cell carcinoma is an aggressive neuroendocrine skin cancer with high morbidity and mortality. In addition to gene mutations and UV-induced damage, the Merkel cell polyomavirus (MCPyV) has been identified as a key driver of Merkel cell carcinogenesis. While UV-mediated DNA damage is known to contribute to MCC pathogenesis via TP53 mutations and reduced expression of DNA damage recognition proteins, the role of MCPyV in the DNA damage response (DDR) pathway remains unknown. Given that measurement...
11h
Hereditary leiomyomatosis and renal cell cancer (HLRCC, OMIM 150800) is an autosomal dominant syndrome characterized by cutaneous leiomyiomas (CLM), benign tumors arising from the erector pili muscle, uterine leiomyomas in female patients and renal cell cancer (RCC) specially the aggressive type 2 papillary form. It is caused by mutations in the fumarate hydratase gene (FH) which codifies the enzyme fumarate hydratase, involved in the Krebs cycle catalyzing the conversion of fumarate to malate. FH...
11h
Introduction: Cutaneous angiosarcoma (CAS) is a rare, malignant tumor of vascular mesenchymal origin accounting for (Source: Journal of the American Academy of Dermatology)
11h
Background: Risankizumab (RZB) is a humanized IgG1 monoclonal antibody that binds to the p19 subunit and selectively inhibits interleukin-23, a cytokine that plays a key role in the development and maintenance of psoriatic lesionsObjective: To report the short- and longer-term rates of malignancies in patients with moderate to severe psoriasis treated with RZB. (Source: Journal of the American Academy of Dermatology)
11h
The objective of this study was to determine if nonprimary site surgery is significantly associated with improved survival outcomes. (Source: Journal of the American Academy of Dermatology)
11h
Nivolumab, a checkpoint inhibitor of programmed cell death receptor-1 (PD-1), is used in the treatment of metastatic melanoma and nonsmall cell lung cancer. Blockade of PD-1 receptor releases inhibition of T-cell activation and allows for an antitumor immune response. As with many immune-mediated therapeutics, the most common cutaneous immune-related adverse events reported in association with nivolumab are vitiligo, rash and pruritis. Other autoimmune and inflammatory skin conditions such as psoriasiform...
11h
Background: Cutaneous squamous cell carcinoma (cSCC) is usually treated by surgical excision. Emerging nonsurgical options include injection with chemotherapeutic agents, such as intralesional 5-FU (IL5FU). Utilization of IL5FU has been published in case reports and reviews, yet has not been included in treatment guidelines due to limited study of its use. (Source: Journal of the American Academy of Dermatology)
11h
Background: One in five Americans will develop skin cancer by the age of 70. High levels of exposure to the sun and other UV-light sources are considered to be the biggest risk factors for the development of all types of skin cancer. Americans are more likely to see a primary care physician than a dermatologist. As such, it is important that doctors of all specialties are able to counsel patients on proper sun protection (Source: Journal of the American Academy of Dermatology)
11h
Cutaneous T-cell lymphomas, CTCLs, comprise a group of malignancies largely represented by two subtypes, mycosis fungoides (MF) and S ézary syndrome (SS). The incidence of CTCL has increased appreciably since the 1970’s, but the pathogenesis is poorly understood. Recent studies have demonstrated clustering of CTCL patient in several geographic areas suggesting that environmental factors may play a role in CTCL pathogenesis. A r etrospective chart review was conducted using the STAT data set from...
11h
Introduction: Total body photography (TBP) is a screening tool shown to enhance melanoma detection and reduce benign nevus biopsies. Such practices are usually limited to individuals with a personal or family history of atypical nevi, melanoma, or nonmelanoma skin cancers. Melanoma depth is the most important prognostic indicator of mortality and early detection improves survival. We previously demonstrated that computer-assisted serial comparison of TBP images can yield small malignant lesions which...
11h
In the most recent “Guidelines of care for the management of cutaneous squamous cell carcinoma” by Kim et al published in the Journal of the American Academy of Dermatology, intralesional methotrexate was not included as a potential alternative to surgical excision. This case series presents three patients with ke ratoacanthoma and well-differentiated squamous cell carcinomas that showed complete clinical resolution with two to three injections of 25 mg/mL methotrexate, each approximately two weeks...
11h
Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer after basal cell carcinoma. While most cases are cured by excision, a substantial number of patients will develop local, regional, or distant recurrences, with the number of cSCC-related deaths approaching that from melanoma. Several clinical decisions, including the extent of surgical margins, the use of adjuvant radiation or chemotherapy, and sentinel lymph node biopsy/completion dissection, could be informed by a patient...
11h
In small amounts, many minerals and metals are essential for biologic function. However, at higher levels they can be toxic and/or potentially carcinogenic. Little is understood regarding metal exposure and risk of skin cancer. Exposure to chromium (Cr), iron (Fe), mercury (Hg), selenium (Se), and zinc (Zn), have been largely unexplored with respect to skin cancer risk. We prospectively examined exposure to these elements and incidence of cutaneous squamous cell carcinoma (SCC) and melanoma in two...
11h
We present the case of a patient with paraneoplastic acral vascular syndrome as an initial manifestation of lung cancer. (Source: Journal of the American Academy of Dermatology)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
11h
Introduction: Melanoma is less common in children than adults, and prognostic factors are not as well understood, making prediction of disease course challenging. We aim to examine clinical, pathologic and molecular predictors of sentinel lymph node (SLN) metastasis, recurrence free survival (RFS) and overall survival (OS) in the pediatric melanocytic neoplasm population seen at Moffitt Cancer Center. (Source: Journal of the American Academy of Dermatology)
11h
Pyoderma gangrenosum (PG) is a sterile, idiopathic, ulcerative, neutrophilic dermatosis that can be associated with trauma or systemic diseases. The lesion typically begins as a pustule that later progresses to an ulcer or deep erosion with violaceous undermined borders. Diagnosis of PG is based on histopathology as well as exclusion of other diagnoses. Approximately 50% of PG cases are associated with systemic diseases, which include inflammatory bowel disease (IBD), rheumatoid arthritis, and hematologic...
11h
Introduction and Objectives: Penile carcinoma is a rare disease that accounts for 0.3% to 0.5% of malignancies among men in the United States. Studies have identified several risk factors for this malignancy, which include phimosis, tobacco use, HPV, advanced age, sexual history and ethnicity. However, few studies have assessed the overall incidence and temporal trends of this disease in Western countries. The purpose of this study is to gain insight on the epidemiology of penile squamous cell carcinoma...
11h
Background: Squamous cell carcinoma (SCC) and squamous cell carcinoma in situ (SCCIS) are the most common malignant tumors of the nail unit and may have prominent subclinical extension, defined as microscopic extension beyond grossly apparent borders. SCC/SCCIS of the nail unit has a greater rate of recurrence than cutaneous SCC/SCCIS of other sites. Increased recurrence after surgical excision may be due to sub-clinical extension, which has not been well defined (Source: Journal of the American...
11h
Background: Merkel cell carcinoma (MCC) is a rare, aggressive malignancy, with high rates of recurrence and metastasis. We aimed to evaluate predictors of sentinel lymph node (SLN) positivity in Merkel cell carcinoma using the National Cancer Database (NCDB). (Source: Journal of the American Academy of Dermatology)
11h
Introduction: Topical 5-Fluorouracil (5-FU) under zinc oxide occlusion has been reported to be effective in reducing actinic damage and as an adjuvant to surgery for squamous cell carcinomas (SCCs) on diffusely photodamaged skin. It has also been shown to increase patient satisfaction as well as compliance and is tolerable without major side effects. Organ transplant patients are at an increased risk of developing skin cancer due to immunosuppressive medications. 5-FU is frequently prescribed as...
11h
We present two new cases of SK, one associated to ovarian carcinoma. First case is a 83-year-old woman who consulted for hands lesions since 5 years ago that caused mild discomfort. As medical history, we should highligh the concomitant diagnosis of ovarian carcinoma. Physical examination showed millimetric keratotic lesions in palms. (Source: Journal of the American Academy of Dermatology)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social...
11h
Introduction: The incidence of melanoma skin cancer, in both children and adults, continues to rise in the United States. Children are particularly vulnerable with studies citing frequent sunburns and cumulative UV exposure before age 20 as a primary cause of cutaneous melanoma in later life. Further, evidence shows 21-50% of total sun exposure may occur before the age of 18. Early exposure to sun care education and changes in behavior may offer an opportunity to curb these trends. (Source: Journal...
11h
Background: Superficial radiation therapy (SRT) is a noninvasive modality to treat NMSC. SRT is a useful treatment option in elderly patients who often present with numerous co-morbidities making them poor surgical candidates. This is especially true for NMSC lesions on the lowers limbs. (Source: Journal of the American Academy of Dermatology)
11h
Background: Melanoma is the most common skin cancer in patients under 20 years. Staging procedures typically follow those in adults; however little is known about utilization of sentinel lymph node biopsy (SLNB) and predictors of positive sentinel nodes. We aimed to assess SLNB utilization and factors affecting SLN positivity in a pediatric melanoma cohort. (Source: Journal of the American Academy of Dermatology)
11h
Verrucous carcinoma (VC) is a rare variant of squamous cell carcinoma (SCC). It is described as a low grade, slow growing, locally infiltrative neoplasm that accounts for 3-8% of all penile SCC. A 64-year-old uncircumcised, paraplegic male presented with a 2-month history of an asymptomatic, enlarging penile lesion with episodic spontaneous bleeding. The patient had been confined to a wheelchair for 15 years due to transverse myelitis and was wearing a diaper secondary to overflow urinary incontinence....
11h
Background: Actinic keratoses (AKs) are precursor lesions to squamous cell carcinoma that arise from keratinocyte dysplasia. Treatment of AKs has traditionally involved cryotherapy, various topical agents such as topical 5-fluorouracil (5-FU), or combination therapy. Due to irritation with use of topical 5-FU, short-contact therapy 5-FU with cryotherapy has been reported. Vitamin D derivatives have also been reported as systemic anti-cancer agents, though clinical data for usage is limited mainly...
11h
In this study, we ran a pilot randomized experiment of skin cancer prevention messages using Facebook advertising to assess the reach and impact of this platform on self-reported outcomes related to melanoma risk. (Source: Journal of the American Academy of Dermatology)
11h
Background: 11 β-hydroxysteroid dehydrogenase type 2 (11βHSD2) deactivates cortisol to cortisone. It is up-regulated in nonmelanoma skin cancer (NMSC) cells. We found that glycyrrhetinic acid (GA)-mediated inhibition of 11βHSD2 protein caused a significant reduction in tumor number, weight, incidence, and signi ficant delay in tumor onset. In addition to the use of specific inhibitors such as GA to sustain the bioavailability of glucocorticoids (GC), modifying the structure of GC molecule to prevent...
11h
Dermatofibroma protuberans (DFSP) is an uncommon, locally aggressive cutaneous soft tissue sarcoma of low-intermediate malignancy that favors young adults. It usually presents as an asymptomatic, indurated, skin-colored plaque that enlarges over a period of months to years. Histologically, it is characterized by its capacity to infiltrate the dermis and subcutaneous tissue in the form of peripheral tentacle-like projections. This feature justifies a high rate of local recurrence, while the rate of...
11h
The objective of this study was to determine what proportion of the subsequent excisions were histologically clear, with no residual tumor cells. (Source: Journal of the American Academy of Dermatology)
11h
Background: Organ transplant patients show a higher incidence of actinic keratosis (AK) and nonmelanoma skin cancer than general population. Criotherapy and daylight-photodynamic-therapy with methyl-aminolevuinate (DL-PDT-MAL) can be used to treat AK. 1-5DL-PDT-MAL is usually a therapy of the field cancerization. Criotherapy treats only visible AK. Organ transplat patients usually receive multiple treatments for AK during their life and sometimes are not well tolerated. (Source: Journal of the American...
11h
Basosquamous carcinoma is an aggressive subtype of basal cell carcinoma that shares histologic features with squamous cell carcinoma as well as the potential to become locally invasive or metastatic. The pathogenesis of basal cell carcinoma (BCC) is most commonly due to mutations in Patch (PTCH) tumor suppressor gene which is part of the hedgehog pathway. Patch inhibits Smoothen (SMO), a transmembrane protein that when unchecked results in the development of BCCs. The targeted inhibitors Vismodegib...
11h
A 63-year-old woman presented to the hospital with a nontender, rapidly enlarging sacral ulcer. The patient reported she felt the wound while she was in the shower and was extremely alarmed by the size. She denied any preceding injury or medical or cosmetic procedures in the area. Her past medical history was significant for endometrial carcinoma, status post bilateral salpingo-oophrectomy, hysterectomy and pelvic radiation. She also reported a sacral fracture one year prior secondary to a fall....
11h
Capecitabine is an oral chemotherapeutic agent that is converted to 5-fluorouracil (5-FU) by thymidine phosphorylase and is frequently utilized for adjuvant therapy in breast and colorectal cancer. The most common cutaneous side effect due to capecitabine is hand-foot syndrome (HFS) which manifests as tingling and erythema that can progress to swelling, blisters, desquamation, and pain. Hyperpigmentation of acral skin can occur in association with HFS, particularly in non-Caucasian patients, but...
11h
We describe the case of a 61-year-old male recently diagnosed with poorly differentiated esophageal adenocarcinoma. Dermatology was consulted for the evaluation of multiple, enlarging painful skin nodules concerning for cutaneous metastases. On physical examination, firm, indurated, minimally mobile subcutaneous nodules were present on the scalp, left cheek, back, abdomen, hands, and right thigh. (Source: Journal of the American Academy of Dermatology)
11h
Background: Squamous cell carcinoma (SCC), however rare in the anogenital skin, is often locally aggressive. Development of anogenital SCC is related to several other dermatologic and related conditions, including condyloma, lichen planus, hidradenitis suppurativa, Crohn ’s disease, lichen sclerosis and immunosuppression of various etiologies. Even when lesions are detected early, surgical excision can be difficult due to the close proximity of other vital structures, and challenges with primary...
11h
Importance: Hispanics are currently the fastest growing ethnic group in the United States, with a projected estimate of becoming 24.4% of the population by 2050. Although malignant skin lesions are less prevalent among darker skin types, they are accompanied with greater morbidity and mortality in Hispanics when compared with non-Hispanic Caucasians. (Source: Journal of the American Academy of Dermatology)
11h
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου