Capecitabine is an oral chemotherapeutic agent that is converted to 5-fluorouracil (5-FU) by thymidine phosphorylase and is frequently utilized for adjuvant therapy in breast and colorectal cancer. The most common cutaneous side effect due to capecitabine is hand-foot syndrome (HFS) which manifests as tingling and erythema that can progress to swelling, blisters, desquamation, and pain. Hyperpigmentation of acral skin can occur in association with HFS, particularly in non-Caucasian patients, but...
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We describe the case of a 61-year-old male recently diagnosed with poorly differentiated esophageal adenocarcinoma. Dermatology was consulted for the evaluation of multiple, enlarging painful skin nodules concerning for cutaneous metastases. On physical examination, firm, indurated, minimally mobile subcutaneous nodules were present on the scalp, left cheek, back, abdomen, hands, and right thigh. (Source: Journal of the American Academy of Dermatology)
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Background: Squamous cell carcinoma (SCC), however rare in the anogenital skin, is often locally aggressive. Development of anogenital SCC is related to several other dermatologic and related conditions, including condyloma, lichen planus, hidradenitis suppurativa, Crohn ’s disease, lichen sclerosis and immunosuppression of various etiologies. Even when lesions are detected early, surgical excision can be difficult due to the close proximity of other vital structures, and challenges with primary...
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Importance: Hispanics are currently the fastest growing ethnic group in the United States, with a projected estimate of becoming 24.4% of the population by 2050. Although malignant skin lesions are less prevalent among darker skin types, they are accompanied with greater morbidity and mortality in Hispanics when compared with non-Hispanic Caucasians. (Source: Journal of the American Academy of Dermatology)
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An 80-year-old Caucasian male previously diagnosed with S ézary syndrome (SS) in 2009 presented to our multidisciplinary cutaneous lymphoma clinic for a second opinion. He had failed therapies with topical steroids, narrow-band UVB, oral bexarotene, interferon-α, vorinostat, and photopheresis. In October 2017, his outside oncologist added pembrolizumab ( PEM) to his monthly photopheresis. After six cycles of PEM, he developed 25-lb weight loss, lymphadenopathy, and skin lesions. On exam, he had erythematous...
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Mycosis fungoides (MF) and Sezary syndrome (SS) are subtypes of extranodal T cell nonHodgkin lymphoma, and are the most common forms of cutaneous T cell lymphoma (CTCL). Although both subtypes involve the skin, SS is characterized by leukemic involvement of malignant T cells that typically match the clone found in the skin. MF has a plethora of clinicopathological variants, one of which is the pigmented purpuric dermatosis (PPD)-like MF. Although the PPD-like MF is rarely reported, it has been previously...
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Immune checkpoint inhibition is an increasingly common therapy for various cancers including melanoma and nonsmall cell lung cancer. Inhibition of the cytotoxic T lymphocyte antigen-4 (CTLA-4) or the programmed death receptor-1 (PD-1)/ PD ligand-1 (PD-L1) signaling pathways enhance T cell activation and promotes cytotoxic activity against cancer cells. However, the nonspecific response promoted by these inhibitors have led to a variety of adverse dermatologic effects. We review the case of a progressive...
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Spiradenocarcinomas (SpAdcs) or malignant eccrine spiradenomas are potentially aggressive skin adnexal tumors. They often present as solitary nodules and are classified as low-grade (LG) or high grade (HG) tumors. We review the clinical and histological features of a LG SpAdc in a 57-year-old male and review treatment options for this tumor. Our patient first noticed a small, subcutaneous nodule two years prior to presentation. Over the course of a year, the nodule doubled in size and became darker...
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This study explores a possible association with tuberculosis. (Source: Journal of the American Academy of Dermatology)
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Background: Poziotinib is a potent, orally available, EGFR and HER2 exon 20-selective tyrosine kinase inhibitor used to treat nonsmall cell lung cancer (NSCLC). During a Phase 2 clinical trial of poziotinib, a high incidence of cutaneous reactions were reported in treated patients. Up to 55% of patients received a dose reduction in response to adverse events, most commonly from skin reaction and diarrhea. (Source: Journal of the American Academy of Dermatology)
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Adult-type xanthogranuloma is an uncommon histiocytic neoplasm that typically presents as a solitary cutaneous lesion that has a predilection for the heck and neck region. While this diagnosis is more commonly made in childhood, it is important for providers to be familiar with in the adult population to avoid misdiagnosis as a malignant entity such as melanoma which can present in a similar manner. Histopathologic examination is crucial for this neoplasm to ensure correct diagnosis and management....
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Publication date: Available online 20 August 2019Source: Journal of Evidence Based Dental PracticeAuthor(s): Analia Veitz-Keenan, Thamar Delia Silvestre Calle, Marco Bergamini (Source: Journal of Evidence Based Dental Practice)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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Authors: Concolino P, Capoluongo E Abstract Introduction: Currently, genetic testing of BRCA1/2 genes includes screening for single nucleotide variants, small insertions/deletions and for copy number variations (CNVs). In fact, many studies document the involvement of BRCA1/2 gene rearrangements in genetic predisposition to breast and ovarian cancer. Large genomic rearrangements (LGRs) of BRCA1 may account for up to one-third of all disease-causing alterations in various populations, while...
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Publication date: Available online 20 August 2019Source: Seminars in Cancer BiologyAuthor(s): Abul Barkat, Sarwar Beg, Sunil K Panda, Khalid S Alharbi, Mahfoozur Rahman, Farhan J AhmedAbstractThe application of nanomedicines in tumor targeting and attaining meaningful therapeutic benefits for the treatment of cancers has been going on for almost two decades. Beyond the lipidic and polymeric nanomedicines-based passive and active targeting, the quest for inventing the new generation of carriers has...
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Publication date: Available online 20 August 2019Source: Seminars in Cancer BiologyAuthor(s): Sobiya Zafar, Sarwar Beg, Sunil K Panda, Mahfoozur Rahman, Khalid S Alharbi, Gaurav K Jain, Farhan J AhmadAbstractCancer, being the most prevalent and resistant disease afflicting any gender, age or social status, is the ultimate challenge for the scientific community. The new generation therapeutics for cancer management has shifted the approach to personalized/precision medicine, making use of patient-...
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ConclusionDepressive symptoms, reduced mobility, and more physical symptoms increased the risk of decrements in older patients' PF and global QoL scores during cancer treatment, and represent potential targets for interventions aiming at improving these outcomes. (Source: Journal of Geriatric Oncology)
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This report describes recommendations from the Worldwide Network for Blood and Marrow Transplantation (WBMT) for establishing HSCT programs with a specific focus on developing countries, and identifies challenges and opportunities for providing this specialized procedure in the resource constrained setting. (Source: Hematology Oncology and Stem Cell Therapy)
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Publication date: Available online 20 August 2019Source: Hematology/Oncology and Stem Cell TherapyAuthor(s): Marcelo C. Pasquini, Alok Srivastava, Syed Osman Ahmed, Mahmoud Aljurf, Yoshiko Atsuta, Carol Doleysh, Sebastian Galeano, Eliane Gluckman, Hildegard Greinix, Gregory Hale, Parameswaran Hari, Shahrukh K. Hashmi, Naynesh Kamani, Mary J. Laughlin, Dietger Niederwieser, Adriana Seber, Jeffrey Szer, John A. Snowden, Koen Van Biesen, Paula WatryAbstractHematopoietic cell transplantation (HCT) is...
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Publication date: Available online 20 August 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Svetlana N. Aleksakhina, Aniruddh Kashyap, Evgeny N. ImyanitovAbstractSystemic therapy often results in the reduction of tumor size but rarely succeeds in eradicating all cancer cells. Drug efflux, persistence of cancer stem cells (CSCs), epithelial-mesenchymal transition (EMT) and down-regulation of apoptosis are the most known general causes of therapy failure. Tumor escape...
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Publication date: Available online 20 August 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Wu-Hu Zhang, Wen-Quan Wang, He-Li Gao, Xian-Jun Yu, Liang LiuAbstractGastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are a group of rare tumors that are increasing in prevalence. The complex tumor immune microenvironment (TIME) plays an important role in tumor development and the response to immunotherapy but is poorly understood. In this review, the components of...
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(Source: OncoTargets and Therapy)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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(Source: OncoTargets and Therapy)
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(Source: OncoTargets and Therapy)
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(Source: OncoTargets and Therapy)
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(Source: Cancer Management and Research)
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(Source: Cancer Management and Research)
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AbstractWhile more than 90% of breast cancer patients in western countries survive for at least 5 years, the survival rate in Tanzania is less than 45% because of late stage at presentation. The aim of this study was to identify patient and health system factors related to early or late stages of a breast cancer diagnosis. The study was conducted at the Ocean Road Cancer Institute (ORCI) in Da r es Salaam, Tanzania, and included interviews with 196 breast cancer patients diagnosed with early (stage...
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Cancer is the second leading cause of death worldwide, and no obvious decline in incidence and mortality has occurred in recent years. It is imperative to further investigate the mechanisms underlying tumor progression. Long noncoding RNAs have received considerable attention in recent years because of their major regulatory roles in gene expression. Among them, PVT1 is well-studied, and substantial evidence indicates that PVT1 plays critical roles in the onset and development of cancers. Normally,...
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Future Oncology, Ahead of Print. (Source: Future Oncology)
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Conclusion: RTQA scores are related to patients’ local control rates in head and neck cancer radiotherapy. (Source: Frontiers in Oncology)
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(Source: Clinical and Translational Oncology)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
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AbstractStrategies that facilitate change to policy, systems, and environmental (PSE) changes can enable behaviors and practices that lead to cancer risk reduction, early detection, treatment access, and improved quality of life among survivors. Comprehensive cancer control is a coordinated collaborative approach to reduce cancer burden and operationalizes PSE change strategies for this purpose. Efforts to support these actions occur at the national, state, and local levels. Resources integral to...
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. (Source: Nutrition and Cancer)
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We describe our experience with five cases in a tertiary pediatric cardiac care center with Abernethy malformation, with review of literature and also discuss possible therapeutic implications. (Source: Annals of Pediatric Cardiology)
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Epigenetic information is characterized by its stable transmission during mitotic cell divisions and plasticity during development and differentiation. This duality contrasts to genetic information, which is essentially static and identical in every cell in an organism except immunoglobulin gene rearrangements in lymphocytes and mutations in cancer cells. Allele-specific analysis of gene expression and epigenetic modifications provides a unique approach to studying epigenetic regulation in normal...
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Adamantinomatous craniopharyngioma (ACP) makes up between 6-8% of pediatric brain tumors and is the most common pediatric tumor arising in the sellar/suprasellar region of the brain. The 10-year survival for patients diagnosed with craniopharyngioma ranges between 64-92%, but complicating factors such as location, common cyst formation, and potential hypothalamic infiltration cause significant morbidity in this population. There are a number of therapeutic options for children with ACP, including...
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Oncogene, Published online: 21 August 2019; doi:10.1038/s41388-019-0955-7Skp2-mediated ubiquitination and mitochondrial localization of Akt drive tumor growth and chemoresistance to cisplatin (Source: Oncogene)
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Conclusion: With a CBR of 12% (3/25), the combination of everolimus and bevacizumab did not reach the study's target response rate and is not considered active in refractory MPNST. PMID: 31427883 [PubMed] (Source: Sarcoma)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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Authors: Chen M, Xu ES, Leisenring NH, Cardona DM, Luo L, Ma Y, Ventura A, Kirsch DG Abstract Myxoid liposarcoma is a malignant soft tissue sarcoma characterized by a pathognomonic t(12;16)(q13;p11) translocation that produces a fusion oncoprotein, FUS-CHOP. This cancer is remarkably sensitive to radiotherapy and exhibits a unique pattern of extrapulmonary metastasis. Here, we report the generation and characterization of a spatially and temporally restricted mouse model of sarcoma driven...
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In conclusion, the data demonstrate that EPC traffic in patients with glioma, representing neoplasia, is different from that in myocardial infarction, representing tissue regeneration. Glioma patients may benefit from therapies aimed at lowering KDR+ cells and HPCs. PMID: 31428150 [PubMed] (Source: Journal of Oncology)
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Authors: Shi M, Sanche L Abstract Malignant gliomas are undifferentiated or anaplastic gliomas. They remain incurable with a multitude of modalities, including surgery, radiation, chemotherapy, and alternating electric field therapy. Convection-enhanced delivery (CED) is a local treatment that can bypass the blood-brain barrier and increase the tumor uptake of therapeutic agents, while decreasing exposure to healthy tissues. Considering the multiple choices of drugs with different antitumor...
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In this study, the expression profiles of circRNAs from 10 PDAC tissues and their paired adjacent nontumor tissues were analyzed through RNA sequencing analysis. An enrichment analysis was employed to predict the functions of the differentially expressed circRNAs. Sequence alignment information and mRNA microarray projects were used to predict the RNA regulatory network. The knockdown of circRNAs by small interfering RNAs followed by wound healing and western blot assays was used to confirm their...
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Discussion: Our results suggest that advanced melanoma patients discontinuing anti-PD-1 therapy due to irAE usually experience durable clinical benefit. However, caution is needed with these agents in patients with underlying autoimmune diseases. PMID: 31428149 [PubMed] (Source: Journal of Oncology)
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Authors: Kang Z, Yang Q, Li Y PMID: 31428152 [PubMed] (Source: Journal of Oncology)
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Peritoneal carcinomatosis (PC) is a rare disease defined as diffused implantation of neoplastic cells in the peritoneal cavity. This clinical picture occurs during the evolution of peritoneal tumors, and it is the main cause of morbidity and mortality of patients affected by these pathologies, though cytoreductive surgery with heated intra-peritoneal chemotherapy (CRS/HIPEC) is yielding promising results. In the present study, we evaluated whether the tumor microenvironment of low-grade and high-grade...
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Metastasis is the predominant cause of cancer-related mortality, despite being a highly inefficient process overall. The vasculature is the gatekeeper for tumor cell seeding within the secondary tissue microenvironment – the rate limiting step of the metastatic cascade. Therefore, factors that regulate vascular physiology dramatically influence cancer outcomes. There are a myriad of physiologic circumstances that not only influence the intrinsic capacity of tumor cells to cross the endothelial barrier,...
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With the development of nanotechnology, significant progress has been made in the design and manufacture of nanoparticles (NPs) for use in clinical treatments. Meanwhile, recent increases in our understanding of the central role of the macrophages in the context of inflammation and cancer have reinvigorated interest in macrophages as a drug target. Macrophages serve an integral role in maintaining the steady state of the immune system and are involved in the processes of cancer and inflammation....
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T-cell engaging bispecific antibodies (biAbs) can mediate potent and specific tumor cell eradication in liquid cancers. Substantial effort has been invested in expanding this concept to solid cancers. To explore their utility in the treatment of ovarian cancer, we built a set of asymmetric biAbs in IgG1-like format that bind CD3 on T cells with a conventional scFv arm and folate receptor 1 (FOLR1) on ovarian cancer cells with a conventional or a chemically programmed Fab arm. For avidity engineering,...
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Authors: Zhao L, Zhang J, Xu L, Abbas HA PMID: 31428655 [PubMed - in process] (Source: Journal of Immunology Research)
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Publication date: Available online 20 August 2019Source: Stem Cell ResearchAuthor(s): Flavia S. Donaires, Raquel M. Alves-Paiva, Fernanda Gutierrez-Rodrigues, Fernanda Borges da Silva, Maria Florencia Tellechea, Lilian Figueiredo Moreira, Barbara A. Santana, Fabiola Traina, Cynthia E. Dunbar, Thomas Winkler, Rodrigo T. CaladoAbstractTelomeropathies are a group of phenotypically heterogeneous diseases molecularly unified by pathogenic mutations in telomere-maintenance genes causing critically short...
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In this study, the reduction-responsive polypeptide micelles based on methoxy poly(ethylene glycol)-block-poly(S-tert-butylmercapto-L-cysteine) copolymers (mPEG113-b-PBMLC4, P4M, and mPEG113-b-PBMLC9, P9M) were developed to control the delivery of doxorubicin (DOX) in OS therapy. Compared to free DOX, P4M/DOX and P9M/DOX exhibited 2.6 and 3.5 times increases in the area under the curve (AUC) of pharmacokinetics, 1.6 and 2.0 times increases in tumor accumulation, and 1.6 and 1.7 times decreases the...
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This study demonstrated that the Fe-GA network-based nanoparticle is a promising diagnostic and therapeutic agent for theranostic application and further clinic translation.Graphical AbstractIllustration of a multifunctional iron-gallic acid (Fe-GA) network-based nanoparticle as a theranostic agent for magnetic resonance imaging-guided photothermal therapy and chemotherapy. The results suggest that Fe-GA network-based nanoplatform is safe and practical, and can effectively kill tumor cells under...
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Publication date: December 2019Source: Materials Science and Engineering: C, Volume 105Author(s): Vishnu Sravan Bollu, Thulasiram Bathini, Ayan Kumar Barui, Arpita Roy, Nagarjuna Chary Ragi, Swamy Maloth, Prabhakar Sripadi, Bojja Sreedhar, Penumaka Nagababu, Chitta Ranjan PatraAbstractIn the present paper, we synthesized and characterized four N-donor polypyridyl copper(II) complexes (C1-C4); [Cu(mono-CN-PIP)2]2+ (C1), [Cu(tri-OMe-PIP)2]2+ (C2), [Cu(di-CF3-PIP)2]2+ (C3) and [Cu(DPPZ)2]2+ (C4). The...
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Publication date: 1 January 2020Source: Materials Chemistry and Physics, Volume 239Author(s): Krzysztof Tadyszak, Jagoda Litowczenko, Łukasz Majchrzycki, Paweł Jeżowski, Karol Załęski, Błażej ScheibeAbstract3D glassy carbon structures with different pore diameters were obtained by pyrolysis of the sucrose via sugar blowing technique. The porous-cellular foam structure was obtained by applying a blowing agent in the form of ammonium chloride before pyrolysis at 1100 °C under argon environment. Physical...
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Publication date: 20 August 2019Source: Cell Reports, Volume 28, Issue 8Author(s): Hanna Sabelström, Rebecca Petri, Ksenya Shchors, Rahul Jandial, Christin Schmidt, Rohit Sacheva, Selma Masic, Edith Yuan, Trenten Fenster, Michael Martinez, Supna Saxena, Theodore P. Nicolaides, Shirin Ilkhanizadeh, Mitchel S. Berger, Evan Y. Snyder, William A. Weiss, Johan Jakobsson, Anders I. PerssonSummaryIdentifying cellular programs that drive cancers to be stem-like and treatment resistant is critical to improving...
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Publication date: 20 August 2019Source: Cell Reports, Volume 28, Issue 8Author(s): Diletta Di Mitri, Michela Mirenda, Jelena Vasilevska, Arianna Calcinotto, Nicolas Delaleu, Ajinkya Revandkar, Veronica Gil, Gunther Boysen, Marco Losa, Simone Mosole, Emiliano Pasquini, Rocco D’Antuono, Michela Masetti, Elena Zagato, Giovanna Chiorino, Paola Ostano, Andrea Rinaldi, Letizia Gnetti, Mariona Graupera, Ana Raquel Martins Figueiredo FonsecaSummaryTumor-associated macrophages (TAMs) represent a major component...
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Publication date: 20 August 2019Source: Cell Reports, Volume 28, Issue 8Author(s): Roberto Costa, Roberta Peruzzo, Magdalena Bachmann, Giulia Dalla Montà, Mattia Vicario, Giulia Santinon, Andrea Mattarei, Enrico Moro, Rubén Quintana-Cabrera, Luca Scorrano, Massimo Zeviani, Francesca Vallese, Mario Zoratti, Cristina Paradisi, Francesco Argenton, Marisa Brini, Tito Calì, Sirio Dupont, Ildikò Szabò, Luigi LeanzaSummaryWnt signaling affects fundamental development pathways and, if aberrantly activated,...
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Publication date: 20 August 2019Source: Cell Reports, Volume 28, Issue 8Author(s): John D. Gagnon, Robin Kageyama, Hesham M. Shehata, Marlys S. Fassett, Darryl J. Mar, Eric J. Wigton, Kristina Johansson, Adam J. Litterman, Pamela Odorizzi, Dimitre Simeonov, Brian J. Laidlaw, Marisella Panduro, Sana Patel, Lukas T. Jeker, Margaret E. Feeney, Michael T. McManus, Alexander Marson, Mehrdad Matloubian, Shomyseh Sanjabi, K. Mark AnselSummaryCoordinate control of T cell proliferation, survival, and differentiation...
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Publication date: 20 August 2019Source: Cell Reports, Volume 28, Issue 8Author(s): Joshua J. Gruber, Justin Chen, Benjamin Geller, Natalie Jäger, Andrew M. Lipchik, Guangwen Wang, Allison W. Kurian, James M. Ford, Michael P. SnyderSummaryIndividuals with a single functional copy of the BRCA2 tumor suppressor have elevated risks for breast, ovarian, and other solid tumor malignancies. The exact mechanisms of carcinogenesis due to BRCA2 haploinsufficiency remain unclear, but one possibility is that...
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Publication date: 20 August 2019Source: Cell Reports, Volume 28, Issue 8Author(s): Adam L. Burrack, Ellen J. Spartz, Jackson F. Raynor, Iris Wang, Margaret Olson, Ingunn M. StromnesSummaryPancreatic ductal adenocarcinoma (PDA) is a lethal cancer resistant to immunotherapy. We create a PDA mouse model and show that neoantigen expression is required for intratumoral T cell accumulation and response to immune checkpoint blockade. By generating a peptide:MHC tetramer, we identify that PDA induces rapid...
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We report that suppression of p16 plays a central role in reprogramming metabolism by increasing nucleotide synthesis. This occurs by activation of mTORC1 signaling, which directly mediates increased translation of the mRNA encoding ribose-5-phosphate isomerase A (RPIA), a pentose phosphate pathway enzyme. p16 loss correlates with activation of the mTORC1-RPIA axis in multiple cancer types. Suppression of RPIA inhibits proliferation only in p16-low cells by inducing senescence both in vitro and in vivo....
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Publication date: 20 August 2019Source: Cell Reports, Volume 28, Issue 8Author(s): Shaun Egolf, Yann Aubert, Miriam Doepner, Amy Anderson, Alexandra Maldonado-Lopez, Gina Pacella, Jessica Lee, Eun Kyung Ko, Jonathan Zou, Yemin Lan, Cory L. Simpson, Todd Ridky, Brian C. CapellSummarySelf-renewing somatic tissues depend upon the proper balance of chromatin-modifying enzymes to coordinate progenitor cell maintenance and differentiation, disruption of which can promote carcinogenesis. As a result, drugs...
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Nanomedicine, Ahead of Print. (Source: Nanomedicine)
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In this study, blood samples extracted by venipuncture from 30 healthy volunteers were used to obtain DNA from buffy coat and whole blood. The purity and integrity of the nucleic acids obtained were assessed by spectrophotometry, fluorimetry, and agarose electrophoresis, and functionality was assessed by PCR and real-time PCR. Another aspect tested in this study was based on the comparison between short-term and long-term storage at -80°C and fresh samples from both matrices to evaluate the storage...
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ConclusionsUse of neoadjuvant therapy was associated with significantly higher complete resection rates compared with upfront surgery although this did not translate to differences in survival outcomes. No differences in perioperative morbidity or mortality were identified. Based on qualitative systematic review, lymphovascular invasion and larger tumor size are potential factors for helping to select those patients who may benefit from neoadjuvant therapy. (Source: The Annals of Thoracic Surgery)
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ConclusionsAdjuvant therapy was associated with improved overall survival. Therefore, consideration should be given to administration of adjuvant therapy to esophageal cancer patients who have persistent node-positive disease after induction therapy and esophagectomy and are able to tolerate additional treatment. (Source: The Annals of Thoracic Surgery)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in...
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ConclusionsPreoperative radiotracer localization of small or indistinct pulmonary lesions is simple and feasible with a high rate of success. It may be an effective and attractive alternative in managing lung lesions. (Source: The Annals of Thoracic Surgery)
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Tumor Spread Through Air Spaces in Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis
ConclusionsOur study indicates that tumor STAS was a potentially significant prognostic predictor for surgical patients with NSCLCs. The prognostic impact of STAS present in the resection margin remains undetermined. Further large-scale prospective studies are warranted to confirm the prognostic significance of STAS in patients with NSCLCs. (Source: The Annals of Thoracic Surgery)
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Spectroscopic measurement of 5-ALA-induced intracellular protoporphyrin IX in pediatric brain tumors
ConclusionWe demonstrate a strong association between intraoperative observations and spectrometric measurements of PPIX fluorescence in tumor tissue. As in former studies, fluorescence signal was more commonly observed in malignant glial tumors. Further prospective controlled trials should be conducted to investigate the feasibility of 5-ALA-guided resection of pediatric brain tumors. (Source: Acta Neurochirurgica)
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ConclusionFluorescein-guided surgery, coupled with intraoperative neurophysiological monitoring, increases the safe resection rate, considering the risks of neurological deficits and the possible malignant transformation. (Source: Acta Neurochirurgica)
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Authors: Schwartz SS, Grant SFA, Herman ME Abstract The association between cancer and dysglycemia has been well documented. It is underappreciated, however, that sustained dysglycemia could potentially be a catalyst towards a pro-cancer physiologic milieu and/or increase the burden of cancer. Hyperglycemia, hyperinsulinemia and energy metabolism at large impact a cascade of growth pathways, epi/genetic modifications, and mitochondrial changes that could feasibly link to tumor processes....
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Contributors : Imed E Gallouzi ; Sergio Di-Marco ; Brenda J SanchezSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusHere we show that, when compared to control mice, muscle specific HuR knockout (muHuR-KO) animals have higher exercise endurance that is associated with a significant increase in oxygen consumption and carbon dioxide production. Histological analysis demonstrates that the absence of HuR significantly enhances the proportion of oxidative type I fibers...
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Contributors : Cigdem Gungormez ; Emine Teker ; Sema Atmanoglu ; Ersin BorazanSeries Type : Expression profiling by arrayOrganism : Homo sapiens ; synthetic constructThe aim of this study is to analyze microRNA expression profile, and through bioinformatic analyses determine the cellular processes of potential target genes and understand their molecular mechanism in stage IIIA colon cancer patients. The microRNA expression profiles of both normal and tumor tissues of seven patients were analyzed...
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Abstract Background Endoscopic transorbital approach (eTOA) has been announced as an alternative minimally invasive surgery to skull base. Owing to the inferior orbital fissure (IOF) connecting the orbit with surrounding pterygopalatine fossa (PPF), infratemporal fossa (ITF), and temporal fossa, the idea of eTOA to anterolateral skull base through IOF is postulated. The aim of this study is to access its practical feasibility. ...
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Abstract Objective Feasibility and value of non-invasive transcranial magnetic brain stimulation (TMS MAGVENTURE® MagPro R30 Denmark) for preoperative diagnosis and surgical planning of brain tumor operations in everyday clinical practice. Methods A prospective monocentric study was conducted, which included preoperative neurological and electrophysiological...
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Abstract Background Because of the restricted volume of the cisternal space, proper patient positioning on the operating table is of utmost importance during surgery by retrosigmoid approaches. Three positions are commonly used: supine, with the head rotated to the side contralateral to the lesion; the semi-sitting position; and the park bench position. Each position has advantages and disadvantages, and the surgeon should choose...
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Abstract Background Paediatric pineoblastomas are rare central nervous system tumours. Patient and treatment factors associated with outcome are poorly defined and limited to small retrospective case series and single case reports. Methods Using the Surveillance, Epidemiology, and End Results (SEER) cancer registry, we investigated clinical...
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Abstract Vestibular schwannomas (VSs) are generally benign and slow-growing tumors, and microsurgical resection is the commonly recommended treatment. Some reports suggested that inserting a cystoperitoneal shunt was effective for treatment of cystic VSs; however, there was no report of a cyst-cisternal shunt which diverts cyst fluid into cistern. We report a case of cystic VS with repeated cyst regrowth within weeks after repeated surgeries. We prevented further recurrence using...
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Abstract Background Patients with vestibular schwannoma (VS) often complain about tiredness, exhaustion, lack of energy, and strength, but such symptoms of fatigue have scarcely been objectified and analyzed in a VS population. We aimed to characterize fatigue in a cohort of patients with VS and compare such symptoms with a control group. Methods ...
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Abstract Background Long-term results for adult patients who underwent surgery for paediatric brain tumours in the first year of life have not been reported. Methods We performed a retrospective study on surgical morbidity, mortality rate, academic achievement and/or work participation in patients who underwent primary tumour resection for a...
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Abstract Background The association between traumatic brain injury (TBI) and coagulopathy is well established. While coagulopathy prophylaxis in TBI involves replenishing coagulation factors with fresh frozen plasma (FFP), its effectiveness is controversial. We investigated the relationship between plasma fibrinogen concentration 3 h after initiating FFP transfusion and outcomes and evaluated the correlation with D-dimer levels at...
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Abstract Background High-sensitivity C-reactive protein (hs-CRP) is a well-recognized biomarker of neurologic complications and clinical outcome of stroke patients. However, whether hs-CRP can predict the occurrence of acute kidney injury (AKI) in aneurysmal subarachnoid hemorrhage (aSAH) patients is still unclear. The objective of this study was to assess the feasibility of using serum hs-CRP level to predict the occurrence of AKI...
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Abstract Background Intraoperative neurophysiological monitoring is widely used in spine surgery (sIONM). But guidelines are lacking and its use is mainly driven by individual surgeons’ preferences and medicolegal advisements. To gain an overview over the current status of sIONM implementation, we conducted a transnational survey in the German-speaking countries. ...
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IJERPH, Vol. 16, Pages 3037: Validity of Wrist-Worn Activity Trackers for Estimating VO2max and Energy Expenditure International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16173037 Authors: Stefanie Passler Julian Bohrer Lukas Blöchinger Veit Senner Activity trackers are a simple and mostly low-priced method to capture physiological parameters. Despite the high number of wrist-worn devices, there is a lack of scientific validation. The purpose of...
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IJERPH, Vol. 16, Pages 3036: Assessment of Nutritional Intakes in Individuals with Obesity under Medical Supervision. A Cross-Sectional Study International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16173036 Authors: Costela Lăcrimioara Șerban Alexandra Sima Corina Marcela Hogea Adela Chiriță-Emandi Iulia Teodora Perva Adrian Vlad Alin Albai Georgiana Nicolae Salomeia Putnoky Romulus Timar Mihai Dinu Niculescu Maria Puiu People...
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IJERPH, Vol. 16, Pages 3038: Testing and Calibration of CDs as Radon Detectors at Highly Variable Radon Concentrations and Temperatures International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16173038 Authors: Dobromir Pressyanov Luis Santiago Quindos Poncela Strahil Georgiev Ivelina Dimitrova Krasimir Mitev Carlos Sainz Ismael Fuente Daniel Rabago The application of the compact disk (CD) method for radon measurements at mines, caves...
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IJERPH, Vol. 16, Pages 3035: Blood Lead Concentrations and Antibody Levels to Measles, Mumps, and Rubella among U.S. Children International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16173035 Authors: Todd A. Jusko Kyra Singh Elizabeth A. Greener Marina Oktapodas Feiler Kelly Thevenet-Morrison B. Paige Lawrence Robert O. Wright Sally W. Thurston Child blood lead concentrations have been associated with measures of immune dysregulation...
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IJERPH, Vol. 16, Pages 3034: Scaling Up Solutions to Toxic Contamination in Communities International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16173034 Authors: James W. Dearing In this special issue of IJERPH, we feature studies conducted by research translation and community engagement teams that are funded through the Superfund Research Program in the United States. These and other teams funded by this program demonstrate how environmental and health...
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