Publication date: Available online 20 August 2019Source: Molecular and Cellular EndocrinologyAuthor(s): Cari M. Koerner, Benjamin S. Roberts, Saskia B. NeherAbstractLipids play a critical role in energy metabolism, and a suite of proteins is required to deliver lipids to tissues. Several of these proteins require an intricate endoplasmic reticulum (ER) quality control (QC) system and unique secondary chaperones for folding. Key examples include apolipoprotein B (apoB), which is the primary scaffold...
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Publication date: Available online 20 August 2019Source: Molecular and Cellular EndocrinologyAuthor(s): Filipy Borghi, Camila L. Morais, Carolina Silva, Priscila C. da Silva, Larissa Y. Ishizu, Gustavo T. Costa, Dora M. Grassi-KassisseAbstractIncreased adipose tissue mass exhibited greater capacity of glucose transformation in lactate, highlighting lactatogenesis as a crucial factor in body size. Classically, lactate produced by isolated adipocytes are expressed per million of cells and were never...
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Publication date: Available online 20 August 2019Source: Addictive BehaviorsAuthor(s): Traci M. Kennedy, Andrea L. Howard, John T. Mitchell, Betsy Hoza, L. Eugene Arnold, Lily T. Hechtman, James M. Swanson, Annamarie Stehli, Brooke S.G. MolinaAbstractPeer substance use strongly predicts adolescent and young adult substance use, but its role in ADHD-related risk for substance use, especially in adulthood, is unclear. In a sample with (n = 516) and without (n = 249) childhood ADHD from the Multimodal...
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Publication date: Available online 20 August 2019Source: Addictive BehaviorsAuthor(s): Joseph J.C. Waring, Emily T. Hébert, Adam C. Alexander, Darla E. Kendzor, Michael S. BusinelleAbstractIntroductionPerceived social support and smoking cues, such as cigarette availability, are important factors that affect smoking cessation outcomes. However, very few studies examine the influences of social support and smoking cues on lapse during a quit attempt.MethodsSocioeconomically disadvantaged smokers participating...
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Publication date: Available online 21 August 2019Source: Aggression and Violent BehaviorAuthor(s): Michaela M. Rogers, Jennifer E. StoreyAbstractThis paper presents the findings of the first review of the research-based evidence reporting the phenomenon of elder homicide. A systematic review of peer-reviewed literature published across the world (between 1982 and 2018) was undertaken. A total of 33 articles were identified and appraised using PRISMA including quantitative (n = 30) and mixed methods...
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Publication date: Available online 21 August 2019Source: Aggression and Violent BehaviorAuthor(s): Anna Gillions, Rachael Cheang, Rui DuarteAbstractViolence and aggression represent a serious problem, with significant cost and impact at individual and societal level. There has been increasing interest in the potential of mindfulness interventions to decrease levels of violence and aggression. This paper systematically reviews the evidence to assess the effectiveness of mindfulness interventions for...
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Publication date: Available online 20 August 2019Source: Aggression and Violent BehaviorAuthor(s): Janet Marsden, Cris Glazebrook, Ruth Tully, Birgit VöllmAbstractBackgroundA lack of concern for the feelings, needs or suffering of others and lack of remorse after hurting or mistreating others are key characteristics of Antisocial Personality Disorder and suggest that impaired emotion processing and empathy may contribute to antisocial behaviour. Whilst psychopathy is more commonly associated with...
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Publication date: Available online 20 August 2019Source: Aggression and Violent BehaviorAuthor(s): Ravit AlfandariAbstractTo date, cyberbullying research has been conducted without coherent, shared conceptual and operational definitions and with no clear, agreed theoretical ground. Hence, there is great confusion as to how to classify, measure and analyze this phenomenon. In response, this article proposes applying the systems approach developed in safety engineering, as a possible theoretical framework...
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Sleep has been hypothesized to rebalance overall synaptic strength after ongoing learning during waking leads to net synaptic potentiation. If so, because synaptic strength and size are correlated, synapses on average should be larger after wake and smaller after sleep. This prediction was recently confirmed in mouse cerebral cortex using serial block-face electron microscopy (SBEM). However, whether these findings extend to other brain regions is unknown. Moreover, sleep deprivation by gentle handling...
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The vermal cerebellum is a hub of sensorimotor integration critical for postural control and locomotion, but the nature and developmental organization of afferent information to this region have remained poorly understood in vivo. Here, we use in vivo two-photon calcium imaging of the vermal cerebellum in awake behaving male and female mice to record granule neuron responses to diverse sensorimotor cues targeting visual, auditory, somatosensory, and motor domains. Use of an activity-independent marker...
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In the present study, we investigated motor cortex (M1) and a small portion of premotor and parietal cortex using intracortical microstimulation in anesthetized capuchin monkeys. Capuchins are the only New World monkeys that have evolved an opposable thumb and use tools in the wild. Like most Old World monkeys and humans, capuchin monkeys have highly dexterous hands. We surveyed a large extent of M1 and found that ~22% of all evoked movements in M1 involved the digits, and the majority of these consisted...
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Diencephalic amnesia can be as debilitating as the more commonly known temporal lobe amnesia, yet the precise contribution of diencephalic structures to memory processes remains elusive. Across four cohorts of male rats, we used discrete lesions of the mammillothalamic tract to model aspects of diencephalic amnesia and assessed the impact of these lesions on multiple measures of activity and plasticity within the hippocampus and retrosplenial cortex. Lesions of the mammillothalamic tract had widespread...
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The cingulate cortex contributes to complex, adaptive behaviors, but the exact nature of its contributions remains unresolved. Proposals from previous studies, including evaluating past actions or selecting future ones, have been difficult to distinguish in part because of an incomplete understanding of the task-relevant variables that are encoded by individual cingulate neurons. In this study, we recorded from individual neurons in parts of both the anterior cingulate cortex (ACC) and posterior...
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Authors: Sonon P, Gomes RG, Brelaz-de-Castro MCA, da Costa LAB, Pereira VRA, de Brito MEF, Dessein AJJ, Diniz GTN, Donadi EA, Lucena-Silva N Abstract While the role of cytokine genes has been well documented in the context of Leishmania (Viannia) braziliensis infection, no studies have addressed the influence of human leukocyte antigen-G (HLA-G) in susceptibility/resistance to American Tegumentary Leishmaniasis (ATL). Here, we evaluated the influences of HLA-G, IL-10, TNF-A and IFN-G in...
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Publication date: Available online 21 August 2019Source: Human PathologyAuthor(s): Nuno Vau, Vanessa Henriques, Liang Cheng, Ana Blanca, Jorge Fonseca, Rodolfo Montironi, Alessia Cimadamore, Antonio Lopez-BeltranSummaryThe aim of the current study was to test whether the grade group assessed in the index tumor nodule predicts biochemical recurrence after surgery. The study cohort series included 144 consecutive patients treated by laparoscopic radical prostatectomy. The following parameters were...
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Authors: En C, ChunJing C, FuChao C, Ping Y, Lin L Abstract The disease progression and morbidity of tuberculosis (TB) infections are determined by virulence of the micro-organism, host genetic factors and environmental factors. The highly polymorphic MHC class I chain-related gene (MIC) could serve as a potential host genetic candidate. To investigate the association of MIC polymorphism with TB infection, 124 patients and 191 ethnically matched controls from Hunan province, Southern China,...
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Authors: Mazzoni A, D'Elios MM, Mayaregua DR, Spinicci M, Strohmeyer M, Cosmi F, Cosmi L PMID: 31400357 [PubMed - as supplied by publisher] (Source: Immunology Letters)
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IJMS, Vol. 20, Pages 4090: Discovery of New Inhibitors of Transforming Growth Factor-Beta Type 1 Receptor by Utilizing Docking and Structure-Activity Relationship Analysis International Journal of Molecular Sciences doi: 10.3390/ijms20174090 Authors: Jiang Deng The transforming growth factor-beta (TGF-β) plays an important role in pathological fibrosis and cancer transformation. Therefore, the inhibition of the TGF-β signaling pathway has therapeutic potential...
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IJMS, Vol. 20, Pages 4089: Heat-Induced Interactions between Whey Protein and Inulin and Changes in Physicochemical and Antioxidative Properties of the Complexes International Journal of Molecular Sciences doi: 10.3390/ijms20174089 Authors: Wang Wang Sun Sun Guo Whey protein and inulin at various weight ratios were dry heated at 60 °C for 5 days under relative humidity of 63%. The heated mixtures were found to have significant changes in browning intensity and...
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IJMS, Vol. 20, Pages 4088: Isolation of a Novel Metalloproteinase from Agkistrodon Venom and Its Antithrombotic Activity Analysis International Journal of Molecular Sciences doi: 10.3390/ijms20174088 Authors: Huang Fan Yin Huang Snake venom contains large amounts of active proteins and peptides. In this study, a novel snake protein, metalloproteinase SP, was successfully isolated from the venom of Agkistrodon acutus by multi-gel chromatography. The isolated protein exhibits...
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IJMS, Vol. 20, Pages 4086: Absorption and Emission Spectroscopic Investigation of the Thermal Dynamics of the Archaerhodopsin 3 Based Fluorescent Voltage Sensor QuasAr1 International Journal of Molecular Sciences doi: 10.3390/ijms20174086 Authors: Penzkofer Silapetere Hegemann QuasAr1 is a fluorescent voltage sensor derived from Archaerhodopsin 3 (Arch) of Halorubrum sodomense by directed evolution. Here we report absorption and emission spectroscopic studies of QuasAr1 in Tris...
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IJMS, Vol. 20, Pages 4087: Over-Expression of CHD4 Is an Independent Biomarker of Poor Prognosis in Patients with Rectal Cancers Receiving Concurrent Chemoradiotherapy International Journal of Molecular Sciences doi: 10.3390/ijms20174087 Authors: Hui-Ching Wang Chia-Lin Chou Ching-Chieh Yang Wei-Lun Huang Yin-Chou Hsu Chi-Wen Luo Tzu-Ju Chen Chien-Feng Li Mei-Ren Pan Neoadjuvant concurrent chemoradiotherapy (CCRT), followed by radical proctectomy, is the standard...
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IJMS, Vol. 20, Pages 4085: Enhancement of Particle Alignment Using Silicone Oil Plasticizer and Its Effects on the Field-Dependent Properties of Magnetorheological Elastomers International Journal of Molecular Sciences doi: 10.3390/ijms20174085 Authors: Khairi Fatah Mazlan Ubaidillah Nordin Ismail Bok-Choi Aziz The existing mold concept of fabricating magnetorheological elastomer (MRE) tends to encounter several flux issues due to magnetic flux losses inside...
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IJMS, Vol. 20, Pages 4084: De Novo Transcriptome Analysis Reveals Abundant Gonad-specific Genes in the Ovary and Testis of Henosepilachna vigintioctopunctata International Journal of Molecular Sciences doi: 10.3390/ijms20174084 Authors: Wei Guo Jing Lü Mujuan Guo Shimin Chen Baoli Qiu Wen Sang Chunxiao Yang Youjun Zhang Huipeng Pan Henosepilachna vigintioctopunctata (Coleoptera: Coccinellidae) is a major pest affecting Solanaceae plants in Asian countries. In...
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IJMS, Vol. 20, Pages 4082: Pachypodol, a Methoxyflavonoid Isolated from Pogostemon cablin Bentham Exerts Antioxidant and Cytoprotective Effects in HepG2 Cells: Possible Role of ERK-Dependent Nrf2 Activation International Journal of Molecular Sciences doi: 10.3390/ijms20174082 Authors: Eun Kyung Kim Ji Hoon Kim Soyeon Jeong Yong Won Choi Hyun Jung Choi Chul Young Kim Young-Mi Kim Oxidative stress has been implicated in the pathogenesis of many diseases including chronic...
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IJMS, Vol. 20, Pages 4081: Functional Characterization of a Drought-Responsive Invertase Inhibitor from Maize (Zea mays L.) International Journal of Molecular Sciences doi: 10.3390/ijms20174081 Authors: Lin Chen Xiaohong Liu Xiaojia Huang Wei Luo Yuming Long Steffen Greiner Thomas Rausch Hongbo Zhao Invertases (INVs) play essential roles in plant growth in response to environmental cues. Previous work showed that plant invertases can be post-translationally regulated...
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IJMS, Vol. 20, Pages 4080: Off-Stoichiometric Reactions at the Cell–Substrate Biomolecular Interface of Biomaterials: In Situ and Ex Situ Monitoring of Cell Proliferation, Differentiation, and Bone Tissue Formation International Journal of Molecular Sciences doi: 10.3390/ijms20174080 Authors: Giuseppe Pezzotti Tetsuya Adachi Francesco Boschetto Wenliang Zhu Matteo Zanocco Elia Marin B. Sonny Bal Bryan J. McEntire The availability of osteoinductive biomaterials has...
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IJMS, Vol. 20, Pages 4083: Human Fetal Bone Marrow-Derived Mesenchymal Stem Cells Promote the Proliferation and Differentiation of Pancreatic Progenitor Cells and the Engraftment Function of Islet-Like Cell Clusters International Journal of Molecular Sciences doi: 10.3390/ijms20174083 Authors: Xing Yu Li Shang Ying Wu Po Sing Leung Pancreatic progenitor cells (PPCs) are the primary source for all pancreatic cells, including beta-cells, and thus the proliferation and differentiation...
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IJMS, Vol. 20, Pages 4078: Different Dynamics in 6aJL2 Proteins Associated with AL Amyloidosis, a Conformational Disease International Journal of Molecular Sciences doi: 10.3390/ijms20174078 Authors: Roberto Maya-Martinez Leidys French-Pacheco Gilberto Valdés-García Nina Pastor Carlos Amero Light-chain amyloidosis (AL) is the most common systemic amyloidosis and is caused by the deposition of mainly insoluble immunoglobulin light chain amyloid fibrils in multiple organs,...
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IJMS, Vol. 20, Pages 4077: Extensive Chromosomal Reorganization in Apistogramma Fishes (Cichlidae, Cichlinae) Fits the Complex Evolutionary Diversification of the Genus International Journal of Molecular Sciences doi: 10.3390/ijms20174077 Authors: Gideão Wagner Werneck Félix da Costa Marcelo de Bello Cioffi Thomas Liehr Eliana Feldberg Luiz Antonio Carlos Bertollo Wagner Franco Molina Neotropical cichlid fishes are one of the most diversified and evolutionarily successful...
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IJMS, Vol. 20, Pages 4074: Radiocontrast Agent Diatrizoic Acid Induces Mitophagy and Oxidative Stress via Calcium Dysregulation International Journal of Molecular Sciences doi: 10.3390/ijms20174074 Authors: Dakota B. Ward Kathleen C. Brown Monica A. Valentovic Contrast-induced acute kidney injury (CI-AKI) is the third most common cause of hospital associated kidney damage. Potential mechanisms of CI-AKI may involve diminished renal hemodynamics, inflammatory responses, and direct...
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IJMS, Vol. 20, Pages 4079: Astrochemistry and Astrobiology: Materials Sciencein Wonderland? International Journal of Molecular Sciences doi: 10.3390/ijms20174079 Authors: Marco d'Ischia Paola Manini Marco Moracci Raffaele Saladino Vincent Ball Helmut Thissen Richard A. Evans Cristina Puzzarini Vincenzo Barone Astrochemistry and astrobiology, the fascinating disciplines that strive to unravel the origin of life, have opened unprecedented and unpredicted vistas...
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IJMS, Vol. 20, Pages 4076: Plakophilin-2 Haploinsufficiency Causes Calcium Handling Deficits and Modulates the Cardiac Response Towards Stress International Journal of Molecular Sciences doi: 10.3390/ijms20174076 Authors: Chantal J.M. van Opbergen Maartje Noorman Anna Pfenniger Jaël S. Copier Sarah H. Vermij Zhen Li Roel van der Nagel Mingliang Zhang Jacques M.T. de Bakker Aaron M. Glass Peter J. Mohler Steven M. Taffet Marc A. Vos Harold V.M. van Rijen...
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IJMS, Vol. 20, Pages 4073: Castration Induces Down-Regulation of A-Type K+ Channel in Rat Vas Deferens Smooth Muscle International Journal of Molecular Sciences doi: 10.3390/ijms20174073 Authors: Susumu Ohya Katsunori Ito Noriyuki Hatano Akitoshi Ohno Katsuhiko Muraki Yuji Imaizumi A-type K+ channels contribute to regulating the propagation and frequency of action potentials in smooth muscle cells (SMCs). The present study (i) identified the molecular components of A-type...
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IJMS, Vol. 20, Pages 4075: Microtubules: A Key to Understand and Correct Neuronal Defects in CDKL5 Deficiency Disorder? International Journal of Molecular Sciences doi: 10.3390/ijms20174075 Authors: Isabella Barbiero Roberta De Rosa Charlotte Kilstrup-Nielsen CDKL5 deficiency disorder (CDD) is a severe neurodevelopmental encephalopathy caused by mutations in the X-linked CDKL5 gene that encodes a serine/threonine kinase. CDD is characterised by the early onset of seizures and impaired...
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Related ArticlesFinite element analysis of the effect of sagittal angle on ankle joint stability in posterior malleolus fracture: a cohort study. Int J Surg. 2019 Aug 17;: Authors: Guan M, Zhao J, Kuang Y, Li G, Tan J Abstract OBJECTIVE: Aim of this study was to establish three-dimensional finite element model of the posterolateral-oblique type of posterior malleolus fracture with different sagittal angle and to explore the effect of sagittal angle on...
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Un ensayo aleatorio no encuentra beneficio con el control intensivo de glucosa.
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Related ArticlesResponse to Letter to the Editor from Peck. J Am Acad Audiol. 2019 Aug 16;: Authors: Roup CM, Post E, Lewis JH PMID: 31429404 [PubMed - as supplied by publisher]
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Related ArticlesEvaluation of a Remote Microphone System with Tri-Microphone Beamformer. J Am Acad Audiol. 2019 Aug 16;: Authors: Wolfe J, Duke M, Schafer E, Jones C, Rakita L, Battles J Abstract BACKGROUND: Children with hearing loss often experience difficulty understanding speech in noisy and reverberant classrooms. Traditional remote microphone use, in which the teacher wears a remote microphone that captures her speech and wirelessly delivers it...
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Related ArticlesSound Localization in Toddlers with Normal Hearing and with Bilateral Cochlear Implants Revealed Through a Novel "Reaching for Sound" Task. J Am Acad Audiol. 2019 Aug 12;: Authors: Bennett EE, Litovsky RY Abstract BACKGROUND: Spatial hearing abilities in children with bilateral cochlear implants (BiCIs) are typically improved when two implants are used compared with a single implant. However, even with BiCIs, spatial hearing is still...
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Related ArticlesTemporal Processing and Speech Perception Performance in Postlingual Adult Users of Cochlear Implants. J Am Acad Audiol. 2019 Aug 16;: Authors: Cesur S, Derinsu U Abstract BACKGROUND: Cochlear implant (CI) listeners had some hearing problems, including catching clues from speech context, persist, particularly in complex listening environments. Among these hearing problems, temporal resolution is considered to be one of the most affected...
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Related ArticlesPredictors of Hearing Aid Use in the Advanced Digital Era: An Investigation of Benefit, Satisfaction, and Self-Efficacy. J Am Acad Audiol. 2019 Aug 16;: Authors: Jilla AM, Johnson CE, Danhauer JL, Anderson M, Smith JN, Sullivan JC, Sanchez KR Abstract BACKGROUND: Untreated sensorineural hearing loss (SNHL) has been linked to depression, social isolation, anxiety, and a reduction in health-related quality of life (QoL), and is independently...
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Related ArticlesThe Effect of Varying Test Administration and Scoring Procedures on Three Tests of (Central) Auditory Processing Disorder. J Am Acad Audiol. 2019 Aug 16;: Authors: Pomponio ME, Nagle S, Smart JL, Palmer S Abstract BACKGROUND: There is currently no widely accepted objective method used to identify (central) auditory processing disorder ([C]APD). Audiologists often rely on behavioral test methods to diagnose (C)APD, which can be highly...
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Related ArticlesEpileptic seizures and outcome in different subtypes of subarachnoid haemorrhage - Results of a single-center retrospective analysis. J Clin Neurosci. 2019 Aug 16;: Authors: Wittstock M, Kurtieiev K, Grossmann A, Storch A, Walter U Abstract BACKGROUND: Symptomatic epileptic seizures are an important complication in subarachnoid haemorrhage (SAH) with a frequency of 0.9-25% with importance for patient outcome. The majority of previous...
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Related ArticlesUtility of surveillance imaging for spontaneous intracerebral hemorrhage. J Clin Neurosci. 2019 Aug 16;: Authors: Kim WJ, Zhang X, Agarwal N, Gross BA, Safonova A, Jankowitz BT, Friedlander RM Abstract INTRODUCTION: Management of spontaneous intracerebral hemorrhage involves reversal of coagulopathy, neurological examinations and repeated imaging. Repeated imaging is employed to identify patients prior to neurological deterioration, however,...
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Related ArticlesNeurosyphilis in the modern era: Literature review and case series. J Clin Neurosci. 2019 Aug 16;: Authors: Skalnaya A, Fominykh V, Ivashchenko R, Averchenkov D, Grazhdantseva L, Frigo N, Negasheva E, Dolya O, Brylev L, Guekht A Abstract The term of neurosyphilis (NS) refers to infection of central nervous system by Treponema pallidum. Classically, it has been divided into early (meningitis, meningovascular) and late forms (general paresis...
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Related ArticlesDifferences in clinical outcomes between traumatic cervical myelopathy and degenerative cervical myelopathy: A comparative study of cervical spinal cord injury without major bone injury and cervical spondylotic myelopathy. J Clin Neurosci. 2019 Aug 16;: Authors: Machino M, Ando K, Kobayashi K, Morozumi M, Tanaka S, Ito K, Kato F, Ishiguro N, Imagama S Abstract A comparative study to examine the surgical outcomes of traumatic cervical...
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Related ArticlesfMRI and electroencephalographic evaluation of sleep deprivation in epilepsy patients: An observational study. J Clin Neurosci. 2019 Aug 16;: Authors: Cartella E, De Salvo S, Bonanno L, Muscarà N, Micchia K, Pisani LR, Corallo F, Pollicino P, Bramanti P, Marino S Abstract BACKGROUND: Sleep deprivation (SD) is considered an important activation test to facilitate the visualization of electroencephalogram (EEG) epileptic abnormalities,...
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Related ArticlesPretreatment intratumoral susceptibility signals correlate with response to high-dose methotrexate and progression-free survival in primary central nervous system lymphoma. J Clin Neurosci. 2019 Aug 16;: Authors: Deguchi S, Nakashima K, Muramatsu K, Mitsuya K, Oishi T, Shirata K, Hayashi N, Sugino T, Endo M, Nakasu Y Abstract We aimed to estimate the frequency of intratumoral susceptibility signals (ITSS) in susceptibility-weighted imaging...
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Related ArticlesMean platelet volume values may not be elevated in patients with vestibular neuritis. J Clin Neurosci. 2019 Aug 16;: Authors: Beyan C, Beyan E PMID: 31427234 [PubMed - as supplied by publisher]
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Related ArticlesImpact of medical student involvement on outcomes following spine surgery: A single center analysis of 6485 patients. J Clin Neurosci. 2019 Aug 16;: Authors: Abecassis ZA, Hopkins B, Win P, Yerneni K, Karras CL, Frankel HG, Ayer A, Dahdaleh NS Abstract Medical student (MS) observation and assistance in the operating room (OR) is a critical component of medical education. Though participation in the operating room has many benefits to...
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As a pioneer in the field of skin of color, I have been dismayed that black patients remain largely overlooked in dermatology education, research, and publications despite comprising 14.3% of the US population. Likewise, the number of blacks in the dermatology workforce remains abysmal, which has important implications for patient care. These statements also apply to Latino patients and other patients of color, including patients of other nonwhite races and ethnicities. In this issue of JAMA Dermatology,...
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This case report describes 4 patients with treatment-resistant granuloma annulare subsequently treated with oral apremilast.
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This cross-sectional study explores black patients’ perceptions of their dermatology experience both in and outside of skin of color clinic settings.
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This case series analyzes the outcomes of patients with primary cutaneous squamous cell carcinoma treated with limited-field irradiation for microscopic residual disease after surgery.
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With advances in computing and software power, physicians can now create virtual 3-dimensional models of patient anatomy using data from 2-dimensional computed tomography imaging. With augmented reality, users can interact with each other and the model, even over long distances, for purposes of teaching or preprocedural decision-making. This video illustrates an example of the process; the 3-dimensional model has been loaded onto a HoloLens (Microsoft) augmented reality viewing device for inspection...
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This Medical News article discusses a controversy around limbic-predominant age-related TDP-43 encephalopathy, or LATE, a recently recognized dementia that mimics Alzheimer disease.
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