Related ArticlesNear-Death High-Frequency Hyper-Synchronization in the Rat Hippocampus. Front Neurosci. 2019;13:800 Authors: Zhang Y, Li Z, Zhang J, Zhao Z, Zhang H, Vreugdenhil M, Lu C Abstract Near-death experiences (NDE) are episodes of enhanced perception with impending death, which have been associated with increased high-frequency (13-100 Hz) synchronization of neuronal activity, which is implicated in cognitive processes like perception, attention...
Related ArticlesIncreased P2X7 Receptor Binding Is Associated With Neuroinflammation in Acute but Not Chronic Rodent Models for Parkinson's Disease. Front Neurosci. 2019;13:799 Authors: Crabbé M, Van der Perren A, Bollaerts I, Kounelis S, Baekelandt V, Bormans G, Casteels C, Moons L, Van Laere K Abstract The purinergic P2X7 receptor is a key mediator in (neuro)inflammation, a process that is associated with neurodegeneration and excitotoxicity in Parkinson's...
Related ArticlesSexual Dimorphism Within Brain Regions Controlling Speech Production. Front Neurosci. 2019;13:795 Authors: de Lima Xavier L, Hanekamp S, Simonyan K Abstract Neural processing of speech production has been traditionally attributed to the left hemisphere. However, it remains unclear if there are structural bases for speech functional lateralization and if these may be partially explained by sexual dimorphism of cortical morphology. We used...
Related ArticlesA Mathematical Approach to Correlating Objective Spectro-Temporal Features of Non-linguistic Sounds With Their Subjective Perceptions in Humans. Front Neurosci. 2019;13:794 Authors: Burns T, Rajan R Abstract Non-linguistic sounds (NLSs) are a core feature of our everyday life and many evoke powerful cognitive and emotional outcomes. The subjective perception of NLSs by humans has occasionally been defined for single percepts, e.g., their...
Brain Insulin Resistance and Hippocampal Plasticity: Mechanisms and Biomarkers of Cognitive Decline.
Related ArticlesBrain Insulin Resistance and Hippocampal Plasticity: Mechanisms and Biomarkers of Cognitive Decline. Front Neurosci. 2019;13:788 Authors: Spinelli M, Fusco S, Grassi C Abstract In the last decade, much attention has been devoted to the effects of nutrient-related signals on brain development and cognitive functions. A turning point was the discovery that brain areas other than the hypothalamus expressed receptors for hormones related...
Related ArticlesOlfactory fMRI Activation Pattern Across Different Concentrations Changes in Alzheimer's Disease. Front Neurosci. 2019;13:786 Authors: Zhang H, Ji D, Yin J, Wang Z, Zhou Y, Ni H, Liu Y Abstract The olfactory involvement is an early feature of Alzheimer's disease (AD). Olfactory functional MRI (fMRI) is an objective method to evaluate the olfactory function, but might be affected by the individual variation and the magnetic susceptibility...
Related ArticlesA 3D Printed Device for Low Cost Neural Stimulation in Mice. Front Neurosci. 2019;13:784 Authors: Morrison TJ, Sefton E, Marquez-Chin M, Popovic MR, Morshead CM, Naguib HE Abstract Electrical stimulation of the brain through the implantation of electrodes is an effective treatment for certain diseases and the focus of a large body of research investigating new cell mechanisms, neurological phenomena, and treatments. Electrode devices...
Related ArticlesMRI-Driven PET Image Optimization for Neurological Applications. Front Neurosci. 2019;13:782 Authors: Zhu Y, Zhu X Abstract Positron emission tomography (PET) and magnetic resonance imaging (MRI) are established imaging modalities for the study of neurological disorders, such as epilepsy, dementia, psychiatric disorders and so on. Since these two available modalities vary in imaging principle and physical performance, each technique has...
Related ArticlesSpatial Patterns of Decreased Cerebral Blood Flow and Functional Connectivity in Multiple System Atrophy (Cerebellar-Type): A Combined Arterial Spin Labeling Perfusion and Resting State Functional Magnetic Resonance Imaging Study. Front Neurosci. 2019;13:777 Authors: Zheng W, Ren S, Zhang H, Liu M, Zhang Q, Chen Z, Wang Z Abstract Multiple system atrophy (MSA) is a progressive neurodegenerative disease. However, little is known about...
Related ArticlesPrenatal Exposure to Methamphetamine: Up-Regulation of Brain Receptor Genes. Front Neurosci. 2019;13:771 Authors: Zoubková H, Tomášková A, Nohejlová K, Černá M, Šlamberová R Abstract Methamphetamine (METH) is a widespread illicit drug. If it is taken by pregnant women, it passes through the placenta and just as it affects the mother, it can impair the development of the offspring. The aim of our study was to identify candidates to investigate...
Related ArticlesMonitoring Behaviorally Induced Biochemical Changes Using Fluorescence Lifetime Photometry. Front Neurosci. 2019;13:766 Authors: Lee SJ, Chen Y, Lodder B, Sabatini BL Abstract All cells respond to extracellular signals by altering their intracellular biochemical state. In neurons, such signaling regulates many aspects of cell and synapse biology and induces changes that are thought to be important for nervous system development, its adaptation...
Related ArticlesViral-Mediated Optogenetic Stimulation of Peripheral Motor Nerves in Non-human Primates. Front Neurosci. 2019;13:759 Authors: Williams JJ, Watson AM, Vazquez AL, Schwartz AB Abstract Objective: Reanimation of muscles paralyzed by disease states such as spinal cord injury remains a highly sought therapeutic goal of neuroprosthetic research. Optogenetic stimulation of peripheral motor nerves expressing light-sensitive opsins is a promising...
Related ArticlesDifferential Role of Pontomedullary Glutamatergic Neuronal Populations in Sleep-Wake Control. Front Neurosci. 2019;13:755 Authors: Erickson ETM, Ferrari LL, Gompf HS, Anaclet C Abstract Parafacial zone (PZ) GABAergic neurons play a major role in slow-wave-sleep (SWS), also called non-rapid eye movement (NREM) sleep. The PZ also contains glutamatergic neurons expressing the vesicular transporter for glutamate, isoform 2 (Vglut2). We hypothesized...
Related ArticlesRAPA-ConvNets: Modified Convolutional Networks for Accelerated Training on Architectures With Analog Arrays. Front Neurosci. 2019;13:753 Authors: Rasch MJ, Gokmen T, Rigotti M, Haensch W Abstract Analog arrays are a promising emerging hardware technology with the potential to drastically speed up deep learning. Their main advantage is that they employ analog circuitry to compute matrix-vector products in constant time, irrespective of...
Related ArticlesElectroencephalography and Functional Magnetic Resonance Imaging-Guided Simultaneous Transcranial Direct Current Stimulation and Repetitive Transcranial Magnetic Stimulation in a Patient With Minimally Conscious State. Front Neurosci. 2019;13:746 Authors: Lin Y, Liu T, Huang Q, Su Y, Chen W, Gao D, Tian X, Huang T, Zhen Z, Han T, Ye H, Wang Y Abstract Objective: A minimally conscious state (MCS) is characterized by discernible behavioral...
Kinematic and Functional Gait Changes After the Utilization of a Foot Drop Stimulator in Pediatrics.
Related ArticlesKinematic and Functional Gait Changes After the Utilization of a Foot Drop Stimulator in Pediatrics. Front Neurosci. 2019;13:732 Authors: Karunakaran KK, Pilkar R, Ehrenberg N, Bentley KS, Cheng J, Nolan KJ Abstract Foot drop is one of the most common secondary conditions associated with hemiplegia post stroke and cerebral palsy (CP) in children, and is characterized by the inability to lift the foot (dorsiflexion) about the ankle. This...
Related ArticlesChemogenetic Modulation of Orexin Neurons Reverses Changes in Anxiety and Locomotor Activity in the A53T Mouse Model of Parkinson's Disease. Front Neurosci. 2019;13:702 Authors: Stanojlovic M, Pallais JP, Kotz CM Abstract Parkinson's disease (PD) is the second most common neurodegenerative disease. PD symptomology is recognized as heterogeneous and in addition to motor function decline includes cognitive, mood, sleep, and metabolic disorders....
Related ArticlesActivity of the Carboxy-Terminal Peptide Region of the Teneurins and Its Role in Neuronal Function and Behavior in Mammals. Front Neurosci. 2019;13:581 Authors: Hogg DW, Husić M, Wosnick D, Dodsworth T, D'Aquila AL, Lovejoy DA Abstract Teneurin C-terminal associated peptides (TCAPs) are an evolutionarily ancient family of 40- to 41-residue bioactive peptides located on the extracellular end of each of the four teneurin transmembrane proteins....
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PTP1B phosphatase as a novel target of oleuropein activity in MCF-7 breast cancer model. Toxicol In Vitro. 2019 Aug 13;:104624 Authors: Przychodzen P, Kuban-Jankowska A, Wyszkowska R, Barone G, Bosco GL, Celso FL, Kamm A, Daca A, Kostrzewa T, Gorska-Ponikowska M Abstract Phosphatase PTP1B has become a therapeutic target for the treatment of type 2-diabetes, whereas recent studies have revealed that PTP1B plays a pivotal role in pathophysiology and development...
[Effects of Bone Marrow Mesenchymal Stem Cells Derived from Patients with Newly Diagnosed Acute Myeloid Leukemia on the Cell Proliferation, Cell Cycle and Immunophenotypes of HL-60 Cells]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2019 Aug;27(4):1259-1264 Authors: Ning HM, Wang J, Su YF, Xu C, Hu JW, Lou X, Li XS, Mao N, Chen H Abstract OBJECTIVE: To explore the role of bone marrow microenvironment(niche) in the development of acute myeloid leukemia (AML)...
[Inhibitory Effect of NPM Gene Knockdown on Proliferation of Chronic Myeloid Leukemia Cell Line K562 and Its Mechanism]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2019 Aug;27(4):1008-1012 Authors: Lin MH, Zheng ZH, Jiang PF, Wu ZJ, Gan DH, Zhang N, Hu JD Abstract OBJECTIVE: To investigate the role of nucleophosmin (NPM) in the proliferation of chronic myeloid leukemia cells (K562 cells) and its mechanism by RNAi technology. METHODS: shRNA was used...
Related ArticlesHomeostasis and systematic ageing as non-equilibrium phase transitions in computational multicellular organizations. R Soc Open Sci. 2019 Jul;6(7):190012 Authors: Lou Y, Chen A, Yoshida E, Chen Y Abstract Being a fatal threat to life, the breakdown of homeostasis in tissues is believed to involve multiscale factors ranging from the accumulation of genetic damages to the deregulation of metabolic processes. Here, we present a prototypical...
Related ArticlesHBV Integration-mediated Cell Apoptosis in HepG2.2.15. J Cancer. 2019;10(17):4142-4150 Authors: Hu X, Jiang J, Ni C, Xu Q, Ye S, Wu J, Ge F, Han Y, Mo Y, Huang D, Yang L Abstract Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and the second leading cause of cancer deaths in the word. Hepatitis B virus (HBV) infection plays an important role in the development of HCC. However, the mechanisms by which HBV...
Related ArticlesOverexpression of SMYD3 in Ovarian Cancer is Associated with Ovarian Cancer Proliferation and Apoptosis via Methylating H3K4 and H4K20. J Cancer. 2019;10(17):4072-4084 Authors: Jiang Y, Lyu T, Che X, Jia N, Li Q, Feng W Abstract Background: Epigenetic regulation has been verified as a key mechanism in tumorigenesis. SET and MYND domain-containing protein 3 (SMYD3), a histone methyltransferase, is a promising epigenetic therapeutic target...
Related ArticlesLong noncoding RNA LINC01089 predicts clinical prognosis and inhibits cell proliferation and invasion through the Wnt/β-catenin signaling pathway in breast cancer. Onco Targets Ther. 2019;12:4883-4895 Authors: Yuan H, Qin Y, Zeng B, Feng Y, Li Y, Xiang T, Ren G Abstract Background: Recently, emerging evidence has indicated crucial roles for long noncoding RNAs (lncRNAs) in breast cancer (BC) development and progression. Our study aimed...
Related ArticlesDesign, Synthesis and Anticancer Evaluation of New Substituted Thiophene-Quinoline Derivatives. Bioorg Med Chem. 2019 Jul 30;:115026 Authors: Othman DIA, Selim KB, El-Sayed MA, Tantawy AS, Amen Y, Shimizu K, Okauchi T, Kitamura M Abstract A series of new isoxazolyl, triazolyl and phenyl based 3-thiophen-2-yl-quinoline derivatives were synthesized adopting click chemistry approach. In addition, the synthesis of new useful synthon, (2-chloroquinolin-3-yl)...
Related Articlesp21 in Cancer Research. Cancers (Basel). 2019 Aug 14;11(8): Authors: Shamloo B, Usluer S Abstract p21 functions as a cell cycle inhibitor and anti-proliferative effector in normal cells, and is dysregulated in some cancers. Earlier observations on p21 knockout models emphasized the role of this protein in cell cycle arrest under the p53 transcription factor activity. Although tumor-suppressor function of p21 is the most studied aspect...
Related ArticlesLoss of Peter Pan (PPAN) Affects Mitochondrial Homeostasis and Autophagic Flux. Cells. 2019 Aug 14;8(8): Authors: Dannheisig DP, Beck E, Calzia E, Walther P, Behrends C, Pfister AS Abstract Nucleolar stress is a cellular response to inhibition of ribosome biogenesis or nucleolar disruption leading to cell cycle arrest and/or apoptosis. Emerging evidence points to a tight connection between nucleolar stress and autophagy as a mechanism...
Related ArticlesSynthesis and Antiproliferative Activity of Novel A-Ring Cleaved Glycyrrhetinic Acid Derivatives. Molecules. 2019 Aug 14;24(16): Authors: Alho DPS, Salvador JAR, Cascante M, Marin S Abstract A series of new glycyrrhetinic acid derivatives was synthesized via the opening of its ring A along with the coupling of an amino acid. The antiproliferative activity of the derivatives was evaluated against a panel of nine human cancer cell lines....
Related ArticlesAlterations of RNA Metabolism by Proteomic Analysis of Breast Cancer Cells Exposed to Marycin: A New Optically Active Porphyrin. Curr Mol Pharmacol. 2019;12(2):147-159 Authors: Taverna E, De Bortoli M, Maffioli E, Corno C, Ciusani E, Trivulzio S, Pinelli A, Tedeschi G, Perego P, Bongarzone I Abstract OBJECTIVE: Marycin is a porphyrin-type compound synthetically modified to spontaneously release fluorescence. This study is aimed at understanding...
Related ArticlesHEME OXYGENASE-1 ARRESTS LEYDIG CELLS FUNCTIONS AND IMPAIRS THEIR REGULATION BY HISTAMINE. J Mol Endocrinol. 2019 Aug 01;: Authors: Raices T, Varela ML, Monzon CM, Correa Torrado MF, Pagotto RM, Besio Moreno M, Mondillo C, Pignataro OP, Pereyra EN Abstract Testicular Leydig cells (LC) are modulated by several pathways, one of them being the histaminergic system. Heme oxygenase-1 (HO-1), whose upregulation comprises the primary response...
Related ArticlesEvaluation of Cytotoxicity and Genotoxicity Induced by Oleic Acid-Coated Iron Oxide Nanoparticles in Human Astrocytes. Environ Mol Mutagen. 2019 Aug 15;: Authors: Fernández-Bertólez N, Costa C, Brandão F, Duarte JA, Teixeira JP, Pásaro E, Valdiglesias V, Laffon B Abstract Iron oxide nanoparticles (ION) are gaining importance as diagnostic and therapeutic tool of central nervous system diseases. Although oleic acid-coated ION (O-ION) have...
Related ArticlesInfection with genotoxin-producing Salmonella enterica synergises with loss of the tumor suppressor APC in promoting genomic instability via the PI3K pathway in colonic epithelial cells. Cell Microbiol. 2019 Aug 14;:e13099 Authors: Martin OCB, Bergonzini A, D'Amico F, Chen P, Shay JW, Dupuy J, Svensson M, Masucci MG, Frisan T Abstract Several commensal and pathogenic Gram-negative bacteria produce DNA damaging toxins that are considered...
Related ArticlesTranscriptome analysis reveals the molecular mechanisms of combined gamma-tocotrienol and hydroxychavicol in preventing the proliferation of 1321N1, SW1783, and LN18 glioma cancer cells. J Physiol Biochem. 2019 Aug 14;: Authors: Abdul Rahman A, Mokhtar NM, Harun R, Jamal R, Wan Ngah WZ Abstract Gamma-tocotrienol (GTT) and hydroxychavicol (HC) exhibit anticancer activity in glioma cancer cells, where the combination of GTT + HC was shown...
Related ArticlesSomatic multicellularity as a satisficing solution to the prediction-error minimization problem. Commun Integr Biol. 2019;12(1):119-132 Authors: Fields C, Levin M Abstract Adaptive success in the biosphere requires the dynamic ability to adjust physiological, transcriptional, and behavioral responses to environmental conditions. From chemical networks to organisms to whole communities, biological entities at all levels of organization...
Related ArticlesS-Adenosylmethionine Affects Cell Cycle Pathways and Suppresses Proliferation in Liver Cells. J Cancer. 2019;10(18):4368-4379 Authors: Yan L, Liang X, Huang H, Zhang G, Liu T, Zhang J, Chen Z, Zhang Z, Chen Y Abstract S-Adenosylmethionine (SAMe) is a kind of common liver-protection medicine. Recent studies have shown that SAMe has the inhibitory effects on hepatocellular carcinoma (HCC). But the specific mechanism has not been elucidated....
Related ArticlesMicroRNA-27a downregulates the expression of Hsp90 and enhances the radiosensitivity in esophageal squamous cell carcinoma. Onco Targets Ther. 2019;12:5967-5977 Authors: Wang X, An D, Liu X, Wang X, Li B Abstract Purpose: Accumulating evidence suggests that microRNAs (miRNAs) possess diverse cellular regulatory roles in radiation responses. In this study, we aimed to identify the role of miR-27a in esophageal squamous cell carcinoma (ESCC)...
Related ArticlesArsenic sulfide nanoformulation induces erythroid differentiation in chronic myeloid leukemia cells through degradation of BCR-ABL. Int J Nanomedicine. 2019;14:5581-5594 Authors: Wang T, Wen T, Li H, Han B, Hao S, Wang C, Ma Q, Meng J, Liu J, Xu H Abstract Background: Chronic myeloid leukemia (CML) is a myeloproliferative disorder due to the existence of BCR-ABL fusion protein that allows the cells to keep proliferating uncontrollably....
Related ArticlesFolate-mediated and pH-responsive chidamide-bound micelles encapsulating photosensitizers for tumor-targeting photodynamic therapy. Int J Nanomedicine. 2019;14:5527-5540 Authors: Ma Z, Hu P, Guo C, Wang D, Zhang X, Chen M, Wang Q, Sun M, Zeng P, Lu F, Sun L, She L, Zhang H, Yao J, Yang F Abstract Background: Nonspecific tumor targeting, potential relapse and metastasis of tumor after treatment are the main barriers in clinical photodynamic...
Related ArticlesApoER2 (Apolipoprotein E Receptor-2) Deficiency Accelerates Smooth Muscle Cell Senescence via Cytokinesis Impairment and Promotes Fibrotic Neointima After Vascular Injury. Arterioscler Thromb Vasc Biol. 2019 Aug 15;:ATVBAHA119313194 Authors: Komaravolu RK, Waltmann MD, Konaniah E, Jaeschke A, Hui DY Abstract OBJECTIVE: Genome-wide studies showed that mutation in apoER2 (apolipoprotein E receptor-2) is additive with ε4 polymorphism in...
Related ArticlesSingle‑cell intratumoral stemness analysis reveals the involvement of cell cycle and DNA damage repair in two different types of esophageal cancer. Oncol Rep. 2019 Jun;41(6):3201-3208 Authors: Wu H, Li Y, Hou Q, Zhou R, Li Z, Wu S, Yu J, Jiang M Abstract Intratumoral heterogeneity, particularly the potential cancer stemness of single cancer cells, has not yet been fully elucidated in human esophageal cancer. Single‑cell transcriptome...
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Related ArticlesAn H-TERT Mutated Skin Metastasis as First Occurrence in a Case of Follicular Thyroid Carcinoma. Front Endocrinol (Lausanne). 2019;10:513 Authors: Monti E, Dono M, Gonella E, Spina B, Pitto F, Petrogalli F, Conte L, Ambrosetti E, Minuto MN, Ansaldo GL, Morbelli S, Zupo S, Giusti M Abstract Differentiated thyroid cancer arising from thyroid follicular epithelial cells is the most frequent endocrine malignancy, and skin metastases are very...
Related ArticlesDevelopment of radiolabeled bis(zinc(II)-dipicolylamine) complexes for cell death imaging. Ann Nucl Med. 2019 May;33(5):317-325 Authors: Aoki M, Odani A, Ogawa K Abstract PURPOSE: Although it has been traditionally surmised that phosphatidylserine (PS) externalization is a hallmark of apoptosis, most other non-apoptotic modes of cell death, such as necrosis, are also associated with PS externalization. Bis(zinc-dipicolylamine) (ZnDPA)...
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How Do We Treat Psoriasis Patients with Hepatitis C Infections in Real-World Situations? A Retrospective Analysis of 34 Patients. J Dermatolog Treat. 2019 Aug 16;:1-17 Authors: Chularojanamontri L, Nimanong S, Wongpraparut C, Silpa-Archa N, Chaiyabutr C, Charoenpipatsin N Abstract Background There is still relatively limited data on psoriasis and hepatitis C virus (HCV) infections. Objective This study investigated the clinical characteristics and treatment...
A comparative study of topical cantharidin and intralesional PPD to treat Molluscum contagiosum. J Dermatolog Treat. 2019 Aug 16;:1-24 Authors: Khattab FM, Nasr MM Abstract BACKGROUND: The immune system plays an important part in the clearance of molluscum contagiosum (MC) and, therefore, there has lately been a trend in using immunotherapy in MC therapy. Tuberculin-purified protein derivatives (PPDs) and topical cantharidin have not earlier been compared...
Topical corticosteroids and risk of diabetes mellitus: systematic review and meta-analysis. J Dermatolog Treat. 2019 Aug 16;:1-15 Authors: Phan K, Smith SD Abstract Background: Topical steroids have been previously associated with potential for hyperglycemia and glucosuria, and thought to have a relatively safe side effect profile. In prolonged use, there is the potential for steroids to be absorbed through the skin and eventually reach systemic circulation....
The treatment of facial dermatitis: challenging evidence based medicine. J Dermatolog Treat. 2019 Aug 16;:1-4 Authors: van de Kerkhof PC PMID: 31418612 [PubMed - as supplied by publisher]
Transcutaneous Electrical Nerve Stimulation (TENS): a review of applications in dermatology. J Dermatolog Treat. 2019 Aug 16;:1-17 Authors: Visconti MJ, Haidari W, Feldman SR Abstract BACKGROUND: A transcutaneous electrical nerve stimulation (TENS) unit is an inexpensive, accessible therapeutic device with multiple dermatology-related uses. OBJECTIVE: This review aims to describe the dermatological applications of TENS. METHODS: PubMed...
TOPICOP© Scale for Steroid Phobia- Difficulties and Suggestions for Application in Clinical Research. J Dermatolog Treat. 2019 Aug 16;:1-6 Authors: Law JY, Tan KW, Choi E, Chandran NS PMID: 31418325 [PubMed - as supplied by publisher]
Prognostic Impact of Socioeconomic Status among Patients with Malignant Melanoma of the Skin; a Population-Based Study. J Dermatolog Treat. 2019 Aug 16;:1-19 Authors: Abdel-Rahman O Abstract Objective: To assess the prognostic impact of socioeconomic status (SES) on the outcome of cases with cutaneous melanoma. Methods: Novel SEER socioeconomic database has been accessed and patients with malignant melanoma of the skin (2000-2015) were reviewed. SES...
Related ArticlesIntense pulsed light treatment for Becker's nevus. J Dermatolog Treat. 2019 Aug 16;:1-22 Authors: Wu PR, Liu LJ, Zhang YX, Liu Y, Lin XX, Ma G Abstract Abstracts Background: Becker's Nevus (BN) is a benign hamartoma with an aesthetically troublesome condition secondary to hyperpigmentation and hypertrichosis. Many treatment modalities have been utilized with variable outcomes. Objectives: To evaluate the efficacy and safety of intense...
Related ArticlesDoes Location Matter? Geographic Variations in Healthcare Resource Use for Atopic Dermatitis in the United States. J Dermatolog Treat. 2019 Aug 16;:1-24 Authors: Wu KK, Nguyen KB, Sandhu JK, Armstrong AW Abstract It is unknown which region of the U.S. offers the best and worst access to care for atopic dermatitis (AD). We conducted a cross-sectional study using the Medical Expenditure Panel Survey (MEPS) from 1996-2015 to compare healthcare...
Related ArticlesComparing the efficacy of Pulsed Dye Laser, Q-Switched Nd-YAG, CO2, and combined CO2 and Q-Switched Nd-YAG Lasers for the Treatment of Cutaneous Macular Amyloidosis. J Dermatolog Treat. 2019 Aug 15;:1-11 Authors: Radmanesh M, Ghanatir F, Radmanesh R Abstract BACKGROUND: No topical and systemic treatment is proven to be effective on Cutaneous Macular Amyloidosis (CMA). The physical removal of the deposited protein by lasers may be a better...
Related ArticlesIntralesional injection of vitamin D3 versus zinc sulfate 2% in treatment of plantar warts: a comparative study. J Dermatolog Treat. 2019 Aug 15;:1-28 Authors: Abd El-Magid WM, Nada EEA, Mossa RA Abstract Background: Plantar warts are common skin lesions caused by the human papilloma virus. It is characterized by presence of a horny ring of hyperkeratosis surrounding the wart, making its elimination a therapeutic challenge. Several destructive...
Related ArticlesContinuous terbinafine and pulse itraconazole for the treatment of non-dermatophyte mold toenail onychomycosis. J Dermatolog Treat. 2019 Aug 15;:1-15 Authors: Shemer A, Gupta AK, Kamshov S, Babaev M, Hermush V, Farhi R, Daniel CR, Foley KA Abstract INTRODUCTION: Although dermatophytes are considered the predominant causative organisms in onychomycosis, non-dermatophyte mold (NDM) infections may be more prevalent than originally thought...
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Publication date: Available online 15 August 2019Source: Behavioural Brain ResearchAuthor(s): Mahsa Pourhamzeh, Roghaye Mozafari, Shole Jamali, Fereshteh Motamedi, Reza Ahadi, Abbas HaghparastAbstractThe orexinergic system is found to cooperate in mediating stress-induced drug relapse. The orexinergic terminals innervate neurons of the hippocampal dentate gyrus (DG) which is a key structure in the maintenance and reinstatement of drug addiction. However, the specific contribution of intra-DG orexin...
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This study is the most comprehensive Australian analysis of immediate breast reconstruction (IBR) utilisation patterns through a population‐based study. It revealed that wide inter‐hospital variation exists in IBR rates within NSW, which raises concerns about potential inequities in access to IBR services and unmet demand in certain areas of NSW. Explaining the underlying drivers for IBR variation is the first step in identifying policy solutions to redress the issue. Background The rate of...
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Μια μελέτη από διεθνή ερευνητική ομάδα με επικεφαλής τον καθηγητή Markus Kleinewietfeld (VIB-UHasselt) έδειξε ότι η υψηλή πρόσληψη αλατιού αναστέλλει την ανάπτυξη του καρκινικού όγκου σε ποντίκια. Το φαινόμενο, σύμφωνα με την έρευνα που δημοσιεύθηκε στο Frontiers in Immunology, φαίνεται να οφείλεται στην αλλαγή της λειτουργίας ορισμένων ανοσοκυττάρων που παίζουν κρίσιμο ρόλο στην απόκριση του οργανισμού απέναντι στον καρκίνο, με την περαιτέρω διερεύνηση των ευρημάτων αυτών να δημιουργούν ελπίδες...
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Εξαιρετικά σημαντικό παράγοντα για τη γνωστική λειτουργία κατά τη γήρανση αποτελούν τα επίπεδα ασβεστίου σε συγκεκριμένα εγκεφαλικά κύτταρα. Σε αυτό το συμπέρασμα κατέληξε έρευνα του Πανεπιστημίου του Λέστερ προσφέροντας νέες ενδείξεις για το πώς και το γιατί οι γνωστικές λειτουργίες φθίνουν κατά τη γήρανση. Όσο μεγαλώνουμε, η μνήμη μας ξεκινά να αποδυναμώνεται και το να μάθουμε νέα πράγματα γίνεται όλο και δυσκολότερο. Ο καθηγητής Nick Hartell από το Πανεπιστήμιο του Λέστερ εξέτασε αν τα επίπεδα...
Ένα πρώιμο σύμπτωμα της νόσου Αλτσχάιμερ θα μπορούσε να αποτελέσει η διαρκής υπνηλία μέσα στη μέρα. Σε αυτό το συμπέρασμα κατέληξαν ερευνητές του Πανεπιστημίου του Σαν Φρανσίσκο έχοντας μάλιστα μία νέα βιολογική εξήγηση για αυτό το φαινόμενο, δείχνοντας πως η νόσος Αλτσχάιμερ βλάπτει άμεσα τις περιοχές του εγκεφάλου που είναι υπεύθυνες για τον ύπνο τις ώρες της ημέρας. Η νέα έρευνα δείχνει ότι αυτές οι περιοχές του εγκεφάλου, συμπεριλαμβανομένου και του τμήματός του που επηρεάζεται από τη ναρκοληψία,...
Τα διφοσφωνικά που χορηγούνται για την αντιμετώπιση της οστεοπόρωσης σχετίζονται με μείωση του κινδύνου πρόωρου θανάτου σύμφωνα με δύο νέες έρευνες που δημοσιεύθηκαν στο Osteoporosis International και στο Journal of Bone and Mineral Research. Δυο έρευνες που έγιναν από Ινστιτούτο Ιατρικών Ερευνών Garvan αποκάλυψαν ότι τα διφωσφονικά, δυναμικοί αναστολείς της οστεοκλαστικής δράσης που χρησιμοποιούνται ευρέως στην αντιμετώπιση της οστικής απώλειας που συνοδεύει την οστεοπόρωση, μειώνουν τον κίνδυνο...
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Related ArticlesCorrelation Between SNOT-22, Nasal Cytology, and Mood Disorders in Patients With Allergic Rhinitis Treated With a Liposomal Nasal Spray. Allergy Rhinol (Providence). 2019 Jan-Dec;10:2152656719866809 Authors: Lauriello M, Di Rubbo V, Sinatti G, Pasqua M, Tucci C, di Marco GP, Necozione S, Eibenstein A Abstract Patients with allergic rhinitis (AR) can suffer from mood disorders. The aim of this study was to investigate the clinical effect...
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Abstract Introduction This paper reports the key findings of the Faculty of Radiation Oncology 2018 workforce census and compares results with previous studies. Methods The census was conducted in mid‐2018 with distribution to all radiation oncologists and trainees listed on the college database in Australia, New Zealand, Singapore and overseas. There were new questions about hours spent on multidisciplinary meetings (MDTS), leadership positions held, management of inpatients, hypofractionation,...
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Abstract Background Lower extremity free flaps are a common way to treat both traumatic and oncologic lower extremity wounds. These patients often suffer postoperative complications. We sought to use the American College of Surgeons National Surgical Quality Improvement Program (ACS‐NSQIP) database to identify variables associated with postoperative complications. Methods Patients who had free flap procedure and a primary diagnosis code for lower extremity pathology were identified in the...
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Abstract Purpose Some preliminary studies reported a link between GLP-1 receptor agonists (GLP-1RAs) and thyroid/pancreatic neoplasms, while its human relevance remained undetermined. The present meta-analysis was performed to collect information on cancers associated with GLP-1RAs in patients with type 2 diabetes mellitus (T2DM). Methods Medline, Embase,...
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October 16, 2017, begins as a normal day at your New Jersey high school. You are chatting with friends in Spanish, the second most-spoken language in the United States. This is something you do every day. But you are interrupted by your teacher, not because you are speaking out of turn, but because you are speaking a language other than English. The teacher tells you, “Men and women are fighting. They are not fighting for your right to speak Spanish…they are fighting for your right to speak American...
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This study confirms and describes the development of the alar fascia. The alar fascia divides the retrovisceral space into two spaces: one anterior (named retropharyngeal or retroesophageal space according to the level) and the other posterior (named danger space). We suggest that this latter space be named the retroalar space. This study suggests that alar fascia development is related to mechanical factors and that the alar fascia permits the sliding of the pharynx and the oesophagus during swallowing....
We studied the topography of ganglion cells in the retina of the Japanese tree frog. The spatial density of GCs increased gradually from the dorsal and ventral periphery towards the equator to form a moderately pronounced visual streak and a distinct area retinae temporalis. Abstract Tree frogs are an interesting and diverse group of frogs. They display a number of unique adaptations to life in the arboreal environment. Vision plays a crucial role in their ecology. The topography of retinal ganglion...
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