Immunologic and immunogenomic aspects of tumor progression. Semin Cancer Biol. 2019 Aug 13;: Authors: Ladányi A, Tímár J Abstract Tumor progression to metastatic disease is characterized by continuous genetic alterations due to instability of the genome. Immune sensitivity was found to be linked to tumor mutational burden (TMB) and the resulting amount of neoantigens. However, APOBEC activity resulting in increase in TMB causes immune evasion. On the...
Squamous cell carcinoma of the nasal cavity: A descriptive analysis of cases from the Head and Neck 5000 study. Clin Otolaryngol. 2019 Aug 16;: Authors: Dale OT, Pring M, Davies A, Leary S, Ingarfield K, Toms S, Waterboer T, Pawlita M, Ness AR, Thomas SJ Abstract OBJECTIVES: This paper aims to provide contemporary epidemiological data on squamous cell carcinoma (SCC) of the nasal cavity, which represents a rare type of head and neck cancer. ...
Related ArticlesSeparation of low versus high grade Crohn's disease-associated small bowel carcinomas is improved by invasive front prognostic marker analysis. J Crohns Colitis. 2019 Aug 16;: Authors: Arpa G, Grillo F, Giuffrida P, Nesi G, Klersy C, Mescoli C, Lenti MV, Lobascio G, Martino M, Latella G, Malvi D, Macciomei MC, Fociani P, Villanacci V, Rizzo A, Ferrero S, Sessa F, Orlandi A, Monteleone G, Biancone L, Cantoro L, Tonelli F, Ciardi A, Poggioli G, Rizzello...
Related ArticlesAdrenal metastasis from endometrial cancer: A case report. World J Clin Cases. 2019 Jul 26;7(14):1844-1849 Authors: Da Dalt G, Friziero A, Grego A, Serafini S, Fassina A, Blandamura S, Sperti C Abstract BACKGROUND: Metastases to adrenal glands originate principally from lung, breast, or gastrointestinal cancers, followed by malignant melanoma and thyroid neoplasms. We present an unusual case of uterine cancer metastasizing to the adrenal...
Related ArticlesCurrent status of the adjuvant therapy in uterine sarcoma: A literature review. World J Clin Cases. 2019 Jul 26;7(14):1753-1763 Authors: Rizzo A, Pantaleo MA, Saponara M, Nannini M Abstract Uterine sarcomas (US) are rare mesenchymal tumours accounting approximately for 3%-7% of all uterine cancers. Histologically, US are classified into mesenchymal tumours or mixed epithelial and mesenchymal tumours. The group of mesenchymal tumours includes...
Related ArticlesCase Series of Cancer-associated Retinopathy (CAR). Cureus. 2019 Jun 10;11(6):e4872 Authors: Naramala S, Ahmad J, Adapa S, Gavini F, Konala VM Abstract Cancer-associated retinopathy (CAR) is a rare paraneoplastic disorder of the retina leading to blindness, associated with multiple cancers. It can lead to rapid progressive visual deterioration with retinal pathology ranging from retinitis pigmentosa to retinal degeneration. It is caused...
Related ArticlesThe PTEN Tumor Suppressor Gene in Soft Tissue Sarcoma. Cancers (Basel). 2019 Aug 14;11(8): Authors: Stefano S, Giovanni S Abstract Soft tissue sarcoma (STS) is a rare malignancy of mesenchymal origin classified into more than 50 different subtypes with distinct clinical and pathologic features. Despite the poor prognosis in the majority of patients, only modest improvements in treatment strategies have been achieved, largely due to the...
Related ArticlesVisceral Kaposi Sarcoma Presenting as Small Bowel Intussusception: A Rare Presentation and Call to Action. Am Surg. 2019 Jul 01;85(7):778-780 Authors: Lovasik BP, Wang VL, Point du Jour KS, Kim SC, Hashmi SS, Haack CI Abstract Surgical emergencies related to visceral involvement of Kaposi sarcoma (KS) are rare complications of the disease. In this report, we describe a case of visceral KS causing small bowel intussusception in a young,...
Related ArticlesAvoiding Pitfalls in Insulinomas by Preoperative Localization with a Dual Imaging Approach. Am Surg. 2019 Jul 01;85(7):742-746 Authors: Ramonell KM, Saunders ND, Sarmiento J, Bercu Z, Martin L, Weber CJ, Sharma J, Patel SG Abstract Insulinomas are rare endocrine malignancies of the pancreas that require surgical resection but can be difficult to localize preoperatively. We sought to review and improve the accuracy of preoperative localization...
Related ArticlesThe Understated Malignancy Potential of Nonoperative Acute Appendicitis. Am Surg. 2019 Jul 01;85(7):712-716 Authors: Seawell J, Sciarretta JD, Pahlkotter M, Muertos K, Onayemi A, Davis JM Abstract Cancer of the appendix is rare and is most commonly found incidentally on pathology after an appendectomy for uncomplicated appendicitis (UA). The medical management alternative with antibiotics and observation remains an ongoing debate. The...
Related Articles[A case of pancreatic neuroendocrine tumor with ring-like enhancement]. Nihon Shokakibyo Gakkai Zasshi. 2019;116(7):597-606 Authors: Nakata A, Nebiki H, Kimura A, Yamamura M, Suekane T, Yamasaki T, Murata A, Shimizu S, Ishii N, Inoue T Abstract An 82-year-old female underwent contrast computed tomography (CT) that revealed multiple ring-like enhanced masses in the pancreatic tail. Additionally, the inside of the masses showed enhancement...
Related Articles[Simultaneous occurrence of an ampullary neuroendocrine tumor and multiple duodenal/jejunal gastrointestinal stromal tumors in a patient with neurofibromatosis type 1]. Nihon Shokakibyo Gakkai Zasshi. 2019;116(7):583-591 Authors: Kitajima R, Morita Y, Furuhashi S, Kiuchi R, Takeda M, Kikuchi H, Watanabe F, Sugimoto K, Sakaguchi T, Takeuchi H Abstract A 60-year-old female visited our hospital because of the identification of two duodenal...
Related Articles[A case of rectal villous adenoma with electrolyte depletion syndrome treated with surgical resection]. Nihon Shokakibyo Gakkai Zasshi. 2019;116(7):576-582 Authors: Suzuki N, Kajiwara A, Usami T, Nakajima Y, Yamamiya A, Konda K, Shimozuma Y, Uchikoshi M, Kurihara T, Yoshida H Abstract A 65-year-old man was previously admitted to our university hospital thrice in the last 2 years because of acute kidney failure. This time he was admitted...
Related ArticlesThoracic Liposarcoma In An End Stage Renal Disease Patient. J Ayub Med Coll Abbottabad. 2019 Apr-Jun;31(2):286-289 Authors: Ishtiaq R, Naeem A, Ratnani I Abstract Liposarcoma arising in the thoracic cavity is a rare entity. It is usually found in the retroperitoneal space and the extremities. No case of thoracic liposarcoma in a patient suffering from the end-stage renal disease has been reported in the literature. We herein present...
Related ArticlesPlasma Cell Leukaemia: A Rare Yet Aggressive Plasma Cell Dyscrasia With A Very Poor Response To Conventional Therapy. J Ayub Med Coll Abbottabad. 2019 Apr-Jun;31(2):272-275 Authors: Khan N, Raza SS, Khan UI, Hafez I, Abdullah MA, Hassan M, Rukh Hijaz AS, Hussain AK, Nadeem MD Abstract Plasma cell leukaemia (PCL) is a very rare plasma cell dyscrasia with a significant number of monoclonal plasma cells in the peripheral blood. It is diagnosed...
Related Articles[Cauda equina syndrome as the first presentation of intravascular large B-cell lymphoma: a lung biopsy case]. Rinsho Ketsueki. 2019;60(4):326-330 Authors: Ide S, Ohara S, Uchida T, Inoue M, Hua J, Hagihara M Abstract A 65-year-old male was admitted for bladder and rectal dysfunction with lower-limb sensory disturbance. Although no abnormalities were detected on magnetic resonance imaging of the brain and spinal cord, an elevation in...
Related Articles[Follicular lymphoma with nodular lesions mimicking gallbladder carcinoma]. Rinsho Ketsueki. 2019;60(4):319-325 Authors: Tokunaga M, Maeda T, Fukuchi N, Tamai K, Minoji T, Sasakawa H, Kondo A, Inoue S, Morita T, Tominaga N Abstract A 68-year-old female was diagnosed with follicular lymphoma (FL) grade 2, based on the excisional biopsy of her enlarged left cervical lymph node. Positron-emission tomography/computed tomography (PET/CT)...
Related Articles[Durable remission of Langerhans cell sarcoma attained by autologous hematopoietic stem cell transplantation following surgical resection]. Rinsho Ketsueki. 2019;60(4):314-318 Authors: Fuseya H, Nakao T, Tsutsumi M, Nakaya Y, Horiuchi M, Yoshida M, Yoshimura T, Hayashi Y, Fukushima H, Inoue T, Aiba T, Yamane T Abstract Langerhans cell sarcoma (LCS) is a rare neoplastic proliferation of Langerhans cells with a poor prognosis. Owing to...
Related Articles[Human herpes virus 8-negative primary effusion lymphoma-like lymphoma recurring as a tumor adjacent to the left atrium]. Rinsho Ketsueki. 2019;60(3):218-222 Authors: Horiuchi M, Nakao T, Tsutsumi M, Nakaya Y, Fuseya H, Yoshida M, Yoshimura T, Hayashi Y, Fukushima H, Inoue T, Yamane T Abstract Primary effusion lymphoma (PEL) is a rare type of non-Hodgkin lymphoma, usually presenting as serous effusions without detectable tumor masses,...
Related Articles[Clinical features of intravascular large B-cell lymphoma: a single-institute retrospective analysis]. Rinsho Ketsueki. 2019;60(3):184-190 Authors: Okuno T, Iwata S, Hayakawa H, Miyao K, Kajiguchi T Abstract Intravascular large B-cell lymphoma (IVLBCL) is a rare form of extranodal non-Hodgkin's lymphoma, and the absence of specific findings makes ante-mortem diagnosis difficult. This study was conducted to identify the clinical findings...
Related ArticlesTAD fusion score: discovery and ranking the contribution of deletions to genome structure. Genome Biol. 2019 03 21;20(1):60 Authors: Huynh L, Hormozdiari F Abstract Deletions that fuse two adjacent topologically associating domains (TADs) can cause severe developmental disorders. We provide a formal method to quantify deletions based on their potential disruption of the three-dimensional genome structure, denoted as the TAD fusion score....
Related ArticlesEnzymatic degradation study of 111In-labeled minigastrin peptides using cathepsin B enzyme and AR42J cancer cell line for the development of neuroendocrine tumor imaging radiopharmaceuticals. Pak J Pharm Sci. 2018 Nov;31(6 (Supplementary):2585-2589 Authors: Naqvi SAR, Yameen M, Hussain Z, Asim S, Usman M, Khan NH, Abbas K Abstract Neuroendocrine tumors (NET) are the rare tumors which often impose graveyard threat. These tumors are characterized...
Related ArticlesBiology and management of primary effusion lymphoma. Blood. 2018 11 01;132(18):1879-1888 Authors: Shimada K, Hayakawa F, Kiyoi H Abstract Primary effusion lymphoma (PEL) is a rare B-cell malignancy that most often occurs in immunocompromised patients, such as HIV-infected individuals and patients receiving organ transplantation. The main characteristic of PEL is neoplastic effusions in body cavities without detectable tumor masses. The...
Related ArticlesGastrointestinal non-Hodgkin lymphomas. Adv Clin Exp Med. 2019 Aug 13;: Authors: Olszewska-Szopa M, Wróbel T Abstract Although gastrointestinal (GI) tract is the most common extranodal site involved in non-Hodgkin lymphoma (NHL), primary gastrointestinal NHL (gNHL) is a rare problem which concerns about 10-15% of NHL patients and 30-40% of extranodal NHL patients. Lymphoid neoplasms may consist of mature B, T and (less commonly) extranodal...
Related ArticlesNeuroendocrine Cancer of the Prostate. Pathol Oncol Res. 2019 Aug 14;: Authors: Kránitz N, Szepesváry Z, Kocsis K, Kullmann T Abstract Neuroendocrine cancer of the prostate is considered to be a rare entity with bad prognosis and limited therapeutic options. We performed a prospective analysis of the patients treated in our hospital for prostate cancer between 1st January 2015 and 31rd December 2018. Neuroendocrine phenomena were tested...
Related ArticlesMedulloblastoma and central nervous system germ cell tumors in adults: is pediatric experience applicable? Childs Nerv Syst. 2019 Aug 14;: Authors: Mascarin M, Coassin E, Franceschi E, Gandola L, Carrabba G, Brandes AA, Massimino M Abstract Medulloblastoma and central nervous system (CNS) germ cell tumors are very rare in adults, while they account for 25% and 5% of brain tumors in children, respectively (Pastore et al. Eur J Cancer 42:2064-208,...
Related ArticlesIntramedullary Spinal Cord Metastases of Malignant Melanoma: A Rare Case Report on Paraplegia in Palliative Care. Indian J Palliat Care. 2019 Jul-Sep;25(3):468-470 Authors: Sonawane R, Ghoshal A, Damani A, Muckaden M, Deodhar JK Abstract Rates of malignant melanoma have been increasing in frequency. Studies have shown that up to 46% of patients with melanoma will experience metastases to the central nervous system. Intramedullary spinal...
Related ArticlesRare Case of Primary Clear Cell Carcinoma of the Urinary Bladder. Niger Med J. 2019 Jan-Feb;60(1):40-42 Authors: Kulkarni MM, Sinai Khandeparkar SG, Joshi AR, Bhayekar P Abstract Cancers of the urinary bladder account for about 3.2% of all cancers worldwide. Clear cell adenocarcinomas (CCAs) of urinary bladder are rare. CCA must be differentiated from benign condition such as nephrogenic adenoma (NA) as well as malignant conditions such...
Related ArticlesHuman germ cell tumours from a developmental perspective. Nat Rev Cancer. 2019 Aug 14;: Authors: Oosterhuis JW, Looijenga LHJ Abstract Human germ cell tumours (GCTs) are derived from stem cells of the early embryo and the germ line. They occur in the gonads (ovaries and testes) and also in extragonadal sites, where migrating primordial germ cells are located during embryogenesis. This group of heterogeneous neoplasms is unique in that...
Related ArticlesClinicopathological spectrum of solitary Plasmacytoma: a single center experience from coastal India. BMC Cancer. 2019 Aug 14;19(1):801 Authors: Basavaiah SH, Lobo FD, Philipose CS, Suresh PK, Sreeram S, Kini H, Sahu KK, Prasad K Abstract BACKGROUND: Plasma cell disorders are a rare group of hematological malignancies that accounts for 10% of all hematological neoplasms. Solitary plasmacytomas are rarer entities accounting for less than...
Related ArticlesDetection of HPV RNA molecules in stratified mucin-producing intraepithelial lesion (SMILE) with concurrent cervical intraepithelial lesion: a case report. Virol J. 2019 06 03;16(1):76 Authors: Fukui S, Nagasaka K, Iimura N, Kanda R, Ichinose T, Sugihara T, Hiraike H, Nakagawa S, Sasajima Y, Ayabe T Abstract BACKGROUND: Stratified mucin-producing intraepithelial lesion (SMILE) is a rare precursor lesion in the uterine cervix that is...
Related ArticlesThyroid Cancer Brain Metastasis: Survival and Genomic Characteristics of a Large Tertiary Care Cohort. Clin Nucl Med. 2019 Jul;44(7):544-549 Authors: Osborne JR, Kondraciuk JD, Rice SL, Zhou X, Knezevic A, Spratt DE, Sabra M, Larson SM, Grewal RK Abstract PURPOSE: Brain metastases (BMs) in patients with differentiated thyroid cancer (DTC) are rare but associated with poor prognosis. We examined risk factors for overall survival (OS)...
Related ArticlesPhysician requests by patients with malignant pleural mesothelioma in Japan. BMC Cancer. 2019 Apr 25;19(1):383 Authors: Nagamatsu Y, Oze I, Aoe K, Hotta K, Kato K, Nakagawa J, Hara K, Kishimoto T, Fujimoto N Abstract BACKGROUND: Malignant pleural mesothelioma (MPM) is a fatal and rare disease that is caused by the inhalation of asbestos. Treatment and care requests made by MPM patients to their physicians were collected and analyzed....
Related Articles18F-FDG PET/CT for Staging and Evaluation of Therapy in a Patient With Unusual Hairy Cell Leukemia Presentation. Clin Nucl Med. 2019 Jul;44(7):e458-e460 Authors: Doma A, Škerget M, Žagar I Abstract Hairy cell leukemia is a rare hematologic malignancy characterized by splenomegaly, pancytopenia, and susceptibility to infections. We report a case of a 66-year-old man, diagnosed with hairy cell leukemia, without severe cytopenias and splenomegaly,...
Related ArticlesA Rare Case of Primary Endometrial Hepatoid Adenocarcinoma on 18F-FDG PET/CT. Clin Nucl Med. 2019 Jul;44(7):e425-e427 Authors: Yin H, Hu Y, Xiu Y, Luo R, Shi H Abstract Primary endometrial hepatoid adenocarcinoma is a rare tumor. We present a case of a 64-year-old woman with vaginal bleeding for 2 months and a markedly elevated serum α-fetoprotein of 3931 ng/mL. Hysteroscopic segmental curettage revealed endometrial adenocarcinoma. A...
Related ArticlesCo-amplification and co-localization: Rare signal pattern in human epidermal growth factor receptor 2 gene fluorescence in situ hybridization testing. Indian J Pathol Microbiol. 2019 Apr-Jun;62(2):355-356 Authors: Gupta A, Patibandla SR, Kasaragadda MR, Goyal M PMID: 30971582 [PubMed - indexed for MEDLINE]
Related ArticlesA soft tissue swelling at angle of mandible: Fine needle aspiration cytology meeting the diagnostic challenge of a rare case. Indian J Pathol Microbiol. 2019 Apr-Jun;62(2):353-354 Authors: Sahu P, Gupta P, Ahuja A, Bhardwaj M, Nigam A PMID: 30971581 [PubMed - indexed for MEDLINE]
Related ArticlesMediastinal mixed germ cell tumor with splenic histiocytosis: A rare coincidence. Indian J Pathol Microbiol. 2019 Apr-Jun;62(2):341-342 Authors: Sood R, Mehta A, Bansal D, Singh N, Purohit SR PMID: 30971575 [PubMed - indexed for MEDLINE]
Related ArticlesSignet ring: A rare morphology of metastatic neuroendocrine tumor. Indian J Pathol Microbiol. 2019 Apr-Jun;62(2):335-336 Authors: Madakshira MG, Radotra BD, Singh V PMID: 30971572 [PubMed - indexed for MEDLINE]
Related ArticlesCarnosic acid regulates cell proliferation and invasion in chronic myeloid leukemia cancer cells via suppressing microRNA-708. J BUON. 2018 May-Jun;23(3):741-746 Authors: Liu D, Wang B, Zhu Y, Yan F, Dong W Abstract PURPOSE: Carnosic acid (CA) is an important polyphenol mainly isolated from the famous spice and the medicinal plant Rosmarinus officinalis. CA has been shown to exhibit tremendous pharmacological properties which include,...
Related ArticlesRare germline variants in DNA repair genes and the angiogenesis pathway predispose prostate cancer patients to develop metastatic disease. Br J Cancer. 2018 07;119(1):96-104 Authors: Mijuskovic M, Saunders EJ, Leongamornlert DA, Wakerell S, Whitmore I, Dadaev T, Cieza-Borrella C, Govindasami K, Brook MN, Haiman CA, Conti DV, Eeles RA, Kote-Jarai Z Abstract BACKGROUND: Prostate cancer (PrCa) demonstrates a heterogeneous clinical presentation...
Related ArticlesChemical meningitis from a leaking craniopharyngioma: a case report. Acta Neurochir (Wien). 2018 06;160(6):1203-1206 Authors: Hakizimana D, Poulsgaard L, Fugleholm K Abstract Recurrent chemical meningitis from cyclic leakage of cyst content from a craniopharyngioma is a rare phenomenon. Here, we report a case of leaking cystic craniopharyngioma presenting with recurrent episodes of sterile meningitis, depression, and paranoia. The diagnosis...
Related ArticlesFirst Line Sorafenib Treatment for Metastatic Medullary Thyroid Cancer: Efficacy and Safety Analysis. Exp Clin Endocrinol Diabetes. 2019 Apr;127(4):240-246 Authors: Kocsis J, Szekanecz É, Bassam A, Uhlyarik A, Pápai Z, Rubovszky G, Mezősi E, Rucz K, Garai I, Nagy E, Uray I, Horváth Z Abstract BACKGROUND: Medullary thyroid cancer (MTC) is a rare disease, the prognosis of advanced and metastatic disease is poor and few therapeutic options...
Related ArticlesFLAIR signal increase of the fluid within the resection cavity after glioma surgery: generally valid as early recurrence marker? J Neurosurg. 2017 Aug;127(2):417-425 Authors: Bette S, Gempt J, Huber T, Delbridge C, Meyer B, Zimmer C, Kirschke JS, Boeckh-Behrens T Abstract OBJECTIVE Recent studies have indicated that a signal intensity increase of the fluid within the resection cavity on FLAIR images may predict tumor recurrence after...
Related ArticlesA rare case of central nervous system amyloidoma treated with fractionated radiotherapy. J Neurosurg. 2017 Aug;127(2):338-341 Authors: Meier T, Hazenfield JM, Girnius S, Hagen M, Warnick RE, Kharofa J Abstract A 54-year-old female presented with multiple episodes of emesis, intractable headaches, worsening balance, and slowly progressive right facial weakness. Imaging demonstrated a 3-cm mass in the left internal capsule and corona radiata...
Related ArticlesComprehensive Genomic Profiling of Adult Renal Sarcomas Provides Insight into Disease Biology and Opportunities for Targeted Therapies. Eur Urol Oncol. 2019 Apr 22;: Authors: Yakirevich E, Madison R, Fridman E, Mangray S, Carneiro BA, Lu S, Cooke M, Bratslavsky G, Webster J, Ross JS, Ali SM Abstract BACKGROUND: Primary adult renal sarcomas (RSs) are rare aggressive neoplasms. Clinical outcomes are extremely poor, and optimal treatment...
Related ArticlesDigging through a genomic goldmine: Defining the optimum upper urinary tract surveillance strategy for Lynch Syndrome. BJU Int. 2019 Aug 13;: Authors: Khan-Ruf S, Thurairajah R, Khan MS, Bultitude M, Thomas K, Nair R Abstract Clinical practice is witnessing a genomics revolution through the introduction of innovative molecular technologies and the continuing identification of novel disease-related genes. This rapidly developing field...
Related ArticlesPrimary Angiosarcoma of the Kidney: Case Report and Comprehensive Literature Review. Open Med (Wars). 2019;14:443-455 Authors: Boni A, Cochetti G, Sidoni A, Bellezza G, Lepri E, Giglio A, Turco M, Vermandois JAR, Zingaro MD, Cirocchi R, Mearini E Abstract Purpose: Angiosarcoma (AS) is an aggressive malignant tumour of endothelial origin, most frequently compelling the skin. The kidney is a rare site of primary occurrence of AS with a...
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