Σάββατο 17 Αυγούστου 2019


Dealing with frequent hitters in drug discovery: a multidisciplinary view on the issue of filtering compounds on biological screenings.
Related ArticlesDealing with frequent hitters in drug discovery: a multidisciplinary view on the issue of filtering compounds on biological screenings. Expert Opin Drug Discov. 2019 Aug 16;:1-14 Authors: Dantas RF, Evangelista TCS, Neves BJ, Senger MR, Andrade CH, Ferreira SB, Silva-Junior FP Abstract Introduction: The timely identification biologically active chemicals, in disease relevant screening assays, is a major endeavor in drug discovery. The...
Expert Opinion on Drug Discovery
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human physiology; +99 new citations
99 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: human physiology These pubmed results were generated on 2019/08/17PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Human physiology
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human physiology; +88 new citations
88 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: human physiology These pubmed results were generated on 2019/08/16PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Human physiology
22h
human physiology; +88 new citations
88 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: human physiology These pubmed results were generated on 2019/08/16PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Human physiology
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Clinical management of early-stage cervical cancer: The role of sentinel lymph node biopsy in tumors ≤2 cm.
Clinical management of early-stage cervical cancer: The role of sentinel lymph node biopsy in tumors ≤2 cm. Eur J Obstet Gynecol Reprod Biol. 2019 Aug 07;241:30-34 Authors: Diaz-Feijoo B, Temprana-Salvador J, Franco-Camps S, Manrique S, Colás E, Pérez-Benavente A, Gil-Moreno A Abstract OBJECTIVE: To evaluate the experience with sentinel lymph node (SLN) biopsy in patients with early-stage cervical cancer at our hospital, and to analyze factors influencing...
Oncology
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Beyond sequence homology: Cellular biology limits the potential of XIST to act as a miRNA sponge.
Beyond sequence homology: Cellular biology limits the potential of XIST to act as a miRNA sponge. PLoS One. 2019;14(8):e0221371 Authors: Marshall EA, Stewart GL, Sage AP, Lam WL, Brown CJ Abstract INTRODUCTION: The sponging of microRNAs by a long non-coding RNA (lncRNA) away from their coding gene targets is a conceptually-simple, yet biologically-complex method of lncRNA-mediated gene regulation. Currently, predictions of genes that participate in sponge-based...
Oncology
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Time-Dependent Measurement of Nrf2-Regulated Antioxidant Response to Ionizing Radiation towards Identifying Potential Protein Biomarkers for Acute Radiation Injury.
Time-Dependent Measurement of Nrf2-Regulated Antioxidant Response to Ionizing Radiation towards Identifying Potential Protein Biomarkers for Acute Radiation Injury. Proteomics Clin Appl. 2019 Aug 16;:e1900035 Authors: Liu K, Singer E, Cohn W, Micewicz ED, McBride WH, Whitelegge JP, Loo JA Abstract PURPOSE: Potential acute exposure to ionizing radiation in nuclear or radiological accidents presents complex mass casualty scenarios that demand prompt triage...
Oncology
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Protein Paucimannosylation is an Enriched N-glycosylation Signature of Human Cancers.
Protein Paucimannosylation is an Enriched N-glycosylation Signature of Human Cancers. Proteomics. 2019 Aug 16;:e1900010 Authors: Chatterjee S, Lee LY, Kawahara R, Abrahams JL, Adamczyk B, Anugraham M, Ashwood C, Sumer-Bayraktar Z, Briggs MT, Chik JHL, Everest-Dass A, Förster S, Hinneburg H, Leite KRM, Loke I, Möginger U, Moh ESX, Nakano M, Recuero S, Sethi MK, Srougi M, Stavenhagen K, Venkatakrishnan V, Wongtrakul-Kish K, Diestel S, Hoffmann P, Karlsson NG, Kolarich D,...
Oncology
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High occurrence of sleep problems in survivors of a childhood brain tumor with neurocognitive complaints: The association with psychosocial and behavioral executive functioning.
High occurrence of sleep problems in survivors of a childhood brain tumor with neurocognitive complaints: The association with psychosocial and behavioral executive functioning. Pediatr Blood Cancer. 2019 Aug 16;:e27947 Authors: van Kooten JAMC, Maurice-Stam H, Schouten AYN, van Vuurden DG, Granzen B, Gidding C, de Ruiter MA, van Litsenburg RRL, Grootenhuis MA Abstract BACKGROUND: Survivors of childhood brain tumors are prone to sleep and neurocognitive...
Oncology
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Advances in Targeted Alpha Therapy for Prostate Cancer.
Advances in Targeted Alpha Therapy for Prostate Cancer. Ann Oncol. 2019 Aug 16;: Authors: De Vincentis G, Gerritsen W, Gschwend JE, Hacker M, Lewington V, O'Sullivan JM, Oya M, Pacilio M, Parker C, Shore N, Sartor O Abstract BACKGROUND: Amongst therapeutic radiopharmaceuticals, targeted alpha therapy (TαT) can deliver potent and local radiation selectively to cancer cells as well as the tumor microenvironment and thereby control cancer while minimizing...
Oncology
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A photovoice study on the bereavement experience of mothers after the death of a child.
A photovoice study on the bereavement experience of mothers after the death of a child. Death Stud. 2019 Aug 16;:1-15 Authors: Kim MA, Yi J, Sang J, Jung D Abstract This study explored the bereavement experience of mothers after losing a child to cancer in Korea, using photovoice. The mothers took photos reflecting five subject areas they selected: (a) if I had one more day with my child, (b) memories with my child, (c) dreaming of my child's healthy...
Oncology
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Evaluation of the QTc interval during lenvatinib treatment in radioiodine-refractory differentiated thyroid cancer: reports from the real-life clinical practice.
Evaluation of the QTc interval during lenvatinib treatment in radioiodine-refractory differentiated thyroid cancer: reports from the real-life clinical practice. Future Oncol. 2019 Aug 16;: Authors: Marina M, Serra MF, Rio PD, Ceresini G Abstract As for other tyrosine kinase inhibitors, a prolongation of ECG-recorded QTc intervals may be observed during lenvatinib treatment; a warning on this phenomenon has been stated. However, methods and frequency...
Oncology
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Illness uncertainty, partner support, and quality of life: A dyadic longitudinal investigation of couples facing prostate cancer.
Illness uncertainty, partner support, and quality of life: A dyadic longitudinal investigation of couples facing prostate cancer. Psychooncology. 2019 Aug 16;: Authors: Varner S, Lloyd G, Ranby KW, Callan S, Robertson C, Lipkus IM Abstract OBJECTIVE: Prostate cancer (PC) and its treatment often result in chronic, negative side-effects that affect both patients and their romantic partners. Illness uncertainty is a chronic stressor that impacts PC patients...
Oncology
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Health status in South Australians caring for people with cancer: a population-based study.
Health status in South Australians caring for people with cancer: a population-based study. Psychooncology. 2019 Aug 16;: Authors: Luckett T, Agar M, DiGiacomo M, Lam L, Phillips J Abstract OBJECTIVES: To compare physical and mental health status between cancer carers versus non-carers in a population-based sample, and explore sociodemographic and caring characteristics associated with poor carer health status. METHODS: The South Australian...
Oncology
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A Systematic Review of Factors Affecting Quality of Life After Post-Mastectomy Breast Reconstruction in Women with Breast Cancer.
A Systematic Review of Factors Affecting Quality of Life After Post-Mastectomy Breast Reconstruction in Women with Breast Cancer. Psychooncology. 2019 Aug 16;: Authors: Sousa H, Castro S, Abreu J, Pereira MG Abstract OBJECTIVE: The aim of this study is to present a broader perspective of factors affecting the quality of life after post-mastectomy breast reconstruction in women with breast cancer by considering these patients' self-reported outcomes....
Oncology
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Feasibility and perception of a question prompt list in outpatient cancer care.
Related ArticlesFeasibility and perception of a question prompt list in outpatient cancer care. J Patient Rep Outcomes. 2019 Aug 15;3(1):53 Authors: Berger Z, Tung M, Yesantharao P, Zhou A, Blackford A, Smith TJ, Snyder C Abstract INTRODUCTION: Management of cancer is often characterized by difficult decisions. The National Coalition for Cancer Survivorship (NCCS) has developed the "Know Yourself" tool, a question prompt list (QPL) to enable patients...
Oncology
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Quality of life in patients with limited (1-3) brain metastases undergoing stereotactic or whole brain radiotherapy : A prospective study of the DEGRO QoL working group.
Related ArticlesQuality of life in patients with limited (1-3) brain metastases undergoing stereotactic or whole brain radiotherapy : A prospective study of the DEGRO QoL working group. Strahlenther Onkol. 2019 Aug 15;: Authors: Steinmann D, Vordermark D, Gerstenberg W, Aschoff R, Gharbi N, Müller A, Schäfer C, Theodorou M, Wypior HJ, Geinitz H, Quality of Life Working Group of the German Radiation Oncology Society (DEGRO) Abstract PURPOSE: Published...
Oncology
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Statin use and its potential therapeutic role in esophageal cancer: a systematic review and meta-analysis.
Related ArticlesStatin use and its potential therapeutic role in esophageal cancer: a systematic review and meta-analysis. Cancer Manag Res. 2019;11:5655-5663 Authors: Zhou C, Zhong X, Gao P, Wu Z, Shi J, Guo Z, Wang Z, Song Y Abstract Purpose: Statins, known as inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG CoA) reductases, are designed to treat lipid disorders, especially hypercholesterolemia. Apart from their role in preventing heart diseases...
Oncology
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Therapeutic Targeting of the IGF Axis.
Related ArticlesTherapeutic Targeting of the IGF Axis. Cells. 2019 Aug 14;8(8): Authors: Osher E, Macaulay VM Abstract The insulin like growth factor (IGF) axis plays a fundamental role in normal growth and development, and when deregulated makes an important contribution to disease. Here, we review the functions mediated by ligand-induced IGF axis activation, and discuss the evidence for the involvement of IGF signaling in the pathogenesis of cancer,...
Oncology
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Effects of acute oral feeding on protein metabolism and muscle protein synthesis in individuals with cancer.
Related ArticlesEffects of acute oral feeding on protein metabolism and muscle protein synthesis in individuals with cancer. Nutrition. 2019 Jun 24;67-68:110531 Authors: van der Meij BS, De Groot LM, Deutz NEP, Engelen MPKJ Abstract Weight loss and muscle loss are common in individuals living with cancer, with ≤50% experiencing involuntary weight loss at any time point in their cancer journey, and between 11% and 74% having sarcopenia or significant...
Oncology
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Effects of medium chain triglycerides on body fat distribution and adipocytokine levels in children with acute lymphoblastic leukemia under chemotherapy.
Related ArticlesEffects of medium chain triglycerides on body fat distribution and adipocytokine levels in children with acute lymphoblastic leukemia under chemotherapy. Medicine (Baltimore). 2019 Aug;98(33):e16811 Authors: Zhang R, Chen J, Zheng H, Li Y, Huang H, Liang Z, Jiang H, Sun J Abstract Glucocorticoids used to treat acute lymphoblastic leukemia (ALL) are associated with cytotoxicity and obesity. The aim of the study was to investigate the effects...
Oncology
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Hospitalization costs of treating colorectal cancer in China: A retrospective analysis.
Related ArticlesHospitalization costs of treating colorectal cancer in China: A retrospective analysis. Medicine (Baltimore). 2019 Aug;98(33):e16718 Authors: Yuan GL, Liang LZ, Zhang ZF, Liang QL, Huang ZY, Zhang HJ, Cheng SA, Peng XX Abstract BACKGROUND: The objective of this study was to explore the influence factors of hospitalization costs of treating colorectal cancer in China. And the study provides new estimates on hospitalization costs and length...
Oncology
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Strategies to prevent brain metastasis.
Related ArticlesStrategies to prevent brain metastasis. Curr Opin Oncol. 2019 Aug 13;: Authors: Soffietti R, Pellerino A, Rudà R Abstract PURPOSE OF REVIEW: The current article reviews the state of art of prevention strategies for brain metastases from solid tumors and touches both old pivotal studies and new directions of personalized molecular approaches. RECENT FINDINGS: Prophylactic cranial irradiation (PCI) has a definite role in the prevention...
Oncology
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The applications of metabolomics in the molecular diagnostics of cancer.
Related ArticlesThe applications of metabolomics in the molecular diagnostics of cancer. Expert Rev Mol Diagn. 2019 Aug 15;: Authors: Cheung PK, Ma MH, Tse HF, Yeung KF, Tsang HF, Chu MKM, Kan CM, Cho WCS, Ng LBW, Chan LWC, Wong SCC Abstract Introduction: Metabolomics, the study of metabolites, is a promising research field for cancers. The metabolic pathway in a tumor cell is different from a normal tissue cell. There are two approaches to study the...
Oncology
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Global extracellular vesicle proteomic signature defines U87-MG glioma cell hypoxic status with potential implications for non-invasive diagnostics.
Related ArticlesGlobal extracellular vesicle proteomic signature defines U87-MG glioma cell hypoxic status with potential implications for non-invasive diagnostics. J Neurooncol. 2019 Aug 14;: Authors: Indira Chandran V, Welinder C, Gonçalves de Oliveira K, Cerezo-Magaña M, Månsson AS, Johansson MC, Marko-Varga G, Belting M Abstract PURPOSE: Glioblastoma multiforme (GBM) is the most common and lethal of primary malignant brain tumors. Hypoxia constitutes...
Oncology
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Integrating Concept Maps into a Medical Student Oncology Curriculum.
Related ArticlesIntegrating Concept Maps into a Medical Student Oncology Curriculum. J Cancer Educ. 2019 Aug 14;: Authors: Brondfield S, Seol A, Hyland K, Teherani A, Hsu G Abstract Expanding frontiers of knowledge have prompted medical schools to reconsider how best to promote learning in the face of information overload. Concept mapping (CM) promotes knowledge retention and integration. Students have perceived CM positively in prior studies, but the...
Oncology
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CaringGuidance™ after breast cancer diagnosis eHealth psychoeducational intervention to reduce early post-diagnosis distress.
Related ArticlesCaringGuidance™ after breast cancer diagnosis eHealth psychoeducational intervention to reduce early post-diagnosis distress. Support Care Cancer. 2019 Aug 14;: Authors: Lally RM, Kupzyk KA, Bellavia G, Hydeman J, Gallo S, Helgeson VS, Erwin D, Mills AC, Brown JK Abstract PURPOSE: Significant cancer-related distress affects 30-60% of women diagnosed with breast cancer. Fewer than 30% of distressed patients receive psychosocial care. Unaddressed...
Oncology
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Vaccinia-based oncolytic immunotherapy Pexastimogene Devacirepvec in patients with advanced hepatocellular carcinoma after sorafenib failure: a randomized multicenter Phase IIb trial (TRAVERSE).
Related ArticlesVaccinia-based oncolytic immunotherapy Pexastimogene Devacirepvec in patients with advanced hepatocellular carcinoma after sorafenib failure: a randomized multicenter Phase IIb trial (TRAVERSE). Oncoimmunology. 2019;8(8):1615817 Authors: Moehler M, Heo J, Lee HC, Tak WY, Chao Y, Paik SW, Yim HJ, Byun KS, Baron A, Ungerechts G, Jonker D, Ruo L, Cho M, Kaubisch A, Wege H, Merle P, Ebert O, Habersetzer F, Blanc JF, Rosmorduc O, Lencioni R, Patt R, Leen AM,...
Oncology
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Genomics applied to the treatment of breast cancer.
Related ArticlesGenomics applied to the treatment of breast cancer. Oncotarget. 2019 Jul 30;10(46):4786-4801 Authors: Hamdan D, Nguyen TT, Leboeuf C, Meles S, Janin A, Bousquet G Abstract Breast cancer remains a major health issue in the world with 1.7 million new cases in 2012 worldwide. It is the second cause of death from cancer in western countries. Genomics have started to modify the treatment of breast cancer, and the developments should become...
Oncology
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Prognostic Nomograms for Predicting Overall Survival and Cancer-Specific Survival of Patients with Major Salivary Gland Mucoepidermoid Carcinoma.
Related ArticlesPrognostic Nomograms for Predicting Overall Survival and Cancer-Specific Survival of Patients with Major Salivary Gland Mucoepidermoid Carcinoma. J Cancer. 2019;10(18):4380-4388 Authors: Hu JQ, Yu PC, Shi X, Liu WL, Zhang TT, Lei BW, Huang NS, Xu WB, Han LT, Ma B, Liao T, Wei WJ, Wang Y, Lu ZW, Wang YL, Ji QH Abstract Background: The aim of this study was to develop and validate prognostic nomograms predicting overall (OS) and cancer-specific...
Oncology
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Workshop on proposal writing on research for health care professionals: a brief report.
Related ArticlesWorkshop on proposal writing on research for health care professionals: a brief report. J Multidiscip Healthc. 2019;12:565-572 Authors: Shrestha S, Danekhu K, Sharma N, Khanal P, Ansari SR, Shrestha S, Piryani RM, Mohamed Ibrahim MI Abstract A one-day workshop on proposal writing for research for health care professionals was organized by Hospital Research Board (HRB), Nepal Cancer Hospital and Research Center Pvt. Ltd, Harisiddhi, Lalitpur,...
Oncology
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HIV status does not have an impact on positron emission tomography-computed tomography (PET-CT) findings or radiotherapy treatment recommendations in patients with locally advanced cervical cancer.
Related ArticlesHIV status does not have an impact on positron emission tomography-computed tomography (PET-CT) findings or radiotherapy treatment recommendations in patients with locally advanced cervical cancer. Int J Gynecol Cancer. 2019 Aug 13;: Authors: Simonds H, Botha MH, Ellmann A, Warwick J, Doruyter A, Neugut AI, Van Der Merwe H, Jacobson JS Abstract INTRODUCTION: Positron emission tomography-computed tomography (PET-CT) imaging is commonly...
Oncology
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Outcomes and outcome measures used in evaluation of communication training in oncology - a systematic literature review, an expert workshop, and recommendations for future research.
Related ArticlesOutcomes and outcome measures used in evaluation of communication training in oncology - a systematic literature review, an expert workshop, and recommendations for future research. BMC Cancer. 2019 Aug 14;19(1):808 Authors: Fischer F, Helmer S, Rogge A, Arraras JI, Buchholz A, Hannawa A, Horneber M, Kiss A, Rose M, Söllner W, Stein B, Weis J, Schofield P, Witt CM Abstract BACKGROUND: Communication between health care provider and patients...
Oncology
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Evaluating the experience of rural individuals with prostate and breast cancer participating in research via telehealth.
Related ArticlesEvaluating the experience of rural individuals with prostate and breast cancer participating in research via telehealth. Rural Remote Health. 2019 Aug;19(3):5269 Authors: Scurrey S, Garland SN, Thoms J, Laing K Abstract INTRODUCTION: Studies that use objective assessments often only recruit individuals in the geographic region in which the study is being conducted, because the assessments require that the researcher and participant be...
Oncology
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Evolving Clinical Utility of Liquid Biopsy in Gastrointestinal Cancers.
Related ArticlesEvolving Clinical Utility of Liquid Biopsy in Gastrointestinal Cancers. Cancers (Basel). 2019 Aug 13;11(8): Authors: Jacobson RA, Munding E, Hayden DM, Levy M, Kuzel TM, Pappas SG, Masood A Abstract Room for improvement exists regarding recommendations for screening, staging, therapy selection, and frequency of surveillance of gastrointestinal cancers. Screening is costly and invasive, improved staging demands increased sensitivity and...
Oncology
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The Developmental Pathways of Preschool Children with Acute Lymphoblastic Leukemia: Communicative and Social Sequelae One Year after Treatment.
Related ArticlesThe Developmental Pathways of Preschool Children with Acute Lymphoblastic Leukemia: Communicative and Social Sequelae One Year after Treatment. Children (Basel). 2019 Aug 13;6(8): Authors: Tremolada M, Taverna L, Bonichini S, Pillon M, Biffi A Abstract Early childhood is considered to be a period of rapid development, with the acquisition of abilities predicting future positive school competences. Motor, cognitive, and social difficulties...
Oncology
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Early versus late arteriovenous malformation responders after stereotactic radiosurgery: an international multicenter study.
Related ArticlesEarly versus late arteriovenous malformation responders after stereotactic radiosurgery: an international multicenter study. J Neurosurg. 2017 Sep;127(3):503-511 Authors: Cohen-Inbar O, Starke RM, Paisan G, Kano H, Huang PP, Rodriguez-Mercado R, Almodovar L, Grills IS, Mathieu D, Silva D, Abbassy M, Missios S, Lee JYK, Barnett GH, Kondziolka D, Lunsford LD, Sheehan JP Abstract OBJECTIVE The goal of stereotactic radiosurgery (SRS) for...
Oncology
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Immunologic and immunogenomic aspects of tumor progression.
Immunologic and immunogenomic aspects of tumor progression. Semin Cancer Biol. 2019 Aug 13;: Authors: Ladányi A, Tímár J Abstract Tumor progression to metastatic disease is characterized by continuous genetic alterations due to instability of the genome. Immune sensitivity was found to be linked to tumor mutational burden (TMB) and the resulting amount of neoantigens. However, APOBEC activity resulting in increase in TMB causes immune evasion. On the...
Rare Cancers
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Squamous cell carcinoma of the nasal cavity: A descriptive analysis of cases from the Head and Neck 5000 study.
Squamous cell carcinoma of the nasal cavity: A descriptive analysis of cases from the Head and Neck 5000 study. Clin Otolaryngol. 2019 Aug 16;: Authors: Dale OT, Pring M, Davies A, Leary S, Ingarfield K, Toms S, Waterboer T, Pawlita M, Ness AR, Thomas SJ Abstract OBJECTIVES: This paper aims to provide contemporary epidemiological data on squamous cell carcinoma (SCC) of the nasal cavity, which represents a rare type of head and neck cancer. ...
Rare Cancers
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Separation of low versus high grade Crohn's disease-associated small bowel carcinomas is improved by invasive front prognostic marker analysis.
Related ArticlesSeparation of low versus high grade Crohn's disease-associated small bowel carcinomas is improved by invasive front prognostic marker analysis. J Crohns Colitis. 2019 Aug 16;: Authors: Arpa G, Grillo F, Giuffrida P, Nesi G, Klersy C, Mescoli C, Lenti MV, Lobascio G, Martino M, Latella G, Malvi D, Macciomei MC, Fociani P, Villanacci V, Rizzo A, Ferrero S, Sessa F, Orlandi A, Monteleone G, Biancone L, Cantoro L, Tonelli F, Ciardi A, Poggioli G, Rizzello...
Rare Cancers
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Adrenal metastasis from endometrial cancer: A case report.
Related ArticlesAdrenal metastasis from endometrial cancer: A case report. World J Clin Cases. 2019 Jul 26;7(14):1844-1849 Authors: Da Dalt G, Friziero A, Grego A, Serafini S, Fassina A, Blandamura S, Sperti C Abstract BACKGROUND: Metastases to adrenal glands originate principally from lung, breast, or gastrointestinal cancers, followed by malignant melanoma and thyroid neoplasms. We present an unusual case of uterine cancer metastasizing to the adrenal...
Rare Cancers
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Current status of the adjuvant therapy in uterine sarcoma: A literature review.
Related ArticlesCurrent status of the adjuvant therapy in uterine sarcoma: A literature review. World J Clin Cases. 2019 Jul 26;7(14):1753-1763 Authors: Rizzo A, Pantaleo MA, Saponara M, Nannini M Abstract Uterine sarcomas (US) are rare mesenchymal tumours accounting approximately for 3%-7% of all uterine cancers. Histologically, US are classified into mesenchymal tumours or mixed epithelial and mesenchymal tumours. The group of mesenchymal tumours includes...
Rare Cancers
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Case Series of Cancer-associated Retinopathy (CAR).
Related ArticlesCase Series of Cancer-associated Retinopathy (CAR). Cureus. 2019 Jun 10;11(6):e4872 Authors: Naramala S, Ahmad J, Adapa S, Gavini F, Konala VM Abstract Cancer-associated retinopathy (CAR) is a rare paraneoplastic disorder of the retina leading to blindness, associated with multiple cancers. It can lead to rapid progressive visual deterioration with retinal pathology ranging from retinitis pigmentosa to retinal degeneration. It is caused...
Rare Cancers
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The PTEN Tumor Suppressor Gene in Soft Tissue Sarcoma.
Related ArticlesThe PTEN Tumor Suppressor Gene in Soft Tissue Sarcoma. Cancers (Basel). 2019 Aug 14;11(8): Authors: Stefano S, Giovanni S Abstract Soft tissue sarcoma (STS) is a rare malignancy of mesenchymal origin classified into more than 50 different subtypes with distinct clinical and pathologic features. Despite the poor prognosis in the majority of patients, only modest improvements in treatment strategies have been achieved, largely due to the...
Rare Cancers
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Visceral Kaposi Sarcoma Presenting as Small Bowel Intussusception: A Rare Presentation and Call to Action.
Related ArticlesVisceral Kaposi Sarcoma Presenting as Small Bowel Intussusception: A Rare Presentation and Call to Action. Am Surg. 2019 Jul 01;85(7):778-780 Authors: Lovasik BP, Wang VL, Point du Jour KS, Kim SC, Hashmi SS, Haack CI Abstract Surgical emergencies related to visceral involvement of Kaposi sarcoma (KS) are rare complications of the disease. In this report, we describe a case of visceral KS causing small bowel intussusception in a young,...
Rare Cancers
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Avoiding Pitfalls in Insulinomas by Preoperative Localization with a Dual Imaging Approach.
Related ArticlesAvoiding Pitfalls in Insulinomas by Preoperative Localization with a Dual Imaging Approach. Am Surg. 2019 Jul 01;85(7):742-746 Authors: Ramonell KM, Saunders ND, Sarmiento J, Bercu Z, Martin L, Weber CJ, Sharma J, Patel SG Abstract Insulinomas are rare endocrine malignancies of the pancreas that require surgical resection but can be difficult to localize preoperatively. We sought to review and improve the accuracy of preoperative localization...
Rare Cancers
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The Understated Malignancy Potential of Nonoperative Acute Appendicitis.
Related ArticlesThe Understated Malignancy Potential of Nonoperative Acute Appendicitis. Am Surg. 2019 Jul 01;85(7):712-716 Authors: Seawell J, Sciarretta JD, Pahlkotter M, Muertos K, Onayemi A, Davis JM Abstract Cancer of the appendix is rare and is most commonly found incidentally on pathology after an appendectomy for uncomplicated appendicitis (UA). The medical management alternative with antibiotics and observation remains an ongoing debate. The...
Rare Cancers
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[A case of pancreatic neuroendocrine tumor with ring-like enhancement].
Related Articles[A case of pancreatic neuroendocrine tumor with ring-like enhancement]. Nihon Shokakibyo Gakkai Zasshi. 2019;116(7):597-606 Authors: Nakata A, Nebiki H, Kimura A, Yamamura M, Suekane T, Yamasaki T, Murata A, Shimizu S, Ishii N, Inoue T Abstract An 82-year-old female underwent contrast computed tomography (CT) that revealed multiple ring-like enhanced masses in the pancreatic tail. Additionally, the inside of the masses showed enhancement...
Rare Cancers
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[Simultaneous occurrence of an ampullary neuroendocrine tumor and multiple duodenal/jejunal gastrointestinal stromal tumors in a patient with neurofibromatosis type 1].
Related Articles[Simultaneous occurrence of an ampullary neuroendocrine tumor and multiple duodenal/jejunal gastrointestinal stromal tumors in a patient with neurofibromatosis type 1]. Nihon Shokakibyo Gakkai Zasshi. 2019;116(7):583-591 Authors: Kitajima R, Morita Y, Furuhashi S, Kiuchi R, Takeda M, Kikuchi H, Watanabe F, Sugimoto K, Sakaguchi T, Takeuchi H Abstract A 60-year-old female visited our hospital because of the identification of two duodenal...
Rare Cancers
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[A case of rectal villous adenoma with electrolyte depletion syndrome treated with surgical resection].
Related Articles[A case of rectal villous adenoma with electrolyte depletion syndrome treated with surgical resection]. Nihon Shokakibyo Gakkai Zasshi. 2019;116(7):576-582 Authors: Suzuki N, Kajiwara A, Usami T, Nakajima Y, Yamamiya A, Konda K, Shimozuma Y, Uchikoshi M, Kurihara T, Yoshida H Abstract A 65-year-old man was previously admitted to our university hospital thrice in the last 2 years because of acute kidney failure. This time he was admitted...
Rare Cancers
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Thoracic Liposarcoma In An End Stage Renal Disease Patient.
Related ArticlesThoracic Liposarcoma In An End Stage Renal Disease Patient. J Ayub Med Coll Abbottabad. 2019 Apr-Jun;31(2):286-289 Authors: Ishtiaq R, Naeem A, Ratnani I Abstract Liposarcoma arising in the thoracic cavity is a rare entity. It is usually found in the retroperitoneal space and the extremities. No case of thoracic liposarcoma in a patient suffering from the end-stage renal disease has been reported in the literature. We herein present...
Rare Cancers
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Plasma Cell Leukaemia: A Rare Yet Aggressive Plasma Cell Dyscrasia With A Very Poor Response To Conventional Therapy.
Related ArticlesPlasma Cell Leukaemia: A Rare Yet Aggressive Plasma Cell Dyscrasia With A Very Poor Response To Conventional Therapy. J Ayub Med Coll Abbottabad. 2019 Apr-Jun;31(2):272-275 Authors: Khan N, Raza SS, Khan UI, Hafez I, Abdullah MA, Hassan M, Rukh Hijaz AS, Hussain AK, Nadeem MD Abstract Plasma cell leukaemia (PCL) is a very rare plasma cell dyscrasia with a significant number of monoclonal plasma cells in the peripheral blood. It is diagnosed...
Rare Cancers
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[Cauda equina syndrome as the first presentation of intravascular large B-cell lymphoma: a lung biopsy case].
Related Articles[Cauda equina syndrome as the first presentation of intravascular large B-cell lymphoma: a lung biopsy case]. Rinsho Ketsueki. 2019;60(4):326-330 Authors: Ide S, Ohara S, Uchida T, Inoue M, Hua J, Hagihara M Abstract A 65-year-old male was admitted for bladder and rectal dysfunction with lower-limb sensory disturbance. Although no abnormalities were detected on magnetic resonance imaging of the brain and spinal cord, an elevation in...
Rare Cancers
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[Follicular lymphoma with nodular lesions mimicking gallbladder carcinoma].
Related Articles[Follicular lymphoma with nodular lesions mimicking gallbladder carcinoma]. Rinsho Ketsueki. 2019;60(4):319-325 Authors: Tokunaga M, Maeda T, Fukuchi N, Tamai K, Minoji T, Sasakawa H, Kondo A, Inoue S, Morita T, Tominaga N Abstract A 68-year-old female was diagnosed with follicular lymphoma (FL) grade 2, based on the excisional biopsy of her enlarged left cervical lymph node. Positron-emission tomography/computed tomography (PET/CT)...
Rare Cancers
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[Durable remission of Langerhans cell sarcoma attained by autologous hematopoietic stem cell transplantation following surgical resection].
Related Articles[Durable remission of Langerhans cell sarcoma attained by autologous hematopoietic stem cell transplantation following surgical resection]. Rinsho Ketsueki. 2019;60(4):314-318 Authors: Fuseya H, Nakao T, Tsutsumi M, Nakaya Y, Horiuchi M, Yoshida M, Yoshimura T, Hayashi Y, Fukushima H, Inoue T, Aiba T, Yamane T Abstract Langerhans cell sarcoma (LCS) is a rare neoplastic proliferation of Langerhans cells with a poor prognosis. Owing to...
Rare Cancers
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[Human herpes virus 8-negative primary effusion lymphoma-like lymphoma recurring as a tumor adjacent to the left atrium].
Related Articles[Human herpes virus 8-negative primary effusion lymphoma-like lymphoma recurring as a tumor adjacent to the left atrium]. Rinsho Ketsueki. 2019;60(3):218-222 Authors: Horiuchi M, Nakao T, Tsutsumi M, Nakaya Y, Fuseya H, Yoshida M, Yoshimura T, Hayashi Y, Fukushima H, Inoue T, Yamane T Abstract Primary effusion lymphoma (PEL) is a rare type of non-Hodgkin lymphoma, usually presenting as serous effusions without detectable tumor masses,...
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[Clinical features of intravascular large B-cell lymphoma: a single-institute retrospective analysis].
Related Articles[Clinical features of intravascular large B-cell lymphoma: a single-institute retrospective analysis]. Rinsho Ketsueki. 2019;60(3):184-190 Authors: Okuno T, Iwata S, Hayakawa H, Miyao K, Kajiguchi T Abstract Intravascular large B-cell lymphoma (IVLBCL) is a rare form of extranodal non-Hodgkin's lymphoma, and the absence of specific findings makes ante-mortem diagnosis difficult. This study was conducted to identify the clinical findings...
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TAD fusion score: discovery and ranking the contribution of deletions to genome structure.
Related ArticlesTAD fusion score: discovery and ranking the contribution of deletions to genome structure. Genome Biol. 2019 03 21;20(1):60 Authors: Huynh L, Hormozdiari F Abstract Deletions that fuse two adjacent topologically associating domains (TADs) can cause severe developmental disorders. We provide a formal method to quantify deletions based on their potential disruption of the three-dimensional genome structure, denoted as the TAD fusion score....
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Enzymatic degradation study of 111In-labeled minigastrin peptides using cathepsin B enzyme and AR42J cancer cell line for the development of neuroendocrine tumor imaging radiopharmaceuticals.
Related ArticlesEnzymatic degradation study of 111In-labeled minigastrin peptides using cathepsin B enzyme and AR42J cancer cell line for the development of neuroendocrine tumor imaging radiopharmaceuticals. Pak J Pharm Sci. 2018 Nov;31(6 (Supplementary):2585-2589 Authors: Naqvi SAR, Yameen M, Hussain Z, Asim S, Usman M, Khan NH, Abbas K Abstract Neuroendocrine tumors (NET) are the rare tumors which often impose graveyard threat. These tumors are characterized...
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Biology and management of primary effusion lymphoma.
Related ArticlesBiology and management of primary effusion lymphoma. Blood. 2018 11 01;132(18):1879-1888 Authors: Shimada K, Hayakawa F, Kiyoi H Abstract Primary effusion lymphoma (PEL) is a rare B-cell malignancy that most often occurs in immunocompromised patients, such as HIV-infected individuals and patients receiving organ transplantation. The main characteristic of PEL is neoplastic effusions in body cavities without detectable tumor masses. The...
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Gastrointestinal non-Hodgkin lymphomas.
Related ArticlesGastrointestinal non-Hodgkin lymphomas. Adv Clin Exp Med. 2019 Aug 13;: Authors: Olszewska-Szopa M, Wróbel T Abstract Although gastrointestinal (GI) tract is the most common extranodal site involved in non-Hodgkin lymphoma (NHL), primary gastrointestinal NHL (gNHL) is a rare problem which concerns about 10-15% of NHL patients and 30-40% of extranodal NHL patients. Lymphoid neoplasms may consist of mature B, T and (less commonly) extranodal...
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Neuroendocrine Cancer of the Prostate.
Related ArticlesNeuroendocrine Cancer of the Prostate. Pathol Oncol Res. 2019 Aug 14;: Authors: Kránitz N, Szepesváry Z, Kocsis K, Kullmann T Abstract Neuroendocrine cancer of the prostate is considered to be a rare entity with bad prognosis and limited therapeutic options. We performed a prospective analysis of the patients treated in our hospital for prostate cancer between 1st January 2015 and 31rd December 2018. Neuroendocrine phenomena were tested...
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Medulloblastoma and central nervous system germ cell tumors in adults: is pediatric experience applicable?
Related ArticlesMedulloblastoma and central nervous system germ cell tumors in adults: is pediatric experience applicable? Childs Nerv Syst. 2019 Aug 14;: Authors: Mascarin M, Coassin E, Franceschi E, Gandola L, Carrabba G, Brandes AA, Massimino M Abstract Medulloblastoma and central nervous system (CNS) germ cell tumors are very rare in adults, while they account for 25% and 5% of brain tumors in children, respectively (Pastore et al. Eur J Cancer 42:2064-208,...
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Intramedullary Spinal Cord Metastases of Malignant Melanoma: A Rare Case Report on Paraplegia in Palliative Care.
Related ArticlesIntramedullary Spinal Cord Metastases of Malignant Melanoma: A Rare Case Report on Paraplegia in Palliative Care. Indian J Palliat Care. 2019 Jul-Sep;25(3):468-470 Authors: Sonawane R, Ghoshal A, Damani A, Muckaden M, Deodhar JK Abstract Rates of malignant melanoma have been increasing in frequency. Studies have shown that up to 46% of patients with melanoma will experience metastases to the central nervous system. Intramedullary spinal...
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Rare Case of Primary Clear Cell Carcinoma of the Urinary Bladder.
Related ArticlesRare Case of Primary Clear Cell Carcinoma of the Urinary Bladder. Niger Med J. 2019 Jan-Feb;60(1):40-42 Authors: Kulkarni MM, Sinai Khandeparkar SG, Joshi AR, Bhayekar P Abstract Cancers of the urinary bladder account for about 3.2% of all cancers worldwide. Clear cell adenocarcinomas (CCAs) of urinary bladder are rare. CCA must be differentiated from benign condition such as nephrogenic adenoma (NA) as well as malignant conditions such...
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Human germ cell tumours from a developmental perspective.
Related ArticlesHuman germ cell tumours from a developmental perspective. Nat Rev Cancer. 2019 Aug 14;: Authors: Oosterhuis JW, Looijenga LHJ Abstract Human germ cell tumours (GCTs) are derived from stem cells of the early embryo and the germ line. They occur in the gonads (ovaries and testes) and also in extragonadal sites, where migrating primordial germ cells are located during embryogenesis. This group of heterogeneous neoplasms is unique in that...
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Clinicopathological spectrum of solitary Plasmacytoma: a single center experience from coastal India.
Related ArticlesClinicopathological spectrum of solitary Plasmacytoma: a single center experience from coastal India. BMC Cancer. 2019 Aug 14;19(1):801 Authors: Basavaiah SH, Lobo FD, Philipose CS, Suresh PK, Sreeram S, Kini H, Sahu KK, Prasad K Abstract BACKGROUND: Plasma cell disorders are a rare group of hematological malignancies that accounts for 10% of all hematological neoplasms. Solitary plasmacytomas are rarer entities accounting for less than...
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Detection of HPV RNA molecules in stratified mucin-producing intraepithelial lesion (SMILE) with concurrent cervical intraepithelial lesion: a case report.
Related ArticlesDetection of HPV RNA molecules in stratified mucin-producing intraepithelial lesion (SMILE) with concurrent cervical intraepithelial lesion: a case report. Virol J. 2019 06 03;16(1):76 Authors: Fukui S, Nagasaka K, Iimura N, Kanda R, Ichinose T, Sugihara T, Hiraike H, Nakagawa S, Sasajima Y, Ayabe T Abstract BACKGROUND: Stratified mucin-producing intraepithelial lesion (SMILE) is a rare precursor lesion in the uterine cervix that is...
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Thyroid Cancer Brain Metastasis: Survival and Genomic Characteristics of a Large Tertiary Care Cohort.
Related ArticlesThyroid Cancer Brain Metastasis: Survival and Genomic Characteristics of a Large Tertiary Care Cohort. Clin Nucl Med. 2019 Jul;44(7):544-549 Authors: Osborne JR, Kondraciuk JD, Rice SL, Zhou X, Knezevic A, Spratt DE, Sabra M, Larson SM, Grewal RK Abstract PURPOSE: Brain metastases (BMs) in patients with differentiated thyroid cancer (DTC) are rare but associated with poor prognosis. We examined risk factors for overall survival (OS)...
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Physician requests by patients with malignant pleural mesothelioma in Japan.
Related ArticlesPhysician requests by patients with malignant pleural mesothelioma in Japan. BMC Cancer. 2019 Apr 25;19(1):383 Authors: Nagamatsu Y, Oze I, Aoe K, Hotta K, Kato K, Nakagawa J, Hara K, Kishimoto T, Fujimoto N Abstract BACKGROUND: Malignant pleural mesothelioma (MPM) is a fatal and rare disease that is caused by the inhalation of asbestos. Treatment and care requests made by MPM patients to their physicians were collected and analyzed....
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18F-FDG PET/CT for Staging and Evaluation of Therapy in a Patient With Unusual Hairy Cell Leukemia Presentation.
Related Articles18F-FDG PET/CT for Staging and Evaluation of Therapy in a Patient With Unusual Hairy Cell Leukemia Presentation. Clin Nucl Med. 2019 Jul;44(7):e458-e460 Authors: Doma A, Škerget M, Žagar I Abstract Hairy cell leukemia is a rare hematologic malignancy characterized by splenomegaly, pancytopenia, and susceptibility to infections. We report a case of a 66-year-old man, diagnosed with hairy cell leukemia, without severe cytopenias and splenomegaly,...
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A Rare Case of Primary Endometrial Hepatoid Adenocarcinoma on 18F-FDG PET/CT.
Related ArticlesA Rare Case of Primary Endometrial Hepatoid Adenocarcinoma on 18F-FDG PET/CT. Clin Nucl Med. 2019 Jul;44(7):e425-e427 Authors: Yin H, Hu Y, Xiu Y, Luo R, Shi H Abstract Primary endometrial hepatoid adenocarcinoma is a rare tumor. We present a case of a 64-year-old woman with vaginal bleeding for 2 months and a markedly elevated serum α-fetoprotein of 3931 ng/mL. Hysteroscopic segmental curettage revealed endometrial adenocarcinoma. A...
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Co-amplification and co-localization: Rare signal pattern in human epidermal growth factor receptor 2 gene fluorescence in situ hybridization testing.
Related ArticlesCo-amplification and co-localization: Rare signal pattern in human epidermal growth factor receptor 2 gene fluorescence in situ hybridization testing. Indian J Pathol Microbiol. 2019 Apr-Jun;62(2):355-356 Authors: Gupta A, Patibandla SR, Kasaragadda MR, Goyal M PMID: 30971582 [PubMed - indexed for MEDLINE]
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A soft tissue swelling at angle of mandible: Fine needle aspiration cytology meeting the diagnostic challenge of a rare case.
Related ArticlesA soft tissue swelling at angle of mandible: Fine needle aspiration cytology meeting the diagnostic challenge of a rare case. Indian J Pathol Microbiol. 2019 Apr-Jun;62(2):353-354 Authors: Sahu P, Gupta P, Ahuja A, Bhardwaj M, Nigam A PMID: 30971581 [PubMed - indexed for MEDLINE]
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Mediastinal mixed germ cell tumor with splenic histiocytosis: A rare coincidence.
Related ArticlesMediastinal mixed germ cell tumor with splenic histiocytosis: A rare coincidence. Indian J Pathol Microbiol. 2019 Apr-Jun;62(2):341-342 Authors: Sood R, Mehta A, Bansal D, Singh N, Purohit SR PMID: 30971575 [PubMed - indexed for MEDLINE]
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Signet ring: A rare morphology of metastatic neuroendocrine tumor.
Related ArticlesSignet ring: A rare morphology of metastatic neuroendocrine tumor. Indian J Pathol Microbiol. 2019 Apr-Jun;62(2):335-336 Authors: Madakshira MG, Radotra BD, Singh V PMID: 30971572 [PubMed - indexed for MEDLINE]
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Carnosic acid regulates cell proliferation and invasion in chronic myeloid leukemia cancer cells via suppressing microRNA-708.
Related ArticlesCarnosic acid regulates cell proliferation and invasion in chronic myeloid leukemia cancer cells via suppressing microRNA-708. J BUON. 2018 May-Jun;23(3):741-746 Authors: Liu D, Wang B, Zhu Y, Yan F, Dong W Abstract PURPOSE: Carnosic acid (CA) is an important polyphenol mainly isolated from the famous spice and the medicinal plant Rosmarinus officinalis. CA has been shown to exhibit tremendous pharmacological properties which include,...
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Rare germline variants in DNA repair genes and the angiogenesis pathway predispose prostate cancer patients to develop metastatic disease.
Related ArticlesRare germline variants in DNA repair genes and the angiogenesis pathway predispose prostate cancer patients to develop metastatic disease. Br J Cancer. 2018 07;119(1):96-104 Authors: Mijuskovic M, Saunders EJ, Leongamornlert DA, Wakerell S, Whitmore I, Dadaev T, Cieza-Borrella C, Govindasami K, Brook MN, Haiman CA, Conti DV, Eeles RA, Kote-Jarai Z Abstract BACKGROUND: Prostate cancer (PrCa) demonstrates a heterogeneous clinical presentation...
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Chemical meningitis from a leaking craniopharyngioma: a case report.
Related ArticlesChemical meningitis from a leaking craniopharyngioma: a case report. Acta Neurochir (Wien). 2018 06;160(6):1203-1206 Authors: Hakizimana D, Poulsgaard L, Fugleholm K Abstract Recurrent chemical meningitis from cyclic leakage of cyst content from a craniopharyngioma is a rare phenomenon. Here, we report a case of leaking cystic craniopharyngioma presenting with recurrent episodes of sterile meningitis, depression, and paranoia. The diagnosis...
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