Protein-RNA recognition is highly affinity driven and regulates a wide array of cellular functions. In this study, we have curated a binding affinity dataset of 40 protein-RNA complexes, for which at least one unbound partner is available in the docking benchmark. The dataset covers a wide affinity range of eight orders of magnitude as well as four different structural classes. On an average, we find the complexes with single-stranded RNA have the highest affinity while the complexes with the duplex...
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Analytical ChemistryDOI: 10.1021/acs.analchem.9b02600
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Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b06743
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The American Academy of Otolaryngology-Head and Neck Surgery Foundation published an updated clinical practice guideline on Aug. 1. The updated guideline includes the addition of 29 new systematic reviews and 36 new randomized controlled trials, as well as an algorithm for clinical implementation of its key action statements. According to the guideline, it remains essential to exclude conductive hearing loss when evaluating for sudden sensorineural hearing loss (SSNHL) in patients who have newly...
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Nature, Published online: 08 August 2019; doi:10.1038/d41586-019-02404-yScientists identify more than 4,000 protein groups — most previously unknown.
Nature, Published online: 08 August 2019; doi:10.1038/d41586-019-02405-xAt rush hour, immobilizing a small fraction of Internet-connected cars would bring Manhattan to a halt.
Nature, Published online: 08 August 2019; doi:10.1038/d41586-019-02383-0The month’s sharpest science shots, selected by Nature’s photo team.
Nature, Published online: 08 August 2019; doi:10.1038/d41586-019-02413-xFive books to open your mind this summer, plus award-winning stories from Nature this year.
Nature, Published online: 08 August 2019; doi:10.1038/d41586-019-02403-zThe plunge in numbers of these enormous species is part of a broader downward trend in freshwater megafauna.
Nature, Published online: 08 August 2019; doi:10.1038/d41586-019-02332-xSome researchers have turned to crowdfunding campaigns to pay for supplies and several scientific institutes are rationing electricity to save money.
Nature, Published online: 08 August 2019; doi:10.1038/d41586-019-02409-7The report on global land use and agriculture from the Intergovernmental Panel on Climate Change comes amid accelerating deforestation in the Amazon.
Nature, Published online: 08 August 2019; doi:10.1038/d41586-019-02362-5Bioethicists hope a national committee will help close loopholes in the country’s biomedical ethics regulations.
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