Πέμπτη 8 Αυγούστου 2019

A structure-based model for the prediction of protein-RNA binding affinity [Article]
Protein-RNA recognition is highly affinity driven and regulates a wide array of cellular functions. In this study, we have curated a binding affinity dataset of 40 protein-RNA complexes, for which at least one unbound partner is available in the docking benchmark. The dataset covers a wide affinity range of eight orders of magnitude as well as four different structural classes. On an average, we find the complexes with single-stranded RNA have the highest affinity while the complexes with the duplex...
RNA In Advance
3h
[ASAP] Supersensitive Photoelectrochemical Aptasensor Based on Br,N-Codoped TiO<sub>2</sub> Sensitized by Quantum Dots
Analytical ChemistryDOI: 10.1021/acs.analchem.9b02600
Analytical Chemistry
4h
[ASAP] Self Adjusting Algorithm for the Nontargeted Feature Detection of High Resolution Mass Spectrometry Coupled with Liquid Chromatography Profile Data
Analytical ChemistryDOI: 10.1021/acs.analchem.9b02422
Analytical Chemistry
4h
[ASAP] Quantitative SO<sub>2</sub> Detection in Combustion Environments Using Broad Band Ultraviolet Absorption and Laser-Induced Fluorescence
Analytical ChemistryDOI: 10.1021/acs.analchem.9b02505
Analytical Chemistry
4h
[ASAP] Improved Dried Blood Spot-Based Metabolomics Analysis by a Postcolumn Infused-Internal Standard Assisted Liquid Chromatography-Electrospray Ionization Mass Spectrometry Method
Analytical ChemistryDOI: 10.1021/acs.analchem.9b02050
Analytical Chemistry
4h
[ASAP] Mesoporous Silica Containers and Programmed Catalytic Hairpin Assembly/Hybridization Chain Reaction Based Electrochemical Sensing Platform for MicroRNA Ultrasensitive Detection with Low Background
Analytical ChemistryDOI: 10.1021/acs.analchem.9b01947
Analytical Chemistry
4h
[ASAP] Rapid Evaluation of the Debromination Mechanism of Eosin in Oil Paint by Direct Analysis in Real Time and Direct Infusion-Electrospray Ionization Mass Spectrometry
Analytical ChemistryDOI: 10.1021/acs.analchem.9b02568
Analytical Chemistry
8h
[ASAP] Dynamic Measurement of Nanoflows: Realization of an Optofluidic Flow Meter to the Nanoliter-per-Minute Scale
Analytical ChemistryDOI: 10.1021/acs.analchem.9b02056
Analytical Chemistry
12h
[ASAP] Label-Free CRISPR/Cas9 Assay for Site-Specific Nucleic Acid Detection
Analytical ChemistryDOI: 10.1021/acs.analchem.9b02641
Analytical Chemistry
12h
[ASAP] Improved Atomic Force Microscopy Stiffness Measurements of Nanoscale Liposomes by Cantilever Tip Shape Evaluation
Analytical ChemistryDOI: 10.1021/acs.analchem.9b00250
Analytical Chemistry
16h
[ASAP] Photoinduced Electrochemiluminescence at Silicon Electrodes in Water
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b06743
Journal of the American Chemical Society: Latest Articles (ACS Publications)
4h
[ASAP] Multistimuli Responsive Nanocomposite Tectons for Pathway Dependent Self-Assembly and Acceleration of Covalent Bond Formation
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b06695
Journal of the American Chemical Society: Latest Articles (ACS Publications)
4h
[ASAP] Quantum Interference Engineering of Nanoporous Graphene for Carbon Nanocircuitry
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b04649
Journal of the American Chemical Society: Latest Articles (ACS Publications)
12h
[ASAP] Effect of Conformation on Electron Localization and Delocalization in Infinite Helical Chains [X(CH<sub>3</sub>)<sub>2</sub>]<sub>8</sub> (X = Si, Ge, Sn, and Pb)
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b04780
Journal of the American Chemical Society: Latest Articles (ACS Publications)
12h
[ASAP] Two-Carbon Ring Expansion of 1-Indanones via Insertion of Ethylene into Carbon–Carbon Bonds
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b07445
Journal of the American Chemical Society: Latest Articles (ACS Publications)
12h
[ASAP] Dynamic Electric Field Alignment of Metal–Organic Framework Microrods
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b06320
Journal of the American Chemical Society: Latest Articles (ACS Publications)
12h
[ASAP] Water Enables Efficient CO<sub>2</sub> Capture from Natural Gas Flue Emissions in an Oxidation-Resistant Diamine-Appended Metal–Organic Framework
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b05567
Journal of the American Chemical Society: Latest Articles (ACS Publications)
12h
​ New Clinical Guideline Issued for Sudden Sensorineural Hearing Loss
The American Academy of Otolaryngology-Head and Neck Surgery Foundation published an updated clinical practice guideline on Aug. 1.  The updated guideline includes the addition of 29 new systematic reviews and 36 new randomized controlled trials, as well as an algorithm for clinical implementation of its key action statements. According to the guideline, it remains essential to exclude conductive hearing loss when evaluating for sudden sensorineural hearing loss (SSNHL) in patients who have newly...
Audiology
5h
Vast pool of new proteins is found, thanks to the human microbiome
Nature, Published online: 08 August 2019; doi:10.1038/d41586-019-02404-yScientists identify more than 4,000 protein groups — most previously unknown.
Nature - Issue - nature.com science feeds
5h
Vast pool of new proteins is found, thanks to the human microbiome
Nature - Issue - nature.com science feeds
7h

How cyberattacks could gridlock New York City
Nature, Published online: 08 August 2019; doi:10.1038/d41586-019-02405-xAt rush hour, immobilizing a small fraction of Internet-connected cars would bring Manhattan to a halt.
Nature - Issue - nature.com science feeds
7h
How cyberattacks could gridlock New York City
Nature - Issue - nature.com science feeds
8h
Blackbirds, brains and bleached anemones — July’s best science images
Nature, Published online: 08 August 2019; doi:10.1038/d41586-019-02383-0The month’s sharpest science shots, selected by Nature’s photo team.
Nature - Issue - nature.com science feeds
10h
Summer briefing: The five must-read and science-fiction books of the season
Nature, Published online: 08 August 2019; doi:10.1038/d41586-019-02413-xFive books to open your mind this summer, plus award-winning stories from Nature this year.
Nature - Issue - nature.com science feeds
10h
Giant freshwater fishes are in alarming decline
Nature, Published online: 08 August 2019; doi:10.1038/d41586-019-02403-zThe plunge in numbers of these enormous species is part of a broader downward trend in freshwater megafauna.
Nature - Issue - nature.com science feeds
10h
Blackbirds, brains and bleached anemones — July’s best science images
Nature - Issue - nature.com science feeds
12h
Giant freshwater fishes are in alarming decline
Nature - Issue - nature.com science feeds
13h
Summer briefing: The five must-read and science-fiction books of the season
Nature - Issue - nature.com science feeds
14h
Mexican science suffers under debilitating budget cuts
Nature, Published online: 08 August 2019; doi:10.1038/d41586-019-02332-xSome researchers have turned to crowdfunding campaigns to pay for supplies and several scientific institutes are rationing electricity to save money.
Nature - Issue - nature.com science feeds
18h
Eat less meat: UN climate change report calls for change to human diet
Nature, Published online: 08 August 2019; doi:10.1038/d41586-019-02409-7The report on global land use and agriculture from the Intergovernmental Panel on Climate Change comes amid accelerating deforestation in the Amazon.
Nature - Issue - nature.com science feeds
18h
Eat less meat: UN climate change report calls for change to human diet
Nature - Issue - nature.com science feeds
20h
Mexican science suffers under debilitating budget cuts
Nature - Issue - nature.com science feeds
20h
China approves ethics advisory group after CRISPR-babies scandal
Nature, Published online: 08 August 2019; doi:10.1038/d41586-019-02362-5Bioethicists hope a national committee will help close loopholes in the country’s biomedical ethics regulations.
Nature - Issue - nature.com science feeds
21h
China approves ethics advisory group after CRISPR-babies scandal
Nature - Issue - nature.com science feeds
21h

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