Publication date: Available online 13 August 2019Source: Ultrasound in Medicine & BiologyAuthor(s): Yaxin Hu, Yancheng Wang, Xin Chen, Siping ChenAbstractVarious physical methods have been developed to modulate the electrophysiologic properties of cells and their biochemical signaling pathways. In this study, we propose a sonomagnetic method using pulsed ultrasound (1.1 MHz frequency, 1.1 or 2.2 MPa pressure, 50 cycles per pulse and 500 Hz pulse repetition frequency) and a static magnetic field...
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Abstract Purpose Electroconvulsive therapy (ECT), has become a widely applied potent treatment in clinical practice for major depressive disorder (MDD) over decades. However, due to its nonspecific and spatially unfocused nature, the underlying mechanisms of ECT remain unclear. Methods In this longitudinal study, 11 patients with MDD underwent magnetic resonance...
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Publication date: Available online 13 August 2019Source: Clinical ImagingAuthor(s): Zachariah Burns, Lena Omar, Lindsay Compton, Jody Hayes, Sunati Sahoo, Kanwal MerchantAbstractBreast cancer typically spreads primarily to regional lymph nodes and subsequently to distant sites via hematogenous routes. Occasionally metastasis can occur through lymphangitic spread, usually to the lungs, resulting in lymphangitic carcinomatosis. Lymphangitic spread of several malignancies have been reported at other...
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Proinflammatory cytokines play an important role in the systemic and focal bone loss associated with chronic inflammatory diseases. Targeting these cytokines with biologics and small molecules has led to a major improvement of the bone health of patients with inflammatory arthritis. Cytokines from the IL-17 family have been shown to be involved in the pathogenesis of several diseases such as spondyloarthritis, psoriatic arthritis, or psoriasis. IL-17A has been the first described and the most studied....
Background. Hyperglycemia plays a vital role in diabetic nephropathy (DN); autophagy and its potential upregulator receptor-interacting protein kinase 2 (RIPK2) are associated with ROS, which play a potential role in regulating NLRP3, and may be involved in inflammation in DN. Aim. In this study, we aimed to explore the mechanisms mediated by RIPK2 in autophagy and the relationship with ROS-NLRP3 of DN, by investigating the levels of RIPK2 and autophagy in glomerular mesangial cells (GMCs) stimulated...
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Publication date: Available online 12 August 2019Source: NeuroImageAuthor(s): Donald J. Hagler, SeanN. Hatton, M. Daniela Cornejo, Carolina Makowski, Damien A. Fair, Anthony Steven Dick, Matthew T. Sutherland, B.J. Casey, Deanna M. Barch, Michael P. Harms, Richard Watts, James M. Bjork, Hugh P. Garavan, Laura Hilmer, Christopher J. Pung, Chelsea S. Sicat, Joshua Kuperman, Hauke Bartsch, Feng Xue, Mary M. HeitzegAbstractThe Adolescent Brain Cognitive Development (ABCD) Study is an ongoing, nationwide...
Publication date: Available online 12 August 2019Source: NeuroImageAuthor(s): Antonino Visalli, Mariagrazia Capizzi, Ettore Ambrosini, Ilaria Mazzonetto, Antonino VallesiAbstractThe brain predicts the timing of forthcoming events to optimize processes in response to them. Temporal predictions are driven by both our prior expectations on the likely timing of stimulus occurrence and the information conveyed by the passage of time. Specifically, such predictions can be described in terms of the hazard...
Publication date: Available online 12 August 2019Source: NeuroImageAuthor(s): Terri L. Scott, Tyler K. PerrachioneAbstractPhonological working memory is the capacity to briefly maintain and recall representations of sounds important for speech and language and is believed to be critical for language and reading acquisition. Whether phonological working memory is supported by fronto-parietal brain regions associated with short-term memory storage or perisylvian brain structures implicated in speech...
Publication date: Available online 12 August 2019Source: NeuroImageAuthor(s): Leonie JT. Balter, Jos A. Bosch, Sarah Aldred, Mark T. Drayson, Jet JCS. Veldhuijzen van Zanten, Suzanne Higgs, Jane E. Raymond, Ali MazaheriAbstractIllness is often accompanied by perceived cognitive sluggishness, a symptom that may stem from immune system activation. The current study used electroencephalography (EEG) to assess how inflammation affected three different distinct attentional processes: alerting, orienting...
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