Neutrophil‐to‐lymphocyte ratio (NLR) is associated with poor prognosis in patients with lung cancer, but the predictive role of NLR on the risk of developing lung cancer is unknown. We investigated the association between NLR and lung cancer mortality in lung cancer‐free adults. A cohort study was performed with 527,124 Korean adults who were free of lung cancer and were followed for up to 16 years. Vital status and lung cancer–related deaths were ascertained through national death records. Hazard...
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by Jamshaid Iqbal, Atif Javed, Muhammad Anwar Baig Sustainable management of leachate produced from the dumpsite is one of the major concerns in developing countries Aquatic plants such as duckweed have the potential to remove pollutants from wastewater which can also be cost-effective and feasible options for leachate treatment. Therefore, the objective of our present study was to examine the growth and nutrient removal efficiency of duckweed (Lemna minor) on leachate. Three tests were performed...
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by Adrián Sánchez-Montalvá, Marta Barios, Fernando Salvador, Ana Villar, Teresa Tórtola, Daniel Molina-Morant, Carles Lorenzo-Bosquet, Juan Espinosa-Pereiro, Israel Molina Background The aim of our study is to describe the FDG-PET/CT findings in patients with tuberculosis and to correlate them with the patient’s prognosis. Methods We retrospectively collected data from patients with tuberculosis, who had an FDG-PET/CT performed prior to treatment initiation from 2010 to 2015. Results Forty-seven...
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by Eric D. Peng, Michael P. Schmitt Corynebacterium diphtheriae is a Gram-positive bacterial pathogen and the causative agent of diphtheria, a severe disease of the upper respiratory tract of humans. Factors required for C. diphtheriae to survive in the human host are not well defined, but likely include the acquisition of essential metals such as zinc. In C. diphtheriae, zinc-responsive global gene regulation is controlled by the Zinc Uptake Regulator (Zur), a member of the Fur-family of transcriptional...
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by Stephanie M. Street, Stephanie A. Eytcheson, Gerald A. LeBlanc Biological rhythms regulate innumerable physiological processes, yet little is known of factors that regulate many of these rhythms. Disruption in the timing of these rhythms can have devastating impacts on population sustainability. We hypothesized that the timing of the molt infradian rhythm in the crustacean Daphnia magna is regulated by the joint action of the protein E75 and nitric oxide. Further, we hypothesized that disruption...
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by Javier Ortuño-Sierra, Marta Bañuelos, Alicia Pérez de Albéniz, Beatriz Lucas Molina, Eduardo Fonseca-Pedrero The study of affective disorders among young population has become increasingly relevant in the last years. The PANAS is a widely used questionnaire devoted to assess positive and negative affect. The main purpose of the current study was to examine the psychometric properties of the Spanish version of the PANAS for children (PANAS). The sample consisted of 1032 children and adolescents...
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by Youngji Cho, Ross S. Osgood, Lauren N. Bell, Edward D. Karoly, Stephanie A. Shore Ozone is an asthma trigger. In mice, the gut microbiome contributes to ozone-induced airway hyperresponsiveness, a defining feature of asthma, but the mechanistic basis for the role of the gut microbiome has not been established. Gut bacteria can affect the function of distal organs by generating metabolites that enter the blood and circulate systemically. We hypothesized that global metabolomic profiling of...
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by Marcel Betsch, Roman Michalik, Maximilian Graber, Michael Wild, Rüdiger Krauspe, Christoph Zilkens Background Leg length inequalities (LLIs) are a common finding in patients with a total hip arthroplasty (THA). Therefore, we compared the effects of simulated LLIs in patients with total hip arthroplasty (THA) with a matched control group. Research question Do LLIs lead to different effects on the musculoskeletal apparatus of patients with a THA then in a control group? Methods In 99 patients...
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by Xintong Zhang, Meng-Cheng Wang, Lingnan He, Luo Jie, Jiaxin Deng The Chinese Big Five Personality Inventory (CBF-PI), a 134-item self-report scale, and its 40-item brief version (CBF-PI-B) are sound psychometric instruments used to measure the Big Five personality domains in the Chinese population. However, their applicability is limited by their length, as well as restricted by assessment conditions. In this study, we developed and validated a new shortened version with 15 items (CBF-PI-15)...
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by Elena della Valle, Paolo Marracino, Olga Pakhomova, Micaela Liberti, Francesca Apollonio Electric fields can be a powerful tool to interact with enzymes or proteins, with an intriguing perspective to allow protein manipulation. Recently, researchers have focused the interest on intracellular enzyme modifications triggered by the application of nanosecond pulsed electric fields. These findings were also supported by theoretical predictions from molecular dynamics simulations focussing on significant...
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by K. D. R. Kappert, M. J. A. van Alphen, L. E. Smeele, A. J. M. Balm, F. van der Heijden Purpose Tongue mobility has shown to be a clinically interesting parameter on functional results after tongue cancer treatment which can be objectified by measuring the Range Of Motion (ROM). Reliable measurements of ROM would enable us to quantify the severity of functional impairments and use these for shared decision making in treatment choices, rehabilitation of speech and swallowing disturbances after...
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by Emel Oz The impact of black cumin usage on some qualitative properties and formation of heterocyclic aromatic amines (HAAs) in meatball production was investigated. It was found that black cumin usage rate, cooking process and temperature had a significant effect (p
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by Sari L. Reisner, Jaclyn M. W. Hughto Background In the U.S., non-binary refers to transgender people who have a gender identity not aligned with their assigned sex at birth, and who identify outside of the traditional male-female binary, such as genderqueer, genderfluid, or gender nonconforming. Few data are available to characterize the health of non-binary adults. Methods The current study sought to fill this gap by conducting a secondary analysis of data from a non-probability sample of transgender...
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by Alexander S. F. Berry, Renzo Salazar-Sánchez, Ricardo Castillo-Neyra, Katty Borrini-Mayorí, Claudia Chipana-Ramos, Melina Vargas-Maquera, Jenny Ancca-Juarez, César Náquira-Velarde, Michael Z. Levy, Dustin Brisson, for the Chagas Disease Working Group in Arequipa Changing environmental conditions, including those caused by human activities, reshape biological communities through both loss of native species and establishment of non-native species in the altered habitats. Dynamic interactions...
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by Florian Miksch, Beate Jahn, Kurt Junshean Espinosa, Jagpreet Chhatwal, Uwe Siebert, Nikolas Popper For the evaluation of infectious-diseases interventions, the transmissible nature of such diseases plays a central role. Agent-based models (ABM) allow for dynamic transmission modeling but publications are limited. We aim to provide an overview of important characteristics of ABM for decision-analytic modeling of infectious diseases. A case study of dengue epidemics illustrates model characteristics,...
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by Rui Chen, Zengqiang Kou, Liuchen Xu, Jie Cao, Ziwei Liu, Xiaojing Wen, Zhiyu Wang, Hongling Wen Background Natural-focal diseases are serious diseases that endanger human health. They threaten about 100 million people in Shandong Province, and cause illness in thousands of people each year. However, information on the epidemiological characteristics of natural-focal diseases in Shandong Province has been limited. The purpose of the study was to describe and analyze the epidemiological characteristics...
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by Hiromu Ito, Kazuhiro Tamura, Takayuki Wada, Taro Yamamoto, Satoru Morita Elucidation of the structure of human sexual networks is not only an interesting topic in the area of social networks but also an important clue for understanding the spreading risk of sexually transmitted infections (STIs). Some previous studies have indicated that sexual networks are scale free, while others have suggested that they are not. We conducted a Web-based survey on sexual contact in Japan to collect data...
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by Kamila Ismailova, Pratiksha Poudel, Alexandr Parlesak, Peder Frederiksen, Berit L. Heitmann The study examined results from previous studies of early life vitamin D exposure and risk of MS in adulthood, including studies on season or month of birth and of migration. A systematic review was conducted using PubMed and Web of Science databases as well as checking references cited in articles. The quality of studies was assessed using the Newcastle-Ottawa scale and the AMSTAR score. Twenty-eight...
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by Dongyin Zhang, Hanping Xu, Li Qiao, Lei Chen According to the coordination control of a dynamic voltage restorer (DVR) and an inductive fault current limiter (FCL), this paper proposes an efficient low-voltage ride-through (LVRT) scheme for a doubly fed induction generator (DFIG) based wind turbine. The DVR is located to the DFIG’s stator circuit for stabilizing the terminal voltage and decreasing the generator current. The inductive FCL is connected to the DFIG’s rotor circuit for suppressing...
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J. Intell., Vol. 7, Pages 19: Gifted and Average-Ability Children’s Potential for Solving Analogy Items Journal of Intelligence doi: 10.3390/jintelligence7030019 Authors: Vogelaar Sweijen Resing Analogical reasoning is assumed to play a large role in learning and problem solving in everyday and school settings. It was examined whether a newly developed dynamic test of analogical reasoning would be sufficiently difficult for identifying young gifted children’s potential...
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Abstract Background Tricuspid annular plane systolic excursion (TAPSE) is frequently used as an objective measure of right-ventricular dysfunction. Abnormal TAPSE values are associated with poor prognosis in a number of disease states; however, the measure is not always easy to obtain in the critically ill. The purpose of this study is to assess the feasibility and accuracy of using a subcostal view and TAPSE measurement as a measure...
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European Journal of Clinical Nutrition, Published online: 27 August 2019; doi:10.1038/s41430-019-0496-8Cross-sectional and longitudinal agreement between two multifrequency bioimpedance devices for resistance, reactance, and phase angle values
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Background: Otomycosis still remains intractable in clinical practice, likely because topical antifungal agents lack efficacy or are potentially toxic to the inner ear end organs. Objectives: The aim of this study was to investigate whether terbinafine solution is a potential candidate for treating intractable otomycosis in humans. In addition, the toxic effect on the inner ear was also assessed by animal models treated with terbinafine. Methods: Guinea pigs were instilled with 0.1 mL terbinafine...
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Diverse organisms, from insects to humans, actively seek out sensory information that best informs goal-directed actions. Efficient active sensing requires congruity between sensor properties and motor strategies, as typically honed through evolution. However, it has been difficult to study whether active sensing strategies are also modified with experience. Here, we...
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Stuttering is a common neurodevelopmental disorder that has been associated with mutations in genes involved in intracellular trafficking. However, the cellular mechanisms leading to stuttering remain unknown. Engineering a mutation in N-acetylglucosamine-1-phosphate transferase subunits α and β (GNPTAB) found in humans who stutter into the mouse Gnptab gene resulted in...
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Abstract Case presentation We report on a German leprosy patient originating from Pakistan who had a relapse more than 5 years after completion of multi-drug therapy (MDT) of his first episode of multibacillary (MB) leprosy. State-of-the-art laboratory techniques (histopathology, PGL-I serology, microscopy and DNA/RNA qPCR) were applied for laboratory confirmation and monitoring of treatment outcome. Serology indicated the relapse long...
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Stem Cells and Development, Ahead of Print.
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Human Gene Therapy, Ahead of Print.
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Intravenous immunoglobulin (IVIg) serves as the first line therapy in Guillain-Barr é syndrome (GBS), however, its action mechanism remains unknown. We hereby stimulated peripheral blood mononuclear cells (PBMCs) from patients with GBS and healthy controls using IVIg and an IgG-derived natural Treg epitopes, namely Tregitopes. Our results showed that IVIg significantly promoted bo th the expansion of CD4+CD25+Foxp3+ regulatory T cells (Tregs) and secretion of IL-10 and TGF-β1 while Tregitopes promoted...
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TNFA, IL1B, HMGB1, IL10, CXCL8, CCL2 and CCR5 gene polymorphisms were investigated in 183 Japanese Encephalitis (JE) cases and 361 healthy controls from North India. Higher frequency of TNFA rs1800629 G/A, CCR5 rs1799987 genotypes with A allele and lower frequency of combination lacking TNFA rs1800629 A, CCR5 rs333 Δ32, andCCR5 rs1799987 A alleles and CCL2 rs1024611 G/G genotype was observed in JE cases. TNFA rs1800629 A and CCR5 rs1799987 A alleles were associated with susceptibility while combination...
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Immune dysregulation during pregnancy may influence behavior and neurodevelopment in offspring, but few human studies have tested this hypothesis. Using structural equation modeling, we examined associations between maternal inflammatory markers at 28 weeks gestation and child neurodevelopmental outcomes at 20 months of age in a sample of 1453 mother-child pairs. We observed several associations between maternal inflammatory markers measured in the late second or early third trimester and child neurodevelopmental...
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Tatiana Prowell, MD, has attended many memorial services. But none before the death of the patient — until this summer. Now, she asks: Why wait until a loved one dies to celebrate them?Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
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After a long delay in implementing a bill, cancer patients can now defer payment on their student loans without interest accrual.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
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Men are often excluded from clinical trials of breast cancer drugs on the basis of sex. The US Food and Drug Administration wants to change that.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
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CONCLUSION: The TVP muscle is substantially reduced in volume, length, and thickness in children with 22q11DS. These findings serve as preliminary support for the association of patient hearing and otologic severity and TVP dysmorphology. PMID: 31446782 [PubMed - as supplied by publisher] (Source: The Cleft Palate-Craniofacial Journal)
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CONCLUSIONS: Multidisciplinary providers play an important role in supporting positive adjustment in patients affected by craniofacial conditions and their families. PMID: 31446785 [PubMed - as supplied by publisher] (Source: The Cleft Palate-Craniofacial Journal)
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