Abstract Inflammation parameters were verified to predict clinical outcomes of metastatic renal cell carcinoma (mRCC) patients treated with tyrosine kinase inhibitors (TKIs). Here, we developed a novel marker, lactate dehydrogenase (tumor burden marker) to lymphocytes (inflammation marker) ratio (LLR), aimed to reveal the prognostic role of LLR for mRCC patients treated with TKIs. We collected clinical data of mRCC patients treated with TKIs. Receiver operating curve analysis was...
Publication date: Available online 5 August 2019Source: Pathology - Research and PracticeAuthor(s): S. Dasgupta, P.C. Ewing-Graham, F.H. Groenendijk, O. Stam, K.E. Biermann, M. Doukas, H.J. Dubbink, M.F. van Velthuysen, W.N.M. Dinjens, M.R. Van BockstalAbstractImmunohistochemistry (IHC) for DNA mismatch repair proteins MLH1, PMS2, MSH2, and MSH6 is used for microsatellite instability (MSI) screening in colorectal carcinoma (CRC) and endometrial carcinoma (EC). Loss of PMS2, with retained MLH1 staining...
Abstract Background Conventional cervical cytology, which has a relatively low sensitivity in diagnosing high‐grade lesions as compared to liquid‐based cytology, is still being practiced in low resource settings. This study aimed at elucidating various cytomorphological patterns, pitfalls, and subtle clues to high‐grade squamous intraepithelial lesion (HSIL) diagnosis on conventional cervical cytology through cytologic‐histologic correlation. Methods Cervical biopsies reported as CIN2/3...
Introduction Intersphincteric resection (ISR) enables radical sphincter‐preserving surgery in a subset of low rectal tumours impinging on the anal sphincter complex (ASC). Excellent anatomical knowledge is essential for optimal ISR. This study describes the role of the longitudinal muscle (LM) in the ASC and implications for ISR and other low rectal and anal pathologies. Materials and Methods Six human adult en‐bloc cadaveric specimens (three males, three females) were obtained from the University...
The scientific community's understanding of neuronal plasticity has evolved considerably over recent decades, thanks largely to Josef Altman. Altman's findings laid the groundwork for an entire subfield of neuroscience research dedicated to exploring the potential of the adult brain to create new neurons, which until then had been considered impossible. From the formative years of this field until the 1990s, when adult neurogenesis was finally accepted as a legitimate topic of study, Altman's work...
Sophisticated volume measurements of brain structures on MRI may improve specificity in determining long‐term progression of multiple sclerosis (MS), but these techniques are laborious. The optic chiasm (OC) is a white matter (WM) structure clearly visible on routine MRI and is related to the optic nerves (ONs), which are known to atrophy in MS. We hypothesized that OC morphometric measurements would show OC atrophy in MS compared to normal patients. If so, this could help establish a novel simplified...
Introduction In clinical settings the pectineal ligament forms a basic landmark for surgical approaches. However, to date, the detailed fascial topography of this ligament is not well understood. The aim of this study was to describe the morphology of the pectineal ligament including its fascial connections to surrounding structures. Material and Methods The spatial‐topographical relations of 10 fresh and embalmed specimens were dissected, stained, slice plastinated and analyzed macroscopically,...
Introduction The epineurium has been accepted as the outer anatomical barrier between the extraneural and intraneural compartments. Our objective was to characterize the microanatomy of the layers surrounding nerves using different tissue‐specific staining methods. Materials and Methods Two hundred forty‐two cross‐sections of human sciatic and median nerves, and brachial plexuses of eight fresh unembalmed cadavers, were examined. The samples were fixed in formaldehyde solution and stained...
Background The sleeve gastrectomy (SG) can be performed with or without antral preservation (distance from the pylorus < 50mm). The objective of this study was to evaluate the distance between the pylorus and the end of the left vagus nerve in order to determine whether it could be used as a constant anatomical landmark to start gastric transection. Methods This was a prospective, non‐randomized study of 120 patients undergoing SG from January to October 2018. The distance measurement between...
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