Πέμπτη 15 Αυγούστου 2019


Warm Autoimmune Hemolytic Anemia
Foreword. This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they exist. The article ends with the author’s clinical recommendations. Stage. A 61-year-old…
The New England Journal of Medicine: Search Results in Hematology\Oncology
3h
Study protocol: Impact of quality improvement interventions on perinatal outcomes in health facilities—a systematic review
About 5.8 million maternal deaths, neonatal deaths and stillbirths occur every year with 99% of them taking place in low- and middle-income countries. Two thirds of them could be prevented through cost-effecti...
Systematic Reviews - Latest Articles
3h
Auriculotherapy to control chemotherapy-induced nausea and vomiting in patients with cancer: protocol of a systematic review
Due to the worldwide rise in cancer incidence, and therefore the rise in the need for antineoplastic chemotherapy, it is important for both healthcare professionals and patients alike that the side effects of ...
Systematic Reviews - Latest Articles
3h
Effects of cataract surgery and intra-ocular lens implantation on visual function and quality of life in age-related cataract patients: a systematic review protocol
Cataract is the leading cause of blindness and low vision worldwide. Presently, cataract surgery is the only treatment for cataract and is very effective in restoring sight. In cataract surgery, the natural le...
Systematic Reviews - Latest Articles
3h
Gender differences in the provision of key post-arrest interventions for out-of-hospital cardiac arrest (OHCA) patients—protocol for a systematic review
Evidence shows that the implementation of optimal post-arrest care significantly increases survival and functional outcomes among patients who experience an out-of-hospital cardiac arrest (OHCA). However, diff...
Systematic Reviews - Latest Articles
1d
Population segmentation based on healthcare needs: a systematic review
Healthcare needs-based population segmentation is a promising approach for enabling the development and evaluation of integrated healthcare service models that meet healthcare needs. However, healthcare policy...
Systematic Reviews - Latest Articles
1d
Memory of pain in adults: a protocol for systematic review and meta-analysis
The way pain is remembered and reported can affect medical decisions taken by patients and health-care professionals. Memory of pain has been investigated extensively for the past few decades; however, the res...
Systematic Reviews - Latest Articles
1d
Phylogenetic Reclassification of Vertebrate Melatonin Receptors to Include Mel1d
The circadian and seasonal actions of melatonin are mediated by high affinity G-protein coupled receptors (melatonin receptors, MTRs), classified into phylogenetically distinct subtypes based on sequence divergence and pharmacological characteristics. Three vertebrate MTR subtypes are currently described: MT1 (MTNR1A), MT2 (MTNR1B), and Mel1c (MTNR1C / GPR50), which exhibit distinct affinities, tissue distributions and signaling properties. We present phylogenetic and comparative genomic analyses...
G3: .Genes, Genomes, Genetics Mission - Online First Articles
4h
Fine Mapping Using Whole-Genome Sequencing Confirms Anti-Mullerian Hormone as a Major Gene for Sex Determination in Farmed Nile Tilapia (Oreochromis niloticus L.)
Nile tilapia (Oreochromis niloticus) is one of the most cultivated and economically important species in world aquaculture. Intensive production promotes the use of monosex animals, through an important dimorphism that favors male growth. Currently, the main mechanism to obtain all-male populations is the use of hormones in feeding during the larval and fry phases. Identifying genomic regions associated with sex determination in Nile tilapia is a research topic of great interest. The objective of...
G3: .Genes, Genomes, Genetics Mission - Online First Articles
4h
Greenlip Abalone (Haliotis laevigata) Genome and Protein Analysis Provides Insights into Maturation and Spawning
Wild abalone (Family Haliotidae) populations have been severely affected by commercial fishing, poaching, anthropogenic pollution, environment and climate changes. These issues have stimulated an increase in aquaculture production; however production growth has been slow due to a lack of genetic knowledge and resources. We have sequenced a draft genome for the commercially important temperate Australian 'greenlip' abalone (Haliotis laevigata, Donovan 1808) and generated 11 tissue transcriptomes from...
G3: .Genes, Genomes, Genetics Mission - Online First Articles
1d
Descemet membrane endothelial keratoplasty (DMEK): an update on safety, efficacy and patient selection
Clinical Ophthalmology
4h
Incidence and outcomes of ocular hypertension from rhegmatogenous retinal detachment surgery in the acute postoperative setting
Clinical Ophthalmology
4h
Treatment of central serous chorioretinopathy with topical NSAIDs
Clinical Ophthalmology
1d
Liraglutide in Children and Adolescents with Type 2 Diabetes
The incidence of type 2 diabetes in children and adolescents is increasing, with the increase driven by childhood obesity, and type 2 diabetes disproportionately affects disadvantaged minorities. Metformin is the regulatory-approved treatment of choice for most youth with type 2 diabetes early in…
The New England Journal of Medicine: Search Results in Endocrinology
4h
Staphylococcus aureus α-toxin: small pore, large consequences
Journal Name: Biological ChemistryIssue: Ahead of print
Biological Chemistry.
4h
Cholesterol Crystal Embolization after Transcatheter Aortic-Valve Replacement
A 79-year-old man was admitted to the hospital after laboratory tests showed a serum creatinine level of 4.0 mg per deciliter (350 μmol per liter) (normal range, 0.7 to 1.2 mg per deciliter [60 to 100 μmol per liter]). He had no fevers, fatigue, weight loss, or myalgias. He had a history of…
The New England Journal of Medicine: Search Results in Images in Clinical Medicine
5h
Placenta Percreta Involving Maternal Bladder
A 32-year-old woman with a history of cesarean section was referred to a multidisciplinary placenta program at 24 weeks of gestation after placenta previa was diagnosed on ultrasonography. The patient reported having intermittent, painless hematuria. Abdominal ultrasonography performed with a full…
The New England Journal of Medicine: Search Results in Images in Clinical Medicine
5h
[ASAP] Ultratrace Metal Speciation Analysis by Coupling of Sector-Field ICP-MS to High-Resolution Size Exclusion and Reversed-Phase Liquid Chromatography
Analytical ChemistryDOI: 10.1021/acs.analchem.9b00222
Analytical Chemistry
5h
[ASAP] Coupling Mixed-Mode Size Exclusion Chromatography with Native Mass Spectrometry for Sensitive Detection and Quantitation of Homodimer Impurities in Bispecific IgG
Analytical ChemistryDOI: 10.1021/acs.analchem.9b02793
Analytical Chemistry
5h
[ASAP] Dispersive Magnetic Solid-Phase Extraction Coupled to Direct Analysis in Real Time Mass Spectrometry for High-Throughput Analysis of Trace Environmental Contaminants
Analytical ChemistryDOI: 10.1021/acs.analchem.9b02197
Analytical Chemistry
9h
[ASAP] “Covalent-Assembly”-Based Fluorescent Probe for Detection of a Nerve-Agent Mimic (DCP) via Lossen Rearrangement
Analytical ChemistryDOI: 10.1021/acs.analchem.9b01006
Analytical Chemistry
9h
[ASAP] Online Comprehensive High pH Reversed Phase × Low pH Reversed Phase Approach for Two-Dimensional Separations of Intact Proteins in Top-Down Proteomics
Analytical ChemistryDOI: 10.1021/acs.analchem.9b01665
Analytical Chemistry
13h
[ASAP] Peptide Nanocarriers for Detection of Heavy Metal Ions Using Resistive Pulse Sensing
Analytical ChemistryDOI: 10.1021/acs.analchem.9b02353
Analytical Chemistry
13h
[ASAP] CANPA: Computer-Assisted Natural Products Anticipation
Analytical ChemistryDOI: 10.1021/acs.analchem.9b02216
Analytical Chemistry
13h
[ASAP] Tandem Mass Spectrometric Quantification of 93 Terpenoids in <italic toggle="yes">Cannabis</italic> Using Static Headspace Injections
Analytical ChemistryDOI: 10.1021/acs.analchem.9b02844
Analytical Chemistry
13h
[ASAP] Essential Spectral Pixels for Multivariate Curve Resolution of Chemical Images
Analytical ChemistryDOI: 10.1021/acs.analchem.9b02890
Analytical Chemistry
13h
[ASAP] Simplify: A Mass Spectrometry Metabolomics Approach to Identify Additives and Synergists from Complex Mixtures
Analytical ChemistryDOI: 10.1021/acs.analchem.9b02377
Analytical Chemistry
13h
[ASAP] Programming Conventional Electron Microscopes for Solving Ultrahigh-Resolution Structures of Small and Macro-Molecules
Analytical ChemistryDOI: 10.1021/acs.analchem.9b01162
Analytical Chemistry
13h
[ASAP] Revealing the Chemical and Structural Evolution of V<sub>2</sub>O<sub>5</sub> Nanoribbons in Lithium-Ion Batteries Using in Situ Transmission Electron Microscopy
Analytical ChemistryDOI: 10.1021/acs.analchem.9b01571
Analytical Chemistry
13h
[ASAP] Model-Based Spectral Library Approach for Bacterial Identification via Membrane Glycolipids
Analytical ChemistryDOI: 10.1021/acs.analchem.9b03340
Analytical Chemistry
13h
[ASAP] The Marriage of Protein and Lanthanide: Unveiling a Time-Resolved Fluorescence Sensor Array Regulated by pH toward High-Throughput Assay of Metal Ions in Biofluids
Analytical ChemistryDOI: 10.1021/acs.analchem.9b01879
Analytical Chemistry
13h
[ASAP] Single-Cell Phenotypic Profiling of CTCs in Whole Blood Using an Integrated Microfluidic Device
Analytical ChemistryDOI: 10.1021/acs.analchem.9b01647
Analytical Chemistry
1d
[ASAP] Functional Fluorescence Microscopy Imaging: Quantitative Scanning-Free Confocal Fluorescence Microscopy for the Characterization of Fast Dynamic Processes in Live Cells
Analytical ChemistryDOI: 10.1021/acs.analchem.9b01813
Analytical Chemistry
1d
[ASAP] Intact-Mass Analysis Facilitating the Identification of Large Human Heart Proteoforms
Analytical ChemistryDOI: 10.1021/acs.analchem.9b02343
Analytical Chemistry
1d
[ASAP] Mitochondria-Immobilized Near-Infrared Ratiometric Fluorescent pH Probe To Evaluate Cellular Mitophagy
Analytical ChemistryDOI: 10.1021/acs.analchem.9b02782
Analytical Chemistry
1d
[ASAP] Chemical Changes On, and Through, The Bacterial Envelope in <italic toggle="yes">Escherichia coli</italic> Mutants Exhibiting Impaired Plasmid Transfer Identified Using Time-of-Flight Secondary Ion Mass Spectrometry
Analytical ChemistryDOI: 10.1021/acs.analchem.9b02533
Analytical Chemistry
1d
[ASAP] Serological Analysis of Herpes B Virus at Individual Epitope Resolution: From Two-Dimensional Peptide Arrays to Multiplex Bead Flow Assays
Analytical ChemistryDOI: 10.1021/acs.analchem.9b01291
Analytical Chemistry
1d
[ASAP] Label-Free Time-of-Flight Secondary Ion Mass Spectrometry Imaging of Sulfur-Producing Enzymes inside Microglia Cells following Exposure to Silver Nanowires
Analytical ChemistryDOI: 10.1021/acs.analchem.9b01704
Analytical Chemistry
1d
[ASAP] MODplus: Robust and Unrestrictive Identification of Post-Translational Modifications Using Mass Spectrometry
Analytical ChemistryDOI: 10.1021/acs.analchem.9b02445
Analytical Chemistry
1d

[ASAP] Ultrasensitive Detection of Amyloid-ß Using Cellular Prion Protein on the Highly Conductive Au Nanoparticles–Poly(3,4-ethylene dioxythiophene)–Poly(thiophene-3-acetic acid) Composite Electrode
Analytical ChemistryDOI: 10.1021/acs.analchem.9b02266
Analytical Chemistry
1d
Psychological effects of gonadotropin-releasing hormone agonist treatment in girls with central precocious puberty
Journal Name: Journal of Pediatric Endocrinology and MetabolismIssue: Ahead of print
Journal of Pediatric Endocrinology and Metabolism.
5h
Parallel changes in gut microbiome composition and function in parallel local adaptation and speciation [NEW RESULTS]
The processes of local adaptation and ecological speciation are often strongly shaped by biotic interactions such as competition and predation. One of the strongest lines of evidence that biotic interactions drive evolution comes from repeated divergence of lineages in association with repeated changes in the community of interacting species. Yet, relatively little is known about the repeatability of changes in gut microbial communities and their role in adaptation and divergence of host populations...
bioRxiv Subject Collection: Evolutionary Biology
5h
Measuring Perceptual Distance of Organismal Color Pattern using the Features of Deep Neural Networks [NEW RESULTS]
A wide range of research relies upon the accurate and repeatable measurement of the degree to which organisms resemble one another. Here, we present an unsupervised workflow for analyzing the relationships between organismal color patterns. This workflow utilizes several recent advancements in deep learning based computer vision techniques to calculate perceptual distance. We validate this approach using previously published datasets surrounding diverse applications of color pattern analysis including...
bioRxiv Subject Collection: Evolutionary Biology
5h
Ancestral reconstruction of sunflower karyotypes reveals dramatic chromosomal evolution [NEW RESULTS]
Mapping the chromosomal rearrangements between species can inform our understanding of genome evolution, reproductive isolation, and speciation. Here we present a systematic survey of chromosomal rearrangements in the annual sunflowers, which is a group known for extreme karyotypic diversity. We build high-density genetic maps for two subspecies of the prairie sunflower, Helianthus petiolaris ssp. petiolaris and H. petiolaris ssp. fallax. Using a novel algorithm implemented in the accompanying R...
bioRxiv Subject Collection: Evolutionary Biology
6h
Phylogenetic weighting does little to improve the accuracy of evolutionary coupling analyses [NEW RESULTS]
Homologous sequence alignments contain important information about the constraints that shape protein family evolution. Correlated changes between different residues, for instance, can be highly predictive of physical contacts within three-dimensional structures. Detecting such co-evolutionary signals via direct coupling analysis is particularly challenging given the shared phylogenetic history and uneven sampling of different lineages from which protein sequences are derived. Current best practices...
bioRxiv Subject Collection: Evolutionary Biology
6h
Increasing growth rate slows adaptation when genotypes compete for diffusing resources [NEW RESULTS]
The rate at which a species responds to natural selection is a central predictor of the species' ability to adapt to environmental change. It is well-known that spatially-structured environments slow the rate of adaptation due to increased intra-genotype competition. Here, we show that this effect magnifies over time as a species becomes better adapted and grows faster. Using a reaction-diffusion model, we demonstrate that growth rates are inextricably coupled with effective spatial scales, such...
bioRxiv Subject Collection: Evolutionary Biology
7h
Unique transcriptional signatures of sleep loss across independently evolved cavefish populations [NEW RESULTS]
Animals respond to sleep loss with compensatory rebound sleep, and this is thought to be critical for the maintenance of physiological homeostasis. Sleep duration varies dramatically across animal species, but it is not known whether evolutionary differences in sleep duration are associated with differences in sleep homeostasis. The Mexican cavefish, Astyanax mexicanus, has emerged as a powerful model for studying the evolution of sleep. While eyed surface populations of A. mexicanus sleep approximately...
bioRxiv Subject Collection: Evolutionary Biology
7h
Mutation accumulation in chromosomal inversions maintains wing pattern polymorphism in a butterfly [NEW RESULTS]
While natural selection favours the fittest genotype, polymorphisms are maintained over evolutionary timescales in numerous species. Why these long-lived polymorphisms are often associated with chromosomal rearrangements remains obscure. Combining genome assemblies, population genomic analyses, and fitness assays, we studied the factors maintaining multiple mimetic morphs in the butterfly Heliconius numata. We show that the polymorphism is maintained because three chromosomal inversions controlling...
bioRxiv Subject Collection: Evolutionary Biology
9h
BASAL RESISTANCE AGAINST A PATHOGEN IS MORE BENEFICIAL THAN IMMUNE PRIMING RESPONSES IN FLOUR BEETLES [NEW RESULTS]
Insects exhibit various forms of immune responses, including basal resistance to pathogens and a form of immune memory ("priming") that can act within or across generations. The evolutionary drivers of such diverse immune functions remain poorly understood. Previously, we found that in the beetle Tribolium castaneum, both resistance and priming evolved as mutually exclusive strategies against the pathogen Bacillus thuringiensis. However, since evolved resistance improved survival far more than priming,...
bioRxiv Subject Collection: Evolutionary Biology
9h
Selection on mutators is not frequency-dependent [NEW RESULTS]
The evolutionary fate of mutator mutations, i.e., genetic variants that raise the genome-wide mutation rate, in asexual populations is often described as being frequency (or number) dependent. This common intuition suggests that mutators can invade a population by hitchhiking with a sweeping beneficial mutation, but only when sufficiently frequent to produce such a mutation before non-mutators do. Here, we use stochastic, agent-based simulations to show that neither the strength nor the sign of selection...
bioRxiv Subject Collection: Evolutionary Biology
9h
Evolution of p38 MAP Kinases in Drosophila [NEW RESULTS]
In order to understand how oxidative stress signal transduction pathways evolve, we analyzed the molecular evolution of the p38 MAPK (p38K) gene family across the genus Drosophila. p38K family genes play a vital role in oxidative stress resistance and are also important for organismal development and immunity. We find that the p38Ka and p38Kb genes are highly conserved across the genus and that p38Kc is more recently evolved. We further find that the p38Kb genomic locus includes conserved binding...
bioRxiv Subject Collection: Evolutionary Biology
15h
Designing gene drives to limit spillover to non-target populations [NEW RESULTS]
The prospect of utilizing CRISPR-based gene-drive technology for controlling populations, such as invasive and disease-vector species, has generated much excitement. However, the potential for spillovers of gene drive alleles from the target population to non-target populations --- events that may be ecologically catastrophic --- has raised concerns. Here, using two-population mathematical models, we investigate the possibility of limiting spillovers and impact on non-target populations by designing...
bioRxiv Subject Collection: Evolutionary Biology
1d
Two different epigenetic pathways detected in wild three-spined sticklebacks are involved in salinity adaptation [NEW RESULTS]
While environmentally inducible epigenetic marks are discussed as one mechanism of transgenerational plasticity, environmentally stable epigenetic marks emerge randomly. When resulting in variable phenotypes, stable marks can be targets of natural selection analogous to DNA sequence-based adaptation processes. We studied both postulated pathways in natural populations of three-spined sticklebacks (Gasterosteus aculeatus) and sequenced their methylomes and genomes across a salinity cline. Consistent...
bioRxiv Subject Collection: Evolutionary Biology
1d
Phylo-comparative analyses reveal the dual role of drift and selection in reproductive character displacement. [NEW RESULTS]
When incipient species meet in secondary contact, natural selection can rapidly reduce costly reproductive interactions by directly targeting reproductive traits. This process, called reproductive character displacement (RCD), leaves a characteristic pattern of geographic variation where divergence of traits between species is greater in sympatry than allopatry. However, because other forces can also cause similar patterns, care must be given in separating pattern from process. Here we show how the...
bioRxiv Subject Collection: Evolutionary Biology
1d
Selection shapes synonymous stop codon use in mammals [NEW RESULTS]
Phylogenetic models of the evolution of protein-coding sequences can provide insights into the selection pressures that have shaped them. In the application of these models synonymous nucleotide substitutions, which do not alter the encoded amino acid, are often assumed to have limited functional consequences and used as a proxy for the neutral rate of evolution. The ratio of nonsynonymous to synonymous substitution rates is then used to categorize the selective regime that applies to the protein...
bioRxiv Subject Collection: Evolutionary Biology
1d
Imperfect strategy transmission can reverse the role of population viscosity on the evolution of altruism [NEW RESULTS]
Population viscosity, i.e., low emigration out of the natal deme, leads to high within-deme relatedness, which is beneficial to the evolution of altruistic behavior when social interactions take place among deme-mates. However, a detrimental side-effect of low emigration is the increase in competition among related individuals. The evolution of altruism depends on the balance between these opposite effects. This balance is already known to be affected by details of the life cycle; we show here that...
bioRxiv Subject Collection: Evolutionary Biology
1d
Physiological variation reflects bioclimatic differences in the Drosophila americana species complex. [NEW RESULTS]
Background: Disentangling the selective factors shaping adaptive trait variation is an important but challenging task. Many studies--especially in Drosophila--have documented trait variation along latitudinal or altitudinal clines, but frequently lack resolution about specific environmental gradients that could be causal selective agents, and often do not investigate covariation between traits simultaneously. Here we examined variation in multiple macroecological factors across geographic space and...
bioRxiv Subject Collection: Evolutionary Biology
1d
Effects of two seminal fluid proteins on post-mating behavior in the simultaneously hermaphroditic flatworm Macrostomum lignano [NEW RESULTS]
Along with sperm, in many taxa male ejaculates also contain a complex mixture of proteins, peptides and other substances found in seminal fluid. Once seminal fluid proteins (SFPs) are transferred to the mating partner, they play crucial roles in mediating post-mating sexual selection, since they can modulate the partner's behavior and physiology in ways that influence the reproductive success of both partners. One way in which sperm donors can maximize their own reproductive success is by changing...
bioRxiv Subject Collection: Evolutionary Biology
1d
Demographic history, linked selection, and recombination shape the genomic landscape of a broadly distributed Pacific salmon [NEW RESULTS]
Understanding the impacts of current human activities on within-species genetic variation requires a thorough description of the historical factors that have shaped the genomic and geographical distribution of nucleotide diversity. Past and current conditions influencing effective population size have important evolutionary implications for the efficacy of selection, increased accumulation of deleterious mutations, and loss of adaptive potential under the nearly neutral theory. Here, we gather extensive...
bioRxiv Subject Collection: Evolutionary Biology
1d

Is adaptation limited by mutation? A timescale-dependent effect of genetic diversity on the adaptive substitution rate in animals [NEW RESULTS]
Whether adaptation is limited by the beneficial mutation supply is a long-standing question of evolutionary genetics, which is more generally related to the determination of the adaptive substitution rate and its relationship with the effective population size Ne. Empirical evidence reported so far is equivocal, with some but not all studies supporting a higher adaptive substitution rate in large-Ne than in small-Ne species. We gathered coding sequence polymorphism data and estimated the adaptive...
bioRxiv Subject Collection: Evolutionary Biology
1d
Inferring putative ancient whole genome duplications in the 1000 Plants (1KP) initiative: access to gene family phylogenies and age distributions [CONFIRMATORY RESULTS]
Polyploidy or whole genome duplications (WGDs) repeatedly occurred during green plant evolution. To examine the evolutionary history of green plants in a phylogenomic framework, the 1KP project sequenced over 1000 transcriptomes across the Viridiplantae. The 1KP project provided a unique opportunity to study the distribution and occurrence of WGDs across the green plants. In the 1KP capstone analyses, we used a total evidence approach that combined inferences of WGDs from Ks and phylogenomic methods...
bioRxiv Subject Collection: Evolutionary Biology
1d
Parallel genomic architecture underlies repeated sexual signal divergence in Hawaiian Laupala crickets [NEW RESULTS]
When the same phenotype evolves repeatedly, we can explore the predictability of genetic changes underlying phenotypic evolution. Theory suggests that genetic parallelism is less likely when phenotypic changes are governed by many small-effect loci compared to few of major effect, because different combinations of genetic changes can result in the same quantitative outcome. However, some genetic trajectories might be favored over others, making a shared genetic basis to repeated polygenic evolution...
bioRxiv Subject Collection: Evolutionary Biology
1d
Density-dependent costs and benefits of male mating success in a wild insect [NEW RESULTS]
Social environments are important determinant of fitness, particularly when same-sex local densities shape both mating success and survival costs. We studied how mating success varied across a range of naturally occurring local male densities in wild field cricket males, Gryllus campestris, monitored by using fully automated RFID-surveillance system. We predicted that mating success as a function of local density follow a concave pattern predicted by the Allee-effect theory. As increasing density...
bioRxiv Subject Collection: Evolutionary Biology
1d
Selection for altruistic defense in structured populations [NEW RESULTS]
We model natural selection for or against an altruistic defense allele of a host (or prey) against a parasite (or predator). The populations are structured in demes and we specify rates for birth, death, and migration events of single individuals.The defense behavior has a fitness cost for the actor and locally reduces parasite growth rates. In a previous study (Hutzenthaler, Jordan, Metzler, 2015), we analytically derived a criterion for fixation or extinction of altruists in the limit of large...
bioRxiv Subject Collection: Evolutionary Biology
1d
Synteny-based analyses indicate that sequence divergence is not the dominant source of orphan genes [NEW RESULTS]
The origin of 'orphan' genes, species-specific sequences that lack detectable homologues, has remained mysterious since the dawn of the genomic era. There are two dominant explanations for orphan genes: complete sequence divergence from ancestral genes, such that homologues are not readily detectable; and de novo emergence from ancestral non-genic sequences, such that homologues genuinely do not exist. The relative contribution of the two processes remains unknown. Here, we harness the special circumstance...
bioRxiv Subject Collection: Evolutionary Biology
1d
Liquid biopsy of cerebrospinal fluid identifies neuronal pentraxin receptor (NPTXR) as a biomarker of progression of Alzheimer’s disease
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM)Issue: Ahead of print
Clinical Chemistry and Laboratory Medicine (CCLM)
6h
Establishment of the intelligent verification criteria for a routine urinalysis analyzer in a multi-center study
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM)Issue: Ahead of print
Clinical Chemistry and Laboratory Medicine (CCLM)
6h
Early species developed much faster than previously thought
When Earth's species were rapidly diversifying nearly 500 million years ago, that evolution was driven by complex factors including global cooling, more oxygen in the atmosphere, and more nutrients in the oceans. But it took a combination of many global environmental and tectonic changes occurring simultaneously and combining like building blocks to produce rapid diversification into new species, according to a new study.
Evolutionary Biology News -- ScienceDaily
6h
Extinct Caribbean bird yields DNA after 2,500 years in watery grave
Scientists have recovered the first genetic data from an extinct bird in the Caribbean, thanks to the remarkably preserved bones of a Creighton's caracara from a flooded sinkhole on Great Abaco Island.
Evolutionary Biology News -- ScienceDaily
9h
AI used to test evolution's oldest mathematical model
Researchers have used artificial intelligence to make new discoveries, and confirm old ones, about one of nature's best-known mimics, opening up whole new directions of research in evolutionary biology.
Evolutionary Biology News -- ScienceDaily
1d
Monster penguin find in Waipara, New Zealand
A new species of giant penguin -- about 1.6 metres tall -- has been identified from fossils found in Waipara, North Canterbury in New Zealand.
Evolutionary Biology News -- ScienceDaily
1d
What a group of bizarre-looking bats can tell us about the evolution of mammals
Bats with skulls and teeth adapted to a wide range of diets are helping scientists understand how major groups of mammals first evolved.
Evolutionary Biology News -- ScienceDaily
1d
Warm Autoimmune Hemolytic Anemia
Foreword. This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they exist. The article ends with the author’s clinical recommendations. Stage. A 61-year-old…
The New England Journal of Medicine: Allergy\Immunology
6h
Eculizumab in Aquaporin-4–Positive Neuromyelitis Optica Spectrum Disorder
Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune, inflammatory disorder of the central nervous system that has a prevalence of 0.5 to 10 persons (predominantly women) per 100,000 population. It is characterized mainly by recurrent optic neuritis and myelitis, and such attacks are…
The New England Journal of Medicine: Allergy\Immunology
6h
Early species developed much faster than previously thought
When Earth's species were rapidly diversifying nearly 500 million years ago, that evolution was driven by complex factors including global cooling, more oxygen in the atmosphere, and more nutrients in the oceans. But it took a combination of many global environmental and tectonic changes occurring simultaneously and combining like building blocks to produce rapid diversification into new species, according to a new study.
Evolutionary Biology News -- ScienceDaily
7h
Extinct Caribbean bird yields DNA after 2,500 years in watery grave
Scientists have recovered the first genetic data from an extinct bird in the Caribbean, thanks to the remarkably preserved bones of a Creighton's caracara from a flooded sinkhole on Great Abaco Island.
Evolutionary Biology News -- ScienceDaily
9h
AI used to test evolution's oldest mathematical model
Researchers have used artificial intelligence to make new discoveries, and confirm old ones, about one of nature's best-known mimics, opening up whole new directions of research in evolutionary biology.
Evolutionary Biology News -- ScienceDaily
1d
Genetic census of the human microbiome
Scientists have analyzed the genetic repertoire of bacteria in the human mouth and gut. The effort marks the first chapter in efforts to compile a compendium of all genes in the human microbiome. Mapping the microbial genome can reveal links between bacterial genes and disease risk and could inform the development of precision therapies.
Evolutionary Biology News -- ScienceDaily
1d
Rapid evolution: New findings on its molecular mechanisms
Evolutionary biologists have analyzed the role of microRNAs in the evolution of new species.
Evolutionary Biology News -- ScienceDaily
1d

Monster penguin find in Waipara, New Zealand
A new species of giant penguin -- about 1.6 metres tall -- has been identified from fossils found in Waipara, North Canterbury in New Zealand.
Evolutionary Biology News -- ScienceDaily
1d
What a group of bizarre-looking bats can tell us about the evolution of mammals
Bats with skulls and teeth adapted to a wide range of diets are helping scientists understand how major groups of mammals first evolved.
Evolutionary Biology News -- ScienceDaily
1d
Biologists pioneer first method to decode gene expression
Biologists have developed the first system for determining gene expression based on machine learning. Considered a type of genetic Rosetta Stone for biologists, the new method leverages algorithms trained on a set of known plant genes to determine a species-wide set of transcribed genes, or 'expressome,' then creates an atlas of expressible genes. The method carries implications across biology, from drug discovery to plant breeding to evolution.
Evolutionary Biology News -- ScienceDaily
1d

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