Abstract Background Thyroid dysfunction (TD) occurs in 13.4% of diabetic patients, which has prompted recommendations for annual thyroid screening in patients with diabetes. However, recommendations for annual screening should be based on disease incidence rather than prevalence. Methods In 1997–1998, seven hundred and thirty patients (618 type 2 diabetes,...
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Abstract Background We aimed to investigate the effects of zoledronic acid treatment on daily living activities, cognitive functions, depression, muscle strength, and performance. Methods The study was conducted retrospectively. Bone mineral densitometry (BMD) values, Katz activities of daily living (ADL), Lawton-Brody instrumental activities of daily living...
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The definitive resource for advanced practice within nursing and the allied health professionsrevised, expanded, and updated throughout.Advanced practice is an established and continuously evolving part of healthcare workforces around the world as a level of practice beyond initial registration. Advanced practitioners are equipped to improve health, prevent disease, and provide treatment and care for patients in a diverse range of settings.Read More...
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Abstract Severe combined immune deficiency (SCID) is caused by an array of genetic disorders resulting in a diminished adaptive immune system due to impaired T lymphocytes. In these patients, active infection at the time of hematopoietic transplantation has been shown to increase morbidity and mortality. To prevent transmission of infections in SCID patients, standardized infection control precautions should be implemented. An online survey regarding SCID-specific protocols was...
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Thyroid, Ahead of Print.
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Activation-induced deaminase (AID) and apolipoprotein B mRNA-editing enzyme catalytic subunit (APOBEC) enzymes convert cytosines to uracils, creating signature mutations that have been used to predict sites targeted by these enzymes. Mutation-based targeting maps are distorted by the error-prone or error-free repair of these uracils and by selection pressures. To directly map uracils created by AID/APOBEC enzymes, here we used uracil-DNA glycosylase and an alkoxyamine to covalently tag and sequence...
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CTP synthase (CTPS) has been demonstrated to form evolutionarily conserved filamentous structures termed cytoophidia whose exact cellular functions remain unclear, but may play a role in intracellular compartmentalization. We have previously shown that the mTOR complex 1 (mTORC1)–S6K1 pathway mediates cytoophidium assembly in mammalian cells. Here, using the fission yeast Schizosaccharomyces pombe as a model of a unicellular eukaryote, we demonstrate that the TOR signaling pathway regulates cytoophidium...
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Pyrroloquinoline quinone (PQQ) is a prominent redox cofactor in many prokaryotes, produced from a ribosomally synthesized and post-translationally modified peptide PqqA via a pathway comprising four conserved proteins PqqB-E. These four proteins are now fairly well characterized and span radical SAM activity (PqqE), aided by a peptide chaperone (PqqD), a dual hydroxylase (PqqB), and an eight-electron, eight-proton oxidase (PqqC). A full description of this pathway has been hampered by a lack of information...
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Taurine, a nonprotein amino acid, is widely distributed in almost all animal tissues. Ingestion of taurine helps to improve obesity and its related metabolic disorders. However, the molecular mechanism underlying the protective role of taurine against obesity is not completely understood. In this study, it was found that intraperitoneal treatment of the mice with taurine alleviated high-fat diet (HFD)-induced obesity, improved insulin sensitivity, and increased energy expenditure and adaptive thermogenesis...
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Abstract Zooplankton biomass and water environment factors in Xiaoxingkai Lake were investigated, and the correlation between biomass and water environment factors was performed using the Pearson correlation analysis and redundancy analysis (RDA). The results showed that the highest zooplankton biomass was recorded in summer and the lowest in spring. Water depth, transparency (SD), electric conductivity, and total nitrogen were the highest in spring, while temperature and total...
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Abstract In this study, a pot experiment was piloted in a greenhouse to evaluate the potential of Celosia argentea var. cristata L. for tolerating/accumulating heavy metals in synthetic wastewater in the presence of Pseudomonas japonica and organic amendment, i.e., moss and compost. Two-week-old seedlings were transferred to pots, and after 4 weeks, the bacterial strain was inoculated, then watered with synthetic wastewater for 5 weeks and harvested after 9 weeks. After harvesting,...
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Abstract Fluoroquinolones (FQs) occur broadly in natural media due to its extensive use, and it has systematic effects on our ecosystem and human immunity. In this study, long-root Eichhornia crassipes was reclaimed as a multi-functional activated carbon (MFAC) to remove fluoroquinolones (FQs) from contaminated water. To get insight into the adsorption mechanism, multiple measurements, including FTIR and XPS analyses, were employed to investigate the adsorption processes of ciprofloxacin...
15h
Abstract The excellent hierarchical porous carbon was fabricated from corn straw–derived hydrochar by chemical activation using potassium oxalate (K2C2O4). SEM, BET, XPS, XRD, and Raman analysis were carried out for the characterization of the as-obtained samples. The morphology of the as-obtained porous carbon with hierarchical porous structures is made up of a large number of nano-particle aggregates and some nanosheet-like structures, possessing a super-large specific surface...
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ObjectiveTo delineate the critical decision-making processes that paediatricians apply when treating children with life-threatening conditions and the psychosocial experience of paediatricians involved in such care. DesignWe conducted semistructured, individual face-to-face interviews for each participant from 2014 to 2015. The content of each interview was subjected to a comprehensive qualitative analysis. The categories of dilemma were extracted from a second-round content analysis. ParticipantsParticipants...
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IntroductionChronic low back pain (CLBP) is the leading cause of disability worldwide. However, there is no consensus in the literature regarding optimal management. Exercise intervention is the most widely used treatment as it likely influences contributing factors such as physical and psychological. Literature evaluating the effects of exercise on CLBP is often generalised, non-specific and employs inconsistent outcome measures. Moreover, the mechanisms behind exercise-related improvements are...
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IntroductionApproximately 25%–35% of the 1991 Gulf War Veteran population report symptoms consistent with Gulf War Illness (GWI), a chronic, multi-symptom illness characterised by fatigue, pain, irritable bowel syndrome and problems with cognitive function. GWI is a disabling problem for Gulf War Veterans, and there remains a critical need to identify innovative, novel therapies. Gut microbiota perturbation plays a key role in the symptomatology of other chronic multi-symptom illnesses, including...
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ObjectivesProstate cancer is the second most common cause of cancer-related death in males after lung cancer, imposing a significant burden on the healthcare system in Australia. We propose the use of autoregressive integrated moving average (ARIMA) models in conjunction with population forecasts to provide for robust annual projections of prostate cancer. DesignData on the incidence and mortality from prostate cancer was obtained from the Australian Institute of Health and Welfare. We formulated...
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Abstract New therapeutic strategies aimed to tackle the rising socio-economic burden of heart failure (HF) have become an impelling priority. The new pharmacological class of angiotensin (Ang) receptor-neprilysin inhibitors (ARNI) prompted a real conceptual change in the treatment of HF moving from only the inhibition of the renin-Ang-aldosterone system and sympathetic nervous system to a strategy based on the concomitant pharmacological enhancement of endogenous natriuretic peptides....
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Abstract Objectives Major spinal corrective surgeries can be associated with critical intra-operative blood loss. The objective of this systematic review and meta-analysis was to assess the safety and efficacy of tranexamic acid (TXA), a commonly used antifibrinolytic agent, in adult spinal deformity (ASD) surgery, defined as fusion of five or more levels. Methods ...
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