Publication date: December 2019Source: Materials Science and Engineering: C, Volume 105Author(s): Buddolla Anantha Lakshmi, Sanghyo KimAbstractNanostructured metal-organic frameworks (N-MOFs) are crystalline coordination nanopolymers in which metals are conjugated with organic and inorganic linker molecules. At present, N-MOFs have attracted significant interest owing to their intrinsically high porosity and ultrahigh surface areas, which allow them to be loaded with a broad array of materials, including...
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Oncogene, Published online: 19 August 2019; doi:10.1038/s41388-019-0960-xInduction of NKG2D ligand expression on tumor cells by CD8+ T-cell engagement-mediated activation of nuclear factor-kappa B and p300/CBP-associated factor (Source: Oncogene)
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Oncogene, Published online: 19 August 2019; doi:10.1038/s41388-019-0952-xAn miR-340-5p-macrophage feedback loop modulates the progression and tumor microenvironment of glioblastoma multiforme (Source: Oncogene)
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Authors: Yu-Hsuan Chen Chun-Wei Wang Ming-Feng Wei Yi-Shin Tzeng Keng-Hsueh Lan Ann-Lii Cheng Sung-Hsin Kuo Our previous study demonstrated that administration of NVP-BEZ235 (BEZ235), a dual PI3K/mTOR inhibitor, before radiotherapy (RT) enhanced the radiotherapeutic effect in colorectal cancer (CRC) cells both in vitro and in vivo. Here, we evaluated whether maintenance BEZ235 treatment, after combinatorial BEZ235 + RT therapy, prolonged the antitumor effect in CRC. K-RAS...
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Oncogene, Published online: 19 August 2019; doi:10.1038/s41388-019-0951-yMUC13 promotes the development of colitis-associated colorectal tumors via β-catenin activity (Source: Oncogene)
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ConclusionsThis study demonstrated the significant association between N2 lymph-node metastases and tumor size and differentiation, CEA levels, and status of vascular invasion and pleural involvement. (Source: Journal of Cancer Research and Clinical Oncology)
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ConclusionPatients with localized extraskeletal ES have comparable OS outcomes to patients with skeletal ES utilizing the standard VDC-IE chemotherapy. However, extraskeletal patients are at significantly higher risk for local recurrence. (Source: Clinical and Translational Oncology)
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ConclusionsCancer incidence in the Alaska EARTH cohort was similar to incidence observed statewide. Risk and protective factors for leading cancers among AN people mirror those observed among other populations. (Source: Cancer Causes and Control)
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ConclusionsWhile urban –rural differences in breast cancer screening are small, they can translate into tens of thousands of rural women not receiving mammograms. Hence, there is a need to continue screening initiatives in these areas to reduce the number of breast cancer deaths. (Source: Cancer Causes and Control)
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. (Source: Nutrition and Cancer)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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AbstractMHC class I-related chain A (MICA) is one of the major ligands for natural killer group 2 member D (NKG2D), which is an activating NK receptor. MICA is expressed on the surface of human epithelial tumor cells, and its shedding from tumor cells leads to immunosuppression. To activate immune response in the tumor microenvironment, we designed an anti-VEGFR2 –MICA bispecific antibody (JZC01), consisting of MICA and an anti-VEGFR2 single chain antibody fragment (JZC00) and explored its potential...
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ConclusionAdvanced tumor stages marked by BCLC stadium C and elevated initial AFP concentrations were associated with lower SF36 total scores and functional sum scores, respectively. During the course of sorafenib treatment, the sub-dimensional score for role limitations due to physical health decreased significantly, whereas TACE performance was associated with a significant improvement of the control of body pain. (Source: Journal of Cancer Research and Clinical Oncology)MedWorm Message: Have you...
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AbstractMicroRNAs (miRNAs) are defined as small, non-coding RNAs that act as post-transcriptional regulators of gene expression. Dysfunction of miRNAs was involved in the initiation and progression of nasopharyngeal carcinoma (NPC). Here, we found that miR-543 was markedly overexpressed in NPC tissues and cell lines. Overexpression of miR-543 promoted the proliferation, cell cycle progression and invasion of NPC cells. Down-regulation of miR-543 inhibited the proliferation and induced apoptosis of...
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Oncogene, Published online: 19 August 2019; doi:10.1038/s41388-019-0963-7Rho GTPases in cancer: friend or foe? (Source: Oncogene)
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British Journal of Cancer, Published online: 19 August 2019; doi:10.1038/s41416-019-0554-yCorrection: Desperately seeking…Models to find the right partner and the best use for checkpoint inhibitors (Source: British Journal of Cancer)
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AbstractDespite major improvements in combatting metastatic melanoma since the advent of immunotherapy, the overall survival for patients with advanced disease remains low. Recently, there is a growing number of reports supporting an “obesity paradox,” in which patients who are overweight or mildly obese may exhibit a survival benefit in patients who received immune checkpoint inhibitors. We studied the relationship between body mass index and progression-free survival and overall survival in a cohort...
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The objective response rate (ORR) and complete response (CR) rate were 81.81% (9/11) and 45.45% (5/11), respectively. The median follow-up time was 6 (1~15) months. The median progression-free survival (PFS) time was 6 months (1~14 months), and 3 patients continued to have a response at the time of this writing. Our study demonstrated that the combination of CD19 CAR-T cells and nivolumab was feasible and safe and mediated potent anti-lymphoma activity, which should be examined further in prospective...
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Conclusions: We demonstrated for the first time the prognostic significance of adnexal CRS confirming also the prognostic role of omental CRS. (Source: Frontiers in Oncology)
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Cancers, Vol. 11, Pages 1207: Tumor Cell Dormancy: Threat or Opportunity in the Fight against Cancer
Authors: Rana Jahanban-Esfahlan Khaled Seidi Masoud H. Manjili Ali Jahanban-Esfahlan Tahereh Javaheri Peyman Zare Tumor dormancy, a clinically undetectable state of cancer, makes a major contribution to the development of multidrug resistance (MDR), minimum residual disease (MRD), tumor outgrowth, cancer relapse, and metastasis. Despite its high incidence, the whole picture of dormancy-regulated molecular programs is far from clear. That is, it is unknown when and which dormant...
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Authors: Kenji Imai Koji Takai Takao Miwa Daisuke Taguchi Tatsunori Hanai Atsushi Suetsugu Makoto Shiraki Masahito Shimizu The aim of this study was to investigate whether rapid depletions of fat mass and skeletal muscle mass predict mortality in hepatocellular carcinoma (HCC) patients treated with sorafenib. This retrospective study evaluated 61 HCC patients. The cross-sectional areas of visceral and subcutaneous fat mass and skeletal muscle mass were measured by computed...
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Authors: Vanessa Barriga Nyanbol Kuol Kulmira Nurgali Vasso Apostolopoulos The progression of breast cancer and its association with clinical outcome and treatment remain largely unexplored. Accumulating data has highlighted the interaction between cells of the immune system and the tumor microenvironment in cancer progression, and although studies have identified multiple facets of cancer progression within the development of the tumor microenvironment (TME) and its constituents,...
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This study evaluated the antiviral activity of intestinal epithelial cells (IECs), which form a single-cell layer separating the bowel wall from pathogens. Isolated primary mouse IECs were subjected to AiV infection and virion production, inducing the mRNA expression of type I/type III IFNs and inflammatory cytokines. The mechanism involved induced the expression of phospho-IFN regulatory factor 3 and mitochondrial antiviral-signaling protein of type I IFN signaling. These findings were also observed...
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Publication date: 15 December 2019Source: Journal of Molecular Structure, Volume 1198Author(s): Bandar A. Babgi, Magda H. Abdellattif, Mostafa A. Hussien, Naser E. EltayebAbstractThe synthesis of the benzoimidazolyl-ferrocene containing compound was achieved by Knovenagel condensation of ferrocene-1-carbaldehyde and (2-benzoimidazolyl) acetonitrile. Single crystal structure of the compound showed intramolecular (hydrogen bonding) NH⋯N interactions, forming an infinite 1D-chain that propagate along...
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This study aims to investigate the antiproliferative activity and potential mechanism of action of the xanthoquinodin JBIR-99, isolated from fungi Parengyodontium album MEXU 30,054 and identified by single-crystal X-ray crystallography. Cytotoxicity of xanthoquinodin was evaluated in a panel of human cancer cells lines and CCD-112-CoN normal colon cells, using the sulforhodamine B assay. PC-3 prostate cancer cells were used in biochemical assays including cell cycle, mitochondrial transmembrane potential...
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Publication date: Available online 18 August 2019Source: Regulatory Toxicology and PharmacologyAuthor(s): Britta Laube, Sandra Michaelsen, Veronika Meischner, Andrea Hartwig, Bernd Epe, Michael SchwarzAbstractOne of the important tasks of the German Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area (known as the MAK Commission) is in the evaluation of a potential for carcinogenicity of hazardous substances at the workplace. Often, this evaluation is...
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(Source: Clinical Epidemiology)
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This study is aimed to investigate the temperature distribution in tumor tissue ... (Source: Theoretical Biology and Medical Modelling)
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In this study, the inhibitory effects of APINACA on eight major human cytochrome P450s (CYPs) and six uridine 5′-diphospho-glucuronosyltransferases (UGTs) in human liver microsomes, as well as on the transport activities of six solute carrier transporters and two efflux transporters in transporter-overexpressed cells, were investigated. APINACA exhibited time-dependent inhibition of CYP3A4-mediated midazolam 1′-hydroxylation (Ki, 4.5 µM; kinact, 0.04686 min−1) and noncompetitive inhibition of UGT1A9-mediated...
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Authors: Rim Wehbe Jacinthe Frangieh Mohamad Rima Dany El Obeid Jean-Marc Sabatier Ziad Fajloun Apitherapy is an alternate therapy that relies on the usage of honeybee products, most importantly bee venom for the treatment of many human diseases. The venom can be introduced into the human body by manual injection or by direct bee stings. Bee venom contains several active molecules such as peptides and enzymes that have advantageous potential in treating inflammation and central...
16h
Radiolabeled Arg ‐Gly‐Asp (RGD) peptide derivatives have immense potential for non‐invasive monitoring of malignancies overexpressing integrin αvβ3 receptors. Easy availability of suitable radiotracers would augment the utility of this class of molecular imaging agents. Towards this, the present article describes the development of an improved lyophilized kit for the routine clinical formulation of [99mTc]Tc complex of HYNIC ‐conjugated dimeric cyclic RGD peptide derivative E‐[c(RGDfK)]2 (E = glutamic...
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Cell Death & Disease, Published online: 19 August 2019; doi:10.1038/s41419-019-1859-8SIRT1-targeted miR-543 autophagy inhibition and epithelial–mesenchymal transition promotion in Helicobacter pylori CagA-associated gastric cancer (Source: Cell death and disease)
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Cell Death & Disease, Published online: 19 August 2019; doi:10.1038/s41419-019-1846-0Downregulation of eukaryotic translation initiation factor 3b inhibited proliferation and metastasis of gastric cancer (Source: Cell death and disease)
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Cell Death & Disease, Published online: 19 August 2019; doi:10.1038/s41419-019-1845-1UPF1 regulates the malignant biological behaviors of glioblastoma cells via enhancing the stability of Linc-00313 (Source: Cell death and disease)
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ConclusionPCAS is a rare cancer that is prone to have poor prognoses. To understand PCAS more thoroughly, more cases with adequate information are needed. (Source: European Journal of Medical Research)
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ConclusionInterventional radiology protocol is safe, feasible and efficacious for treatment for esophagogastric anastomotic leakage. (Source: La Radiologia Medica)
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In conclusion, our data showed that pan-Trk IHC is a reasonable screening test for diagnosing secretory carcinoma of the salivary gland. (Source: Virchows Archiv)
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AbstractImmune checkpoint inhibitors (CPI) are increasingly being used in oncology, and many autoimmune side effects have been described. Diabetes mellitus (DM) has been reported in approximately 1% of subjects treated with programmed cell death-1 and programmed death ligand 1 (PD-1/PD-L1) inhibitors, alone or in association with CTLA-4 inhibitors. In the present mini-review, we aimed to describe different clinical pictures and pathophysiology associated with these forms of diabetes. Data on CPI-related...
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ConclusionsPhysicians should be aware of the possibility of the emergence of primary malignancies in patients with a history of papillary thyroid carcinoma, especially lung cancer as it is a common site of papillary thyroid carcinoma metastases. Using appropriate diagnostic evaluations in order to choose the best therapeutic option is of utmost importance. (Source: Journal of Medical Case Reports)
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Abstract Venous ulcers are the most severe manifestation of post-thrombotic syndrome (PTS). We have previously demonstrated that formation of compact fibrin clots resistant to lysis is observed in patients following deep-vein thrombosis (DVT) who developed PTS. The current study investigated whether unfavourable fibrin clot properties can predict post-thrombotic venous ulcers. In a cohort study on 186 consecutive patients following DVT, we determined plasma fibrin clot characteristics,...
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I appreciate the effort to elicit patients’ expectations on a large scale.1 But I wonder whether we should also survey what doctors need from 21st century patients. I am aware of a 2018 survey of...
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Have you looked outside? Summer’s overThese lollies aren’t designed to cool you down on a hot day: they’re for postoperative patients.After having their tonsils out?No, although some evidence shows...
11h
Dozens of former patients at a psychiatric hospital who claim that they were experimented on by being held down and given sodium amytal as children in the 1960s and ’70s will receive compensation in...
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Doctors have warned that the current situation in Indian administered Kashmir, where the government has imposed a security lockdown and communications blackout, is preventing people from seeking...
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The independent inquiry into Liverpool Community Health NHS Trust announced in June 20191 is the culmination of a well worn path. Concerns about care are raised and ignored, staff are denigrated or...
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When James Swarray, a health officer in Sierra Leone, stepped into the red zone on his first day at the Moyamba Ebola clinic, he wondered if this was the end.“The victims of the Ebola virus were...
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The headlines about late diagnosis of cancers feed into a false narrative that misleads the public to believe that if any chronic disease had been diagnosed a bit earlier, the outcome would have been...
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Toxins, Vol. 11, Pages 480: Immunohistochemical Review of Leydig Cell Lesions in Ochratoxin A-Treated Fischer Rats and Controls Toxins doi: 10.3390/toxins11080480 Authors: Diana Herman Peter Mantle Ochratoxin A is best known as a potent renal carcinogen in male rats and mice after necessarily protracted ingestion, although valid extrapolation to any human disease has not been verified. The hypothesis that the toxin is a cause of human testicular cancer was proposed a decade ago and...
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Toxins, Vol. 11, Pages 478: The Degradation of Deoxynivalenol by Using Electrochemical Oxidation with Graphite Electrodes and the Toxicity Assessment of Degradation Products Toxins doi: 10.3390/toxins11080478 Authors: Suli Xiong Xiao Li Changsong Zhao Jingqi Gao Wenjuan Yuan Jie Zhang Deoxynivalenol (DON) is a common mycotoxin, which is known to be extremely harmful to human and livestock health. In this study, DON was degraded by electrochemical oxidation (ECO) using...
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Toxins, Vol. 11, Pages 479: Perennial Ryegrass Alkaloids Increase Respiration Rate and Decrease Plasma Prolactin in Merino Sheep under Both Thermoneutral and Mild Heat Conditions Toxins doi: 10.3390/toxins11080479 Authors: Michelle L. E. Henry Stuart Kemp Iain J. Clarke Frank R. Dunshea Brian J. Leury A study was undertaken to determine the effects of feeding two levels of perennial ryegrass alkaloids (nil vs. moderate) under two climatic conditions. Alkaloids were fed via...
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Toxins, Vol. 11, Pages 477: Suppressive Effects of Bee Venom-Derived Phospholipase A2 on Mechanical Allodynia in a Rat Model of Neuropathic Pain Toxins doi: 10.3390/toxins11080477 Authors: Seunghui Woo Geehoon Chung Hyunsu Bae Sun Kwang Kim Bee venom (BV) has a long history of being used in traditional Korean medicine to relieve pain. Here, we investigated the effect of BV-derived phospholipase A2 (bvPLA2), a major component of BV, on peripheral nerve injury-induced neuropathic...
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Abstract Background Terminally differentiated keratinocytes acquire corneocyte protein envelopes (CPE) complexed with corneocyte lipid envelopes (CLE). These two structural components of the corneocyte envelopes (CE) undergo maturation by gaining in hydrophobicity, rigidity and surface area. Linoleoyl acylceramides are processed by 12R‐lipoxygenase (12R‐LOX) and other enzymes before transglutaminase (TG) attaches ω‐hydroxyceramides to involucrin in the CPE. Concurrently, structural proteins are...
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Abstract Background Morbidity & Mortality (M&M) meetings are a critical component of clinical governance. They have the potential to improve patient outcomes, quality of care, attitudes towards patient safety and they contribute to the education of clinical staff. This study aimed to evaluate individual surgeons’ experience of these meetings, and to explore their perceived usefulness and barriers to open discussion of adverse...
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Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
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Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
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Publication date: Available online 18 August 2019Source: Journal of Oral Biology and Craniofacial ResearchAuthor(s): Sourav Sarkar, N.T. Prashanth, E.S. Shobha, Vinod Rangan, G. NikhilaAbstractObjectivesThe aim of this study is to compare the effectiveness of Platelet Rich Fibrin gel and Chitosan gel dressing in providing hemostasis in patients receiving Oral Antiplatelet Therapy and also to evaluate their surgical healing outcome following dental extractions.MethodologyA total of 60 patients under...
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Abstract Although 12–13% of Namibians are reported to struggle with psychological distress, very few practitioners are available to provide mental health services in Namibia. Those practitioners who are available are often trained from Western counseling and psychiatric perspectives that may not readily align to beliefs about illness held constructed in Namibian cultures. Institutional effort is invested in the education and use of mental health practitioners, including counselors,...
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Abstract In this article, we investigate how an increasingly popular therapeutic modality, family constellation therapy (FCT), functions simultaneously as a technology of the self (Foucault, Technologies of the self: a seminar with Michel Foucault, University of Massachusetts Press, Amherst, 1988) as well as what we here call a “technology of the social.” In FCT, the self is understood as an assemblage of ancestral relationships that often creates problems in the present day....
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The Wuliang Mountains of the Jingdong region is a settlement area of the Yi community located in south-western Yunnan Province in China. Due to its unique geographical location, this area harbours abundant med...
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Rejuvenation Research, Volume 22, Issue 4, Page 353-358, August 2019.
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Rejuvenation Research, Volume 22, Issue 4, Page 282-288, August 2019.
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Rejuvenation Research, Volume 22, Issue 4, Page 281-281, August 2019.
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Rejuvenation Research, Volume 22, Issue 4, Page 289-298, August 2019.
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Rejuvenation Research, Volume 22, Issue 4, Page 362-363, August 2019.
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Rejuvenation Research, Volume 22, Issue 4, Page 299-305, August 2019.
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Rejuvenation Research, Volume 22, Issue 4, Page 335-341, August 2019.
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Rejuvenation Research, Volume 22, Issue 4, Page 348-352, August 2019.
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Rejuvenation Research, Volume 22, Issue 4, Page 313-324, August 2019.
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Rejuvenation Research, Volume 22, Issue 4, Page 325-334, August 2019.
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Rejuvenation Research, Volume 22, Issue 4, Page 364-365, August 2019.
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Rejuvenation Research, Volume 22, Issue 4, Page 342-347, August 2019.
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Semin Speech LangDOI: 10.1055/s-0039-1694996Evidence-based practice (EBP) is a well-established framework for supporting clinical decision making in the discipline of speech-language pathology. The benefits of using evidence to inform clinical practice are acknowledged by clinicians and researchers alike. Even so, after over two decades of EBP advocacy, much clinical uncertainty remains and models supporting the evaluation of interventions require review and reconsideration. The EBP model, while...
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Semin Speech LangDOI: 10.1055/s-0039-1694997 Background and Purpose The aim of the study was to compare transcription-based speech intelligibility and scaled speech severity for the detection of mild speech impairments, by studying these metrics across talkers with Parkinson's disease (PD), age- and sex-matched older adults, and younger adults. An additional aim was to determine the impact of listener experience on these clinical measures. Methods Fifteen speakers from each...
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Abstract Background The spatial distribution of substance use services impacts their use, with greater access to services associated with more positive outcomes. Findings from availability of primary healthcare indicate service shortages exist in areas characterized by social deprivation. This study investigated whether community social deprivation was associated with a lack of availability of substance use treatment or mutual aid...
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Abstract Background Canada is facing an urgent challenge to reduce the harms associated with opioids: from January 2016 to December of 2018, more than 11,500 individuals lost their lives due to opioid related harms. This review examines responses to the opioid crisis thus far, the lessons learned from these initiatives and the knowledge gaps that still need to be addressed across the four pillar model adopted by the CDSS. ...
45m
Abstract Background The pre-industrial diet of the Swedish peasantry did not include mushrooms. In the 1830s, some academic mycologists started information campaigns to teach people about edible mushrooms. This propaganda met with sturdy resistance from rural people. Even at the beginning of the last century, mushrooms were still only being occasionally eaten, and mostly by the gentry. During the twentieth century, the Swedish urban...
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Abstract Obesity rates continue to rise in children, and little guidance exists regarding the need for adjustment away from total body weight-based doses for those prescribing drugs to this population of children. A majority of drugs prescribed to children with obesity result in either sub-therapeutic or supra-therapeutic concentrations, placing these children at risk for treatment failure and drug toxicities. In this review, we highlight available obesity-specific pharmacokinetic...
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Title: FDA Approves Inrebic Capsules for MyelofibrosisCategory: Health NewsCreated: 8/16/2019 12:00:00 AMLast Editorial Review: 8/19/2019 12:00:00 AM
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JCM, Vol. 8, Pages 1259: Cytokine Profile in Patients with Aseptic Loosening of Total Hip Replacements and Its Relation to Metal Release and Metal Allergy Journal of Clinical Medicine doi: 10.3390/jcm8081259 Authors: Rune J. Christiansen Henrik J. Münch Charlotte M. Bonefeld Jacob P. Thyssen Jens J. Sloth Carsten Geisler Kjeld Søballe Morten S. Jellesen Stig S. Jakobsen Metal release from total hip replacements (THRs) is associated with aseptic loosening (AL)....
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JCM, Vol. 8, Pages 1257: Low Muscle Mass as a Prognostic Factor for Early Postoperative Outcomes in Pediatric Patients Undergoing the Fontan Operation: A Retrospective Cohort Study Journal of Clinical Medicine doi: 10.3390/jcm8081257 Authors: Jimi Oh Won-Jung Shin DaUn Jeong Tae-Jin Yun Chun Soo Park Eun Seok Choi Jae Moon Choi Mijeung Gwak In-Kyung Song The impact of low muscle mass on pediatric cardiac patients remains unclear. We investigated the impact of...
14h
JCM, Vol. 8, Pages 1258: Prediction of Transplant-Free Survival through Albumin-Bilirubin Score in Primary Biliary Cholangitis Journal of Clinical Medicine doi: 10.3390/jcm8081258 Authors: Koji Fujita Takako Nomura Asahiro Morishita Tingting Shi Kyoko Oura Joji Tani Hideki Kobara Kunihiko Tsutsui Takashi Himoto Tsutomu Masaki Albumin–bilirubin (ALBI) grade is defined using the ALBI score, which is calculated based on total serum bilirubin and albumin....
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JCM, Vol. 8, Pages 1254: Kidney Disease in HIV Infection Journal of Clinical Medicine doi: 10.3390/jcm8081254 Authors: Gaetano Alfano Gianni Cappelli Francesco Fontana Luca Di Lullo Biagio Di Iorio Antonio Bellasi Giovanni Guaraldi Antiretroviral therapy (ART) has significantly improved life expectancy of infected subjects, generating a new epidemiological setting of people aging withHuman Immunodeficiency Virus (HIV). People living with HIV (PLWH), having longer life...
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JCM, Vol. 8, Pages 1255: Oral Health in Adults with Congenital Heart Disease Journal of Clinical Medicine doi: 10.3390/jcm8081255 Authors: Matthias Folwaczny Saskia Wilberg Caspar Bumm Stefan Hollatz Renate Oberhoffer Rhoia Clara Neidenbach Harald Kaemmerer Iris Frasheri Oral bacteria and odontogenic oral infections are responsible for a high portion of cases with infective endocarditis. Hence, oral health in patients with congenital heart disease (CHD) gains particular...
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JCM, Vol. 8, Pages 1253: Multi-Omics Characterization of the Spontaneous Mesenchymal–Epithelial Transition in the PMC42 Breast Cancer Cell Lines Journal of Clinical Medicine doi: 10.3390/jcm8081253 Authors: Sugandha Bhatia James Monkman Tony Blick Pascal HG Duijf Shivashankar H. Nagaraj Erik W. Thompson Epithelial–mesenchymal plasticity (EMP), encompassing epithelial–mesenchymal transition (EMT) and mesenchymal–epithelial transition (MET),...
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JCM, Vol. 8, Pages 1256: Systemic Sclerosis Serum Steers the Differentiation of Adipose-Derived Stem Cells Toward Profibrotic Myofibroblasts: Pathophysiologic Implications Journal of Clinical Medicine doi: 10.3390/jcm8081256 Authors: Mirko Manetti Eloisa Romano Irene Rosa Bianca Saveria Fioretto Emanuela Praino Serena Guiducci Florenzo Iannone Lidia Ibba-Manneschi Marco Matucci-Cerinic Systemic sclerosis (SSc; scleroderma) is characterized by life-threatening...
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JCM, Vol. 8, Pages 1251: Comparison of Radiographic Progression-Free Survival and PSA Response on Sequential Treatment Using Abiraterone and Enzalutamide for Newly Diagnosed Castration-Resistant Prostate Cancer: A Propensity Score Matched Analysis from Multicenter Cohort Journal of Clinical Medicine doi: 10.3390/jcm8081251 Authors: Kazumasa Komura Yuya Fujiwara Taizo Uchimoto Kenkichi Saito Naoki Tanda Tomohisa Matsunaga Atsushi Ichihashi Takeshi Tsutsumi Takuya Tsujino...
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JCM, Vol. 8, Pages 1252: Blood Flow Restriction Increases the Neural Activation of the Knee Extensors During Very Low-Intensity Leg Extension Exercise in Cardiovascular Patients: A Pilot Study Journal of Clinical Medicine doi: 10.3390/jcm8081252 Authors: Hayato Ishizaka Azusa Uematsu Yuta Mizushima Naohiro Nozawa Satoshi Katayanagi Kazuhisa Matsumoto Kaori Nishikawa Reiko Takahashi Tomoe Arakawa Tatsuya Sawaguchi Tomohiro Yasuda Suomi Yamaguchi Hironaga...
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Company: ConfidentialQualification: Bachelor's DegreeExperience: 2 to 7location: DubaiRef: 24021802Summary: Perform skin analysis and evaluation to determine laser treatments
55m
Abstract A 9-year-old boy sustained an ulnohumeral dislocation with a medial epicondyle fracture and experienced incomplete post-traumatic median nerve palsy in addition to post-traumatic stiffness following closed reduction and cast immobilization. When his motor palsy and stiffness did not improve, MRI and ultrasound were obtained, which demonstrated entrapment of the median nerve in an osseous tunnel at the fracture site, compatible with type 2 median nerve entrapment. Subsequently,...
55m
Abstract Ulnar nerve compression at the elbow, specifically the cubital tunnel, is the second most common upper extremity compression neuropathy. Many patients presenting with compression symptoms will subsequently undergo surgical intervention. We review the open surgical treatment of cubital tunnel syndrome and review the expected postoperative imaging appearance of those treatments on magnetic resonance imaging (MR), including: simple or in situ decompression, medial epicondylectomy,...
55m
Abstract There is a large variety of conditions that can result in ‘bone marrow edema’ or ‘bone marrow lesions’ (BML) in the wrist on magnetic resonance imaging (MRI). The combination of clinical history and the distribution of the BML can serve as a valuable clue to a specific diagnosis. This article illustrates the different patterns of BML in the wrist to serve as a useful guide when reviewing wrist MRI studies. Imaging artefacts will also be briefly covered.
55m
Abstract Retro-odontoid pseudotumor, or mass-like retro-odontoid soft tissue thickening, is an uncommon but important imaging finding that may be associated with rheumatoid arthritis, crystal deposition diseases, as well as non-inflammatory conditions such as cervical degenerative changes and mechanical alterations. Retro-odontoid pseudotumor is commonly associated with atlantoaxial microinstability or subluxation. MRI and CT have an important role in the detection and diagnosis...
55m
Abstract Variations of the anatomy of the hamstring muscle complex are uncommon. In particular, absence of some or all of the hamstring muscles is rarely described in the literature. This report presents a case of absent semimembranosus musculature detected incidentally on knee magnetic resonance imaging (MRI), then found to be bilateral on MRI of both thighs performed shortly thereafter. Imaging also demonstrated atypical morphologies of the semitendinosus and biceps femoris...
55m
Abstract Objective To evaluate the diagnostic performance of knee ultrasound for anterior cruciate ligament (ACL) and posterior cruciate ligament (PCL) injuries. Materials and methods PubMed and EMBASE databases were searched for diagnostic accuracy studies that used ultrasound for diagnosing ACL and PCL injuries. Bivariate and hierarchical...
55m
Abstract Objective We describe a novel and safe needle-holding method that we have termed the ‘dual steristrip technique’. This technique can be used to stabilize the bone biopsy needle without the need for the radiologist’s hand to be in close proximity to the X-ray beam during CT-guided intervention. Materials and methods The dual steristrip...
55m
Abstract Intraosseous myoepithelial carcinoma is an extremely rare type of bone tumor that most often presents in the long tubular bones, but also occurs in small tubular bones and the axial skeleton. We report the radiographic images and complete magnetic resonance (MR) features of a 44-year-old male with right knee pain of 7 months’ duration. The radiographic findings and convention MR images indicated a giant cell tumor of the bone. The dynamic contrast-enhanced images showed...
55m
Abstract Objective The aim of this study was to compare the diagnostic accuracy of nuclear imaging modalities in the detection of aseptic loosening of total knee arthroplasty (TKA). Materials and methods MEDLINE, EMBASE, and the Cochrane Database of Systematic Reviews were searched from database inception to December 2018 in accordance with...
55m
Abstract Objective The aim of the study was to determine the diagnostic accuracy of imaging modalities to detect pseudarthrosis after thoracolumbar spinal fusion, with surgical exploration as reference standard. Materials and methods A systematic literature search for original studies was performed on the diagnostic accuracy of imaging as index...
55m
Abstract Objective Literature regarding intramuscular calf vein thrombosis (IMCVT) or infrapopliteal deep vein thrombosis (DVT) evaluation by magnetic resonance imaging (MRI) is limited, particularly with regard to routine unenhanced knee examinations. We attempt to correlate routine unenhanced MRI findings with ultrasound evaluations of the lower extremity deep venous system. ...
55m
Abstract Objective To review histologic diagnoses of soft-tissue masses (STMs) ≤ 2 cm with indeterminate imaging features encountered in musculoskeletal oncology clinic at a tertiary referral center. Materials and methods This was an IRB-approved retrospective review of patients with STMs ≤ 2 cm, referred to our tertiary care orthopedic oncology...
55m
Abstract Objective Using digitally reconstructed radiographs (DRRs), we determined how changes in the projection angle influenced the assessment of the subtalar joint. Materials and methods Weightbearing computed tomography (CT) scans were acquired in 27 healthy individuals. CT scans were segmented and processed to create DRRs of the hindfoot....
55m
Abstract Myxofibrosarcoma is a malignant fibroblastic soft tissue neoplasm containing a variable amount of myxoid stroma that commonly presents as a slow-growing mass in elderly patients. The neoplasm may be superficial or deep to the muscle fascia and characteristically has an infiltrative growth pattern with a dominant or multinodular mass. We describe an unusual case of high-grade myxofibrosarcoma of the wrist and forearm that infiltrated the muscles, tendons, and wrist joint,...
55m
Abstract Osteoblastoma is a rare, benign primary tumor of bone, accounting for < 1% of all bone tumors. We report the case of a 27-year-old female who developed pain and swelling five and a half years after a clavicular fracture and was subsequently found to have an osteoblastoma arising at the fracture site. This is the first reported case of an osteoblastoma developing after a fracture, although osteoid osteomas, which are histologically indistinguishable from osteoblastomas,...
55m
Abstract Coracoid stress fractures are a rare sports injury but present a management challenge, with the focus on optimising return-to-play, whilst minimising complications. Potential contributing mechanisms for the injury are briefly discussed and a novel approach to accurate fracture fixation under CT guidance is described. The ability of radiologists to orient themselves in 3D with a volume dataset on a workstation provides an image-guided option for percutaneous fixation...
55m
Abstract Glenohumeral osteoarthritis is a prevalent degenerative disease that can lead to excruciating pain and debility. End-stage osteoarthritis can be treated by both conservative and surgical interventions. Along with a comprehensive history and physical exam, pre-operative imaging with plain radiographs, computerized tomography, and magnetic resonance imaging plays an essential role in the decision-making process guiding whether the patient undergoes a shoulder hemiarthroplasty,...
55m
Aim This meta‐analysis aimed to evaluate whether endocuff‐assisted colonoscopy (EAC) could improve adenoma detection rate (ADR) compared to standard colonoscopy (SC). Methods PubMed, Embase, Scopus, Cochrane databases and Google Scholar were searched up to March 2019. All pure randomized controlled trials (RCTs) comparing ADR between EAC and SC were included. Dichotomous data were pooled to obtain the odds ratio (OR) with a 95% confidence interval (CI), whereas continuous data were pooled...
58m
Last week during our school’s scheduled meetings in preparation for a new academic year, I shared a workshop with teachers titled, “Getting Started with Student Blogging.” I’ve been blogging as a teacher since 2003, and remain a strong advocate for the benefits of empowering students to share their ideas, perspectives and voices beyond the traditional walls of the classroom to connect with an authentic audience. The advent of social media has definitely “normalized” teen sharing and digital publishing,...
1h
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