Abstract Loss of heterozygosity or mutation of the family with sequence similarity 46, member C (FAM46C) gene on chromosome band 1p12 is associated with shorter overall survival of patients with multiple myeloma (MM). In this study, using human MM cell lines (KMS‐11, OCI‐My5, and ANBL‐6), we generated FAM46C‐/‐ cell clones and examined the effect of disruption of FAM46C on cell survival and cellular signaling. MTT assay showed increased clonogenicity of FAM46C‐/‐ KMS‐11 cells compared to wild‐type...
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British Journal of Cancer, Published online: 17 March 2020; doi:10.1038/s41416-020-0789-7Female reproductive factors and the risk of lung cancer in postmenopausal women: a nationwide cohort study
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British Journal of Cancer, Published online: 17 March 2020; doi:10.1038/s41416-020-0797-7The prognostic significance of immune microenvironment in breast ductal carcinoma in situ
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British Journal of Cancer, Published online: 17 March 2020; doi:10.1038/s41416-020-0792-zA novel model of liver cancer stem cells developed from induced pluripotent stem cells
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British Journal of Cancer, Published online: 17 March 2020; doi:10.1038/s41416-020-0794-xSerine-dependent redox homeostasis regulates glioblastoma cell survival
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British Journal of Cancer, Published online: 17 March 2020; doi:10.1038/s41416-020-0793-yDifferential prognostic impact of CD8+ T cells based on human leucocyte antigen I and PD-L1 expression in microsatellite-unstable gastric cancer
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Background and Objective Hyperhidrosis (HH) is associated with impairments in quality of life (QOL) and elevated anxiety. Microwave thermolysis is a newer treatment that reduces sweating, yet effects on QOL and emotional symptoms have not been examined. Two treatment sessions are recommended to achieve 80% amelioration of clinical HH. We hypothesized that microwave thermolysis would reduce sweat severity, improve QOL, and reduce anxiety in young adults suffering from axillary HH in a prospective...
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Background and Objectives Microfocused ultrasound with visualization (MFU‐V) has been approved for the treatment of skin laxity on several areas including the eyebrows, neck, and submental area. This study aims to determine the efficacy of MFU‐V for the treatment of abdominal skin laxity using two different treatment protocols. Study Design/Materials and Methods Thirty female patients with abdominal skin laxity were enrolled. Each side of the abdomen was randomly assigned to receive a...
Mon Mar 16, 2020 10:19
Background and Objectives In our previous proof‐of‐principle study, transcranial photobiomodulation (tPBM) with 1,064‐nm laser was reported to significantly increase concentration changes of oxygenated hemoglobin (∆[HbO]) and oxidized‐state cytochrome c oxidase (∆[oxi‐CCO]) in the human brain. This paper further investigated (i) its validity in two different subsets of young human subjects at two study sites over a period of 3 years and (ii) age‐related effects of tPBM by comparing sham‐controlled...
Mon Mar 16, 2020 10:19
Background and Objective Patient‐reported outcomes and blinded observer rating scales are subjective and unreliable but are extensively utilized to evaluate cosmetic office‐based treatments, including ablative lasers. This study aims to assess the practicality of using non‐invasive and minimally invasive methods for objective skin assessment following a skin rejuvenation treatment. Study Design/Materials and Methods Twelve patients received a single 1,470/2,940 nm laser treatment for...
Mon Mar 16, 2020 10:19
Abstract Objectives The incentives underlying men's hunting acquisition patterns among foragers are much debated. Some argue that hunters preferentially channel foods to their households, others maintain that foods are widely redistributed. Debates have focused on the redistribution of foods brought to camp, though the proper interpretation of results is contested. Here we instead address this question using two nutritional variables, employed as proxies for longer‐term food access. We also...
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First molecular confirmation of Entamoeba histolytica in orangutans. Abstract Key to the success of orangutan conservation management practices is the prevention of the introduction of infectious diseases to the remaining populations. Previous reports of Entamoeba spp. positive orangutans are of concern as Entamoeba spp. infection has been linked to morbidity and mortality in primates. It remains to be determined if the Entamoeba species infecting orangutans is the pathogenic Entamoeba histolytica....
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Abstract The objective of this study was to evaluate the influence of hydrofluoric acid (HF) concentration, etching time, and application of phosphoric acid (PA) followed by neutralization with sodium bicarbonate on the bond strength between a feldspar ceramic and resin cement. Thus, 80 blocks (10 x 12 x 2 mm) of glass ceramic (VM - Vita Mark II - Vita Zahnfabrik) were made and randomly assigned to eight groups (n = 10) according to the factors: HF concentration (5 and 10%), etching time (60 and...
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Abstract The aim of this study was to verify the oral habits, symptoms, and characteristics of some children aged 8 to 10 years that could be associated with possible sleep bruxism. A cross-sectional study was performed. Questionnaires were sent to parents to obtain information on sex, age, school shift, sleep quality, parents’ perception of children’s behavior, and children’s oral habits (nail biting, object biting, and lip biting), and symptoms such as headache or earache. In addition, parents...
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Abstract This study aimed to assess the reliability and validity of Brazilian-Portuguese versions of the Health Literacy in Dentistry (HeLD) scale in a sample of elderly Brazilian participants. HeLD was initially translated into and cross-culturally adapted to the Brazilian Portuguese language. The reliability and validity of HeLD were then assessed in a sample of 535 non-institutionalized older persons who also completed a questionnaire containing sociodemographic and health information. Data were...
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Background Clinical experience is limited for primary central nervous system (CNS) lymphoma that arises from the dura mater, which is denoted with the term primary dural lymphoma (PDL). This study was aimed at determining the relative incidence, presentation, and outcomes of PDL. Methods The institutional databases of the Divisions of Neuro‐Oncology at the Massachusetts General Hospital and the Yale School of Medicine were retrospectively searched for patients with primary CNS lymphoma....
Mon Mar 16, 2020 23:51
Limited evidence exists on the role of modifiable lifestyle factors on the risk of lymphoma. In this work, the associations between adherence to healthy lifestyles and risks of Hodgkin lymphoma (HL) and non‐Hodgkin lymphoma (NHL) were evaluated in a large‐scale European prospective cohort. Within the European Prospective Investigation into Cancer and Nutrition (EPIC), 2,999 incident lymphoma cases (132 HL and 2,746 NHL) were diagnosed among 453,808 participants after 15 years (median) of follow‐up....
Mon Mar 16, 2020 23:45
There is limited evidence regarding a possible association between exposure to ambient air pollutants and the risk of non‐Hodgkin lymphoma (NHL). Previous epidemiological studies have relied on crude estimations for air pollution exposure and/or small numbers of NHL cases. The objective of this study was to analyze this association based on air pollution modeled at the address level and NHL cases identified from the nation‐wide Danish Cancer Registry. We identified 20,874 incident NHL cases diagnosed...
Mon Mar 16, 2020 23:45
Mon Mar 16, 2020 23:45
Mon Mar 16, 2020 23:44
Mon Mar 16, 2020 23:44
Background:The safety and effectiveness of dual therapy (direct oral anticoagulant [DOAC] plus P2Y12 inhibitor) versus triple therapy (vitamin K antagonist plus aspirin and P2Y12 inhibitor) in patients with nonvalvular atrial fibrillation (AF) after percutaneous coronary intervention (PCI) is unclear.Purpose:To examine the effects of dual versus triple therapy on bleeding and ischemic outcomes in adults with AF after PCI.Data Sources:Searches of PubMed, EMBASE, and the Cochrane Library (inception...
Mon Mar 16, 2020 23:44
Pancreatic ductal adenocarcinoma (PDAC) is the fourth most common cause of cancer death, with more than 80% of patients diagnosed at advanced stages and a 5-year survival of only 9%. The best hope for improving the prognosis of PDAC is to detect the cancer at early stages when more patients can undergo maximal therapy (that is, chemotherapy and resective surgery). A sequential risk-tailored strategy for early detection of PDAC is being developed in a large prospective cohort of patients with new-onset...
Mon Mar 16, 2020 23:44
Post hoc analyses of randomized trial data can help answer important questions by making use of valuable data collected in controlled settings. Using trial data to compare nonrandomized exposures requires care because the comparisons are not protected by randomization. This article helps readers understand the potential biases that need to be considered when evaluating such studies.
Mon Mar 16, 2020 23:44
In their article, Khan and colleagues report a meta-analysis that addresses the care of patients with atrial fibrillation after coronary stent placement who require anticoagulation to mitigate stroke risk and antiplatelet therapy to promote stent patency. The editorial discusses the findings and how to best balance the risks for bleeding and thrombosis that such patients face.
Mon Mar 16, 2020 23:44
Mon Mar 16, 2020 02:00
Mon Mar 16, 2020 23:44
Mon Mar 16, 2020 23:44
Background:Chronic obstructive pulmonary disease (COPD) is characterized by frequent exacerbations.Purpose:To evaluate the comparative effectiveness and adverse events (AEs) of pharmacologic interventions for adults with exacerbation of COPD.Data Sources:English-language searches of several bibliographic sources from database inception to 2 January 2019.Study Selection:68 randomized controlled trials that enrolled adults with exacerbation of COPD treated in out- or inpatient settings other than intensive...
Mon Mar 16, 2020 23:44
In high-risk ICU patients, early palliative care consultation increased transition to DNR/DNI status
Mon Mar 16, 2020 23:44
Mon Mar 16, 2020 23:44
García-Albéniz and colleagues used observational data to model screening and estimate the value of breast cancer screening in women aged 70 to 84 years. The editorialist discusses the findings and why future physicians are likely to tailor breast screening recommendations to individual patients using risk-simulation models.
Mon Mar 16, 2020 23:44
Background:Randomized trials have shown that initiating breast cancer screening between ages 50 and 69 years and continuing it for 10 years decreases breast cancer mortality. However, no trials have studied whether or when women can safely stop screening mammography. An estimated 52% of women aged 75 years or older undergo screening mammography in the United States.Objective:To estimate the effect of breast cancer screening on breast cancer mortality in Medicare beneficiaries aged 70 to 84 years.Design:Large-scale,...
Mon Mar 16, 2020 23:44
Successful payment reform requires strong incentives for provider organizations to limit health care spending. Often overlooked in the debate over how to strengthen global budget models is that incentives to lower spending may differ markedly by organization type, even if the terms of a payment contract are the same. Understanding why incentives vary across provider organizations is critical for moving payment reform forward.
Mon Mar 16, 2020 23:44
Mon Mar 16, 2020 23:44
Mon Mar 16, 2020 23:44
Mon Mar 16, 2020 23:44
Background:Cannabis use disorder (CUD) is a growing concern, and evidence-based data are needed to inform treatment options.Purpose:To review the benefits and risks of pharmacotherapies for the treatment of CUD.Data Sources:MEDLINE, PsycINFO, Cochrane Database of Systematic Reviews, and clinical trial registries from inception through September 2019.Study Selection:Pharmacotherapy trials of adults or adolescents with CUD that targeted cannabis abstinence or reduction, treatment retention, withdrawal...
Mon Mar 16, 2020 23:44
Background:Sugar-sweetened beverage (SSB) consumption is linked to adverse health outcomes.Objective:To evaluate the impact of the 2017 Cook County, Illinois, Sweetened Beverage Tax (SBT) on the volume of taxed and untaxed beverages sold in Cook County and its 2-mile border area.Design:Pre–post intervention–comparison site difference-in-differences study.Setting:Cook County, Illinois, and St. Louis City and County, Missouri, 2016 to 2017.Participants:Universal product code–level store scanner data...
Mon Mar 16, 2020 23:44
In their article, Solomon and colleagues reported prespecified safety analyses comparing adverse events in users of low-dose methotrexate plus folic acid compared with those randomly assigned to placebo using data from the Cardiovascular Inflammation Reduction Trial. The editorialist discusses the implications of the findings for monitoring patients with rheumatic diseases treated with low-dose methotrexate.
Mon Mar 16, 2020 23:44
Mon Mar 16, 2020 23:44
Background:Low-dose methotrexate (LD-MTX) is the most commonly used drug for systemic rheumatic diseases worldwide and is the recommended first-line agent for rheumatoid arthritis. Despite extensive clinical use for more than 30 years, few data on adverse event (AE) rates derive from randomized, placebo-controlled trials, where both causality and magnitude of risk can be inferred.Objective:To investigate AE rates, risk, and risk differences comparing LD-MTX versus placebo.Design:Prespecified secondary...
Mon Mar 16, 2020 23:44
Mon Mar 16, 2020 23:44
Disclosure of an author's pertinent relationships may influence how readers assess a published work. An international group of medical journal editors proposes changes to how authors' disclosure information is collected in order to simplify the process for authors, avoid inconsistencies, and improve transparency for readers.
Mon Mar 16, 2020 23:44
Mon Mar 16, 2020 23:44
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