Objective: To assess the applicability of the piezoelectric device in translabyrinthine-approach exposure of the internal auditory canal. Methods: In three cases with vestibular schwannoma, the bone around the internal auditory canal was completely removed by means of piezosurgery. Evaluation was performed by an experienced surgeon, and a second relatively inexperienced surgeon. Results: Irrespective of surgical experience, piezosurgery proved to be a safe method for exposure of the...
Mon Mar 16, 2020 23:25
Objective: To identify demographic and audiometric predictors of bothersome tinnitus within a large clinical cohort. Study Design: Retrospective chart review. Setting: Tertiary care hospital. Patients: 51,989 English-speaking patients between 18 and 80 years of age that received initial audiometric evaluations at the Massachusetts Eye and Ear Infirmary between the years 2000 and 2016. Main Outcome Measures: Patients were categorized according to whether or not tinnitus was...
Mon Mar 16, 2020 23:25
Objective: The aim of this article is to develop and validate a disease-specific, patient-reported outcome measure for vestibular migraine. Setting: Tertiary care vestibular center. Patients: Adult patients with definite or probable vestibular migraine per Barany Society Criteria. Study Design: This was a prospective cohort study. VM-PATHI (Vestibular Migraine Patient Assessment Tool and Handicap Inventory) was developed with expert input, literature review, and patient feedback....
Mon Mar 16, 2020 23:25
Objective: USH2A-related disorders are characterised by genetic and phenotypic heterogeneity, and are associated with a spectrum of sensory deficits, ranging from deaf blindness to blindness with normal hearing. It has been previously proposed that the presence of specific USH2A alleles can be predictive of unaffected hearing. This study reports the clinical and genetic findings in a group of patients with USH2A-related disease and evaluates the validity of the allelic hierarchy model. Patients...
Mon Mar 16, 2020 23:25
Objective: Validation of the preoperative sound simulation test for vibroplasty-hearing so-called “Direct Drive Simulation” (DDS) in case of mixed hearing loss. Study Design: Retrospective data analysis. Setting: Tertiary referral center with a large hearing implant program. Main Outcome Measure: Comparison of sound impression during preoperative Direct Drive Simulation, and postoperative testing with the activated active middle ear implant (AMEI) under free-field condition and...
Mon Mar 16, 2020 23:25
Objective: The aim of the study is to examine trends in the age of patients receiving cochlear implants and to determine the effect of age on the rate of perioperative complications. Study Design: Retrospective analysis of deidentified administrative claims data from a US commercial insurance database (Optum). Patients: Individuals undergoing cochlear implantation between 2003 and 2016. Setting: US hospital and outpatient facilities serving commercially insured patients. Intervention:...
Mon Mar 16, 2020 23:25
Objective: We compared the sound transmission using different types of total ossicular replacement prostheses (TORP); we then studied the performance of a new TORP that we designed inspired by the columella, the single ossicle found in birds. Methods: Stapedial vibrations were measured on nine freshly frozen human temporal bones with laser Doppler vibrometry. We then compared the performances of eight common TORP positions or designs as well as the new silver prototype of bird-type prosthesis,...
Mon Mar 16, 2020 23:25
Objective: To analyze outcomes of cochlear implantation (CI) in prelingually-deafened, late-implanted patients. Data Sources: A search of MEDLINE and EMBASE was performed in February 2018 using SCOPUS for the intersection of “cochlear implant,” “prelingual,” “deaf,” and “delay.” Review Methods: Two independent reviewers screened all abstracts and titles for relevance, with conflicts resolved by either the primary or senior author. All articles passing this screen were subjected to a...
Mon Mar 16, 2020 23:25
No abstract available
Mon Mar 16, 2020 23:25
Objective: Cochlear implant (CI) technology and techniques have advanced over the years. There has not been the same degree of change in programming and there remains a lack of standardization techniques. The purpose of this study is to compare performance in cochlear implant subjects using experienced clinician (EC) standard programming methods versus an Artificial Intelligence, FOXTM based algorithm for programming. Study Design: Prospective, nonrandomized, multicenter study using within-subject...
Mon Mar 16, 2020 23:25
Objective: To evaluate the efficacy of on demand and low dose intratympanic gentamicin (ITG) in patients with intractable Meniere's disease (MD). Study Design: Clinical chart review. Setting: Secondary care center. Patients: Subjects with MD who failed conventional treatment and underwent on demand ITG infiltration from June 2013 to December 2018. Intervention: 0.4 to 0.5 ml of buffered gentamicin were administered through an intratympanic route. A total of 5 mg in case of...
Mon Mar 16, 2020 23:25
Objective: This study investigated the audiological and tinnitus outcomes of cochlear implantation (CI) in adults with single-sided deafness (SSD) and tinnitus. Study Design: Multicentered prospective, non-randomized intervention study. Setting: Six French CI centers. Patients: Twenty-six patients with SSD and incapacitating tinnitus (Tinnitus Handicap Inventory [THI] >58) underwent cochlear implantation. Interventions: First, CIs delivered only masking white noise stimulation...
Mon Mar 16, 2020 23:25
Objective: Closely paralleling previous radiologic studies, recent population-based prevalence data suggest sporadic vestibular schwannoma (VS) affects over one in 2,000 adults and up to one in 500 in those aged 70 years or older. Attributable to increased utilization of magnetic resonance imaging and screening protocols for asymmetrical sensorineural hearing loss, the increasing detection rate of sporadic VS fundamentally changes the perception of VS as a whole. The primary objective of the current...
Mon Mar 16, 2020 23:25
Objectives: The HiFocus Mid-Scala electrode array (HFms) is designed to sit within the scala tympani without touching either the lateral wall or the modiolus. The aim of this study was to compare the HFms to the Helix perimodiolar electrode array. Method: Two groups of recipients with Helix (n = 22 ears) and HFms (n = 29 ears) electrode arrays were retrospectively identified and matched by age at implantation and duration of severe to profound deafness. Most comfortable listening levels (M),...
Mon Mar 16, 2020 23:25
Hypothesis: Outer sulcus cell features and distribution are hypothesized to differ throughout regions of the human cochlea and between diseased and normal specimens. Background: Outer sulcus cells play a role in inner ear fluid homeostasis. However, their anatomy and distribution in the human are not well described. Methods: Temporal bone specimens with normal hearing (n = 10), Menière's disease (n = 10), presbycusis with flat audiograms (n = 4), and presbycusis with sloping audiograms...
Mon Mar 16, 2020 23:25
Objective: Cochlear implant (CI) users struggle with tasks of pitch-based prosody perception. Pitch pattern recognition is vital for both music comprehension and understanding the prosody of speech, which signals emotion and intent. Research in normal-hearing individuals shows that auditory-motor training, in which participants produce the auditory pattern they are learning, is more effective than passive auditory training. We investigated whether auditory-motor training of CI users improves complex...
Mon Mar 16, 2020 23:25
Objective: We describe our experience using the extracorporeal video microscope, the “exoscope” for repair of a temporal bone encephalocele. Method: The patient is a 69-year-old male with a right temporal lobe encephalocele herniating through a tegmen defect. He underwent definitive tegmen defect repair and bipolar cauterization of the encephalocele. The authors elected for a combined transmastoid and transtemporal approach in order to isolate the tegmen defect and provide watertight repair....
Mon Mar 16, 2020 23:25
Objective: Our objective was to compare outcomes in speech and quality of life in those undergoing cochlear implantation for single-sided deafness (SSD), with the aim to characterize the clinical impact of underlying diagnosis in the affected ear and pre-operative hearing status. Study Design: Prospective case series. Setting: Academic Cochlear Implant Center. Patients: 42 adult patients implanted with the diagnosis of SSD. Interventions: Patients were evaluated at 3-, 6-,...
Mon Mar 16, 2020 23:25
Objective: The objective of this work was to study the feasibility of minimally invasive cochlear implantation under intraoperative computerized tomography-scan coupled to navigation. Materials and Methods: Five human resin temporal bones (two adults and three children) were used. Initially, a temporal bone imaging was obtained by the intraoperative CT-scan coupled to the navigation (O-ARM). The navigation-assisted drilling began at the mastoid surface creating a conical tunnel (4–2 mm in...
Mon Mar 16, 2020 23:25
Objective: The cochlear nucleus (CN) is the target of the auditory brainstem implant (ABI). Most ABI candidates have Neurofibromatosis Type 2 (NF2) and distorted brainstem anatomy from bilateral vestibular schwannomas. The CN is difficult to characterize as routine structural MRI does not resolve detailed anatomy. We hypothesize that diffusion tensor imaging (DTI) enables both in vivo localization and quantitative measurements of CN morphology. Study Design: We analyzed 7 Tesla (T) DTI images...
Mon Mar 16, 2020 23:25
Objectives: The purpose of this study was to compare the hearing preservation outcomes of patients who received extended versus single-dose steroid therapy in cochlear implant surgery. Design: Case–control. Setting: Tertiary referral centers in Taiwan from April 2017 to 2019. Participants: A total of 70 patients aged 1 to 78 years old (mean = 18.04, standard deviation [SD] = 21.51) who received cochlear implantation via the round window approach were included in the study. Prospectively,...
Mon Mar 16, 2020 23:25
Objective: To conduct a systematic review of posterior semicircular canal dehiscence (PSCD) and to present a series of patients with PSCD with and without classic third-window symptoms. Data Sources: PubMed, Scopus, and the Cochrane Library from inception until April 2019. Case series of five patients seen in a multidisciplinary, vestibular-focused, neurotology clinic. Study Selection: Inclusion criteria: PSCD studies of symptomatology, diagnostic testing, radiology, and histopathology....
Mon Mar 16, 2020 23:25
Objective: To compare the speech perception outcomes for patients with preoperative severe versus profound hearing loss with a cochlear implant (CI). Study Design: Retrospective patient review. Setting: Cochlear implant program. Patients: Cochlear implant adult recipients (16 yr and above) having surgery between 2008 and 2015 with speech perception results and four frequency averaged severe (70–89 dBHL) or profound (90 dBHL and above) hearing loss. Prelingual deaf adults were included...
Mon Mar 16, 2020 23:25
Objective: Comprehensive molecular profiling of radioresistant and cystic vestibular schwannoma (VS) subtypes. Study Design: Our study utilized whole-exome sequencing (WES), RNA-sequencing (RNAseq), and correlated clinical data from 12 samples (2 samples of solid sporadic subtype, 8 with cystic changes, and 2 previously irradiated). Setting: Academic medical center. Patients: Patients diagnosed with VS who required surgical treatment. Inclusion: Cystic and radioresistant tumors...
Mon Mar 16, 2020 23:25
Objective: Due to the microscopic nature of otologic surgery, photographic image quality suffers from an inherent inability to maintain all the planes of surgery in focus under binocular microscopy. Our goal was to perform simple editing techniques to create improved imaging for educational and research purposes in the field of Otology and Neurotology. Patients/Design: The study was a proof of concept performed with series of cases including patients undergoing transmastoid and transcanal...
Mon Mar 16, 2020 23:25
Objective: To determine the role of neurophysiological preoperative and intraoperative parameters in providing prognostic information regarding facial nerve (FN) function at 1 year after translabyrinthine acoustic neuroma (AN) resection surgery. Study Design: Prospective observational study in a tertiary referral center. Patients treated via translabyrinthine surgical approach for sporadic AN microresection between December 2015 and 2018. Methods: Patients underwent preoperative (electroneurography-ENG,...
Mon Mar 16, 2020 23:25
Objective: Virtual reality (VR) simulation training can improve temporal bone (TB) cadaver dissection skills and distributed, self-regulated practice is optimal for skills consolidation. Decentralized training (DT) at the trainees’ own department or home offers more convenient access compared with centralized VR simulation training where the simulators are localized at one facility. The effect of DT in TB surgical training is unknown. We investigated the effect of decentralized VR simulation training...
Mon Mar 16, 2020 23:25
Hypothesis: Furosemide alters the permeability of the intrastrial fluid–blood barrier. Background: The cochlear sensory cells are protected by the blood-perilymph and intrastrial fluid–blood barriers, which hinder substances, including gadolinium-based contrast agents (GdCAs), to enter the endolymphatic space. High-dose furosemide causes transient shift of hearing thresholds and morphological changes in stria vascularis. Furosemide is also known to enhance drug-induced ototoxicity. Methods:...
Mon Mar 16, 2020 23:25
Objective: Assess the changes in Eustachian tube (ET) function (ETF) with balloon dilation of Eustachian tube (BDET). Study Design: Prospective cohort for repeated testing measures. Setting: Clinical research center. Patients: Eleven adults with at least one patent ventilation tube (VT) inserted for chronic ET dysfunction (ETD) and history of otitis media with effusion. Interventions: Subjects with evidence of moderate to severe ETD on the side with a VT underwent unilateral...
Mon Mar 16, 2020 23:25
Hypothesis: To develop a mouse model for temporary and persistent tinnitus using the gap startle paradigm. Background: Behavioral animal models for tinnitus are classified into conditioning- and reflex-based types. Gap prepulse inhibition of the acoustic startle (GPIAS) is based on the acoustic startle modification by a silent gap and gap detection deficit caused by tinnitus gap filling. Methods: We used C57BL/6J mice inherently susceptible to hearing loss and potentially predisposed...
Mon Mar 16, 2020 23:25
Objective: To evaluate and compare the STAM classification, STAMCO classification and the EAONO/JOS staging system as predictors for cholesteatoma recidivism and postoperative hearing, using a large patient cohort in our tertiary referral center. Method: Two hundred thirty-one patients who underwent surgery for primary cholesteatoma between 2003 and December 2012 were included and retrospectively classified and staged according to the STAM classification, STAMCO classification, and EAONO/JOS...
Mon Mar 16, 2020 23:25
Superior canal dehiscence (SCD) is a bony defect of the superior semicircular canal (SCC). Patients with SCD Syndrome (SCDS) may experience symptoms such as aural fullness, pulsatile tinnitus, hyperacusis, autophony, or pressure or noise-induced vertigo (1–3). The defect can be repaired in various ways, but there is potential for loss of perilymphatic fluid during transmastoid approaches that could result in postoperative sensorineural hearing loss (4–11). We hypothesize that if the procedure were...
Mon Mar 16, 2020 23:25
Objectives: The aim of this study is to investigate and compare the clinical outcomes of minimally invasive ponto surgery (MIPS) to the linear incision technique with soft tissue preservation (LIT-TP) for percutaneous bone-anchored hearing implants (BAHI). Study Design: Prospective cohort study with a historical control group. Setting: Tertiary referral center. Patients: Twenty-five patients were prospectively included in the test group. The control group consisted of 25 patients...
Mon Mar 16, 2020 23:25
No abstract available
Mon Mar 16, 2020 23:25
Objective: Several reports have suggested that the incidence of otosclerosis is declining. However, due to the limitations of epidemiologic databases within the United States, little is known about the incidence of congenital stapes footplate fixation (CSFF), much less epidemiological trends over the past 50 years. The current study was conceived to characterize the epidemiology of CSFF over the past five decades using the unique resources of the Rochester Epidemiology Project (REP). Study Design:...
Mon Mar 16, 2020 23:25
No abstract available
Mon Mar 16, 2020 23:25
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