Authors: Correa AF, Ruth KJ, Al-Saleem T, Pei J, Dulaimi E, Kister D, Collins M, Abbosh PH, Slifker MJ, Ross E, Uzzo RG, Testa JR Abstract Measurement of a tumor's overall genomic instability has gathered recent interest over the identification of specific genomic imbalances, as it may provide a more robust measure of tumor aggressiveness. Here we demonstrate the association of tumor genomic instability in the prediction of disease recurrence in patients with clinically localized clear...
Sun Mar 01, 2020 00:00
Journal of Palliative Medicine, Ahead of Print. (Source: Journal of Palliative Medicine)
Tue Mar 03, 2020 00:00
ConclusionsIn this study we found that many individuals with serious health problems experienced significant physical, emotional, and social suffering due to a lack of access to pain and symptom relief and other essential components of palliative care. Humanitarian responses should develop and incorporate palliative care and symptom relief strategies that address the needs of all people with serious illness-related suffering and their caregivers. (Source: PLoS Medicine)
Tue Mar 03, 2020 00:00
Authors: Russell AL, Kopsky DJ, Hesselink JMK Abstract Chronic sciatic pain is difficult to treat. Patients often suffer from considerable pain and are severely hampered in their everyday activities. Most pharmacologic analgesic treatments have disappointing effects, and often are limited due to adverse events. New treatments are therefore needed. Surprisingly we found fast pain reduction after applying topical phenytoin cream at the painful dermatome in a 55-year-old patient suffering...
Tue Mar 03, 2020 22:43
We report a patient with diffuse, chronic pruritus secondary to peripheral T Cell Lymphoma (PTCL) who had same day response to mirtazapine after a litany of other agents were unsuccessful. PMID: 32118497 [PubMed - as supplied by publisher] (Source: Journal of Pain and Palliative Care Pharmacotherapy)
Tue Mar 03, 2020 22:43
Authors: McPherson T, Fontane P, Bilger R Abstract Topical pain therapy offers several potential advantages as an alternative or adjunct to oral analgesic therapy, including decrease in concurrent oral drug use, lower abuse potential, lower side effects and toxicity, and localized effects. A variety of drugs and cream bases designed to promote transdermal delivery allow for unlimited customization of compounded topical pain creams (CTPC) for specific patients. The purpose of this study...
Tue Mar 03, 2020 22:43
Authors: Kachrani R, Santana A, Rogala B, Pawasauskas J Abstract Chemotherapy-induced peripheral neuropathy (CIPN) is a chronic symptom associated with chemotherapy treatment. Symptoms and severity vary based on chemotherapeutic agent used and dose. At present, effective options for the prevention and treatment of CIPN are inadequate and clinical guidance is limited. Unknown mechanism of action, lack of efficacy in many traditional neuropathic pain medications, and inconsistent evidence...
Tue Mar 03, 2020 22:43
ConclusionPML remains a rare complication of ofatumumab treatment. Nevertheless, clinicians should maintain a certain level of suspicion for this risk, especially in the context of patients presenting with clinical syndromes of encephalopathy and focal neurologic deficits. Furthermore, research to better our understanding of the manifold links between B-cell function and JCV regulation could provide valuable information for use in the future prevention and treatment of PML. (Source: Journal of Medical...
Tue Mar 03, 2020 00:00
(Source: Memo - Magazine of European Medical Oncology)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Sun Mar 01, 2020 00:00
CONCLUSIONS: This meta-analysis demonstrated that fan therapy may be an effective intervention for dyspnea at rest in patients with terminal cancer. PMID: 32114788 [PubMed - in process] (Source: The American Journal of Hospice and Palliative Care)
Tue Mar 03, 2020 13:32
We describe a strategy for difficult conversations that is tailored for use by surgeons and modeled on surgical principles. (Source: Current Surgery Reports)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Tue Mar 03, 2020 00:00
We describe the adaptation of MCP-WTC and the application of this intervention to meet the unique needs of those exposed to the terrorist attacks of September 11, 2001 (9/11), participated in the rescue, recovery, and clean-up effort at Ground Zero, and were diagnosed with WTC-related cancer. We highlight the novel aspects of this intervention which have been designed to facilitate meaning-making in the context of the patient's response to 9/11 and subsequent diagnosis of cancer. SIGNIFICANCE...
Mon Mar 02, 2020 00:00
Palliative care is underutilized and affects healthcare costs in ruptured abdominal aortic aneurysms
Palliative care (PC) is a multidisciplinary approach to managing patients who are seriously ill. The American College of Surgeons has recognized and advocated for PC, and PC improves symptom management and quality of life,1 reduces healthcare costs,2 and improves physician-patient communication.3 (Source: Surgery)
Mon Mar 02, 2020 00:00
The objectives of this study were to obtain patient evaluations of the content, structure, and delivery modality of Meaning-Centered Pain Coping Skills Training (MCPC), a novel psychosocial intervention for patients with advanced cancer and pain. MCPC aims to help patients connect with valued sources of meaning in their lives (e.g., family relationships), while providing training in evidence-based cognitive and behavioral skills (e.g., guided imagery) to reduce pain. METHODS: Semi-structured...
Mon Mar 02, 2020 00:00
Journal of Palliative Medicine, Ahead of Print. (Source: Journal of Palliative Medicine)
Mon Mar 02, 2020 00:00
CONCLUSIONS: Aggressive end-of-life care is common for patients who have discussed the withdrawal of mechanical ventilation. There are significantly higher rates of symptom relief medications administered in patients who have been withdrawn from mechanical ventilation. PMID: 32115985 [PubMed - as supplied by publisher] (Source: The American Journal of Hospice and Palliative Care)
Sun Mar 01, 2020 00:00
CONCLUSION: There is a strong association between the 2 markers used in the measurement of functional decline-Frailty measured by CFS and Palliative Performance Score measured by PPS. Frailty and palliative performance scores can strongly predict HR and survivability of the long-term care resident. PMID: 32116000 [PubMed - as supplied by publisher] (Source: The American Journal of Hospice and Palliative Care)
Sun Mar 01, 2020 00:00
CONCLUSIONS: Primary family caregivers of HBPC need support and must learn home care skills by means of the holistic approach. It is crucial to establish assessment tools for caregivers' preparedness for HBPC, including biopsychosocial and cultural considerations. PMID: 32116010 [PubMed - as supplied by publisher] (Source: The American Journal of Hospice and Palliative Care)
Sun Mar 01, 2020 00:00
This article will offer PC providers 5 useful tips for implementing ACP in outpatient settings utilizing the EHR. PMID: 32115994 [PubMed - as supplied by publisher] (Source: The American Journal of Hospice and Palliative Care)
Sun Mar 01, 2020 00:00
Burnout is common in physicians who care for patients with serious illness, with rates greater than 60% in some studies. Risk factors for burnout include working on small teams and/or in small organizations, working longer hours and weekends, being younger than 50 years, burdensome documentation requirements, and regulatory issues. Personal factors that can protect against burnout include mindfulness, exercise, healthy sleep patterns, avoiding substance abuse, and having adequate leisure time. Institutional...
Mon Mar 02, 2020 00:00
Deepika Phogat, Venkatesan Manu, Ritu MehtaJournal of Marine Medical Society 2020 22(1):69-72 Introduction: The spectrum of mediastinal masses comprises of lesions of various origins. Although the clinicoradiological findings and the location of these lesions within different mediastinal compartments help narrow down the differentials, tissue diagnosis remains the gold standard for diagnosis. The image-guided percutaneous transthoracic fine-needle aspiration cytology (FNAC) and/or core-needle biopsy...
Tue Mar 03, 2020 00:00
Shalendra Singh, S Ushakiran Singh, Deepak Dwivedi, Kaminder Bir KaurJournal of Marine Medical Society 2020 22(1):94-95 Fat embolism is a life-threatening complication of trauma. Early recognition and prompt treatment help in reducing morbidity. We report a case of fracture right shaft of the femur in a young adult which was being managed conservatively in the hospital ward and subsequently developed fat embolism syndrome (FES) followed by acute respiratory distress syndrome. All clinical parameters...
Tue Mar 03, 2020 00:00
Neha Sharma, Rohith R Pisharody, Chaitanya Kodange, Kaushik Chatterjee, Sunil Goyal, Priyadarshee Patra, Puneet KhannaJournal of Marine Medical Society 2020 22(1):5-8 In the military parlance, screening implies evaluation or investigation of something as part of a methodical survey, to assess suitability for a particular role or purpose. Psychological screening to assess fitness for induction into military service has a long and tumultuous history. From being limited to tests of intelligence, the...
Tue Mar 03, 2020 00:00
Abdul Nasser, Trishna TaralkarJournal of Marine Medical Society 2020 22(1):81-83 Corticosteroid hormones play a significant role in the control of vascular smooth muscle tone by their permissive effects in potentiating vasoactive responses to vasoconstrictors. Inadequate cortisol response in stress conditions such as the perioperative period, despite normal serum cortisol concentrations is defined as relative adrenal insufficiency. We report a patient who underwent vaginal hysterectomy and developed...
Tue Mar 03, 2020 00:00
Saurabh Bobdey, Sougat RayJournal of Marine Medical Society 2020 22(1):9-12 In the realm of infectious diseases, a global outbreak is a worst-case scenario. In the past, outbreaks such as plague, Spanish flu, severe acute respiratory syndrome, and H1N1 (swine flu) have caused great human suffering. The novel coronavirus, christened as Covid-19, is a zoonotic disease which originated from the Wuhan province in China and spread like wildfire killing people and devastating the global economy. Mammoth...
Tue Mar 03, 2020 00:00
Sougat Ray, Sunil GoyalJournal of Marine Medical Society 2020 22(1):1-4
Tue Mar 03, 2020 00:00
Sanjay Maurya, Vipin V Nair, Onkar Singh, SK SinghJournal of Marine Medical Society 2020 22(1):13-17 Background: Limbs are most commonly involved in combat trauma. There is insufficient data on limb injuries sustained in the combat zone of Indian Armed Forces. This study aims to analyze limb injuries in 166 cases at a tertiary care center in counter insurgency operational area. Materials and Methods: All casualties with limb injuries who presented to the center from January 2014 to December 2019...
Tue Mar 03, 2020 00:00
Sandeep Gupta, Srujana BhaskarJournal of Marine Medical Society 2020 22(1):75-76
Tue Mar 03, 2020 00:00
Dinesh Kumar Kalra, Sanjay Pratap Singh, Ajay Kumar Sahni, Naveen Grover, Mahadevan Kumar, Deepti KalraJournal of Marine Medical Society 2020 22(1):18-24 Background: Metallo-beta-lactamases (MBLs)-producing Gram-negative bacilli (GNB) are one of the significant multidrug-resistant pathogens causing healthcare-associated infection (HAI) worldwide. The present study aimed to compare the phenotypic and molecular methods to detect MBLs-producing GNB causing HAI, namely Acinetobacter baumannii, Escherichia...
Tue Mar 03, 2020 00:00
Vikas Kulshrestha, Rishi Dhillan, Munish SoodJournal of Marine Medical Society 2020 22(1):87-90 Profunda femoris artery injury following osteosynthesis of the proximal femur fracture is a rare complication and is usually caused by iatrogenic trauma or rarely due to bony spikes. Presentation can be delayed because of nonspecific features such as pain, swelling, anemia, fever, and hematoma. We report a case of posttraumatic profunda femoris aneurysm which presented more than a year after surgery...
Tue Mar 03, 2020 00:00
Gaurav Mittal, Mohammed Schezan Iqbal, Yogesh Sharma, Manish Prasad, Nishant LambaJournal of Marine Medical Society 2020 22(1):25-29 Context: Osteoporosis is a commonplace metabolic disorder affecting millions of women worldwide. This study highlights the prevalence of various risk factors associated with the development of osteoporosis in postmenopausal women in the Indian population and the determination of risk of fractures in the same using questionnaire-based tools. Aims: The aim of the study...
Tue Mar 03, 2020 00:00
Amit Bahuguna, Disha Dabbas, Prince Yuvraj SinghJournal of Marine Medical Society 2020 22(1):101-102
Tue Mar 03, 2020 00:00
Sachin Taneja, Deboleena Mukherjee, Kirti TyagiJournal of Marine Medical Society 2020 22(1):30-34 Background and Aim: This study deals with isocentric variations along with the setup reproducibility and determines the random and systematic errors in a cohort of 25 (females) left-sided breast cancer patients treated with megavoltage X-rays using an online electronic portal imaging (EPI) protocol. Materials and Methods: This is a hospital-based cross-sectional observational study which was carried...
Tue Mar 03, 2020 00:00
Elias AdikwuJournal of Marine Medical Society 2020 22(1):62-68 Background and Objectives: The clinical use of cyclophosphamide-doxorubicin (CP-DOX) in breast cancer treatment may cause hepatotoxicity. This study assessed the protective effect of alpha-lipoic acid (ALA) against hepatotoxicity induced by CP-DOX in albino rats. Materials and Methods: Thirty-six adult male albino rats were randomized into six groups (A-F) of n = 6. Group A (control) was treated intraperitoneally (ip) with 0.3 mL of...
Tue Mar 03, 2020 00:00
Yogesh Sharma, Vivek Mathew Philip, Saurabh SharmaJournal of Marine Medical Society 2020 22(1):35-39 Background: Oral nonsteroidal anti-inflammatory drugs have been used in the management of musculoskeletal pain due to inconsistent skin penetration of topical formulations. The quick penetrating solution of diclofenac is a novel topical solution of diclofenac diethylamine (4.64%), which has increased skin penetration. The present study was designed to compare the efficacy and safety of quick penetrating...
Tue Mar 03, 2020 00:00
Rajat BandyopadhyayJournal of Marine Medical Society 2020 22(1):73-74
Tue Mar 03, 2020 00:00
Vivek Aggarwal, VK Sashindran, Puja DudejaJournal of Marine Medical Society 2020 22(1):40-43 Aim and Objectives: This study aimed to assess the morbidity profile and health care needs of elderly veterans and their elderly dependants residing in an urban gated society. Methodology: This cross -sectional observational study was done by house to house survey of veterans and their dependents more than 60 years residing in gated urban cooperative housing society. A predesigned questionnaire to assess...
Tue Mar 03, 2020 00:00
Meghna Barmase, Deepa DeewanJournal of Marine Medical Society 2020 22(1):77-80 Intramural pregnancy is a very rare form of ectopic gestation. There are very few cases published in the literature. The management strategies differ with respect to severity of presentation, average gestational age, and viability of the pregnancy at the time of diagnosis. Here, we report a case of intramural pregnancy, which was managed conservatively with review of data on this rare condition, with respect to its etiology,...
Tue Mar 03, 2020 00:00
Preema Sinha, Sunmeet Sandhu, Jasvinder Kaur Bhatia, N Anand, Arun Kumar YadavJournal of Marine Medical Society 2020 22(1):44-49 Background: Accurate diagnosis of immune-mediated dermatological diseases requires an evaluation of clinical, histopathological, and immunofluorescence findings. Immunofluorescence detects antibodies bound to antigens in tissue and in circulating body fluids. It acts as a valuable adjunct to clinical and histopathological diagnosis in patients of autoimmune bullous diseases...
Tue Mar 03, 2020 00:00
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