Contributors : Giorgia Alvisi ; Simone Puccio ; Jolanda Brummelman ; Elisa Paoluzzi Tomada ; Emilia Mazza ; Enrico LugliSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAnti-tumor immune responses are counteracted by CD4+ regulatory T (Treg) cells in the tumor micronenvironment, but the molecular mechanisms responsible for the enhanced suppressive activity of Tregs are poorly defined. High-dimensional single cell profiling of millions of single CD4+ and CD8+...
Tue Mar 03, 2020 05:00
Contributors : Hailong Ruan ; Ke ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRecently, cytoophidium, a non-membrane-bound intracellular polymeric structure, has been shown to exist in various organisms, including tumor tissues, but its function and mechanism have not yet been examined. Examination of cytoophidia-assembled gene IMPDH and CTPS mRNA levels showed that only IMPDH1 levels were significantly higher in the clear cell renal cell carcinoma (ccRCC)....
Tue Mar 03, 2020 05:00
Contributors : Mirjana Kessler ; Karen Hoffmann ; Hans Mollenkopf ; Thomas Meyer ; Hilmar BergerSeries Type : Expression profiling by arrayOrganism : Homo sapiensHigh-grade serous ovarian cancer (HGSOC) creates a unique clinical challenge due to late detection, limited therapeutic options and wide-spread resistance to chemotherapy, all of which lead to very low survival rates. It is now widely recognized that this cancer emerges as metastasis from the fallopian tube and the lack of suitable in vitro...
Tue Mar 03, 2020 05:00
PD-1 blockade therapy has revolutionized cancer treatments. However, a substantial population of patients is unresponsive. To rescue unresponsive patients, the mechanism of unresponsiveness to PD-1 blockade therapy must be elucidated. Using a 'bilateral tumor model' where responsive and unresponsive tumors were inoculated into different sides of the mouse belly, we demonstrated that unresponsive tumors can be categorized into two groups: with and without systemic immunosuppressive property (SIP)....
Tue Mar 03, 2020 01:00
AbstractA major limitation in the pharmacological treatment of clinically detectable primary cancers and their metastases is their limited accessibility to anti-cancer drugs (cytostatics, inhibitory antibodies, small-molecule inhibitors) critically impairing therapeutic efficacies. Investigations on the tissue distribution of such drugs are rare and have only been based on fresh frozen material or methanol-fixed cell culture cells so far. In this paper, we expand the detection of cisplatin-induced...
Tue Mar 03, 2020 00:00
Authors: Disha Varijakzhan Chou-Min Chong Aisha Abushelaibi Kok-Song Lai Swee-Hua Erin Lim Middle Eastern countries are primarily known for their dry sand deserts; however, they have a wider physiographic range which includes upland plateau and mountain ranges. The Middle East is home to various types of plants, such as Phoenix dactylifera (date palm tree), Scrophularia striata (herbaceous plants), and Opuntia ficus-indica (cactus). These plants have been found to have various...
Tue Mar 03, 2020 00:00
Authors: Heba M. Abo-Salem Amr Nassrallah Ahmed A.F. Soliman Manal S. Ebied Mohamed E. Elawady Sayeda A. Abdelhamid Eslam R. El-Sawy Yazeed A. Al-Sheikh Mourad A. M. Aboul-Soud The present work aims to design and synthesize novel series of spiro pyrazole-3,3’-oxindoles analogues and investigate their bioactivity as antioxidant and antimicrobial agents, as well as antiproliferative potency against selected human cancerous cell lines (i.e., breast, MCF-7; colon, HCT-116...
Tue Mar 03, 2020 00:00
ConclusionOn the review of contemporary literature, no significant difference was found in rates of postoperative VTE or bleeding complications between patients receiving extended duration heparin VTE prophylaxis and those receiving inpatient prophylaxis after open abdominopelvic surgery for malignancy.This raises the question of how extended duration prophylaxis has become common practice in this population, and whether this needs to be re-evaluated. (Source: Perioperative Medicine)
Tue Mar 03, 2020 00:00
. (Source: Health Communication)
Tue Mar 03, 2020 00:00
In this study, 40 patients with preeclampsia and 32 gestational age matched normotension pregnant women were recruited. Using quantitative real-time polymerase chain reaction (qRT-PCR), we found higher expression of GAS5 in placenta of preclamsia affected women. The level of GAS5 existed strongly in correlation with Thrombin Time indicating coagulation function and other clinical parameters by Pearson correlation analysis. Then we constructed the GAS5 lentivirus expression vectors and transfected...
Tue Mar 03, 2020 00:00
Recent studies suggested that microRNA-3127 (miR-3127) was dysregulated in multiple tumor types and has important roles in tumorigenesis and cancer progression. However, its biological roles and the mechanisms that regulate its expression in bladder cancer (BCA) remain to be determined. The expression level of miR-3127 was measured in BCA tissues and its cellular functions were examined using both in vitro and in vivo experiments. The interaction between miR-3127 and long non-coding RNA (lncRNA)...
Tue Mar 03, 2020 00:00
AbstractGenomic technologies are having an increasing impact across medicine, including primary care. To enable their wider adoption and realize their potential, education of primary health-care practitioners will be required. To enable the development of such resources, understanding where GPs currently access genomic information is needed. One-hundred fifty-nine UK GPs completed the survey in response to an open invitation, between September 2017 and September 2018. Questions were in response to...
Tue Mar 03, 2020 00:00
Prostate Cancer and Prostatic Diseases, Published online: 03 March 2020; doi:10.1038/s41391-020-0211-9Phase 2 trial of monoamine oxidase inhibitor phenelzine in biochemical recurrent prostate cancer (Source: Prostate Cancer and Prostatic Diseases)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Tue Mar 03, 2020 00:00
AbstractTreatment switching frequently occurs in clinical trials due to ethical reasons. Intent-to-treat analysis without adjusting for switching yields biased and inefficient estimates of the treatment effects. In this paper, we propose a class of semiparametric semi-competing risks transition survival models to accommodate two-way time-varying switching. Theoretical properties of the proposed method are examined. An efficient expectation –maximization algorithm is derived to obtain maximum likelihood...
Tue Mar 03, 2020 00:00
Oncolytic viruses are of growing interest to cancer researchers and clinicians, due to their selectivity for tumor cells over healthy cells and their immunostimulatory properties. The immune response to an oncolytic virus plays a critical role in treatment efficacy. However, uncertainty remains regarding the circumstances under which the immune system either assists in eliminating tumor cells or inhibits treatment via rapid viral clearance, leading to the cessation of the immune response. In this...
Tue Mar 03, 2020 00:00
ConclusionThe present study showed that both TSS and eTSS increased on a yearly basis. We believe that the present study will be the basis of future epidemiological investigations of pituitary surgery. (Source: Acta Neurochirurgica)
Tue Mar 03, 2020 00:00
ConclusionsPrognosis of early-stage lung adenocarcinoma treated with sublobar resection was not inferior to that treated with lobectomy in carefully selected cases. Further investigations, including randomized controlled trials, are needed to identify the equivalent oncologic efficacy of sublobar resections. (Source: Indian Journal of Thoracic and Cardiovascular Surgery)
Tue Mar 03, 2020 00:00
ConclusionSignificant prognostic factors differ among patients stratified by the presence of surgical resection for SSTs. Preoperative CEA level in surgical candidates and initial treatment response in non-surgical patients were the independent factors associated with OS. Surgical candidates are expected to have more favorable survival than patients with unresectable SSTs. (Source: General Thoracic and Cardiovascular Surgery)
Tue Mar 03, 2020 00:00
Somatic Mutational Analysis by Exome Sequencing Endometrial Carcinosarcomas (study page |release notes) (Source: dbGaP, the database of Genotypes and Phenotypes)
Mon Mar 02, 2020 20:00
On the occasion of the 90th anniversary of National Council on Radiation Protection and Measurements (NCRP) and its 55th anniversary since being Congressionally Chartered, the theme of “Providing Best Answers to Your Most Pressing Questions about Radiation” is most appropriate. The question proposed here is, “What are the new frontiers for the NCRP with its breadth of talent and expertise in the rapidly evolving era of precision medicine?” Three closely related themes are presented for new applications...
Tue Mar 03, 2020 10:41
The process of nuclear fission, which was discovered in 1938, opened the door to the production of nuclear weapons, which were used in 1945 by the United States against Japan in World War II, and to the detonation of>500 nuclear weapons tests in the atmosphere by the United States, the former Soviet Union, the United Kingdom, China, and France from 1946–1980. Hundreds of radionuclides, most of them short-lived, were produced in the atmospheric tests. The radioactive clouds produced by the explosions...
Tue Mar 03, 2020 10:41
(Source: Critical Reviews in Food Science and Nutrition)
Tue Mar 03, 2020 09:35
ConclusionSMI-BF grade was more affected by vessels of larger inner diameter, while CEUS-EI was more affected by vessels of smaller inner diameter. SMI alone is sufficient for evaluation of blood flow in thyroid nodules, and the diagnostic value of SMI-BF of the periphery is comparable to CEUS hypoenhancement to differentiate thyroid cancer. (Source: Journal of Medical Ultrasonics)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory...
Tue Mar 03, 2020 00:00
The diagnostic performance of 18F-sodium fluoride positron emission tomography/computed tomography (PET/CT) (NaF), 18F-fluorocholine PET/CT (FCH) and diffusion-weighted whole-body magnetic resonance imaging (DW-M... (Source: BMC Medical Imaging)
Mon Mar 02, 2020 01:00
Introduction: The present study was conducted to compare the efficacy and side effects of Spironolactone and Eplerenone in management of ascites due to liver cirrhosis. Materials and methods: 105 patients of ascites with liver cirrhosis were randomized into three groups of 35 patients each. Group I was given Spironolactone 100 mg, group II was given Eplerenone 100 mg and group III was given Eplerenone 50 mg. All patients were put on salt-restricted diet (less than or equal to 2 g of sodium)...
Tue Mar 03, 2020 08:05
Conclusion Annual MRI strategy demonstrated a satisfactory performance in the surveillance of HCC, in terms of detecting most of the lesions in earlier curable stages and indicating high sensitivity with no additional benefit of biannual AFP. New risk stratified screening algorithms may further increase the yield of HCC surveillance among cirrhotic patients. (Source: European Journal of Gastroenterology and Hepatology)
Tue Mar 03, 2020 08:05
Conclusion Our study supports a strategy to avoid a relevant proportion of rectal cancer cases through a combined reduction of alcohol consumption and cigarette smoking. (Source: European Journal of Gastroenterology and Hepatology)
Tue Mar 03, 2020 08:05
Conclusion: There is a positive correlation between IMP3 expression and TNM stages of the pancreatic cancer. Higher expression of IMP3 on EUS-FNA specimens can suggest poorer prognosis. (Source: European Journal of Gastroenterology and Hepatology)
Tue Mar 03, 2020 08:05
Conclusions The application of this predictive model in patients with anastomotic leaks proved to be valid in a different cohort from that in which it was derived. Its usefulness in clinical practice may be anticipated, favoring stenting in patients with a chance of success>50%. However, we must be cautious in patients with a lower probability of success and a case-by-case decision should be made. (Source: European Journal of Gastroenterology and Hepatology)
Tue Mar 03, 2020 08:05
In this study, we investigated the role of hemogram parameters in predicting advanced liver fibrosis in chronic HCV patients. Methods Patients who underwent percutaneous liver biopsy due to chronic HCV infection between 01.01.2011 and 01.08.2019 were included in this study. Liver biopsies were evaluated according to Ishak method. Patients were classified into those with mild fibrosis (F ≤ 2) and advanced fibrosis (F ≥ 3). Hemogram parameters of these groups were compared and their efficacy in...
Tue Mar 03, 2020 08:05
In conclusion, this is the largest report of MCL pts. treated with 90Y-IT to date. 90Y-IT was most often used as consolidation after first- and second-line chemotherapy and may improve the results achieved using chemoimmunotherapy alone. However, the results are less encouraging compared to treatment with small molecules such as ibrutinib. (Source: Annals of Hematology)
Tue Mar 03, 2020 00:00
Dysphagia is a common and serious complication after (chemo)radiotherapy (CRT) for head-and-neck cancer (HNC) patients. Prophylactic swallowing exercises (PSE) can have a significantly positive effect on post-... (Source: Trials)
Mon Mar 02, 2020 01:00
Behavior change is not simple, and the introduction of guidelines or protocols does not mean that they will be followed. As such, implementation strategies are vital for the uptake and sustainability of change...
Tue Mar 03, 2020 02:00
Authors: Hemati M, Rasouli Nejad Z, Shokri MR, Ghahremanfard F, Mir Mohammadkhani M, Kokhaei P Abstract Interleukin 27 (IL-27) belongs to IL-12 cytokine family, has shown anti-tumor potential in several solid tumors, as well as hematologic malignancies. IL-27 can inhibit tumor growth and progression through direct and indirect mechanisms, such as inhibition of proliferation, angiogenesis, induction of apoptosis in tumor cells, and anti-tumor immune response. B-CLL is characterized by remarkable...
Fri Feb 28, 2020 00:00
This study investigated the effects of lipopolysaccharide (LPS), a major component of Gram-negative bacilli, on proliferation, migration and invasion of prostate cancer cells and the protective effects of 1α,25(OH)2D3 (calcitriol). PC-3 and DU145 cells were stimulated with LPS (2.0 μg/mL) in the presence or absence of 1α,25(OH)2D3 (100 nM). Our results shown that 1α,25(OH)2D3 reduced the proportion of S phase cells in LPS-stimulated PC-3 and DU145 cells, and down-regulated the nuclear protein levels...
Fri Feb 28, 2020 00:00
Corrigendum to "Tanshinone IIA ameliorates the bleomycin-induced endothelial-to-mesenchymal transition via the Akt/mTOR/p70S6K pathway in a murine model of systemic sclerosis" [Int. Immunopharmacol. 77 (2019) 105968]. Int Immunopharmacol. 2020 Feb 27;:106318 Authors: Jiang Y, Hu F, Li Q, Shen C, Yang J, Li M PMID: 32115350 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Thu Feb 27, 2020 00:00
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