Abstract Animal models are a significant component of biomedical research and play an important role in translational studies. Traditionally, rodent models have been the mainstay and principal choice of researchers but in recent years, there have been significant changes in the landscape of animal modeling. For example, newer techniques have greatly expanded the use and successful application of large animal models such as pigs for translational studies. The evolving types and...
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Conclusions: Diagnosis and treatment of sBCC in a single visit is an efficient and cost-effective management option for those who are proficient in identifying low-risk sBCC. PMID: 32116084 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Tue Mar 03, 2020 13:10
Conclusion: Use of 5-ASA was not associated with a lowered cancer risk in Chinese IBD patients. Addition of statin/aspirin provided no additional benefit.Key summaryInflammatory bowel diseases (IBD) including Crohn's disease and ulcerative colitis are associated with increased risk of both intestinal and extra- intestinal cancers.Various medications including 5-aminosalicylate acid (5-ASA), statins and aspirin have been studied for their chemoprevention effects. However, most studies focused on colorectal...
Tue Mar 03, 2020 12:22
Authors: Liu F, Yan JR, Chen S, Yan GP, Pan BQ, Zhang Q, Wang YF, Gu YT Abstract Currently, fluorescent imaging is one of the most promising diagnostic approaches for facile detection of cancers in situ in thanks to a fluorescent probe. Two novel polypeptide-based fluorescent probes for different biomarkers to cancers are reported here. These probes focused on tyrosine-isoleucine-glycine-serine-arginine (YIGSR) and arginine-glycine-aspartic (RGD), which receptors play an important role...
Tue Mar 03, 2020 12:04
Authors: Zhang X, Yu Y, Shen J, Qi W, Wang H Abstract A new type of nanocomposite composed of carboxylated single-walled carbon nanotubes (CNTs-COOH), reduced graphene oxide (rGO), bovine serum albumin-Ag hybride (Ag@BSA), and poly(3,4-ethylenedioxythiophene) (PEDOT) was fabricated to develop an ultrasensitive electrochemical platform for the detection of carcinoembryonic antigen (CEA) as a model of biomarkers. Two steps are involved for the fabrication of the organic/inorganic nanocomposites....
Tue Mar 03, 2020 12:04
Authors: Wang J, Wang H, Cao W, Zhang Q, Zhong W Abstract Sensitive electrochemiluminescence (ECL) bioanalysis could be achieved by exploring the amplification principle or strategy. This work described the first proof-of-concept study for coupling dual coreactants (K2S2O8 and H2O2) with localized surface plasmon resonance (LSPR) of silver nanoparticles (AgNPs) enhancement as an effective signal amplification strategy for ECL immunosensor. Specifically, AgNPs as an excellent conductor and...
Tue Mar 03, 2020 12:04
In this study, we use DNA MUC1 aptamer as a protective agent and target molecule in the synthesis of ultra-small fluorescent gold nanoclusters (MUC1-AuNCs) via a simple one-step method. MUC1-AuNCs exhibited red fluorescence emission with excellent stability over a wide pH range and under strong illumination. Confocal images showed that the synthesized MUC1-AuNCs efficiently targeted mucin overexpressing 4T1 cancer cells, but were not observed in 293T normal cells. Furthermore, the MUC1-AuNCs had...
Tue Mar 03, 2020 12:04
Authors: Li Z Abstract Hydrogen peroxide (H2O2) plays an important role in intracellular signal transduction pathway. It has been closely associated with the occurrence and development of tumors as well as the recent studied ferroptosis. In this work, monitoring the H2O2 level during the ferroptosis process in living cancer cells was achieved by using a new practical fluorescence probe, HP, accompanying with a series of property evaluation and model construction. As a practical tool, HP...
Tue Mar 03, 2020 12:04
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