From strawberry gingivitis to palatal perforation: the clinicopathological spectrum of oral mucosal lesions in granulomatosis with polyangiitis

From strawberry gingivitis to palatal perforation: the clinicopathological spectrum of oral mucosal lesions in granulomatosis with polyangiitis:

Abstract

Background

Reports of oral manifestations of granulomatosis with polyangiitis usually refer to single‐case reports; “strawberry gingivitis” has been increasingly reported.

Objective

To study the clinicopathological findings of four patients in which the diagnosis of granulomatosis with polyangiitis was suspected from the observation of their oral lesions and compare these to existent data.

Methods

Retrospective study of a case series.

Results

One patient presented typical “strawberry gingivitis” with localized disease and negative ANCA results. Two patients presented rapidly growing oral ulcers associated with systemic compromise and high ANCA levels. One patient presented with a chronic granulomatous lesion that leaded to palatal perforation.

Conclusion

Oral manifestations of granulomatosis with polyangiitis may vary from rapidly evolving lesions in acutely ill patients to chronic and locally destructive lesions in slowing developing disease. These differences are also evident in the histopathological findings.