Abstract Background Researchers often rely on trial participants to self-report clinical outcomes (for example, fractures, re-operations). Little information exists as to the ‘accuracy’ of participant-reported clinical outcomes, particularly in randomised controlled trials (RCTs). To help address this evidence gap, we report four case studies, nested within different RCTs where participant-reported clinical outcome data were compared...
Abstract Background Hospital to home transition care is a most stressful period for stroke survivors and their caregivers to learn self-management of stroke-related health conditions and to engage in rehabilitation. Health coaching has been identified as a strategy to enhance self-management of poststroke care at home. However, interventions in this field that are informed by a health coaching framework are scarce. This study will...
Abstract Background Single-sided deafness (SSD) describes the presence of a unilateral severe to profound sensorineural hearing loss. SSD disrupts spatial hearing and understanding speech in background noise. It has functional, psychological and social consequences. Potential options for rehabilitation include hearing aids and auditory implants. Benefits and harms of these interventions are documented inconsistently in the literature,...
Abstract Background Acute respiratory distress syndrome (ARDS) is caused by rapid-onset (within hours) acute inflammatory processes in lung tissue, and it is a life-threatening condition with high mortality. The treatment of ARDS to date is focused on the prevention of further iatrogenic damage of the lung rather than the treatment of the initial inflammatory process. Several preclinical studies have revealed a beneficial effect...
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Abstract An improved model for investigating dual effects of vegetation density variations and groundwater level fluctuations on water transport and dissipation in the soil-plant-atmosphere continuum (SPAC) of raised field wetlands was developed through combining the HYDRUS and the dual crop coefficient models. The results showed the following: (1) the improved model was reliable for soil water and evapotranspiration simulation. For soil water, the coefficient of determination (R2)...
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Summary Ignaz Semmelweis’ (1818–1865) discovery of the endemic causes of febris puerperalis is a striking example of the role of pathology in medicine. Transdisciplinarity encounters Semmelweis’ biography, which is neither linear nor totally focused on medicine. He completed the philosophicum (artisterium), studying the septem artes liberales (1835–1837) in Pest, comprising humanities and natural science. After moving to Vienna, he began to study law, but turned to medicine as...
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