Exposure to critical incidents and hence potentially traumatic events is endemic in law enforcement. The study of law enforcement officers’ experience of moral injury and their exposure to potentially morally injurious incidents, and research on moral injury’s relationship with different forms of traumatization (e.g. compassion fatigue, post-traumatic stress disorder) are in their infancy. The present study aims to build on prior research and explores the role of moral injury in predicting post-traumatic...
07:02
Mothers can recognize their own children by body odor. Besides signaling familiarity, children’s body odors may provide other information relevant to maternal caregiving behavior, such as the child’s developmental status. Thus, we explored whether mothers are able to classify body odors on pre- vs. postpubertal status above chance levels. In total, 164 mothers were presented with body odor samples of their own and four unfamiliar, sex-matched children who varied in age (range 0–18 years). Pubertal...
07:02
Previous research has shown that parental support has beneficial effects on the psychological well-being of adolescents. Going beyond prior research, the present study made distinctions between information, emotional, and financial parental support and examined adolescents from United States (N = 1,002), China (N = 1,172), South Korea (N = 3,993), and Japan (N = 1,112). The frequency and impact of different types of perceived parental support on adolescents’ positive self-belief and distress levels...
Tue Mar 03, 2020 16:01
Authors: Annese T, Ingravallo G, Tamma R, De Giorgis M, Maiorano E, Perrone T, Albano F, Specchia G, Ribatti D Abstract Mantle cell lymphoma (MCL) is an aggressive and rare B-cell non-Hodgkin lymphoma classified in two clinicopathological subtypes according to SOX11 expression and mutation state of immunoglobulin variable region heavy chain (IgVH) gene. The transcription factor SOX11, overexpressed in 78%-93% of MCL patients, plays a central role in modulating tumor microenvironment prosurvival...
Fri Feb 28, 2020 00:00
Authors: Barrueto L, Caminero F, Cash L, Makris C, Lamichhane P, Deshmukh RR Abstract The interaction of the host immune system with tumor cells in the tissue microenvironment is essential in understanding tumor immunity and development of successful cancer immunotherapy. The presence of lymphocytes in tumors is highly correlated with an improved outcome. T cells have a set of cell surface receptors termed immune checkpoints that when activated suppress T cell function. Upregulation of...
Wed Feb 26, 2020 00:00
Authors: Jiang X, Wang S, Zhou C, Wu J, Jiao Y, Lin L, Lu X, Yang B, Zhang W, Xiao X, Li Y, Wu X, Wang X, Chen H, Zhao L, Fei Y, Yang H, Zhang W, Zhang F, Chen H, Zhang J, Li B, Yang H, Wang J, Liu X, Zhang X Abstract The pathogenesis of rheumatoid arthritis (RA), a systemic autoimmune disease characterized by autoreactive T-cell accumulation and pro-inflammatory cytokine overproduction, is unclear. Systematically addressing T-cell receptor (TCR) repertoires of different CD4+ T-cell subsets...
Thu Feb 27, 2020 00:00
Authors: Rothan HA, Byrareddy SN Abstract Coronavirus disease (COVID-19) is caused by SARS-COV2 and represents the causative agent of a potentially fatal disease that is of great global public health concern. Based on the large number of infected people that were exposed to the wet animal market in Wuhan City, China, it is suggested that this is likely the zoonotic origin of COVID-19. Person-to-person transmission of COVID-19 infection led to the isolation of patients that were subsequently...
Wed Feb 26, 2020 00:00
JAK/STAT signaling controls the fate of CD8+CD103+ tissue-resident memory T cell in lupus nephritis.
Authors: Zhou M, Guo C, Li X, Huang Y, Li M, Zhang T, Zhao S, Wang S, Zhang H, Yang N Abstract Autoimmune mediated inflammation and renal damage in lupus nephritis (LN) depends partly on the infiltration of lymphocytes in glomeruli and renal interstitium. Here we identified a population of CD8+ T cells with a CD103+-phenotype in the healthy kidneys of human and mouse. These cells were typically CD69+CD103+ tissue-resident memory T cells (TRM) in the kidney. CD8+ TRM cells were expanded...
Tue Feb 18, 2020 00:00
Journal of cell science
Mon Mar 02, 2020 16:41
Nature climate change
Mon Mar 02, 2020 16:37
Nature climate change
Mon Mar 02, 2020 16:37
Nature ecology & evolution
Mon Mar 02, 2020 16:36
Nature genetics
Mon Mar 02, 2020 16:36
The Journal of General Physiology
Mon Mar 02, 2020 16:32
AbstractAn outbreak involving 14 patients infected by an extensively drug resistance Pseudomonas aeruginosa strain was detected in a hospital in Madrid, Spain. Our objective was to evaluate an alternative strategy to investigate in-depth the outbreak by means of molecular and genomic approaches. Pulsed-Field-Gel-Electrophoresis was applied as a first-line approach, followed by a more refined whole genome sequencing analysis. Single nucleotide polymorphisms identified by whole genome sequencing, were...
02:00
AbstractReligion and spirituality are important social determinants that drive public health practice. The field of epidemiology has played a vital role in answering long-standing questions of whether religion is causally associated with health and mortality. As epidemiologists (e.g., Kawachi (Am J Epidemiol. 2019 https://doi.org/10.1093/aje/kwz204) and Chen and VanderWeele (Am J Epidemiol. 2018;187(11):2355–2364)) spark new conversations about methods (e.g., outcomes-wide analysis) used to establish...
02:00
Abstract Gliomas are the most common malignant tumor in the central nervous system and are also one of the leading causes of death in cancer patients. Recently, mounting evidence suggested that both long noncoding RNAs (lncRNAs) and microRNAs play important roles in the proliferation and invasion of cancers, including gliomas. However, the role of lncRNA RP11‐626G11.3 in glioma‐genesis is still uncovered. Results indicated that lncRNA RP11‐626G11.3 was up‐regulated in glioma tissues and cell lines,...
06:49
Abstract Overexpression of RAD51 is found in many cancers including breast cancer and is associated with poor survival. Compared with normal cells, RAD51 promoter is hyperactive in cancer cells indicating that RAD51 is transcriptionally activated. However, little is known about the mechanisms and factors involved in RAD51 transcription regulation. Transcription corepressor, C‐terminal binding protein 1 (CtBP1), is an oncogene repressing a panel of tumor suppressors transcription, which contributes...
Tue Mar 03, 2020 12:45
So‐called insight problems are widely studied because they tap into the creative thinking that is crucial for solving real problems. However, insight problems are typically presented in static formats (on paper, computer) that allow no physical interaction with the problem elements, whereas such an interaction might in fact reduce the load on limited cognitive resources, such as working memory (WM) capacity, thereby facilitating solutions. To test this proposition, 124 young adults were allowed to...
06:44
This is the first report of patients' accounts of their experiences with ICM treatment, related SEs, and its impact on daily life. This research is an integral initial step in the development of an instrument that will measure treatment‐related SEs in patients treated with ICMs. Abstract Background Minimal qualitative data exist on the experiences of cancer patients treated with immune checkpoint inhibitors or costimulatory antibodies. Understanding the day to day experiences of patients being...
06:43
The cover image is based on the Original Research OSdlbcl: An online consensus survival analysis web server based on gene expression profiles of diffuse large B-cell lymphoma by Huan Dong et al., https://doi.org/10.1002/cam4.2829. Cover image © Huan Dong and Xiangqian Guo Images.
06:43
The first HPV vaccines licensed targeted two HPV types responsible for most cervical cancers. A 9-valent vaccine (9vHPV), targeting 5 additional types, was introduced in 2016 and is currently the only HPV vacc...
Tue Mar 03, 2020 02:00
Abstract Background Either a random-parameters logit (RPL) or latent class (LC) model can be used to model or explain preference heterogeneity in discrete-choice experiment (DCE) data. The former assumes continuous distribution of preferences across the sample, while the latter assumes a discrete distribution. This study compared RPL and LC models to explore preference heterogeneity when analyzing patient preferences for psoriasis treatments....
02:00
Abstract Objectives The primary objective of this study was to predict healthcare cost trajectories for patients with newly diagnosed acute myeloid leukemia (AML) receiving allogeneic hematopoietic cell transplantation (alloHCT), as a function of days since chemotherapy initiation, days relative to alloHCT, and days before death or last date of insurance eligibility (LDE). An exploratory objective examined patients with AML receiving...
02:00
06:26
Abstract Purpose To report acute toxicities in breast cancer (BC) patients (pts) recruited in a prospective trial and treated with accelerated partial-breast irradiation (APBI) using Volumetric Modulated Arc Therapy (VMAT) delivered with a hypofractionated schedule. Methods From March 2014 to June 2019, pts with early-stage BC (Stage I), who underwent...
02:00
Chemo-radiotherapy integration in unresectable locally advanced non-small-cell lung cancer: a review
Abstract Approximately one-third of all non-small-cell lung cancer (NSCLC) are locally-advanced at diagnosis, and 15–17% of these tumors are unresectable at presentation. Definitive chemo-radiotherapy (CRT) represents the standard therapeutic approach. However, the literature has shown that only 15% of patients are alive at 5 years and this percentage has remained unchanged despite various attempts of improvement. The recent introduction of immunotherapy has not only strongly...
02:00
Abstract Background Soft tissue sarcomas (STS) have a high risk of relapse in spite of the use of (neo)adjuvant chemotherapy. In this context, looking for new prognostic biomarkers is an interesting field of research. Our aim is to analyze the prognostic impact of neutrophil-to-lymphocyte ratio (NLR) and other serum markers in patients with STS who received chemotherapy with curative intent. ...
Tue Mar 03, 2020 02:00
The White House Coronavirus Task Force appeared at a press briefing March 2 to provide updates about testing strategies and public health coordination to address the current outbreak of the coronavirus COVID-19.Medscape Medical News (Source: Medscape Critical Care Headlines)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
02:42
Signed by nearly 700 health experts, the letter, sent to Vice President Pence and other federal, state, and local officials, outlines ways to ensure science-based mitigation efforts.Medscape Medical News (Source: Medscape Critical Care Headlines)
01:47
TUESDAY, March 3, 2020 -- Survivors of the neonatal intensive care unit (NICU) are at an increased risk for psychiatric disorders during childhood and adolescence, according to a study recently published in Archives of Disease in Childhood. Andreea... (Source: Drugs.com - Pharma News)
Tue Mar 03, 2020 13:00
Traumatic brain injuries are complex situations in which the emergency medical services must quickly determine the risk of deterioration using minimal diagnostic methods. The aim of this study is to analyze whether the use of early warning scores can help ... (Source: SafetyLit)
Tue Mar 03, 2020 12:02
American consumers awoke this week to the coronavirus threat and are beginning to display a symptom of the illness seen in Asia and Europe - hoarding.Reuters Health Information (Source: Medscape Critical Care Headlines)
Mon Mar 02, 2020 22:56
El Salvador's President Nayib Bukele said on Friday that migration authorities will be ordered to deny entry to most travelers arriving from Iran, which has one of the largest outbreaks of the new coronavirus outside China.Reuters Health Information (Source: Medscape Critical Care Headlines)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Mon Mar 02, 2020 22:48
At the epicenter of Europe's worst outbreak of coronavirus to date, daily lives have taken on an eerie, aimless calm. It's at night that the worry takes over.Reuters Health Information (Source: Medscape Critical Care Headlines)
Mon Mar 02, 2020 22:34
Illinois has"successfully contained" the new coronavirus to two confirmed cases, with both patients recovering fully and returning home, Governor J.B. Pritzker said on Friday.Reuters Health Information (Source: Medscape Critical Care Headlines)
Mon Mar 02, 2020 22:34
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