Abstract Introduction A fixed-dose combination (FDC) of ibuprofen and acetaminophen has been developed that provides greater analgesic efficacy than either agent alone at the same doses without increasing the risk for adverse events. Methods We report three clinical phase I studies designed to assess the pharmacokinetics (PK) of the FDC of ibuprofen/acetaminophen...
02:00
Illinois has"successfully contained" the new coronavirus to two confirmed cases, with both patients recovering fully and returning home, Governor J.B. Pritzker said on Friday.Reuters Health Information (Source: Medscape Critical Care Headlines)
Mon Mar 02, 2020 22:34
The rapid spread of the coronavirus increased fears of a pandemic on Friday, with six countries reporting their first cases and the World Health Organization (WHO) raising its global spread and impact risk alert to"very high."Reuters Health Information (Source: Medscape Critical Care Headlines)
Mon Mar 02, 2020 22:26
Abstract Oral positioning radiotherapy stents are devices that protect healthy structures adjacent to the target volume of head and neck radiotherapy treatment, leading to reduced acute and chronic side effects. It is described here a digital workflow to produce an oral positioning radiotherapy stent and analyze its efficacy by measuring dosimetric variations with and without this stent. An oral positioning radiotherapy stent was created according to a digital workflow that included intraoral scanning,...
06:02
Abstract Purpose To compare in vitro fracture load, surface wear, and roughness after thermal cycling and cyclic mechanical fatigue loading among cemented microhybrid resin‐based composite and ceramic occlusal veneers fabricated at two thicknesses (1.5 and 2.5 mm). Materials and Methods Sixty‐four extracted premolars without root canal treatment were prepared and restored with occlusal veneers of two thicknesses (1.5 and 2.5 mm), using four different materials: microhybrid composite...
Tue Mar 03, 2020 14:06
Abstract Glutathione S-transferase Pi (GSTP1) was originally identified as one of the cytosolic phase II detoxification enzymes and was also considered to function via its non-catalytic, ligand-binding activity. Autophagy is a self-protective mechanism of the cell to remove unnecessary or dysfunctional components, which plays a crucial role in balancing the beneficial and detrimental effects of immunity and inflammation. However, little...
02:00
Abstract Although the E3 ubiquitin ligase Zinc and ring finger 3 (ZNRF3) negatively regulates the Wnt signaling pathway, its function in rheumatoid arthritis (RA) is elusive. Here, the effects and the mechanism of ZNRF3 on a mouse model of collagen-induced arthritis (CIA) and human fibroblast-like synoviocytes (FLS) obtained from RA patients were determined. Our results showed that ZNRF3 was highly expressed in tissues and FLSs compared...
Tue Mar 03, 2020 02:00
Abstract Sodium butyrate (NaBu), a histone deacetylase inhibitor, has shown to exert beneficial actions attenuating inflammation in a number of intestinal and extra-intestinal diseases. However, the effects of NaBu on persistent inflammatory processes as in a response to implantation of foreign material have not been investigated. Synthetic matrix of polyether-polyurethane sponge was implanted in mice’s subcutaneous layer of the dorsal...
Tue Mar 03, 2020 02:00
Abstract The present study examines suicide notes, using a sample of suicide notes from published corpora (N = 50), combined with a sample of recent suicide notes from a suicide website (N = 50). The present study proposes a model of differentiation in completed suicides. The characteristics of the suicide notes were analysed using a content dictionary developed by Giles in 2007, and the data subjected to smallest space analysis. Four themes of suicide completer were discovered: Egoistic Victim,...
05:51
Summary Ichthyoses comprise a heterogeneous group of hereditary disorders of keratinization characterized by a highly varied clinical picture. A distinction is made between common hereditary ichthyoses (ichthyosis vulgaris and X‐linked ichthyosis), which usually manifest themselves in the first year of life, and rare, sometimes severe congenital ichthyoses. Patients with very mild symptoms often do not even realize they have ichthyosis. The diagnosis is usually based on clinical evaluation. Molecular...
05:45
Abstract After a sexual assault (SA), victims often disclose their SA to an informal support provider (SP) to receive social support; however, many survivors do not disclose or wait months or years to tell anyone. While research exists on disclosure, social reactions of informal SPs to disclosure, and how those reactions affect the victim both positively and negatively, little research exists on reasons for and impact of adult SA survivors’ nondisclosure to informal social network...
02:00
Abstract Youth in residential treatment centers have high rates of internalizing and externalizing symptoms, and most youth in residential placements do not demonstrate long-term positive improvements in mental health. These youth also often experience high levels of exposure to violence and trauma, yet little is known about the interrelationships between exposure to violence, trauma, and mental health outcomes including internalizing and externalizing symptoms. As such, the primary...
Tue Mar 03, 2020 02:00
This investigator-initiated trial was designed to provide novel data regarding: 1) the safety of durvalumab, tremelimumab and selumetinib combination therapy; 2) whether this combination can improve PFS in metastatic NSCLC; 3) potential biomarkers of response and resistance based on pre- and on-treatment biopsies and peripheral blood.
Tue Mar 03, 2020 02:00
Barriers to lung cancer screening (LCS) are unknown. We conducted a case-control study comparing LCS-eligible participants to non-participants (818 total). Non-participants were more likely to be female, active smokers, have lower pack-years, renal failure, a history of prior malignancy, and less likely to have COPD or CAD. Education about lung cancer screening, verification of insurance coverage, and having convenient screening locations could improve participation.
Tue Mar 03, 2020 02:00
Abstract Background & objective Tracheostomy patients often have cough and early post‐operative pain problems. Typically, patients will receive a normal sterile saline (NSS) nebulizer via a tracheostomy tube. The goal of this research was to establish whether the use of lidocaine together with NSS nebulization through a tracheostoma would be more effective at reducing the cough and pain symptoms compared to the standard NSS nebulization. Materials & methods This prospective, cross‐over...
05:34
Abstract The authors provide an updated, systematic and comprehensive summary of the literature concerning management of the N0 neck in patients for whom primary irradiation for squamous cell carcinoma of the larynx has been unsuccessful and salvage surgery in the form of total laryngectomy (TL) advocated. Bibliographic databases MEDLINE, Cochrane, Pubmed and EMBASE were searched from inception to April 2019, with no language restrictions. The Preferred Reporting Items for Systematic Reviews and...
05:34
Provide justification for why you think a program should contract or close. Full disclosure - some of this information (and suspicious programs) is gleaned from the google spreadsheet that interviewees had this year but is validated by me actually looking. These are examples that I have evaluated myself. Anyone who would like to is welcome to submit their reasoning to me anonymously that I will vet and post on your behalf here. Example #1 - Baylor. Currently looking for 2... Programs...
01:41
Hadn't seen this posted. Here's a good summary of the changes to program requirements that will be put in place starting July 1. https://www.acgme.org/Portals/0/PFAssets/ProgramResources/RadiationOncology_Summary_PR-Changes2019.pdf?ver=2019-08-26-120824-023 There aren't any changes that are blatantly obvious at reducing the # of programs, but overall it places a number of more stringent requirements and increases in case #s that will squeeze small programs and increase the cost... Summary...
01:13
(Source: BMJ Comments)
Tue Mar 03, 2020 23:03
Hello, I am noticing a lot of programs on average have 18 months of clinical time and then 18 months of research time. I am interested in private practice but would like to go to a university program for exposure. How should I make use of the research time to best help me with my career and/or marketability for private practice jobs? (Source: Student Doctor Network)
Tue Mar 03, 2020 08:32
Hypoxia is a hallmark of solid cancers, supporting proliferation, angiogenesis and escape from apoptosis. There is still limited understanding of how cancer cells adapt to hypoxic conditions and survive. We analyzed transcriptome changes of human lung and breast cancer cells under chronic hypoxia. Hypoxia induced highly concordant changes in transcript abundance, but divergent splicing responses, underlining the cell type-specificity of alternative splicing programs. While RNA-binding proteins were...
Tue Mar 03, 2020 22:32
Group II introns are mobile genetic elements that perform both self-splicing and intron mobility reactions. These ribozymes are comprised of a catalytic RNA core that binds to an intron-encoded protein (IEP) to form a ribonucleoprotein (RNP) complex. Splicing proceeds through two competing reactions: hydrolysis or branching. Group IIC intron ribozymes have a minimal RNA architecture, and splice almost exclusively through hydrolysis in ribozyme reactions. Addition of the IEP allows the splicing reaction...
Tue Mar 03, 2020 18:30
Abstract Background Heat shock proteins (HSPs) are released in response to stress situations, such as heat, inflammation, infection. They are also involved in the tumor cell proliferation and prevention of apoptosis. Heat shock protein 105 (Hsp105/110) is a high‐molecular‐weight protein which has been reported in many cancer types but few studies have been carried out on oral squamous cell carcinoma (OSCC). In the current study we have focused on HSP105 expression on OSCC and evaluated their...
05:22
Abstract Objective This study sought to describe the clinical and laboratory procedures and to discuss aspects involved in obtaining satisfactory aesthetics on substrates presenting different colors. Clinical considerations This case report describes the clinical and laboratory procedures for obtaining an optimal esthetic result using different ceramic framework materials veneered with feldspathic ceramic over substrates of different colors. Zirconia frameworks were used for darkened...
05:21
Abstract Seventeen children at six institutions with neurofibromatosis type 2 (NF2)‐related vestibular schwannomas received bevacizumab. Eight of the 13 patients with initial hearing loss (61%) showed objective hearing improvement within six months of treatment. No patients showed hearing deterioration during therapy; however, only two patients showed objective radiological response. Seven of eight patients had tumor progression or worsening hearing loss upon cessation of treatment. Bevacizumab...
05:12
Abstract Background The role of adjuvant radiotherapy (RT) remains unclear in patients with localized, completely resected (group I) alveolar rhabdomyosarcoma (ARMS). Procedure Patients with group I ARMS enrolled on any one of three prior Children's Oncology Group (COG) clinical trials (D9602, D9803, or ARST0531) were analyzed. All patients received systemic chemotherapy and 36 Gy adjuvant RT (if given) to the primary site at week 12 or week 4 for D9602/D9803 and ARST0531, respectively....
05:12
Abstract Background Proliferation of large granular lymphocytes (LGL) and T‐cell LGL (T‐LGL) in peripheral blood along with demonstration of clonality are the hallmarks of a heterogeneous group of disorders, including T‐LGL leukemia or T‐LGL lymphocytosis. They are often associated with neutropenia and responsive to immunosuppression. The true nature of this entity is not well understood. Some cases are reported as reactive phenomena with very limited experience in pediatric population. ...
05:12
Abstract Background Essential thrombocythemia (ET) is rare in children, and pediatric guidelines are lacking. Therefore, we aimed to evaluate ET diagnosis and treatment in a pediatric cohort. Procedure Data of patients with ET from three hospitals were reviewed. Molecular diagnosis included JAK2V617F, CALR, and MPL mutations. Patients were evaluated for acquired von Willebrand syndrome (AVWS). Follow‐up included clinical symptoms, adverse events, and treatment. Results Twelve...
05:12
Abstract Background Hepatoblastoma (HB) is the most common pediatric liver malignancy, occurring mainly during the first 4 years of life. Recent studies unraveled the frequent, coordinated activation of Wnt/β‐catenin and YAP/Hippo (where YAP is yes‐associated protein) pathways in human HB samples. Furthermore, it was found that concomitant overexpression of activated forms of β‐catenin and YAP in the mouse liver triggers HB formation in YAP/β‐catenin mice. Cyclin‐dependent kinases 9 (CDK9)...
05:12
Abstract Background Vitiligo is an acquired disease that involves low pigment variation in the skin. The use of cultured melanocytes for treatment of recalcitrant vitiligo has become a well‐established treatment modality. In vitro cultured melanocytes present an effective autologous transplantation treatment modality for vitiligo. The present study investigated the in vitro culture of epidermal melanocytes sampled from multiple body parts, as well as the differences in total propagation time....
05:05
Abstract Background Cellular senescence, a phenomenon of irreversible growth arrest of mammalian cells, is involved in various age‐related phenomena in organisms. Hair follicle dermal papilla (DP) cells play important roles in the regulation of hair growth and loss. Aims We examined the implication of cellular senescence of DP cells in androgenetic alopecia (AGA), the most common form of male hair loss, and searched for the compounds that have a beneficial effect on the prevention of AGA....
05:05
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