IJMS, Vol. 21, Pages 1725: Liraglutide Suppresses Tau Hyperphosphorylation, Amyloid Beta Accumulation through Regulating Neuronal Insulin Signaling and BACE-1 Activity International Journal of Molecular Sciences doi: 10.3390/ijms21051725 Authors: Salinee Jantrapirom Wutigri Nimlamool Nipon Chattipakorn Siriporn Chattipakorn Piya Temviriyanukul Woorawee Inthachat Piyarat Govitrapong Saranyapin Potikanond Neuronal insulin resistance is a significant feature...
Tue Mar 03, 2020 02:00
IJMS, Vol. 21, Pages 1729: Tuberous Sclerosis Complex Axis Controls Renal Extracellular Vesicle Production and Protein Content International Journal of Molecular Sciences doi: 10.3390/ijms21051729 Authors: Fahad Zadjali Prashant Kumar Ying Yao Daniel Johnson Aristotelis Astrinidis Peter Vogel Kenneth W. Gross John J. Bissler The tuberous sclerosis complex (Tsc) proteins regulate the conserved mTORC1 growth regulation pathway. We identified that loss of...
Tue Mar 03, 2020 02:00
IJMS, Vol. 21, Pages 1726: Salinity Stress-Mediated Suppression of Expression of Salt Overly Sensitive Signaling Pathway Genes Suggests Negative Regulation by AtbZIP62 Transcription Factor in Arabidopsis thaliana International Journal of Molecular Sciences doi: 10.3390/ijms21051726 Authors: Nkulu Kabange Rolly Qari Muhammad Imran In-Jung Lee Byung-Wook Yun Salt stress is one of the most serious threats in plants, reducing crop yield and production. The salt overly sensitive...
Tue Mar 03, 2020 02:00
IJMS, Vol. 21, Pages 1728: Molecular Biology of Spermatogenesis: Novel Targets of Apparently Idiopathic Male Infertility International Journal of Molecular Sciences doi: 10.3390/ijms21051728 Authors: Rossella Cannarella Rosita A. Condorelli Laura M. Mongioì Sandro La Vignera Aldo E. Calogero Male infertility affects half of infertile couples and, currently, a relevant percentage of cases of male infertility is considered as idiopathic. Although the male contribution...
Tue Mar 03, 2020 02:00
IJMS, Vol. 21, Pages 1727: Potent Impact of Plastic Nanomaterials and Micromaterials on the Food Chain and Human Health International Journal of Molecular Sciences doi: 10.3390/ijms21051727 Authors: Yung-Li Wang Yu-Hsuan Lee I-Jen Chiu Lin Chiu Plastic products are inexpensive, convenient, and are have many applications in daily life. We overuse plastic-related products and ineffectively recycle plastic that is difficult to degrade. Plastic debris can be fragmented...
Tue Mar 03, 2020 02:00
IJMS, Vol. 21, Pages 1721: Conformational Insight on WT- and Mutated-EGFR Receptor Activation and Inhibition by Epigallocatechin-3-Gallate: Over a Rational Basis for the Design of Selective Non-Small-Cell Lung Anticancer Agents International Journal of Molecular Sciences doi: 10.3390/ijms21051721 Authors: Cristina Minnelli Emiliano Laudadio Giovanna Mobbili Roberta Galeazzi Non-small cell lung cancer (NSCLC) represents a difficult condition to treat, due to epidermal...
Tue Mar 03, 2020 02:00
IJMS, Vol. 21, Pages 1730: Modulation of the In Vivo Inflammatory Response by Pro- Versus Anti-Inflammatory Intervertebral Disc Treatments International Journal of Molecular Sciences doi: 10.3390/ijms21051730 Authors: Carla Cunha Graciosa Q. Teixeira Cláudia Ribeiro-Machado Catarina L. Pereira Joana R. Ferreira Maria Molinos Susana G. Santos Mário A. Barbosa Raquel M. Goncalves Inflammation is central in intervertebral disc (IVD) degeneration/regeneration...
Tue Mar 03, 2020 02:00
IJMS, Vol. 21, Pages 1731: Differential Cytotoxicity Induced by Transition Metal Oxide Nanoparticles is a Function of Cell Killing and Suppression of Cell Proliferation International Journal of Molecular Sciences doi: 10.3390/ijms21051731 Authors: Larry M. Tolliver Natalie J. Holl Fang Yao Stephen Hou Han-Jung Lee Melissa H. Cambre Yue-Wern Huang The application of nanoparticles (NPs) in industry is on the rise, along with the potential for human exposure. While...
Tue Mar 03, 2020 02:00
IJMS, Vol. 21, Pages 1722: Arabidopsis RETICULON-LIKE4 (RTNLB4) Protein Participates in Agrobacterium Infection and VirB2 Peptide-Induced Plant Defense Response International Journal of Molecular Sciences doi: 10.3390/ijms21051722 Authors: Fan-Chen Huang Hau-Hsuan Hwang Agrobacterium tumefaciens uses the type IV secretion system, which consists of VirB1-B11 and VirD4 proteins, to deliver effectors into plant cells. The effectors manipulate plant proteins to assist in T-DNA transfer,...
Tue Mar 03, 2020 02:00
IJMS, Vol. 21, Pages 1717: Rosa davurica Pall. Improves Propionibacterium acnes-Induced Inflammatory Responses in Mouse Ear Edema Model and Suppresses Pro-Inflammatory Chemokine Production via MAPK and NF-κB Pathways in HaCaT Cells International Journal of Molecular Sciences doi: 10.3390/ijms21051717 Authors: Du Hyeon Hwang Dong Yeol Lee Phil-Ok Koh Hye Ryeon Yang Changkeun Kang Euikyung Kim Acne, also known as acne vulgaris, is a common disorder of human skin...
Tue Mar 03, 2020 02:00
IJMS, Vol. 21, Pages 1720: Evaluation of Seven Different RNA-Seq Alignment Tools Based on Experimental Data from the Model Plant Arabidopsis thaliana International Journal of Molecular Sciences doi: 10.3390/ijms21051720 Authors: Stephanie Schaarschmidt Axel Fischer Ellen Zuther Dirk K. Hincha Quantification of gene expression is crucial to connect genome sequences with phenotypic and physiological data. RNA-Sequencing (RNA-Seq) has taken a prominent role in the study...
Tue Mar 03, 2020 02:00
IJMS, Vol. 21, Pages 1716: Co-Administration of the Traditional Medicines Hachimi-Jio-Gan and Hochu-Ekki-To Can Reverse Busulfan-Induced Aspermatogenesis International Journal of Molecular Sciences doi: 10.3390/ijms21051716 Authors: Ning Qu Miyuki Kuramasu Kenta Nagahori Yuki Ogawa Shogo Hayashi Yoshie Hirayanagi Hayato Terayama Kaori Suyama Kou Sakabe Masahiro Itoh Busulfan is used as a chemotherapeutic drug to treat childhood and adult chronic...
Tue Mar 03, 2020 02:00
IJMS, Vol. 21, Pages 1723: Regulatory Mechanism of MicroRNA Expression in Cancer International Journal of Molecular Sciences doi: 10.3390/ijms21051723 Authors: Zainab Ali Syeda Siu Semar Saratu’ Langden Choijamts Munkhzul Mihye Lee Su Jung Song Altered gene expression is the primary molecular mechanism responsible for the pathological processes of human diseases, including cancer. MicroRNAs (miRNAs) are virtually involved at the post-transcriptional level and bind...
Tue Mar 03, 2020 02:00
IJMS, Vol. 21, Pages 1718: Regulation of Small GTPase Rab20 by Ikaros in B-Cell Acute Lymphoblastic Leukemia International Journal of Molecular Sciences doi: 10.3390/ijms21051718 Authors: Jonathon L Payne Chunhua Song Yali Ding Pavan Kumar Dhanyamraju Yevgeniya Bamme Joseph W Schramm Dhimant Desai Arati Sharma Chandrika Gowda Sinisa Dovat Ikaros is a DNA-binding protein that regulates gene expression and functions as a tumor suppressor in B-cell...
Tue Mar 03, 2020 02:00
IJMS, Vol. 21, Pages 1719: Deciphering the Biological Activities of Dunaliella sp. Aqueous Extract from Stressed Conditions on Breast Cancer: from in Vitro to in Vivo Investigations International Journal of Molecular Sciences doi: 10.3390/ijms21051719 Authors: Fatma Elleuch Patrick Baril Mohamed Barkallah Federico Perche Slim Abdelkafi Imen Fendri Chantal Pichon In order to harness local resources to improve well-being and human health, we aim in this study...
Tue Mar 03, 2020 02:00
IJMS, Vol. 21, Pages 1715: GABAergic Input Affects Intracellular Calcium Levels in Developing Granule Cells of Adult Rat Hippocampus International Journal of Molecular Sciences doi: 10.3390/ijms21051715 Authors: Davide Lattanzi Michael Di Palma Riccardo Cuppini Patrizia Ambrogini In the dentate gyrus (DG) of the mammalian hippocampus, granule neurons are generated from neural stem cells (NSCs) throughout the life span and are integrated into the hippocampal network....
Tue Mar 03, 2020 02:00
IJMS, Vol. 21, Pages 1713: Abnormal Lysosomal Positioning and Small Extracellular Vesicle Secretion in Arterial Stiffening and Calcification of Mice Lacking Mucolipin 1 Gene International Journal of Molecular Sciences doi: 10.3390/ijms21051713 Authors: Owais M. Bhat Xinxu Yuan Sarah Camus Fadi N. Salloum Pin-Lan Li Recent studies have shown that arterial medial calcification is mediated by abnormal release of exosomes/small extracellular vesicles from vascular smooth...
Tue Mar 03, 2020 02:00
IJMS, Vol. 21, Pages 1714: Circulating RNAs as Potential Biomarkers in Amyotrophic Lateral Sclerosis
IJMS, Vol. 21, Pages 1714: Circulating RNAs as Potential Biomarkers in Amyotrophic Lateral Sclerosis International Journal of Molecular Sciences doi: 10.3390/ijms21051714 Authors: Metka Ravnik-Glavač Damjan Glavač Amyotrophic lateral sclerosis (ALS) is a complex multi-system neurodegenerative disorder with currently limited diagnostic and no therapeutic options. Despite the intense efforts no clinically applicable biomarkers for ALS are yet established. Most current research...
Tue Mar 03, 2020 02:00
IJMS, Vol. 21, Pages 1712: Role of the TRPC1 Channel in Hippocampal Long-Term Depression and in Spatial Memory Extinction International Journal of Molecular Sciences doi: 10.3390/ijms21051712 Authors: Xavier Yerna Olivier Schakman Ikram Ratbi Anna Kreis Sophie Lepannetier Marie de Clippele Younès Achouri Nicolas Tajeddine Fadel Tissir Roberta Gualdani Philippe Gailly Group I metabotropic glutamate receptors (mGluR) are involved in various...
Tue Mar 03, 2020 02:00
IJMS, Vol. 21, Pages 1711: Dysregulated Gut Homeostasis Observed Prior to the Accumulation of the Brain Amyloid-β in Tg2576 Mice International Journal of Molecular Sciences doi: 10.3390/ijms21051711 Authors: Pedram Honarpisheh Caroline R. Reynolds Maria P. Blasco Conesa Jose F. Moruno Manchon Nagireddy Putluri Meenakshi B. Bhattacharjee Akihiko Urayama Louise D. McCullough Bhanu P. Ganesh Amyloid plaques in Alzheimer’s disease (AD) are associated...
Tue Mar 03, 2020 02:00
Abstract Insufficient sleep has been considered a seizure trigger in people with epilepsy for thousands of years. Here, we reviewed the evidence upon which this axiomatic association might be predicated. After evaluating evidence suggesting insufficient sleep as an EEG activator, we systematically reviewed the literature for longitudinal studies measuring the effect of insufficient sleep on seizure risk. Ultimately, published works designed to prove a causal relationship were of low level of evidence...
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Abstract Objectives Podcasts are audio recordings distributed via the Internet. We review the availability of podcasts on the topic of radiology. Methods A search for podcasts relating to radiology was performed using search engines and free public websites that either hosted or distributed podcasts. Only English language podcast series...
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Abstract Objectives This study aimed to investigate the application of shear wave elastography (SWE) in the early damage detection through assessing the endometrial elasticity after artificial abortion. Methods A total of nulliparous women (20–30 years) who received ultrasonography in our hospital were recruited between January 2017 and...
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Abstract Background Ninety years after the Dutch theoretical physicist H.A. Lorentz died, detailed investigation of his scientific heritage yielded the set of nine original prints of radiographs that W.C. Roentgen made during his experiments and had sent him, among half a dozen other scientists, on January 1st, 1896. Main text Through...
Tue Mar 03, 2020 02:00
Abstract The aim of the study is to perform an analysis of the results that have been compiled in the nine years that the examination has existed.
Tue Mar 03, 2020 02:00
Blood Cancer Journal, Published online: 03 March 2020; doi:10.1038/s41408-020-0296-3Inferior outcome of allogeneic stem cell transplantation for secondary acute myeloid leukemia in first complete remission as compared to de novo acute myeloid leukemia
Tue Mar 03, 2020 02:00
Blood Cancer Journal, Published online: 03 March 2020; doi:10.1038/s41408-020-0295-4Serum free light chain level at diagnosis in myeloma cast nephropathy—a multicentre study
Tue Mar 03, 2020 02:00
Blood Cancer Journal, Published online: 03 March 2020; doi:10.1038/s41408-020-0293-6A shared somatic translocation involving CUX1 in monozygotic twins as an early driver of AMKL in Down syndrome
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