Abstract Objective To assess the association of public health parameters with the regional variation in the initial treatment for prostate cancer. Methods We used data from German epidemiologic cancer registries for the years 2009–2013. Presence of a certified cancer center, a radiotherapy and/or urology institution, the district-specific GDP, and population...
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Abstract Objectives We aimed to determine the impact of washout period in patients with multiple myeloma between bortezomib‐based induction regimens and the collection of stem cells. Methods This was a single center historical prospective study, including all sequential newly diagnosed patients with myeloma between 2012 and 2017 that were given a first line bortezomib‐based induction therapy (≤6 cycles) followed by stem cell collection (n=75). Results We found a statistically...
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Abstract Introduction Therapy related acute lymphoblastic leukemia(t‐ALL) is an increasingly recognized subset of therapy related acute leukemia. There are limited data on the role of allogeneic hematopoietic stem cell transplantation(HSCT) in t‐ALL. Recent reports suggest comparable outcomes of t‐ALL with de‐novo ALL after HSCT. Patients and Methods We retrospectively reviewed all patients of t‐ALL who underwent HSCT at our centre. Patients were analysed for prior malignancy, therapy,...
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Abstract Objective Hemolysis is a sporadically reported but potentially serious side effect of the proteasome inhibitor carfilzomib. We aimed to investigate the frequency of hemolysis in an unselected cohort. Methods We performed a retrospective, single‐center study of the incidence of hemolysis in patients treated with carfilzomib, based mainly on consecutive haptoglobin levels. The patients were diagnosed with myeloma (n=20), AL‐amyloidosis (n=3), and light chain deposition disease...
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Abstract Emotional arousal is one of several factors that determines the strength of a memory and how efficiently it may be retrieved. The systems at play are multifaceted; on one hand, the dopaminergic mesocorticolimbic system evaluates the rewarding or reinforcing potential of a stimulus, while on the other, the noradrenergic stress response system evaluates the risk of threat, commanding attention, and engaging emotional and physical behavioral responses. Sex‐specific patterns in the anatomy...
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Background The cervical cancer screening recommendation for transgender female‐to‐male (FTM) patients is the same as that for cisgender females. A lack of literature on testosterone‐induced changes in cervical cytology in these patients may result in interpretation errors, especially without a proper clinical history. The aim of this study was to delineate the Papanicolaou (Pap) test findings in this patient population. Methods A pathology laboratory information system was used to obtain...
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Complementing previous studies on the antecedents of abusive supervision at the organizational and individual level, this study investigates how a team‐level factor (i.e., team performance) influences abusive supervision. Drawing on the conservation of resources theory, we propose that low team performance may elicit abusive supervision by making supervisors emotionally exhausted. Furthermore, when faced with low team performance, supervisors with a high prevention focus may experience greater emotional...
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Abstract Keratoacanthoma centrifugum marginatum (KCM) is a rare variant of keratoacanthoma (KA). This condition is difficult to diagnose because of its large size and expansive nature and may be diagnosed as a malignant tumor. There are various treatments such as surgery and oral retinoids; however, limited studies have verified their effectiveness. Here, we report a case of KCM on the anterior chest of a 50‐year‐old woman and evaluate the efficacy of oral retinoids. In this case, oral retinoids...
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Abstract Basal cell carcinomas (BCC) are the most common types of skin neoplasm. The finger, toe, and nail unit are uncommon and rare locations of BCC. Only a few patients with foot BCC have been reported, and ungual BCC is even less frequent. We present a patient with a BCC on the left first toe. Clinically, it appeared as a brown‐colored plaque with an irregular border on the nail fold and dorsum of the left thumb. Histopathological findings were consistent with the pigmented type of BCC. Surgical...
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Abstract Trichloroacetic acid (TCA) peeling may be effective in solar lentigines, but with concerns regarding potential tumorigenesis. Cryopeeling would be better with improving the whole sun‐damaged skin. We aimed to compare the efficacy and safety of cryopeeling and TCA 35% peeling for treatment of solar lentigines and assess their influence on the number of epidermal Langerhans cells (LC). Twenty‐five patients were treated with TCA 35% and cryopeeling on the right and left hands, respectively....
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ACS NanoDOI: 10.1021/acsnano.0c00173
Tue Mar 03, 2020 07:00
ACS Infectious DiseasesDOI: 10.1021/acsinfecdis.9b00497
Tue Mar 03, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b12250
Tue Mar 03, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b13295
Tue Mar 03, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c02428
Tue Mar 03, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b12003
Tue Mar 03, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c00300
Tue Mar 03, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c01003
Tue Mar 03, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b13876
Tue Mar 03, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b12998
Tue Mar 03, 2020 07:00
Abstract A 71‐year‐old man is admitted for nose bleeds recurring for several days. His medical background shows in particular major depression for which he has been receiving sertraline for several years. The workup shows anemia, and no anomalies on head and neck CT angiography. However, further explorations suggest an acquired thrombopathy that could have contributed to the bleeding. During sertraline exposure, platelet functional exploration and platelet secretion were abnormal. Sertraline is often...
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Abstract Objectives To determine the prognostic significance of preoperative prognostic nutritional index (PNI) in patients with primary oral squamous cell carcinoma (OSCC) after ablative surgery. Materials and Methods A total of 333 patients from two tertiary referral centers were enrolled as training and validation cohorts. The PNI was calculated as 10× serum albumin (g/dL) + 0.005× total lymphocyte number (per mm3) and its optimal cutoff value for patient stratification was identified...
03:32
Abstract Objectives This study aimed to characterize surface properties such as roughness (Ra) and surface free energy (SFE) of glazed and polished yttria‐stabilized zirconia and to evaluate in vitro adherence of fungus Candida albicans and salivary bacteria, Staphylococcus epidermidis, mixed with C. albicans to these substrata. Additionally, the influence of salivary proteins (albumin, mucin and α– amylase) on yeast adhesion was studied. Material and methods Ra and SFE of glazed...
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Planta MedDOI: 10.1055/a-1118-3828 Ocotea fasciculata presents yangambin (YAN) and its isomer epi-yangambin (EPI-YAN) as major lignans, which are employed as the plant markers for quality control purposes and as potential pharmacological compounds. However, a gap between the pure isomers and safety and efficacy protocols is faced by the scientific community. In this context, this work aimed to report (i) a new and advantageous purifying process in a semi-preparative scale for YAN and EPI-YAN...
Tue Mar 03, 2020 01:00
Planta MedDOI: 10.1055/a-1107-9370 Azadirachta indica, commonly known as neem, is an evergreen tree of the tropics and sub-tropics native to the Indian subcontinent with demonstrated ethnomedicinal value and importance in agriculture as well as in the pharmaceutical industry. This ancient medicinal tree, often called the “wonder tree”, is regarded as a chemical factory of diverse and complex compounds with a plethora of structural scaffolds that is very difficult to mimic by chemical...
Tue Mar 03, 2020 01:00
IJMS, Vol. 21, Pages 1738: APP Maturation and Intracellular Localization Are Controlled by a Specific Inhibitor of 37/67 kDa Laminin-1 Receptor in Neuronal Cells International Journal of Molecular Sciences doi: 10.3390/ijms21051738 Authors: Antaripa Bhattacharya Adriana Limone Filomena Napolitano Carmen Cerchia Silvia Parisi Giuseppina Minopoli Nunzia Montuori Antonio Lavecchia Daniela Sarnataro Amyloid precursor protein (APP) is processed along both...
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IJMS, Vol. 21, Pages 1740: Correction: Cherkaoui, M., Lollier, V., Geairon, A., Bouder, A., Larré, C., Rogniaux, H., Jamet, E., Guillon, F. and Francin-Allami, M. Cell Wall Proteome of Wheat Grain Endosperm and Outer Layers at Two Key Stages of Early Development. Int. J. Mol. Sci. 2020, 21, 239 International Journal of Molecular Sciences doi: 10.3390/ijms21051740 Authors: Mehdi Cherkaoui Virginie Lollier Audrey Geairon Axelle Bouder Colette Larré Hélène Rogniaux Elisabeth...
Tue Mar 03, 2020 02:00
IJMS, Vol. 21, Pages 1739: Transient Receptor Potential Canonical (TRPC) Channels as Modulators of Migration and Invasion International Journal of Molecular Sciences doi: 10.3390/ijms21051739 Authors: Muhammad Yasir Asghar Kid Törnquist Calcium (Ca2+) is perhaps the most versatile signaling molecule in cells. Ca2+ regulates a large number of key events in cells, ranging from gene transcription, motility, and contraction, to energy production and channel gating. To accomplish...
Tue Mar 03, 2020 02:00
IJMS, Vol. 21, Pages 1734: Advances and Challenges in Bacterial Spot Resistance Breeding in Tomato (Solanum lycopersicum L.) International Journal of Molecular Sciences doi: 10.3390/ijms21051734 Authors: Pragya Adhikari Tika B. Adhikari Frank J. Louws Dilip R. Panthee Bacterial spot is a serious disease of tomato caused by at least four species of Xanthomonas. These include X. euvesicatoria (race T1), X. vesicatoria (race T2), X. perforans (races T3 and T4), and X. gardneri,...
Tue Mar 03, 2020 02:00
IJMS, Vol. 21, Pages 1736: Glucose Exerts an Anti-Melanogenic Effect by Indirect Inactivation of Tyrosinase in Melanocytes and a Human Skin Equivalent International Journal of Molecular Sciences doi: 10.3390/ijms21051736 Authors: Sung Hoon Lee Il-Hong Bae Eun-Soo Lee Hyoung-June Kim Jongsung Lee Chang Seok Lee Sugars are ubiquitous in organisms and well-known cosmetic ingredients for moisturizing skin with minimal side-effects. Glucose, a simple sugar used as...
Tue Mar 03, 2020 02:00
IJMS, Vol. 21, Pages 1735: Schiff Base Ancillary Ligands in Bis(diimine) Copper(I) Dye-Sensitized Solar Cells International Journal of Molecular Sciences doi: 10.3390/ijms21051735 Authors: Elias Lüthi Paola Andrea Forero Cortés Alessandro Prescimone Edwin C. Constable Catherine E. Housecroft Five 6,6’-dimethyl-2,2’-bipyridine ligands bearing N-arylmethaniminyl substituents in the 4- and 4’-positions were prepared by Schiff base condensation...
Tue Mar 03, 2020 02:00
IJMS, Vol. 21, Pages 1733: MicroRNA-24-3p Targets Notch and Other Vascular Morphogens to Regulate Post-ischemic Microvascular Responses in Limb Muscles International Journal of Molecular Sciences doi: 10.3390/ijms21051733 Authors: Marchetti Meloni Anwar Zen Sala-Newby Slater Ford Caporali Emanueli MicroRNAs (miRs) regulate complex processes, including angiogenesis, by targeting multiple mRNAs. miR-24-3p-3p directly represses eNOS, GATA2,...
Tue Mar 03, 2020 02:00
IJMS, Vol. 21, Pages 1737: Amino Acids 563–566 of the Na+/H+ Exchanger Isoform 1 C-Terminal Cytosolic Tail Prevent Protein Degradation and Stabilize Protein Expression and Activity International Journal of Molecular Sciences doi: 10.3390/ijms21051737 Authors: Xiuju Li Debajyoti Dutta Martin Jung Richard Zimmermann Larry Fliegel Isoform one of the mammalian Na+/H+ exchanger is a plasma membrane protein that is ubiquitously present in humans. It regulates intracellular...
Tue Mar 03, 2020 02:00
IJMS, Vol. 21, Pages 1732: Transcriptome Analysis Reveals Long Intergenic Non-Coding RNAs Contributed to Intramuscular Fat Content Differences between Yorkshire and Wei Pigs International Journal of Molecular Sciences doi: 10.3390/ijms21051732 Authors: Qianqian Li Ziying Huang Wenjuan Zhao Mengxun Li Changchun Li Intramuscular fat (IMF) content is closely related to various meat traits, such as tenderness, juiciness, and flavor. The IMF content varies considerably...
Tue Mar 03, 2020 02:00
IJMS, Vol. 21, Pages 1724: Melatonin Modulates Dendrite Maturation and Complexity in the Dorsal- and Ventral- Dentate Gyrus Concomitantly with Its Antidepressant-Like Effect in Male Balb/C Mice International Journal of Molecular Sciences doi: 10.3390/ijms21051724 Authors: Gerardo Bernabé Ramírez-Rodríguez Diana Montserrat Palacios-Cabriales Leonardo Ortiz-López Erika Montserrat Estrada-Camarena Nelly Maritza Vega-Rivera Adult neurogenesis occurs in the dentate gyrus...
Tue Mar 03, 2020 02:00
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