ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00670
Tue Mar 03, 2020 07:00
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00649
Tue Mar 03, 2020 07:00
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00559
Tue Mar 03, 2020 07:00
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00660
Tue Mar 03, 2020 07:00
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00512
Tue Mar 03, 2020 07:00
ACS Pharmacology & Translational ScienceDOI: 10.1021/acsptsci.0c00001
Tue Mar 03, 2020 07:00
ACS Pharmacology & Translational ScienceDOI: 10.1021/acsptsci.9b00109
Tue Mar 03, 2020 07:00
ACS Synthetic BiologyDOI: 10.1021/acssynbio.9b00404
Tue Mar 03, 2020 07:00
ACS Synthetic BiologyDOI: 10.1021/acssynbio.9b00400
Tue Mar 03, 2020 07:00
ACS Synthetic BiologyDOI: 10.1021/acssynbio.9b00388
Tue Mar 03, 2020 07:00
Chemical Research in ToxicologyDOI: 10.1021/acs.chemrestox.9b00305
Tue Mar 03, 2020 07:00
Chemical Research in ToxicologyDOI: 10.1021/acs.chemrestox.9b00442
Tue Mar 03, 2020 07:00
Journal of Natural ProductsDOI: 10.1021/acs.jnatprod.9b01168
Tue Mar 03, 2020 07:00
Abstract To investigate the application of short elastin-like polypeptides (ELPs) in the purification of bioactive proteins, short hydrophobic ELP[I]n (n = 30, 40, 50) tags were constructed. Both the ELP[I]n tags and the ELP[I]n–Trx fusion proteins could be stably expressed in Escherichia coli and purified by inverse transition cycling, respectively. Total protein concentrations determined by BCA protein assay showed that the yield of the fusion proteins decreased with increasing...
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Abstract In this report, activity and stability of horseradish peroxidase (HRP) entrapped in polyacrylamide gel in the presence of proline (HEP) are compared with that of enzyme entrapped in absence of proline (HE). Within polyacrylamide (8%) beads, 80% entrapment yield for peroxidase was observed in the presence as well as absence of proline. The HEP (1.5 M proline) showed 170% higher activity compared to HE. HEP also showed significant increase in KM, Vmax and Kcat. At 8th...
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Abstract Biofilm formation of a nitrogen-fixing cyanobacterium Anabaena torulosa with a beneficial fungus Trichoderma viride (An-Tr) was examined under laboratory conditions. A gradual enhancement in growth over A. torulosa alone was recorded in the biofilm, with 15–20% higher values in nitrogen fixation, IAA and exopolysaccharide production illustrating the synergism among the partners in the biofilm. To investigate the role of such biofilms in priming seed attributes, mesocosm...
Tue Mar 03, 2020 02:00
Abstract The desulfurization of fuel is currently enforced to meet environmental legislation and prevent pollution. The use of specific biodesulfurizing microbes with a unique 4S pathway allows the desulfurization without compromising the quality of fuel. These specific microbes can be screened by the detection of 2-hydroxybiphenol (2-HBP) in desulfurizing mixture of dibenzothiophene (DBT). At present, colorimetric Gibb’s assay is the most commonly employed screening method which...
Tue Mar 03, 2020 02:00
Abstract The anti-amyloidogenic potential and cyclooxygenase anti-inflammatory activity of Lasianthus trichophlebus extracts were evaluated. The MeOH extract (LTM) and chloroform extract (LTC) exhibited significant cytotoxic inhibition against the neuroblastoma SH-SY5Y cell with an IC50 of 17.52 μg/mL and 12.28 μg/mL, respectively. Thioflavin T assay indicated the LTC extract inhibition (70.56% at 50 μg/mL) to be statistically comparable (p < 0.05) to the positive control....
Tue Mar 03, 2020 02:00
Abstract Streptomyces toxytricini produces bioactive metabolite recognized as lipstatin and its intermediate orlistat. The main focus of this study is to enhance lipstatin production by strain improvement and precursor feeding. In this study, strain improvement to enhance the production of lipstatin was carried out by different doses (50, 100, 150, 200, and 250 Gy) of gamma radiation and precursors (Linoleic acid, Oleic acid, and l-Leucine). Screening showed that the highest...
Tue Mar 03, 2020 02:00
Abstract Social determinants of health—defined by the World Health Organization as “the social factors and physical conditions of the environment in which people are born, live, learn, play, work, and age”—are increasingly discussed as having relevance in community mental health service systems. This brief report describes how self-direction—an approach in which people with serious mental health conditions choose the services and supports that work best for them to support their...
Tue Mar 03, 2020 02:00
Abstract Coronary ostial stenosis is an uncommon lesion but one that may be associated with significant and potentially lethal reduction in distal artery blood flow. While most commonly due to atherosclerosis, it may also be caused by aortic arteritis, congenital webs or post-surgical complications following aortic valve replacement. Three cases of lethal ischemic heart disease are reported where occult ostial narrowing/occlusion was first identified at autopsy. Case 1: A 70-year-old...
Tue Mar 03, 2020 02:00
Abstract The carcass of a 15-year-old female Bottlenose dolphin (Tursiops aduncus) was retrieved from the Port River near Adelaide, South Australia, Australia. The animal was emaciated with five thick nylon fishing lines emerging from the oropharynx attached to a tangle of nylon and monofilament fishing line that also contained wire and eight fishing hooks. The mouth had been cut by the line and a circumferential curvilinear superficial abrasion/indentation from fishing line encircled...
Tue Mar 03, 2020 02:00
Abstract We present the case of a 17-year-old man, who died after 2,4-dinitrophenol (DNP) and clenbuterol consumption, which he likely took for physical enhancement. Forensic post-mortem examination revealed a yellowish skin colour and nonspecific signs of asphyxia. Analytical confirmation of the intoxication was obtained in blood and urine, with high levels of DNP and clenbuterol. Both of these substances are used by bodybuilders as DNP enhance lipolysis and clenbuterol has anabolic...
Tue Mar 03, 2020 02:00
MacromoleculesDOI: 10.1021/acs.macromol.9b01880
Tue Mar 03, 2020 07:00
Molecular PharmaceuticsDOI: 10.1021/acs.molpharmaceut.9b01259
Tue Mar 03, 2020 07:00
Molecular PharmaceuticsDOI: 10.1021/acs.molpharmaceut.9b01228
Tue Mar 03, 2020 07:00
Related ArticlesCommercial Devices-Based System Designed to Improve the Treatment Adherence of Hypertensive Patients. Sensors (Basel). 2019 Oct 18;19(20): Authors: da Silva VJ, da Silva Souza V, Guimarães da Cruz R, Mesquita Vidal Martinez de Lucena J, Jazdi N, Ferreira de Lucena Junior V Abstract This paper presents an intelligent system designed to increase the treatment adherence of hypertensive patients. The architecture was developed to allow communication...
Tue Mar 03, 2020 14:22
Related ArticlesOn the Possibility of Predicting Glycaemia 'On the Fly' with Constrained IoT Devices in Type 1 Diabetes Mellitus Patients. Sensors (Basel). 2019 Oct 18;19(20): Authors: Rodríguez-Rodríguez I, Rodríguez JV, Chatzigiannakis I, Zamora Izquierdo MÁ Abstract Type 1 Diabetes Mellitus (DM1) patients are used to checking their blood glucose levels several times per day through finger sticks and, by subjectively handling this information, to...
Tue Mar 03, 2020 14:22
Related ArticlesAugmenting Clinical Outcome Measures of Gait and Balance with a Single Inertial Sensor in Age-Ranged Healthy Adults. Sensors (Basel). 2019 Oct 18;19(20): Authors: O'Brien MK, Hidalgo-Araya MD, Mummidisetty CK, Vallery H, Ghaffari R, Rogers JA, Lieber R, Jayaraman A Abstract Gait and balance impairments are linked with reduced mobility and increased risk of falling. Wearable sensing technologies, such as inertial measurement units (IMUs),...
Tue Mar 03, 2020 14:22
Related ArticlesAssisted Grasping in Individuals with Tetraplegia: Improving Control through Residual Muscle Contraction and Movement. Sensors (Basel). 2019 Oct 18;19(20): Authors: Fonseca L, Tigra W, Navarro B, Guiraud D, Fattal C, Bó A, Fachin-Martins E, Leynaert V, Gélis A, Azevedo-Coste C Abstract Individuals who sustained a spinal cord injury often lose important motor skills, and cannot perform basic daily living activities. Several assistive...
Tue Mar 03, 2020 14:22
An Exploration of Machine Learning Methods for Robust Boredom Classification Using EEG and GSR Data.
Related ArticlesAn Exploration of Machine Learning Methods for Robust Boredom Classification Using EEG and GSR Data. Sensors (Basel). 2019 Oct 20;19(20): Authors: Seo J, Laine TH, Sohn KA Abstract In recent years, affective computing has been actively researched to provide a higher level of emotion-awareness. Numerous studies have been conducted to detect the user's emotions from physiological data. Among a myriad of target emotions, boredom, in particular,...
Tue Mar 03, 2020 14:22
Related ArticlesParylene-Coated Polytetrafluoroethylene-Membrane-Based Portable Urea Sensor for Real-Time Monitoring of Urea in Peritoneal Dialysate. Sensors (Basel). 2019 Oct 20;19(20): Authors: Park M, Kim J, Kim K, Pyun JC, Sung GY Abstract A portable urea sensor for use in fast flow conditions was fabricated using porous polytetrafluoroethylene (PTFE) membranes coated with amine-functionalized parylene, parylene-A, by vapor deposition. The urea-hydrolyzing...
Tue Mar 03, 2020 14:22
Related ArticlesA Review of Force Myography Research and Development. Sensors (Basel). 2019 Oct 20;19(20): Authors: Xiao ZG, Menon C Abstract Information about limb movements can be used for monitoring physical activities or for human-machine-interface applications. In recent years, a technique called Force Myography (FMG) has gained ever-increasing traction among researchers to extract such information. FMG uses force sensors to register the variation...
Tue Mar 03, 2020 14:22
Related ArticlesAssessing Older Adults' Daily Mobility: A Comparison of GPS-Derived and Self-Reported Mobility Indicators. Sensors (Basel). 2019 Oct 19;19(20): Authors: Fillekes MP, Kim EK, Trumpf R, Zijlstra W, Giannouli E, Weibel R Abstract Interest in global positioning system (GPS)-based mobility assessment for health and aging research is growing, and with it the demand for validated GPS-based mobility indicators. Time out of home (TOH) and number...
Tue Mar 03, 2020 14:22
Related ArticlesAn Innovative Technique for Identification of Missing Persons in Natural Disaster Based on Drone-Femtocell Systems. Sensors (Basel). 2019 Oct 19;19(20): Authors: Avanzato R, Beritelli F Abstract The recent development of the IoT (Internet of Things), which has enabled new types of sensors that can be easily interconnected to the Internet, will also have a significant impact in the near future on the management of natural disasters (mainly...
Tue Mar 03, 2020 14:22
Related Articles[Application of immunohistochemical study for the verification of diffuse axonal injury and determination of cause-and-effect relationships]. Sud Med Ekspert. 2020;63(1):53-55 Authors: Shmarov LA, Kochoyan AL, Stragis VB, Fedulova MV, Shai AN Abstract Aim of this study is to establish a possibility of finding morphologic signs of diffuse axonal injury early after the injury. Use of immunohistochemical examination of the brain to detect...
Tue Mar 03, 2020 14:59
Related ArticlesPlasma tau protein and Aβ42 level as markers of cognitive impairment in patients with Parkinson's disease. Adv Clin Exp Med. 2020 Jan;29(1):115-121 Authors: Chojdak-Łukasiewicz J, Małodobra-Mazur M, Zimny A, Noga L, Paradowski B Abstract BACKGROUND: Parkinson's disease (PD) is a progressive neurodegenerative disorder with a characteristic clinical picture. Apart from classical movement disorders, a significant role is also played by non-motor...
Tue Mar 03, 2020 14:59
Related ArticlesPredictors of blood pressure control in patients with resistant hypertension after intensive management in two expert centres: the Brussels-Torino experience. Blood Press. 2019 10;28(5):336-344 Authors: Pappaccogli M, Di Monaco S, Coralie G, Petit G, Eula E, Ritscher S, Lengelé JP, Fanelli E, Severino F, Renkin J, Avataneo V, Wallemacq P, Toennes SW, de Timary P, Rabbia F, Persu A Abstract Background: Management of resistant hypertension...
Tue Mar 03, 2020 14:59
Related ArticlesSelf-Reported Childhood Maltreatment and Erotic Target Identity Inversions Among Men with Paraphilic Infantilism. J Sex Marital Ther. 2019;45(8):781-795 Authors: Fuss J, Jais L, Grey BT, Guczka SR, Briken P, Biedermann SV Abstract Adults with paraphilic infantilism may desire to wear diapers or engage in infant-like role play. Erotic target identity inversions (ETII) and childhood maltreatment have been hypothesized to cause regressive...
Tue Mar 03, 2020 14:59
Related ArticlesA Compendium of Mutational Signatures of Environmental Agents. Cell. 2019 05 02;177(4):821-836.e16 Authors: Kucab JE, Zou X, Morganella S, Joel M, Nanda AS, Nagy E, Gomez C, Degasperi A, Harris R, Jackson SP, Arlt VM, Phillips DH, Nik-Zainal S Abstract Whole-genome-sequencing (WGS) of human tumors has revealed distinct mutation patterns that hint at the causative origins of cancer. We examined mutational signatures in 324 WGS human-induced...
Tue Mar 03, 2020 14:59
Related ArticlesAge-related changes in the pulp chamber of maxillary and mandibular molars on cone-beam computed tomography images. Oral Radiol. 2018 09;34(3):219-223 Authors: Sue M, Oda T, Sasaki Y, Ogura I Abstract OBJECTIVES: Secondary dentine is laid on pulp chamber walls with increasing age, and decreases pulp chamber size. This study aimed to investigate age estimation on cone-beam computed tomography (CBCT) images for forensic science, and the...
Tue Mar 03, 2020 14:59
Related ArticlesRecognition of Facial Emotion and Affective Prosody in Children at High Risk of Criminal Behavior. J Int Neuropsychol Soc. 2019 01;25(1):57-64 Authors: van Zonneveld L, de Sonneville L, van Goozen S, Swaab H Abstract OBJECTIVE: Emotion recognition is an important aspect of emotion processing, which is needed for appropriate social behavior and normal socialization. Previous studies in adults with antisocial personality disorder or psychopathy,...
Tue Mar 03, 2020 14:59
Related ArticlesAssociation between eating frequency and eating behaviours related to appetite from 4 to 7 years of age: Findings from the population-based birth cohort generation XXI. Appetite. 2019 01 01;132:82-90 Authors: Vilela S, Severo M, Moreira T, Oliveira A, Hetherington MM, Lopes C Abstract The examination of specific characteristics of eating habits in childhood and its influence on eating behaviours is needed to better understand the establishment...
Tue Mar 03, 2020 14:59
Related ArticlesThe Implementation of Functional Family Therapy (FFT) as an Intervention for Youth Probationers in Singapore. J Marital Fam Ther. 2019 Oct;45(4):684-698 Authors: Gan DZQ, Zhou Y, Hoo E, Chong D, Chu CM Abstract Family functioning is predictive of youth recidivism in Singapore. However, there is a lack of family based interventions for youth offenders on community probation. Evidence-based family interventions developed in Western populations,...
Tue Mar 03, 2020 14:59
Related ArticlesEffect of negative motivation on the behavioral and autonomic correlates of deception. Psychophysiology. 2019 01;56(1):e13284 Authors: Suchotzki K, Gamer M Abstract In forensic contexts, lying is often motivated by the will to avoid negative consequences (e.g., an arrest). Previous research investigating the effect of motivation on deception has, however, nearly exclusively focused on the effect of positive motivation (e.g., via financial...
Tue Mar 03, 2020 14:59
Publication date: May 2020Source: Accident Analysis & Prevention, Volume 139Author(s): A. Karimi, M. Bassani, AM. Boroujerdian, L. Catani
Tue Mar 03, 2020 16:23
Publication date: May 2020Source: Accident Analysis & Prevention, Volume 139Author(s): Noga Guggenheim, Orit Taubman – Ben-Ari, Elisheva Ben-Artzi
Tue Mar 03, 2020 16:23
Publication date: May 2020Source: Accident Analysis & Prevention, Volume 139Author(s): Zihan Hong, Ying Chen, Yang Wu
Tue Mar 03, 2020 16:23
Abstract There are more than 3 million patients with pacemakers and internal cardioverter defibrillators (also known as cardiac‐implanted electronic devices or CIEDs) in the US (1), and the number of patients presenting to emergency departments (EDs) with CIED complications is likely to increase. Patients may present with complaints of chest pain, shortness of breath, sensation of shock, syncope, fatigue or dizziness as a sign of CIED malfunction and the device would need to be interrogated. Earlier...
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Abstract The confirmed and suspected cases of the 2019 novel coronavirus disease (COVID‐19) have increased not only in Wuhan, Hubei Province but also China and the world. Enormous demand for handling the COVID‐19 outbreak challenged both the healthcare personnel and medical supply system. In West China Hospital, Emergency Department (ED) undertook the mission of clinical reception, primary diagnosis, and interim treatment for the suspected cases of COVID‐19.
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