Τρίτη 3 Μαρτίου 2020


Plasmodium falciparum DDX55 is a nucleocytoplasmic protein and a 3′-5′ direction-specific DNA helicase
Abstract Malaria is one of the major causes of mortality as well as morbidity in many tropical and subtropical countries around the world. Although artemisinin combination therapies (ACTs) are contributing to substantial decline in the worldwide malaria burden, it is becoming vulnerable by the emergence of artemisinin resistance in Plasmodium falciparum leading to clinical failure of ACTs in Southeast Asia. Helicases play important role in nucleic acid metabolic processes and have...
Latest Results for Protoplasma
Tue Mar 03, 2020 02:00
Ifenprodil rapidly ameliorates depressive-like behaviors, activates mTOR signaling and modulates proinflammatory cytokines in the hippocampus of CUMS rats
Abstract Rationale The rapid-onset and long-lasting antidepressant properties of ketamine have prompted investigations into a variety of agents that target N-methyl-D-aspartate receptors (NMDARs) for the treatment of major depressive disorder (MDD). According to the literature, ifenprodil (a GluN2B-containing NMDAR antagonist) can potentiate the antidepressant-like effects of certain antidepressant drugs in mice. Here, we report that a...
Latest Results for Psychopharmacology
02:00
ITV versus mid-ventilation for treatment planning in lung SBRT: a comparison of target coverage and PTV adequacy by using in-treatment 4D cone beam CT
Abstract Background The internal target volume (ITV) approach and the mid-ventilation (MidV) concept are the two main respiratory motion-management strategies under free breathing. The purpose of this work was to compare the actual in-treatment target coverage during volumetric modulated arctherapy (VMAT) delivered through both ITV-based and MidV-based planning target volume (PTV) and to provide knowledge in choosing the optimal...
Latest Results for Radiation Oncology
Tue Mar 03, 2020 02:00
Type 2 diabetes – unmet need, unresolved pathogenesis, mTORC1-centric paradigm
Abstract The current paradigm of type 2 diabetes (T2D) is gluco-centric, being exclusively categorized by glycemic characteristics. The gluco-centric paradigm views hyperglycemia as the primary target, being driven by resistance to insulin combined with progressive beta cells failure, and considers glycemic control its ultimate treatment goal. Most importantly, the gluco-centric paradigm considers the non-glycemic diseases associated with T2D, e.g., obesity, dyslipidemia, hypertension,...
Latest Results for Reviews in Endocrine and Metabolic Disorders
02:00
The Ethics of Gene Editing from an Islamic Perspective: A Focus on the Recent Gene Editing of the Chinese Twins
Abstract In light of the development of “CRISPR” technology, new promising advances in therapeutic and preventive approaches have become a reality. However, with it came many ethical challenges. The most recent worldwide condemnation of the first use of CRISPR to genetically modify a human embryo is the latest example of ethically questionable use of this new and emerging field. Monotheistic religions are very conservative about such changes to the human genome and can be considered...
Latest Results for Science and Engineering Ethics
Tue Mar 03, 2020 02:00
A Design Approach for a Valve Based on a Magnetic Shape Memory Actuator
Abstract With the motivation to meet the increasing requirements on fast-switching pneumatic valves, Magnetic Shape Memory alloys (MSM) are considered as a promising alternative to conventional actuators. Regarding the desired strokes, forces and actuation frequencies MSM alloys meet the requirements best among other solid-state transducers for valve applications. However, the hysteresis in the magneto-mechanical behavior is challenging during the sizing process of a component...
Latest Results for Shape Memory and Superelasticity
Tue Mar 03, 2020 02:00
Systematic Trends of Transformation Temperatures and Crystal Structure of Ni–Mn–Ga–Fe–Cu Alloys
Abstract Here we report a systematic research on effects of Fe and Cu upon properties relevant for the magnetic shape memory effect of Ni–Mn–Ga ferromagnetic shape memory alloys. Fe and Cu were identified as elements with potential synergism to increase the martensite transformation temperature of Ni–Mn–Ga magnetic shape memory (MSM) alloys. Eighteen Ni–Mn–Ga–Fe–Cu alloys with different systematic trends in substituting the ternary elements with Cu and Fe have been investigated....
Latest Results for Shape Memory and Superelasticity
Tue Mar 03, 2020 02:00
Effect of dynamic position changes during colonoscope withdrawal: a meta-analysis of randomized controlled trials
Abstract Background Colonoscopies are considered to be the primary screening test and gold standard test for colorectal cancer. Position changes during colonoscope withdrawal are believed to be associated with an increased adenoma detection rate (ADR) and polyp detection rate (PDR). However, previous results conflicted, and this study aimed to elucidate the effectiveness of dynamic position changes during colonoscope withdrawal. ...
Latest Results for Surgical Endoscopy
Tue Mar 03, 2020 02:00
Seasonal Dynamics of Flooded Tropical Grassland Communities in the Pantanal Wetland
Abstract We aimed to answer the following questions: do vegetation structure and functional characteristics of grassland types differ between hydrological periods (i.e., aquatic and terrestrial phase) in the Pantanal wetland? What general plant functional traits characterize these communities? We sampled 37 sites in three grassland types in the Cuiabá river megafan, in the northern Pantanal, Brazil, in both the aquatic and terrestrial phases. We determined, from the literature,...
Latest Results for Wetlands
Tue Mar 03, 2020 02:00
Evaluation of Contralateral Ear in Unilateral Chronic Otitis Media: Necessary or Not?
Abstract Eustachian tube appears to be central to the pathogenesis of all forms of otitis media. The reported frequency of bilateral disease ranges from 27 to 55%. The affected ear may well be the end point of the pathology in the contra lateral ear (CLE). Cross sectional observational study. One hundred patients who had unilateral chronic otitis media (COM) were enrolled in the study. Diseased ear was divided into either mucosal or squamosal type. Otoendoscopy, pure tone audiometry,...
Otolaryngology Indian
Tue Mar 03, 2020 02:00

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