AbstractBenign myofibroblastic lesions can clinically and histologically be mistaken for sarcoma. Excessive and potentially disfiguring surgical treatment can be avoided by ruling out malignancy. We present the case of a low-grade, myofibroblastic lesion of the lip, which shows how detailed clinical examination rather than reliance on histopathological information alone helped to achieve this. Differential diagnoses of myofibroblastic lesions are also discussed.
Mon Mar 02, 2020 02:00
AbstractWe are reporting a case of internal herniation of the bowel through the foramen of Winslow. This is a very rare condition that prompts an urgent operative intervention due to its potential fatal complications, as it is usually accompanied by bowel strangulation and ischemia. Due to the vague clinical picture, the diagnosis only reached using imaging techniques such as computed tomography or as a surgical surprise during the operation. Key aspects of surgical interventions are hernia reduction,...
Mon Mar 02, 2020 02:00
AbstractAlthough osteochondritis dissecans (OD) is well-described in the bibliography, cases of OD in the 1st metatarsophalangeal joint (MTP) are rare clinical situations. We present a 25-year-old male who presented to our department for big toe pain on the left side. Clinical and radiological examination showed the typical findings of OD lesion on the 1st metatarsal head (MH), establishing the diagnosis of OD. Intraoperatively the articular cartilage of the partially detached part of the MH was...
Mon Mar 02, 2020 02:00
AbstractThe atlas (C1) and axis (C2) have distinct morphologies to support the skull and facilitate head rotation and neck flexion. Congenital defects of C1 posterior arch are rare. We present a case of a 59-year-old man with both an absent C1 posterior arch with concomitant os odontoideum. The patient presented with neck crepitus, moderate neck pain and progressive worsening upper limbs paraesthesia and pain. Computed tomography (CT) revealed non-union between the odontoid process and body of axis...
Mon Mar 02, 2020 02:00
AbstractAcute appendicitis is the most common surgical pathology worldwide, frequently, the patient history and clinical examination are so similar to other appendicular pathologies that preoperative diagnosis is almost impossible for the medical team. Neuroma of the appendix is a rare tumor of neural origin that usually resembles the symptoms of acute appendicitis. Pathology along with close follow-ups are key, as the diagnosis is based on the presence of nerve neuronal cells in the appendicular...
Mon Mar 02, 2020 02:00
In recognition of World Hearing Day today, I am sharing guidelines and insights—from nearly four decades as an audiologist—on providing hearing screening for clients and patients at critical junctures. Communication sciences and disorders professionals continue to learn more about the effects of hearing loss on speech, language development, and cognition. Obviously, audiologists conduct hearing screenings, but they often aren’t on treatment teams in many of these situations. Speech-language pathologists...
Tue Mar 03, 2020 16:15
ASHA debuts a new engagement experience to help boost your interactions with clients, students, families, colleagues, and others in your professional world. That’s Unheard Of offers you information in quick, digestible bites, catering to the few minutes you might every so often—waiting in line for coffee, store checkout, airport check in, carpool, or for a doctor’s appointment. What is “That’s Unheard Of”? Not your typical digital tool, the new site provides resources you can take advantage of...
Fri Feb 28, 2020 16:15
Chronic pain is an enigma for both pain doctors and their patients: difficult to understand (as everyone’s pain is different), challenging to treat effectively, and frustrating to live with. Desperate patients sometimes turn to drastic and irreversible surgical procedures, like amputating nerves to relieve pain, and unfortunately even those procedures may fail to provide the hoped-for results. Fortunately there have been great strides in research related to pain perception and our nervous system’s...
Tue Mar 03, 2020 16:30
Abstract Objectives Conventional guided bone regeneration (GBR) limits the amount of bone graft due to limited soft tissue expansion. We hypothesize that the use of tissue expander will successfully augment soft tissue prior to bone graft, allowing for sufficient amount of grafting which will lead to a more stable and effective vertical bone graft. The authors aimed to evaluate effectiveness of the novel self‐inflating tissue expander for vertical augmentation in terms of soft tissue expansion,...
04:54
Abstract Objective The aim of this study was to determine the relationship between OHRQoL and General health‐related quality of life (GHRQoL) in partially edentulous patients before and after implant placement. Material and methods After obtaining informed consent, using convenient sampling method, 102 participants (64 female and 38 male participants with an age range of 18‐81 years) were included in the study. Participants were required to fill EuroQol‐5D (EQ‐5D) and The Oral Health...
04:54
Purpose. Patient-reported outcomes (PROs) were evaluated in the phase 3 IMmotion151 trial (NCT02420821) to inform overall treatment/disease burden of atezolizumab plus bevacizumab versus sunitinib in patients with previously untreated metastatic renal cell carcinoma (mRCC). Experimental design. Patients were randomized 1:1 to receive atezolizumab 1200 mg IV q3w plus bevacizumab 15 mg/kg IV q3w or sunitinib 50 mg PO QD 4 weeks on/2 weeks off. Patients completed the MD Anderson Symptom Inventory (MDASI),...
Tue Mar 03, 2020 17:29
The adoptive transfer of genetically engineered Chimeric Antigen Receptor (CAR) T-cells has opened a new frontier in cancer therapy. Unlike the paradigm of targeted therapies, the efficacy of CAR T-cell therapy depends not only on the choice of target, but also on a complex interplay of tumor, immune, and stromal cell communication. This presents both challenges and opportunities from a discovery standpoint. Whereas cancer consortia have traditionally focused on the genomic, transcriptomic, epigenomic,...
Tue Mar 03, 2020 17:29
Purpose: Inter-patient clinical variability in soft tissue sarcomas (STS) highlights the need for novel prognostic markers supporting patient risk stratification. As sarcomas might exhibit a more mesenchymal or a more epithelial state, we focused on epithelial-mesenchymal and mesenchymal-epithelial transitions (EMT/MET) for prognostic clues, and selected three histotypes with variable aggressiveness. Experimental Design: The expression of EMT/MET-related factors was measured by qRT-PCR in 55 tumor...
Tue Mar 03, 2020 17:29
Abstract Introduction Despite widespread access to antiretroviral therapy (ART), the burden of advanced HIV disease in South Africa is high. This translates into an increased risk of AIDS‐related opportunistic infections, including invasive mycoses. Methods Using a limited number of non‐culture‐based diagnostic assays, we aimed to determine the prevalence of invasive mycoses and tuberculosis among hospitalised adults with very advanced HIV (CD4 counts <100 cells/µl) at a large academic...
04:46
Abstract Introduction The prevalence of azole resistance in C. parapsilosis is very low in most parts of the world. However, South Africa has reported an exceptionally high prevalence of azole resistance in C. parapsilosis strains isolated from candidaemia cases. We aimed to determine the possible molecular mechanisms of fluconazole resistance in C. parapsilosis isolates obtained through surveillance at a large neonatal unit at a South African academic hospital. Methods We sequenced the...
04:46
The research materials here cover the recent work of one of many groups digging deeper in the mechanisms of cellular senescence, in search of novel ways to make senescent cells less harmful to surrounding tissues, or means to selectively destroy them outright. The accumulation of senescent cells with age is now well proven to contribute to aging, generating chronic inflammation and disrupting tissue function via a potent mix of signals known as the senescence-associated secretory phenotype, or SASP....
Tue Mar 03, 2020 21:36
This popular science article is a decent introduction to the still young field of senolytic therapies to selectively destroy senescent cells in aged tissues. That said, the author fails to note any of the numerous senolytic programs other than those of the Mayo Clinic and Unity Biotechnology - which represent an increasingly small portion of the field as a whole. The accumulation of lingering senescent cells is one of the contributing causes of aging; these errant cells secrete a potent mix of signals...
Tue Mar 03, 2020 12:18
Can targeting a tumours' surroundings, rather than the tumour itself, be a way of preventing metastasis? Related items fromOnMedica Breast cancer deaths down due to screening and new therapies UK cancer survival improved, but lags behind similar nations Genetic risk model could guide prostate cancer screening Blood test for breast cancer may be a step closer Doctors urge government to act on rising alcohol impact (Source: OnMedica Blogs)
Tue Mar 03, 2020 00:00
The future of healthcare is shaping up in front of our very eyes with advances in digital technologies, such as artificial intelligence, VR/AR, 3D-printing, robotics or nanotechnology. We have to familiarize with the latest developments in order to be able to control technology and not the other way around. The future of healthcare lies in working hand-in-hand with technology and healthcare workers have to embrace emerging technologies in order to stay relevant in the coming years. Be bold, curious...
Tue Mar 03, 2020 08:00
The Methuselah Foundation is one of the oldest of the present generation of organizations focused on advancing human rejuvenation, founded more than 15 years ago. At that time there was none of the present enthusiasm for treating aging as a medical condition, and indeed the concept was mocked outside the scientific community and actively discouraged within research circles by leading scientists in the field of gerontology. The Methuselah Foundation and its network of allies are a large part of the...
Mon Mar 02, 2020 20:29
Conditions: Caregiver Burnout; Cancer Interventions: Behavioral: Progressive muscle relaxation; Other: Attention matched control Sponsor: Hacettepe University Not yet recruiting (Source: ClinicalTrials.gov)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Tue Mar 03, 2020 18:00
Conditions: Non-Hodgkin Lymphoma; DLBCL; Diffuse Large B Cell Lymphoma Interventions: Other: 24-hour dietary recall; Other: Hand grip strength; Other: International Physical Activity Questionnaire; Other: Patient-reported outcomes survey; Other: Pittsburgh Sleep Quality Index; Other: Functional Assessment of Cancer Treatment - Lymphoma; Other: urin e sample (optional); Other: fecal sample (optional) Sponsor: George Washington University Not yet recruiting (Source: ClinicalTrials.gov)
Tue Mar 03, 2020 18:00
Conditions: Pain; Nasopharyngeal Carcinoma; Head and Neck Cancer; Radiation Induced Oral Mucositis Interventions: Drug: Fentanyl; Drug: Morphine Sponsor: Jiarong Chen, MD Not yet recruiting (Source: ClinicalTrials.gov)
Tue Mar 03, 2020 18:00
Conditions: Fatigue; Depression; Pain; Sleep Disturbance; Stress; Survivorship; Breast Cancer; Dietary Habits Interventions: Behavioral: Personalized Meal Plan; Behavioral: Dietary Omega-3LC intervention Sponsors: University of Connecticut; Hartford HealthCare; Seafood Industry Research Fund; Alaskan Seafood Marketing Institute; Academy of Nutrition and Dietetics Recruiting (Source: ClinicalTrials.gov)
Tue Mar 03, 2020 18:00
Open Label, Dose Escalation Study for the Safety and Efficacy of STP705 in Adult Patients With isSCC
Conditions: Bowen's Disease; Cutaneous Squamous Cell Carcinoma in Situ Intervention: Drug: STP705 Sponsors: Sirnaomics; Amarex Clinical Research Recruiting (Source: ClinicalTrials.gov)
Tue Mar 03, 2020 18:00
Condition: Rectal Cancer Intervention: Diagnostic Test: Whether to have intestinal-related disease Sponsor: Peking University Third Hospital Completed (Source: ClinicalTrials.gov)
Tue Mar 03, 2020 18:00
Condition: Breast Cancer Intervention: Other: Referrals Recommendations Sponsor: UNC Lineberger Comprehensive Cancer Center Not yet recruiting (Source: ClinicalTrials.gov)
Tue Mar 03, 2020 18:00
Condition: Refusal of Breast Surgery in Patients With Breast Cancer With a cCR After NST and a Confirmed Pathological Complete Response (pCR) Using VAB and SLNB Intervention: Procedure: Vacuum-assisted biopsy Sponsor: N.N. Petrov National Medical Research Center of Oncology Recruiting (Source: ClinicalTrials.gov)
Tue Mar 03, 2020 18:00
Condition: Colorectal Neoplasms Intervention: Procedure: Invitation procedure Sponsor: University of Aarhus Recruiting (Source: ClinicalTrials.gov)
Tue Mar 03, 2020 18:00
Condition: Pancreatic Cancer Intervention: Diagnostic Test: Cytology staining Sponsor: Gangnam Severance Hospital Not yet recruiting (Source: ClinicalTrials.gov)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Tue Mar 03, 2020 18:00
Conditions: Malignant Melanoma; Angiosarcoma Intervention: Other: CICS-1 (investigational device),SPM-011(investigational drug) Sponsors: Cancer Intelligence Care Systems, Inc.; Stella Pharma Corporation Recruiting (Source: ClinicalTrials.gov)
Tue Mar 03, 2020 18:00
Condition: Rectal Cancer Intervention: Drug: Durvalumab (MEDI4736) Sponsors: Grupo Espanol Multidisciplinario del Cancer Digestivo; AstraZeneca; Vall d'Hebron Institute of Oncology (VHIO) Recruiting (Source: ClinicalTrials.gov)
Tue Mar 03, 2020 18:00
Conditions: Breast Cancer; Lymphedema Intervention: Sponsor: UNC Lineberger Comprehensive Cancer Center Not yet recruiting (Source: ClinicalTrials.gov)
Tue Mar 03, 2020 18:00
Condition: Prostate Cancer Intervention: Other: Decision Navigation Intervention (DNI) Sponsors: Weill Medical College of Cornell University; New York Methodist Hospital; New York Presbyterian Queens Not yet recruiting (Source: ClinicalTrials.gov)
Tue Mar 03, 2020 18:00
Conditions: Breast Lesion; Breast Cancer; B3 Breast Lesion; Atypical Breast Lesion Intervention: Sponsor: Assistance Publique - Hôpitaux de Paris Not yet recruiting (Source: ClinicalTrials.gov)
Tue Mar 03, 2020 18:00
Phase II Neoadjuvant Chemotherapy vs. Letrozole + Abemaciclib in HR+/HER2- High/Intermediate Risk BC
Condition: Early Breast Cancer Interventions: Drug: Doxorubicin; Drug: Cyclophosphamide; Drug: Taxane; Drug: Letrozole; Drug: Abemaciclib; Drug: LHRH Analogue Sponsors: Spanish Breast Cancer Research Group; Eli Lilly and Company Not yet recruiting (Source: ClinicalTrials.gov)
Tue Mar 03, 2020 18:00
Conditions: Anastomotic Leak; Gastric Cancer; Surgery; Testing, Reality; Gastroscopy Intervention: Procedure: Introperative leak testing Sponsor: Nanchong Central Hospital Recruiting (Source: ClinicalTrials.gov)
Tue Mar 03, 2020 18:00
Condition: Colorectal Neoplasms Intervention: Behavioral: Improvement Cycles Sponsors: Institute for Clinical Effectiveness and Health Policy; Inter-American Development Bank Active, not recruiting (Source: ClinicalTrials.gov)
Tue Mar 03, 2020 18:00
Conditions: Carcinoma, Non-Small-Cell Lung; Pain, Postoperative; Postoperative Nausea and Vomiting; Infection; Air Leakage; Atrial Fibrillation Intervention: Other: Prolong in-hospital stay Sponsor: Rigshospitalet, Denmark Not yet recruiting (Source: ClinicalTrials.gov)
Tue Mar 03, 2020 18:00
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