Τετάρτη 4 Μαρτίου 2020


Efficacy of Two-Step Surgery on Severely Protruding Axillary Accessory Breast: First-Step Mammary Gland Excision Followed by Second-Look Redundant Skin Excision
Abstract Background Symptoms of axillary accessory breasts (AABs) vary among patients. Mildly protruding AABs do not require skin excision, whereas severely protruding AABs might. We report a novel technique that includes mammary gland excision followed 6 months later by second-look redundant skin excision, if necessary. Objectives We aimed to evaluate...
Latest Results for Aesthetic Plastic Surgery
Wed Mar 04, 2020 02:00
Response to Commentary on: Dorsal Roof Technique for Dorsum Preservation in Rhinoplasty
Abstract Rhinoplasty is a sophisticated surgery that needs high technical skills with knowledge. The DR technique is a refined technique to deal with the selected cases which are challenging for rhinology (wide dorsum, base and humpy nose). Still, so many things are unknown and one life span will be never enough to solve it. However, the author thinks that any solution fills the gaps, is the only thing we can improve the medicine. ...
Latest Results for Aesthetic Plastic Surgery
Wed Mar 04, 2020 02:00
Disease or function? What matters most for self-rated health in older people depends on age
Abstract Background Self-rated health (SRH) holistically captures older adults’ health status from the perspective of the individual. Aims To explore the accuracy of five objective health indicators related to diseases, physical function, cognition and disability in discriminating SRH among the youngest and oldest old. ...
Latest Results for Aging Clinical and Experimental Research
Wed Mar 04, 2020 02:00
Does sedentary time increase in older adults in the days following participation in intense exercise?
Abstract Background Older adults have the highest sedentary time across all age groups, and only a small portion is meeting the minimum recommendations for weekly physical activity. Little research to date has looked at how changes in one of these behaviours influences the other. Aim To assess changes in 24-h movement behaviours (sedentary time, light intensity...
Latest Results for Aging Clinical and Experimental Research
Wed Mar 04, 2020 02:00
Factors related to poor adherence in Latvian asthma patients
Abstract Background The problem of nonadherence to therapy is a key reason of insufficient asthma control. Evaluating the beliefs about asthma medication, cognitive and emotional perceptions may help to identify patients with poor adherence to treatment in clinical practice which need additional attention in order to increase the likelihood of them taking their asthma medication according to the prescribed treatment protocol. The...
Latest Results for Allergy, Asthma
Wed Mar 04, 2020 02:00
Relationship between serum inhibitory activity for IgE and efficacy of Artemisia pollen subcutaneous immunotherapy for allergic rhinitis: a preliminary self-controlled study
Abstract Background Biomarkers of clinical efficacy for subcutaneous immunotherapy (SCIT) on allergic rhinitis (AR) have not been identified yet. This study aims to assess the clinical relevance of serum inhibitory activity for IgE by the method of enzyme-linked immunosorbent facilitated antigen binding (ELIFAB) during SCIT for Artemisia-sensitized AR patients. Methods...
Latest Results for Allergy, Asthma
Wed Mar 04, 2020 02:00
Food allergy among university students: uncharted territory
Abstract Background Food allergy is a growing global health concern, with limited studies conducted in developing countries. High-risk behavior regarding allergies is common among young adults, making them prone to severe allergic reactions. This study aimed to estimate the prevalence of food allergies among Imam Abdulrahman Bin Faisal University (IAU) students and to determine the rate of high-risk behaviors in this group. ...
Latest Results for Allergy, Asthma
Wed Mar 04, 2020 02:00
Clinical outcomes and prognostic factors in patients with multiple myeloma in South Tyrol: a retrospective single-center analysis
Abstract High-dose chemotherapy followed by autologous stem cell transplantation (HD-ASCT) as well as the introduction of novel agents (NA) significantly improved survival for patients with multiple myeloma (MM). A total of 150 unselected newly diagnosed MM patients treated at our institution from 1998 to 2017 were retrospectively analyzed. Median age at diagnosis was 69 years (range 33–93 years) with a median follow-up of 48.6 months. The median overall survival (OS) for the entire...
Latest Results for Annals of Hematology
02:00
18 F-FDG maximum standard uptake value predicts PD-L1 expression on tumor cells or tumor-infiltrating immune cells in non-small cell lung cancer
Abstract Objectives Programmed cell death-ligand 1 (PD-L1) is expressed on tumor cells (TC) and tumor-infiltrating immune cells (IC). We conducted a retrospective study to investigate the relationship between PD-L1 expression on TC/IC and 18F-FDG uptake in patients with surgically resected non-small cell lung cancer (NSCLC). Methods Total 362 NSCLC...
Latest Results for Annals of Nuclear Medicine
Wed Mar 04, 2020 02:00
Oral colonisation by antimicrobial-resistant Gram-negative bacteria among long-term care facility residents: prevalence, risk factors, and molecular epidemiology
Abstract Background For residents of long-term care facilities (LTCFs), antimicrobial-resistant bacteria (ARB) are a risk factor, yet their oral colonisation, potentially leading to aspiration pneumonia, remains unclear. This study was undertaken to survey the prevalence, phenotypic characteristics, and molecular epidemiology of antimicrobial-resistant Gram-negative bacteria in the oral cavity of LTCF residents, and to analyse the...
Latest Results for Antimicrobial Resistance and Infection Control
Wed Mar 04, 2020 02:00
Diketopiperazines and other bioactive compounds from bacterial symbionts of marine sponges
Abstract Humanity faces great challenges, such as the rise of bacterial antibiotic resistance and cancer incidence. Thus, the discovery of novel therapeutics from underexplored environments, such as marine habitats, is fundamental. In this study, twelve strains from the phylum Firmicutes and thirty-four strains from the phylum Proteobacteria, isolated from marine sponges of the Erylus genus, collected in Portuguese waters, were tested for bioactivities and the secondary metabolites...
Latest Results for Antonie van Leeuwenhoek
Wed Mar 04, 2020 02:00
Insights into the pH-dependent, extracellular sucrose utilization and concomitant levan formation by Gluconobacter albidus TMW 2.1191
Abstract Many bacteria and archaea produce the polydisperse fructose polymer levan from sucrose upon biofilm formation via extracellular levansucrases (EC 2.4.1.10). We have investigated levansucrase-release and -activities as well as molecular size of the levan formed by the acetic acid bacterium Gluconobacter albidus TMW 2.1191 at varying environmental pH conditions to obtain insight in the ecological role of its constitutively expressed levansucrase and the produced levan. A...
Latest Results for Antonie van Leeuwenhoek
Wed Mar 04, 2020 02:00
Bat guano-dwelling microbes and antimicrobial properties of the pygidial gland secretion of a troglophilic ground beetle against them
Abstract Bat guano is an important source of microbial diversity in caves and can be a source of potential pathogens. Laemostenus (Pristonychus) punctatus is a guanophilic ground beetle species, which pygidial gland secretion exhibits action against pathogenic and other microbes. The distribution and diversity of microbes in bat guano from a karstic cave were determined in this study. Additionally, antimicrobial activity of the pygidial gland secretion of L. (P.) punctatus against...
Latest Results for Applied Microbiology and Biotechnology
02:00
The effects of scattered radiation from a semitransparent edge on MTF measurement: verification of several factors by Monte Carlo simulation
Abstract Accurate evaluation of image quality not only characterizes system performance but also allows quantitative understanding of various image quality factors and the resulting image quality changes. The presampled modulation transfer function (MTF) can be useful in determining system resolution characteristics and response reduction caused by certain image quality factors. Although many studies have been conducted to accurately measure the MTF, there is still ample room for...
Latest Results for Australasian Physical
Wed Mar 04, 2020 02:00
Editorial
Latest Results for best practice onkologie
Sun Mar 01, 2020 02:00
Kutane Lymphome
Zusammenfassung Kutane Lymphome umfassen prognostisch heterogene Subgruppen. Die Mycosis fungoides ist das häufigste Hautlymphom und weist einen stadienhaften Verlauf (Patches, Plaques, Tumoren, Erythrodermie) auf. Zu den Behandlungsoptionen zählen in frühen Stadien hautgerichtete Therapiemaßnahmen, während in fortgeschrittenen Stadien und beim Sézary-Syndrom Systemtherapien mit z. B. Bexaroten, Interferon oder Brentuximab vedotin indiziert sind. Seltenere T‑Zell-Lymphome wie...
Latest Results for best practice onkologie
Sun Mar 01, 2020 02:00
Dysregulations of mitochondrial quality control and autophagic flux at an early age lead to progression of sarcopenia in SAMP8 mice
Abstract The senescence-accelerated mouse (SAM) prone 8 (SAMP8) has been demonstrated for muscular aging research including sarcopenia, but its underlying mechanisms remain scarce. Physiological indices and histology of skeletal muscle were analyzed in SAMP8 mice at different ages. SAMP8 mice exhibited typical features of sarcopenia at 40 weeks of age and were more time-efficient than that at 88 weeks of age in bothSAM resistant 1 (SAMR1) and C57BL/6 mice. Increase in FoxO3a-mediated...
Latest Results for Biogerontology
Wed Mar 04, 2020 02:00
Association of CYP2A6 gene deletion with cancers in Japanese elderly: an autopsy study
Abstract Background CYP2A6 is an enzyme involved in oxidation of a number of environmental chemicals, including nicotine, pro-carcinogenic nitrosamines and polycyclic aromatic hydrocarbons (PAHs). The whole gene deletion of CYP2A6 (CYP2A6*4) is prevalent in East Asian population. Whether or not CYP2A6*4 associates with cancer is still controversial. Methods...
Latest Results for BMC Cancer
Wed Mar 04, 2020 02:00
Germline BRCA , chemotherapy response scores, and survival in the neoadjuvant treatment of ovarian cancer
Abstract Background To analyze the effects of BRCA1/2 mutations on chemotherapy response scores (CRS) and survival in a cohort of patients with advanced-stage ovarian cancer who were treated with neoadjuvant chemotherapy (NAC) followed by interval debulking surgery (IDS). Methods We retrospectively reviewed the medical records of 169...
Latest Results for BMC Cancer
Wed Mar 04, 2020 02:00
Influence of Casein kinase II inhibitor CX-4945 on BCL6-mediated apoptotic signaling in B-ALL in vitro and in vivo
Abstract Background Casein kinase II (CK2) is involved in multiple tumor-relevant signaling pathways affecting proliferation and apoptosis. CK2 is frequently upregulated in acute B-lymphoblastic leukemia (B-ALL) and can be targeted by the ATP-competitive CK2 inhibitor CX-4945. While reduced proliferation of tumor entities including B-ALL after CX-4945 incubation has been shown in vitro and in vivo, the detailed way of action is...
Latest Results for BMC Cancer
Wed Mar 04, 2020 02:00
Serum miRNAs, a potential prognosis marker of loco-regionally advanced nasopharyngeal carcinoma patients treated with CCRT
Abstract Background Serum miRNA was once found as potential disease survival index,thus we investigated the role of miRNA in predicting prognosis in loco-regionally advanced NPC patients treated with CCRT. Methods This study included two phases: (i) We enrolled 3 NPC patients with recurrence or distant metastasis (experimental group,...
Latest Results for BMC Cancer
Wed Mar 04, 2020 02:00
Risk factors for aspiration pneumonia during concurrent chemoradiotherapy or bio-radiotherapy for head and neck cancer
Abstract Background Aspiration pneumonia is one of the most important side effects of chemoradiotherapy (CRT) and bio-radiotherapy (BRT) in patients with head and neck cancer (HNC). Aspiration pneumonia can lead to cancer-related mortality in HNC patients. However, the relationship between aspiration pneumonia occurring during CRT or BRT for HNC and treatment outcomes in HNC patients is not well characterized. In this study, we...
Latest Results for BMC Cancer
Wed Mar 04, 2020 02:00
LncRNA SNHG5 promotes nasopharyngeal carcinoma progression by regulating miR-1179/HMGB3 axis
Abstract Background Long noncoding RNAs (lncRNAs) have been reported to be important regulators in pathogenesis of human cancers, including nasopharyngeal carcinoma (NPC). Here, we mainly aimed to explore the mechanisms of LncRNA-SNHG5/ miR-1179/HMGB3 axis in NPC progression. Methods RT-qPCR and Western blot analysis were employed to...
Latest Results for BMC Cancer
Wed Mar 04, 2020 02:00
Relationship of lymphovascular invasion with lymph node metastasis and prognosis in superficial esophageal carcinoma: systematic review and meta-analysis
Abstract Background The development of tumor cells inside the lymphatics or blood vessels is known as lymphovascular invasion (LVI). The correlation between LVI, lymph node metastasis (LNM), and the diagnosis of superficial esophageal carcinoma (SEC) remains unclear. Methods We searched Embase, PubMed, Web of Science, and Cochrane Library...
Latest Results for BMC Cancer
Wed Mar 04, 2020 02:00
Lymph node metastasis in young and middle-aged papillary thyroid carcinoma patients: a SEER-based cohort study
Abstract Background Lymph node metastasis (LNM) occurs frequently in young papillary thyroid carcinoma (PTC) patients, though the mortality rates are low. We aimed to analyze the relationship between age at diagnosis and LNM in PTC at a population level to elucidate the clinical behavior of PTC. Methods Data of adult patients with surgically...
Latest Results for BMC Cancer
Wed Mar 04, 2020 02:00
Prognostic value of tumor-infiltrating lymphocytes in patients with triple-negative breast cancer: a systematic review and meta-analysis
Abstract Background The objective of this systematic review and meta-analysis was to determine the prognostic value of total tumor-infiltrating lymphocytes (TILs) and subtypes of TILs (CD4+, CD8+, and FOXP3+) in triple-negative breast cancer (TNBC). Methods A systematic search of the MEDLINE, EMBASE, and Web of Science databases was conducted...
Latest Results for BMC Cancer
Wed Mar 04, 2020 02:00
Clinical significance of peripheral blood and tumor tissue lymphocyte subsets in cervical cancer patients
Abstract Background Alterations in peripheral blood lymphocytes in cervical cancer have been reported, although conflicting views exist. The present study investigated the distributions of lymphocyte subsets in tumor tissue and peripheral blood samples from cervical cancer patients and precancerous lesion patients, and evaluated the correlations of lymphocyte subsets with clinicopathological and prognostic variables. ...
Latest Results for BMC Cancer
Wed Mar 04, 2020 02:00
Sarcopenia as a predictor of mortality in women with breast cancer: a meta-analysis and systematic review
Abstract Background Breast cancer is the most commonly diagnosed cancer and the leading cause of cancer death in women worldwide. Recently, studies have been published with inconsistent findings regarding whether sarcopenia is a risk factor for mortality in breast cancer patients. Therefore, the aim of this systematic review and meta-analysis was to systematically assess and quantify sarcopenia as a risk factor for mortality in...
Latest Results for BMC Cancer
Wed Mar 04, 2020 02:00
Incidence of advanced-stage breast cancer in regular participants of a mammography screening program: a prospective register-based study
Abstract Background The European Guidelines for breast cancer screening suggest that the impact of population-based mammography screening programmes (MSP) may be assessed using the relative reduction in the incidence of advanced breast cancer (ABC, that is, stage UICC II and higher) as a surrogate indicator of screening effectiveness. Methods ...
Latest Results for BMC Cancer
Wed Mar 04, 2020 02:00
Increased PD-1-positive macrophages in the tissue of gastric cancer are closely associated with poor prognosis in gastric cancer patients
Abstract Background Programmed cell death 1 (PD-1) is one of the immune checkpoint molecules that negatively regulate the function of T cells. Although recent studies indicate that PD-1 is also expressed on other immune cells besides T cells, its role remains unclear. This study aims to evaluate PD-1 expression on macrophages and examine its effect on anti-tumor immunity in gastric cancer (GC) patients. ...
Latest Results for BMC Cancer
Wed Mar 04, 2020 02:00
Efficacy of bevacizumab combined with chemotherapy in the treatment of HER2-negative metastatic breast cancer: a network meta-analysis
Abstract Background It is not known what combination of bevacizumab and chemotherapy agents is the best therapeutic regimen. Comparative study results among the efficacies of bevacizumab plus chemotherapy remain controversial in patients with HER2-negative metastatic breast cancer. Methods We searched Pubmed, Embase, and Cochrane Library...
Latest Results for BMC Cancer
Wed Mar 04, 2020 02:00
Granulomatosis with polyangiitis in a patient treated with dabrafenib and trametinib for BRAF V600E positive lung adenocarcinoma
Abstract Background Dabrafenib and trametinib combination therapy is approved for the treatment of patients with BRAF V600E positive tumors including melanoma and lung cancer. The effect of BRAF and MEK inhibitors on the immune system is not fully understood although a number of case reports indicate autoimmune side effects related to the use of these drugs. Here, we discuss a case of a patient diagnosed with granulomatosis with...
Latest Results for BMC Cancer
Wed Mar 04, 2020 02:00

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