Abstract Severe combined immunodeficiency (SCID) is a group of syndromes resulting from genetic defects causing severe deficiency in T cell and B cell function. These conditions are life-threatening and result in susceptibility to serious infections. SCID is often fatal in the first year of life if not detected and properly treated. SCID and related T cell lymphopenias can be detected in newborns by a simple screening test, the T cell receptor excision circle (TREC) assay, using...
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Abstract Tumor-infiltrating CD8 T cells are instrumental to antitumor immunity. In this study, we found that a subset of CXCR5-expressing CD8 T cells, termed follicular cytotoxic T (Tfc) cells, potently infiltrated the untreated tumors from non-small cell lung cancer (NSCLC) patients. On average, Tfc cells represented 14% of total tumor-infiltrating CD8 T cells and 6.6% of total tumor-infiltrating lymphocytes. Upon antigenic stimulation, Tfc cells presented significantly higher...
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Abstract Background The first HPV vaccines licensed targeted two HPV types responsible for most cervical cancers. A 9-valent vaccine (9vHPV), targeting 5 additional types, was introduced in 2016 and is currently the only HPV vaccine available in the United States. Previous studies demonstrated high rates of HPV infection in Alaska Native (AN) women. We sought to measure prevalence of high risk HPV types in AN women undergoing...
Tue Mar 03, 2020 02:00
Abstract We aimed to determine the effect of soluble epoxide hydrolase (sEH) inhibition on chronic experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis (MS), associated with changes in inflammasome-dependent and -independent inflammatory and anti-inflammatory pathways in the CNS of mice. C57BL/6 mice were used to induce chronic EAE by using an injection of MOG35–55 peptide/PT. Animals were observed daily and scored for EAE signs for 25 days after...
Tue Mar 03, 2020 02:00
Abstract Objectives Podcasts are audio recordings distributed via the Internet. We review the availability of podcasts on the topic of radiology. Methods A search for podcasts relating to radiology was performed using search engines and free public websites that either hosted or distributed podcasts. Only English language podcast series...
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Abstract Objectives This study aimed to investigate the application of shear wave elastography (SWE) in the early damage detection through assessing the endometrial elasticity after artificial abortion. Methods A total of nulliparous women (20–30 years) who received ultrasonography in our hospital were recruited between January 2017 and...
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Abstract Background Ninety years after the Dutch theoretical physicist H.A. Lorentz died, detailed investigation of his scientific heritage yielded the set of nine original prints of radiographs that W.C. Roentgen made during his experiments and had sent him, among half a dozen other scientists, on January 1st, 1896. Main text Through...
Tue Mar 03, 2020 02:00
Abstract The aim of the study is to perform an analysis of the results that have been compiled in the nine years that the examination has existed.
Tue Mar 03, 2020 02:00
In the original publication of the article, the first name and last name of the authors were interchanged.
Tue Mar 03, 2020 02:00
Abstract Objective We aim to estimate the association between working hour mismatches and mental well-being. We also investigate the confounding and moderating role of job quality in this association. Methods We use cross-sectional data from the European Working Conditions Survey of 2015 in the analysis. The sample includes 9345 male and 10,998 female employees...
Tue Mar 03, 2020 02:00
Summary Introduction Durvalumab has been shown to confer a survival benefit after definitive chemoradiotherapy in the patients with locally advanced non-small cell lung cancer, but no studies have attempted to identify risk factors for pneumonitis after durvalumab therapy. The purpose of this study was to investigate associations between clinical and radiation dose-volume factors, and the severity of pneumonitis. Methods We retrospectively assessed the cases of 30 patients who...
Tue Mar 03, 2020 02:00
Summary This phase 1 study sought to characterize the safety, tolerability, and pharmacokinetic behavior of VLX1570, a small molecule inhibitor of the deubiquitinases (DUBs) that remove sterically bulky ubiquitin chains from proteins during processing in the19S regulatory subunit of the proteasome, in patients with relapsed and refractory multiple myeloma (MM). Fourteen patients were treated with escalating doses of VLX1570 ranging from 0.05 to 1.2 mg/kg as a brief intravenous...
Tue Mar 03, 2020 02:00
Tue Mar 03, 2020 02:00
Samenvatting Spelen hoort bij een gezond leven: digitaal spelen net zo zeer. De analyses in dit artikel laten zien dat gamen – ook frequent gamen – niet gepaard hoeft te gaan met geestelijke of lichamelijke gezondheidsproblemen. In tegendeel: hobbygamers roken, blowen en drinken minder vaak dan niet-gamende jongeren – ze spelen zo’n 14 uur per week en ervaren weinig problemen. Zo’n 7 % van de jongens behoort tot de risicogamende groep. Deze groep vertoont vijf keer zo vaak lichamelijke...
Tue Mar 03, 2020 02:00
Abstract The purpose of current research was to explore the effect of high temperature-short time (HTST) and different ultrasound times intervals on the strawberry juice for a period of 14 days. Strawberry fruits were treated at 72 °C for 15 s by HTST and also sonicated at 20 kHz and 100% amplitude for 5, 10, and 15 min. The main objective is to evaluate the effect of treatments and storage time on color, total antioxidants, total phenolics, ascorbic acid and microbial content...
Tue Mar 03, 2020 14:07
Abstract The study aimed at the development of elephant foot yam starch (EFYS) based edible film through blending of Xanthan (XG) and agar–agar (AA). Film thickness and density increased with increase in concentration of hydrocolloids and the respective highest value 0.199 mm and 2.02 g/cm3 were found for the film possessing 2% AA. The film barrier properties varied with hydrocolloids and the lowest value of water vapour transmission rate (1494.54 g/m2) and oxygen transmission...
Tue Mar 03, 2020 14:07
Abstract The effect of pectinolytic enzyme preparation (PEP) produced by the fungus Thermomucor indicae-seudaticae-N31 (PEP-N31) on total phenolic content, concentrations of methanol and color of grape juice was studied. Positive results were found when PEP-N31 was used to extract phenolic compounds after the grapes had been blanched for 3 min and macerated for 1 h. The resulting juice had better yield, color characteristics and higher phenolic content (1637.21 mg.L-1, as gallic...
Tue Mar 03, 2020 14:07
Abstract Due to the difference of raw materials and brewing technology, the quality and flavours of vinegar are different. Different kinds of vinegar have different functions and effects. Therefore, it is important to classify the vinegar varieties correctly. This work presented a new fuzzy feature extraction algorithm, called fuzzy Foley–Sammon transformation (FFST), and designed the electronic nose (E-nose) system for classifying vinegar varieties successfully. Principal component...
Tue Mar 03, 2020 14:07
Abstract The effects of dynamic ultra-high pressure homogenization (UHPH) on the structure and functional properties of whey protein were investigated in this study. Whey protein solution of 10 mg/mL (1% w/w) was prepared and processed by a laboratory scale high pressure homogenizer with different pressures (25, 50, 100, 150, 200, and 250 MPa) at an initial temperature of 25 °C. Then, the solution samples were evaluated in terms of secondary structure, sulfhydryl and disulfide...
Tue Mar 03, 2020 14:07
Abstract The present study aimed to determine the effect of adding protein hydrolysates obtained after 30, 60, and 90 min enzymatic hydrolysis of fish roe on properties of silver carp sausages enriched with fish oil during storage at 4 °C for 30 days. Properties of the fortified sausages were determined by assessment of primary and secondary oxidation, fatty acid composition, microbial spoilage, texture, and organoleptic properties. The results indicated that the hydrolysates...
Tue Mar 03, 2020 14:07
Abstract The study was conducted to determine the engineering properties of horse gram varieties namely GPM-6, PAYIUR-2, and BHK as a function of moisture content in range of 10–30%. The average length, width, thickness, geometric mean diameter, arithmetic mean diameter, thousand kernel weight, sphericity, porosity and angle of repose ranged from 5.43 to 6.53 mm, 3.96 to 4.48 mm, 2.21 to 2.99 mm, 3.62 to 4.41 mm, 3.86 to 4.64 mm, 30.32 to 49.11 g, 63.56 to 72.66%, 35.20 to 38.76%...
Tue Mar 03, 2020 14:07
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