Abstract This article reviews the disorders of thunderclap, cough, exertional and sexual headache. These are a group of paroxysmal and precipitated headaches, which often occur in bouts with prolonged remissions. Indometacin seems to be the most effective preventative. Each can occur in primary and secondary form. Thunderclap headache is the most frequently reported headache syndrome associated with a secondary pathology. Discussed are the complexities of whether all patients...
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Abstract Insects have established close relationships with a wide variety of microorganisms, which play a key role in insect ecology and evolution. Fruit flies in the Tephritidae family have economic importance at the global level, including species such as Anastrepha obliqua, which is an important pest in the neotropical region. Although several studies have been performed on the microbiota associated with fruit flies, there are still large gaps in our knowledge about the bacterial...
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Healthcare staff on leave and those who have retired could be called “back to duty,” and non-urgent care could be delayed, as doctors are forced to prioritise dealing with covid-19, the UK...
Tue Mar 03, 2020 16:21
Is there some sort of higher calling to join the medical profession, or is it simply a highly skilled job? This age old debate generates more heat than light, and it’s not clear why the two need to...
Tue Mar 03, 2020 14:46
Two urologists have been suspended from the UK medical register, one for mistakenly removing the vagina of a sex change patient who did not want it removed, and the other for altering the patient’s...
Tue Mar 03, 2020 14:06
“It gives me immense satisfaction to give people the time and attention they need,” says Sakkarai Ambalavanan. Regardless of the pressures of his role, he always tries to find calm in the...
Tue Mar 03, 2020 12:51
From April 2020, patients will have full online access to prospective data from their patient record, including the free text of consultations. While I welcome the move towards shared medicine and...
Tue Mar 03, 2020 12:50
What the NHS will ultimately look like under the Conservative party has yet to be determined, but the potential impact of American private healthcare interests remains part of the discussion.1 During...
Tue Mar 03, 2020 12:50
Park and colleagues make a compelling point about the need for increased joint working during terror incidents.1 We describe a collaborative training concept that lays the foundation for...
Tue Mar 03, 2020 12:26
What is this, the Beard Management Journal?Now calm down, we’re not about to start dolling out fashion tips for your facial fuzz. We’re talking about how having a hairy face could stop protective...
Tue Mar 03, 2020 12:11
Park and colleagues discuss medical responses to a terrorist attack, mentioning the model used by the French National Police Special Intervention Unit.1 Another model is the one chosen by the French...
Tue Mar 03, 2020 11:16
Authors: Minoia C, Bari A, Nassi L, Banzi R, Gerardi C, Lenti V, Calabrese M, Spina M, Guarini A Abstract Several outpatient models for the follow-up of cancer survivors have been developed worldwide. A multidisciplinary approach is often necessary to guarantee the best monitoring of long-term toxicities. Guidelines also indicate a close education on healthy lifestyles. In this context, we have analyzed the Italian follow-up modalities of lymphoma survivors, with the aim to have a starting...
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CONCLUSIONS: Since the previous publication and after the diffusion of new-born screening, the most frequent diagnostic method, to the majority of autonomous regions, and the inclusion of adult patients to the registry, the REHem has increased by more than 240 cases, reaching a total of 959 records. PMID: 32113697 [PubMed - as supplied by publisher] (Source: Medicina Clinica)
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Radiation cystitis, a severely debilitating condition characterized by fibrosis, vascular damage, and compromised bladder function, develops in cancer survivors who received pelvic radiation treatment. This is the first study to compare the effects of radiation on the bladder across different murine genetic backgrounds, which may explain differences in patients ’ sensitivity to developing radiation cystitis after radiation cancer treatment. AbstractA subset of patients receiving radiation therapy...
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ConclusionFast induction of eWBH with homogenous thermal distribution is feasible in pigs using the Vith èr WBH device. Severe hemodynamic disturbances, rhabdomyolysis, and hyperkalemia were observed. (Source: Physiological Reports)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
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Cancer-related anemia is present in more than 60% of newly diagnosed cancer patients and is associated with substantial morbidity and high medical costs. Drugs that enhance erythropoiesis are urgently required to decrease transfusion rates and improve quality of life. Clinical studies have observed an unexpected improvement in hemoglobin and RBC transfusion-independence in patients with acute myeloid leukemia (AML) treated with the isocitrate dehydrogenase 2 (IDH2) mutant-specific inhibitor enasidenib,...
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Recent findings have shown that inhibitors targeting bromodomain and extraterminal domain (BET) proteins, such as the small molecule JQ1, are potent growth inhibitors of many cancers and hold promise for cancer therapy. However, some reports have also revealed that JQ1 can activate additional oncogenic pathways and may affect epithelial-to-mesenchymal transition (EMT). Therefore, it is important to address the potential unexpected effect of JQ1 treatment, such as cell invasion and metastasis. Here,...
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Peptide MHC class II–based (pMHCII-based) nanomedicines trigger the formation of multicellular regulatory networks by reprogramming autoantigen-experienced CD4+ T cells into autoimmune disease–suppressing T regulatory type 1 (TR1) cells. We have shown that pMHCII-based nanomedicines displaying liver autoimmune disease–relevant yet ubiquitously expressed antigens can blunt various liver autoimmune disorders in a non–disease-specific manner without suppressing local or systemic immunity against infectious...
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Oncogenic KRAS is a major driver in lung adenocarcinoma (LUAD) that has yet to be therapeutically conquered. Here we report that the SLC7A11/glutathione axis displays metabolic synthetic lethality with oncogenic KRAS. Through metabolomics approaches, we found that mutationally activated KRAS strikingly increased intracellular cystine levels and glutathione biosynthesis. SLC7A11, a cystine/glutamate antiporter conferring specificity for cystine uptake, was overexpressed in patients with KRAS-mutant...
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Tregs require specific epigenetic signatures to induce and maintain their suppressive function in the context of inflammation and cancer surveillance. In this issue of the JCI, Xiong and colleagues identify a critical role for the epigenetic repressor REST corepressor 1 (CoREST) in promoting Treg suppressive transcriptional and functional programs. Pharmacologic inhibition and genetic loss of CoREST in Tregs impaired organ allograft tolerance and unleashed antitumor immunity via epigenetic activation...
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Cover illustration The boot print on the moon, taken during Apollo 11 mission in 1969. The name selenium comes from the Greek word for moon, Selene, and GPx4 contains selenium as selenocysteine in the catalytic site. GPx4 is an important negative regulator of ferroptosis, so its specific inhibition may open new perspectives for cancer therapy. The cover refers to the article “Inactivation of the glutathione peroxidase GPx4 by the ferroptosis‐inducing molecule RSL3 requires the adaptor protein 14‐3‐3ε”...
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Publication date: June 2020Source: Journal of Environmental Chemical Engineering, Volume 8, Issue 3Author(s): Manviri Rani, Rachna, Uma Shanker (Source: Journal of Environmental Chemical Engineering)
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Publication date: Available online 2 March 2020Source: Chinese Chemical LettersAuthor(s): Zhaoqing Shi, Qianqian Li, Lin Mei (Source: Chinese Chemical Letters)
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AbstractMammalian sirtuins (SIRTs 1 ‐7), are a family of NAD+‐dependent deacetylases with distinct subcellular localization and biological functions that regulate various important cellular processes. Among these, SIRTs ‐3, ‐4, and ‐5 are located in the mitochondria and have been implicated in caloric restriction, oxidative stress, aging, and various human diseases. Emerging evidence has found dysregulation of mitochondrial sirtuins in multiple dermatological conditions, including responses to ultraviolet...
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This study examines escalating doses of benzoporphyrin derivative (BPD)‐mediated intraperitoneal PDT combined with the EGFR‐inhibitor cetuximab in a canine model. In the presen ce or absence of small bowel resection (SBR) and cetuximab, we observed a tolerable safety and toxicity profile related to the light dose received. Additionally, our findings that BPD levels are higher in the small bowel compared to other anatomical regions, and that the risk of anastomotic failure decreases at lower light...
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The research measures the expected body surface exposure of solar UVR to kiteboarders. Measured exposures are presented for 17 body sites. The expected body orientation is derived from video vector analysis of kiteboarders filmed in motion. A novel methodology for deriving UVR exposure in aquatic sports is presented with positive implications for skin cancer prevention, policy development, consumer education and sun protection awareness. AbstractKiteboarding is an aquatic sporting discipline that...
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AbstractIn the present work we study the photodynamic action of cercosporin (cerco), a naturally occurring photosensitizer, on human cancer multicellular spheroids. U87 spheroids exhibit double the uptake of cerco than T47D and T98G spheroids as shown by flow cytometry on the single cell level. Moreover, cerco is efficiently internalized by cells throughout the spheroid as shown by confocal microscopy, for all three cell lines. Despite their higher cerco uptake, U87 spheroids show the least vulnerability...
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In this study, sur factants were used to increase HAL solubility in the cell culture medium and serum, followed byin vitro fluorescence formation measurement in human pancreatic cancer cells (SW1990) andin vivo fluorescence detection in tumor ‐bearing mice. The results showed that Tween 80 (TW80) and Kolliphor® HS 15 (HS15) increased the solubility of HAL in the selected media. Although TW80 and HS15 exhibitedin vitro cytotoxicity at high concentrations (5 mg/mL), they facilitated fluorescent signal...
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AbstractUltraviolet (UV) radiation is among the most prevalent environmental factors that influence human health and disease. Even one hour of UV irradiation extensively damages the genome. To cope with resulting deleterious DNA lesions, cells activate a multitude of DNA damage response pathways, including DNA repair. Strikingly, UV ‐induced DNA damage formation and repair are affected by chromatin state. When cells enter S phase with these lesions, a distinct mutation signature is created via error‐prone...
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Journal of Natural ProductsDOI: 10.1021/acs.jnatprod.9b01168 (Source: Journal of Natural Products)
Tue Mar 03, 2020 06:00
CONCLUSIONS: The increased expression of NID1 in early to advanced naive as compared to the treated groups with Lung metastasis makes it a promising marker which has pro-metastatic role in Breast cancer. PMID: 32116201 [PubMed - as supplied by publisher] (Source: Recent Patents on Anti-Cancer Drug Discovery)
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Publication date: Available online 3 March 2020Source: Journal of Advanced ResearchAuthor(s): Ferlizza Enea, Solmi Rossella, Miglio Rossella, Nardi Elena, Mattei Gabriella, Sgarzi Michela, Lauriola Mattia (Source: Journal of Advanced Research)
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Authors: Noel B, Singh SK, Lillard JW, Singh R Abstract Breast cancer (BrCa) is the most commonly diagnosed cancer and the second leading cause of cancer-related death in women. Alarming increases in the cases quests for more effective treatment of BrCa. As most chemotherapeutic drugs are associated with drug resistance, cancer relapse, and side effects, scientists are turning to agents with more efficacy, such as natural compounds for treatment and prevention of BrCa. Selected natural...
00:53
We report an unusual case of low-grade fibromatosis-like metaplastic carcinoma (LG-FLMC) of the breast. This exceedingly rare epithelial breast malignancy has been reported only 68 times in the past 20 years, ... (Source: Diagnostic Pathology)
Tue Mar 03, 2020 01:00
ConclusionsRT rates for older women with early-stage breast cancer are declining with patient-level variation based on factors related to life expectancy and locoregional recurrence. Facility-level variation suggests opportunities to improve care delivery by focusing on barriers to de-implementation ofroutine use of RT. (Source: Breast Cancer Research and Treatment)
Tue Mar 03, 2020 00:00
Cells and extracellular matrix (ECM) components represent the multifaceted and dynamic environment that distinguishes each organ. Cancer is characterized by the dysregulation of the composition and structure of the tissues, giving rise to the tumor milieu. In this review, we focus on the microenvironmental analysis of colorectal cancer (CRC) and rhabdomyosarcoma (RMS), two different solid tumors. While a lot is known about CRC environment, for RMS, this aspect is mostly unexplored. Following the...
Tue Mar 03, 2020 00:00
Publication date: Available online 2 March 2020Source: Gynecologic Oncology ReportsAuthor(s): Omar Najjar, Aaron Varghese, Maryam Shahi, Russell Vang, Stephanie Gaillard, Thomas Smith, Amanda N. Fader (Source: Gynecologic Oncology Reports)
Tue Mar 03, 2020 23:42
Publication date: Available online 2 March 2020Source: Gynecologic Oncology ReportsAuthor(s): Rachael Marian Lobo, Mohammed Taha, Jonathan Jeremy Herod, Afaf Al Ansari, Sanaa Syed, Hind Al Malik, Hanan Farghaly (Source: Gynecologic Oncology Reports)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Tue Mar 03, 2020 23:42
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