We found that the mass‐specific lung volumes and the mass‐specific volume of exchange tissue were larger in the lungs of high‐altitude resident waterfowl than in those of low‐altitude resident and high‐altitude migratory waterfowl. We also found evidence of an inverse relationship between the percentage increase in pulmonary O2 extraction and the percentage increase in ventilation across species that is independent of the volume density of the exchange tissue. Abstract We examined the morphology...
Mon Mar 16, 2020 19:00
Malaria is transmitted by the Plasmodium parasite, and most of the cases reported in the United States are often as a result of patients with recent return from endemic areas. Prompt diagnosis and treatment, particularly if there is severe parasitemia and drug failure, is essential in preventing mortality. Our patient had an unusual rapid rise in parasite but susceptible to intravenous artesunate.
Mon Mar 16, 2020 17:20
Once coined the “Forgotten Disease,” Lemierre’s syndrome is a rare condition that results from oropharyngeal infection with the gram-negative, anaerobic Fusobacterium necrophorum. The typical progression of illness involves spread to adjacent structures such as the internal jugular vein with resulting thrombophlebitis. Septic emboli to distant sites are also a common sequela. Here, we present a case of Lemierre’s syndrome in a 20-year-old, otherwise healthy, male. The patient presented with fever,...
Mon Mar 16, 2020 16:05
Analytical ChemistryDOI: 10.1021/acs.analchem.9b05645
Mon Mar 16, 2020 06:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b05627
Mon Mar 16, 2020 06:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b04681
Mon Mar 16, 2020 06:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b05468
Fri Mar 13, 2020 06:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b05807
Fri Mar 13, 2020 06:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b03813
Fri Mar 13, 2020 06:00
Yeast surface display is a powerful technology used to isolate and engineer proteins to improve their activity, specificity, and stability. In this method, gene expression is regulated by promoters, and secret...
Mon Mar 16, 2020 02:00
Anthropogenic perturbations such as water overexploitation introduce novel selective pressures to the natural environments, impacting on the genomic variability of organisms and thus altering the evolutionary trajectory of its populations. Bad agricultural practices and defective policies in Cuatro Cienegas, Coahuila, Mexico, have strongly impacted its water reservoir, pushing entire hydrological systems to the brink of extinction together with their native populations. Here, we studied the effects...
Mon Mar 16, 2020 02:00
Van Vliet & Doebeli (1) (henceforth VVD) present a multi-level selection framework simulating host-microbiome evolutionary dynamics. The model explores the conditions under which the association between hosts and their 'helper' microbiome - microbes that developed a trait that provides a benefit to the host at a cost to themselves - is strong enough to allow for selection at the holobiont level. The model is an important contribution to the holobiont debate, making the notion quantifiable and...
Mon Mar 16, 2020 02:00
Genetic variation is the fuel of evolution, with standing genetic variation especially important for short-term evolution and local adaptation. To date, studies of spatio-temporal patterns of genetic variation in natural populations have been challenging, as comprehensive sampling is logistically difficult, and sequencing of entire populations costly. Here, we address these issues using a collaborative approach, sequencing 48 pooled population samples from 32 locations, and perform the first continent-wide...
Mon Mar 16, 2020 02:00
It is commonly asserted that when extrinsic mortality is high, individuals should invest early in reproduction. This intuition thrives in the literature on life-history theory and human behavior, yet it has been criticized repeatedly on the basis of mathematical models. The intuition is indeed wrong; but a recent theoretical criticism has confused the reason why it is wrong, thereby obscuring earlier and sounder criticisms. In the present article, based on the simplest possible model, we sought to...
Mon Mar 16, 2020 02:00
Mutational load is the depression in a population's mean fitness that results from the unceasing influx of deleterious mutations. Here, we directly estimate the mutational load in a population of mismatch repair-deficient *Saccharomyces cerevisiae*. We partition the load into two components. To estimate the load due to nonlethal mutations, we measure the competitive fitness of hundreds of randomly selected clones from both mismatch repair-deficient and -proficient populations. Computation of the...
Mon Mar 16, 2020 02:00
The fraction of the human genome that is functional is a question of both evolutionary and practical importance. Studies of sequence divergence have suggested that the functional fraction of the human genome is likely to be no more than ~15%. In contrast, the ENCODE project, a systematic effort to map regions of transcription, transcription factor association, chromatin structure, and histone modification, assigned function to ~80% of the human genome. In this paper we examine whether and how an...
Mon Mar 16, 2020 02:00
Cancers, Vol. 12, Pages 703: Dual Targeting of the p38 MAPK-HO-1 Axis and cIAP1/XIAP by Demethoxycurcumin Triggers Caspase-Mediated Apoptotic Cell Death in Oral Squamous Cell Carcinoma Cells Cancers doi: 10.3390/cancers12030703 Authors: Chien Yang Yang Ku Lee Tsai Lin Yang Demethoxycurcumin (DMC) is a curcumin analogue with better stability and higher aqueous solubility than curcumin after oral ingestion and has the potential to treat diverse...
Mon Mar 16, 2020 02:00
Cancers, Vol. 12, Pages 701: A Comparative Analysis of Tumors and Plasma Circulating Tumor DNA in 145 Advanced Cancer Patients Annotated by 3 Core Cellular Processes Cancers doi: 10.3390/cancers12030701 Authors: Kristian Larson Radhamani Kannaiyan Ritu Pandey Yuliang Chen Hani M. Babiker Daruka Mahadevan Matched-targeted and immune checkpoint therapies have improved survival in cancer patients, but tumor heterogeneity contributes to drug resistance. Our study...
Mon Mar 16, 2020 02:00
Cancers, Vol. 12, Pages 702: STAT3 Mutation Is Associated with STAT3 Activation in CD30+ ALK− ALCL Cancers doi: 10.3390/cancers12030702 Authors: Emma I. Andersson Oscar Brück Till Braun Susanna Mannisto Leena Saikko Sonja Lagström Pekka Ellonen Sirpa Leppä Marco Herling Panu E. Kovanen Satu Mustjoki Peripheral T-cell lymphomas (PTCL) are a heterogeneous, and often aggressive group of non-Hodgkin lymphomas. Recent advances in the molecular...
Mon Mar 16, 2020 02:00
Cancers, Vol. 12, Pages 700: Identification of Deregulated Pathways, Key Regulators, and Novel miRNA-mRNA Interactions in HPV-Mediated Transformation Cancers doi: 10.3390/cancers12030700 Authors: Iris Babion Viktorian Miok Annelieke Jaspers Angelina Huseinovic Renske D. M. Steenbergen Wessel N. van Wieringen Saskia M. Wilting Next to a persistent infection with high-risk human papillomavirus (HPV), molecular changes are required for the development of cervical...
Mon Mar 16, 2020 02:00
Cancers, Vol. 12, Pages 699: The Capacity of High-Grade Serous Ovarian Cancer Cells to Form Multicellular Structures Spontaneously along Disease Progression Correlates with Their Orthotopic Tumorigenicity in Immunosuppressed Mice Cancers doi: 10.3390/cancers12030699 Authors: Alicia Goyeneche Michael-Anthony Lisio Lili Fu Rekha Srinivasan Juan Valdez Capuccino Zu-hua Gao Carlos Telleria Many studies have examined the biology, genetics, and chemotherapeutic...
Mon Mar 16, 2020 02:00
Publication date: Available online 16 March 2020Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Nasibe Soltaninezhad, Nahid Jalilevand, Mohammad Kamali, Reyhane Mohamadi
Mon Mar 16, 2020 17:30
Publication date: Available online 15 March 2020Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): HyoGeun Choi, Gibbeum Kim, Byeong Joon Kim, Sung Kwang Hong, Hyung-Jong Kim, Hyo-Jeong Lee
Mon Mar 16, 2020 17:30
Publication date: Available online 15 March 2020Source: Journal of Oral and Maxillofacial SurgeryAuthor(s): Rabie M. Shanti, James Choi, William W. Thomas, Neil P. Sheth, Steven B. Cannady
Mon Mar 16, 2020 17:11
Publication date: Available online 16 March 2020Source: Journal of Bodywork and Movement TherapiesAuthor(s): Ben Schram, Robin Orr, Ben Hinton, Geoff Norris, Rodney Pope
Mon Mar 16, 2020 17:07
Publication date: Available online 15 March 2020Source: Journal of Bodywork and Movement TherapiesAuthor(s): Timas Peteraitis, Fred Smedes
Mon Mar 16, 2020 17:07
Publication date: Available online 15 March 2020Source: Journal of Bodywork and Movement TherapiesAuthor(s): Brian T. Swanson, Heather M. Bromaghin, Nate Bubacy, Austin Messick, Larissa Tinker
Mon Mar 16, 2020 17:07
Publication date: Available online 15 March 2020Source: Journal of Bodywork and Movement TherapiesAuthor(s): Christian Lunghi, Giacomo Consorti, Marco Tramontano, Jorge E. Esteves, Francesco Cerritelli
Mon Mar 16, 2020 17:07
Publication date: Available online 15 March 2020Source: Journal of Bodywork and Movement TherapiesAuthor(s): Andrea Bergna, Luca Vismara, Giovanni Parravicini, Fulvio Dal Farra
Mon Mar 16, 2020 17:07
Rejuvenation Research, Ahead of Print.
Thu Mar 12, 2020 09:00
Mon Mar 16, 2020 16:57
Barrett's esophagus (BE) is a consequence of gastroesophageal reflux disease and is predisposed to esophageal adenocarcinoma (EAC). EAC is an exemplar model of inflammation‐associated cancer. Glucocorticoids suppress inflammation through glucocorticoid receptor (GR) and serum‐ and glucocorticoid‐induced kinase‐1 (Sgk1) expressions. Therefore, we immunolocalized GR and Sgk1 in EAC and the adjacent BE tissues and studied their association with clinical disease course in 87 patients with EAC who underwent...
Mon Mar 16, 2020 16:57
In this qualitative study, semi‐structured interviews were conducted to investigate the causes of underperforming urological surgery trainees in Australia and New Zealand. Behavioural issues were considered the most likely cause of trainee underperformance, which are also the most challenging to remedy. However, in addition to trainee factors, causative factors related to supervision and training were identified. Abstract Background Urological surgical trainees who underperform are difficult...
Mon Mar 16, 2020 16:43
A single‐centre review of patients with infective endocarditis of the mitral valve showed that infectious diseases review at the index admission was protective against mortality. There was no difference in outcomes between surgery and medical therapy alone. Abstract Background Infective endocarditis (IE) of the mitral valve is an illness associated with significant morbidity and mortality. We describe the long‐term outcomes of mitral valve endocarditis at a single centre. Methods All...
Mon Mar 16, 2020 16:43
This retrospective review of patients with metastatic spine disease evaluated the prognostic ability of four existing scoring systems in a local New Zealand population. All four scores performed adequately; however, serum albumin and primary tumour type were most significant. A simplified, objective score using these items performed best in our population and may be applicable to populations with similar distributions of primary tumour types and adjuvant treatment options. Abstract Background...
Mon Mar 16, 2020 16:43
Right‐sided Bochdalek hernias are an uncommon and challenging problem. These hernias can contain bowel, kidney and even liver but can still be successfully repaired using minimally invasive techniques, especially in the elective setting and when an emergency bowel resection is not required. Abstract Background Right‐sided Bochdalek hernias are uncommon congenital diaphragmatic hernias that can be challenging to manage because they can contain bowel, omentum, kidney or liver. Methods...
Mon Mar 16, 2020 16:43
Stem Cells and Development, Ahead of Print.
Thu Mar 12, 2020 09:00
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