Publication date: Available online 16 March 2020Source: Clinical NeurophysiologyAuthor(s): Graham A. McLeod, Michelle-Lee Jones, Marcus C. Ng
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Η επιστημονική ομάδα από ερευνητικά ιδρύματα της Βαλένθια κατάφερε να αλληλουχίσει ολόκληρο το γονιδίωμα τριών δειγμάτων από ασθενείς που είχαν νοσήσει από τη COVID-19. Τα δείγματα είχαν ληφθεί στο Εργαστήριο Μικροβιολογίας του Πανεπιστημιακού Νοσοκομείου της Βαλένθια. Η αλληλούχιση του γονιδιώματος του νέου κορωνοϊού θα συμβάλλει στην παγκόσμια επιστημονική προσπάθεια για να εντοπιστούν οι πηγές μετάδοσής του και πως τα διαφορετικά στελέχη του έχουν καταφέρει να εξαπλωθούν. «Πρωταρχικός στόχος...
Mon Mar 16, 2020 19:17
Η ατμοσφαιρική ρύπανση, που προκαλούν οι κινητήρες των οχημάτων, είναι πιθανόν να συντελέσει σε αύξηση της θνησιμότητας από τον νέο κορωνοϊό SARS-CoV-2, ειδικά στα μεγάλα αστικά κέντρα. Στην επισήμανση αυτή προχώρησε η Ευρωπαϊκή Συμμαχία για τη Δημόσια Υγεία (EPHA) προειδοποιώντας ότι ο μολυσμένος αέρας στις αστικές περιοχές, που ήδη συντελεί σε επιδείνωση της υπέρτασης, του διαβήτη και πολλών αναπνευστικών παθήσεων, μπορεί να συντελέσει και σε μεγαλύτερη συνολικά θνησιμότητα καθώς ο νέος κορωνοϊός...
Mon Mar 16, 2020 18:48
Νέα έρευνα του Πανεπιστημίου του Μichigan έδειξε πως ο τρόπος που ο εγκέφαλος των εφήβων ανταποκρίνεται στα τηλεοπτικά διαφημιστικά μηνύματα, μαρτυρά τι θα φάνε το βράδυ. Στην έρευνα συμμετείχαν 171 έφηβοι ηλικίας 13-16 ετών, οι οποίοι εκτέθηκαν σε διαφημίσεις junk food όπως cheeseburgers και πατάτες τηγανητές, υγιεινά πιάτα με σαλάτες και σάντουιτς κοτόπουλου στη σχάρα, και τέλος σε διαφημίσεις με άλλο περιεχόμενο χωρίς φαγητό. Οι εγκεφαλικές αντιδράσεις καταγράφηκαν με την τεχνική της Λειτουργικής...
Mon Mar 16, 2020 15:04
Νέα έρευνα έφερε στο φως πιο ανησυχητικά στοιχεία για την επιβλαβή δράση στο ήπαρ ενός ευρέως χρησιμοποιούμενου παυσίπονου σε σχέση με ό,τι ήταν ήδη γνωστό. Πρόκειται για τη δραστική ουσία ιβουπροφαίνη με αναλγητική, αντιπυρετική και αντιφλεγμονώδη δράση, η οποία ανήκει στα μη στεροειδή αντιφλεγμονώδη φάρμακα (ΜΣΑΦ) και για την οποία έχει ήδη τεκμηριωθεί ότι σχετίζεται με αυξημένο κίνδυνο καρδιακών προβλημάτων έως και εγκεφαλικού επεισοδίου. Ωστόσο, η σύνδεσή της με επιπλοκές στην ηπατική λειτουργία...
Mon Mar 16, 2020 13:40
Η ανθρωπότητα παρατηρεί με κομμένη την ανάσα την επέλαση του νέου κορωνοϊού SARS-CoV-2, που μέχρι και το απόγευμα της Παρασκευής είχε εξαπλωθεί σε περισσότερες από 135 χώρες, έχοντας στοιχίσει τη ζωή σε περισσότερα από 5.000 άτομα. Η Ελλάδα έχει ήδη καταγράψει τον πρώτο θάνατο από κορωνοϊό, ενώ μέχρι την Παρασκευή τα επιβεβαιωμένα κρούσματα είχαν φτάσει τα 190. Εξ αυτών 11 χαρακτηρίζονται «ορφανά», δηλαδή χωρίς γνωστή πηγή μετάδοσης, ενώ σε σοβαρή κατάσταση νοσηλεύονται τουλάχιστον πέντε συμπολίτες...
Mon Mar 16, 2020 08:45
Νέα έρευνα από το Πανεπιστήμιο της Νότιας Καλιφόρνια έδειξε πως ο συνδυασμός συγκεκριμένων φαρμάκων που χρησιμοποιούνται για τη ρύθμιση της αρτηριακής πίεσης και της χοληστερόλης μπορούν να μειώσουν τον κίνδυνο εμφάνισης της νόσου Αλτσχάιμερ και της άνοιας. Πρόκειται για ευρέως χρησιμοποιούμενα αντιυπερτασικά σκευάσματα και τις στατίνες, χρήση των οποίων κάνει περίπου ένας στους τέσσερις ηλικιωμένους άνω των 65 ετών. Τα ευρήματα που δημοσιεύτηκαν στο PLOS One, κρίνονται ενθαρρυντικά, δεδομένου του...
Mon Mar 16, 2020 08:44
Οι κάτοικοι των πόλεων, τα παιδιά και οι ηλικιωμένοι παίρνουν περισσότερα αντιβιοτικά από ό,τι οι κάτοικοι των αγροτικών περιοχών και οι άνθρωποι μέσης ηλικίας, ενώ η χρήση των φαρμάκων αυτών μειώνεται καθώς αυξάνεται το επίπεδο μόρφωσης των ατόμων στις εύπορες χώρες. Τα δεδομένα αυτά αποτελούν τις τρεις πιο κυρίαρχες τάσεις που εντοπίστηκαν από ερευνητές του Πανεπιστημίου της Βόννης σε μελέτη που θα δημοσιευθεί στο International Journal of Hygiene and Environmental Health. Οι επιστήμονες αξιολόγησαν...
Mon Mar 16, 2020 08:02
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Abstract Overview Lung cancer is one of the deadliest cancers in the world. Its histological classification depends on early diagnosis and successful treatment. Therefore, having specific biomarkers for a quick sorting widens the successful output of lung cancer treatment. Material and methods High-throughput sequencing (RNA-seq) was performed of small...
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To evaluate the sensitivity and specificity of the Allplex™ Entero-DR, a quantitative PCR-based method, for the detection of β-lactamase-encoding genes and vancomycin-resistance determinants in 156 previously ...
The aim of our research was to evaluate the relationship involving left ventricular ejection fraction, low density lipoprotein, B-type natriuretic peptide, Troponin I and coronary flow reserve, and to determin...
After the large-scale earthquake in 2011, the disaster medical assistance team (DMAT) was made responsible for medical activities during the hyperacute phase of a disaster or accident in Japan. The medicines t...
To evaluate the expression of a set of miRNAs to identify differentially expressed miRNAs that might be considered reliable biomarkers on Diabetic Retinopathy (DR) blood samples.
According to the gene-environment interaction model the pathogenesis of psychosis relies on an adverse neuro-socio-developmental pathway. Perinatal stress represents an important risk factor for the developmen...
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Abstract Background The CD-TK double suicide gene has become an effective therapy for bladder cancer. A novel molecular-targeted ultrasound (US) method has been developed to precisely guide nanobubbles loaded with this gene to regions within bladder tumor cells and is widely used due to its efficiency in delivering drugs to the target tumor. Methods ...
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Abstract Purpose There is an increasing agreement that acromegaly caused by growth hormone (GH) cell adenoma has two distinct subtypes: densely granulated (DG) and sparsely granulated (SG). We hypothesized that differential molecular signatures may explain their behavior. Methods Total transcriptome sequencing was performed on ten DG and seven SG adenomas....
Abstract Purpose Peroxisome proliferator-activated receptor γ (PPARγ) gene is strongly associated with type 2 diabetes mellitus, as well as postprandial lipemia, and plays an important role in Wnt dependent adipogenesis in subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT). We aimed to study the expression of PPARγ gene in SAT and VAT to find out its correlation with postprandial hypertriglyceredemia and glucose intolerance....
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Publication date: Available online 16 March 2020Source: Behavioural Brain ResearchAuthor(s): Punita Kumari, Meetu Wadhwa, Garima Chauhan, Shahnawaz Alam, Koustav Roy, Prabhash Kumar Jha, Krishna Kishore, Koushik Ray, Sanjeev kumar, Tapas Chandra Nag, Usha Panjwani
Publication date: Available online 16 March 2020Source: Behavioural Brain ResearchAuthor(s): Stuart F. White, Yoojin Lee, Michael W. Schlund, Elizabeth A. Shirtcliff, Cecile D. Ladouceur
Publication date: Available online 16 March 2020Source: Behavioural Brain ResearchAuthor(s): Avila G, Picazo O, Chuc-Meza E, García-Ramirez M
Publication date: Available online 16 March 2020Source: Behavioural Brain ResearchAuthor(s): Fang Wang, Xiaohui Wu, Jerry Gao, Yongchao Li, Yuncheng Zhu, Yiru Fang
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Abstract Simulation of musculoskeletal systems using dynamic optimization is a powerful approach for studying the biomechanics of human movements and can be applied to human‐robot interactions. The simulation results of human movements augmented by robotic devices may be used to evaluate and optimize the device design and controller. However, simulations are limited by the accuracy of the models which are usually simplified for computation efficiency. Typically, the powered robotic devices are...
Abstract In this work we study a bone remodeling model for the evolution of the myeloma disease. The biological problem is written as a coupled nonlinear system consisting of parabolic partial differential equations. They are written in terms of the concentrations of osteoblasts and osteoclasts, the density of the relative bone and the concentration of the tumor cells. Then, we deal with the numerical analysis of this variational problem, introducing a numerical approximation by using the finite...
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Covalent attachment of probe molecules to atomic force microscopy (AFM) cantilever tips is an essential technique for the investigation of their physical properties. This allows us to determine the stretching force, desorption force and length of polymers via AFM-based single molecule force spectroscopy with high reproducibility.
Here, we provide protocols to perform three simple injury-induced axon degeneration (axon death) assays in Drosophila melanogaster to evaluate the morphological and functional preservation of severed axons and their synapses.
This report describes screening of different detergents for preparing the visual GPCR, rhodopsin, and its complex with mini-Go. Biochemical methods characterizing the quality of the complex at different stages during purification are demonstrated. This protocol can be generalized to other membrane protein complexes for their future structural studies.
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Abstract The motor-cognitive model holds that motor imagery relies on executive resources to a much greater extent than do overt actions. According to this view, engaging executive resources with an interference task during motor imagery or overt actions will lead to a greater lengthening of the time required to imagine a movement than to execute it physically. This model is in contrast to a currently popular view, the functional equivalence model, which holds that motor imagery...
Abstract The present study examined the impact of white noise on word recall performance and brain activity in 40 healthy adolescents, split in two groups (normal and low) depending on their auditory working memory capacity (AWMC). Using functional magnetic resonance imaging, participants performed a backward recall task under four different signal-to-noise ratio (SNR) conditions: 15, 10, 5, and 0-dB SNR. Behaviorally, normal AWMC individuals scored significantly higher than low...
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Publication date: Available online 15 March 2020Source: TalantaAuthor(s): Milica Velimirovic, Stephan Wagner, Fazel Abdolahpur Monikh, Toni Uusimäki, Ralf Kaegi, Thilo Hofmann, Frank von der Kammer
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As the Wuhan coronavirus epidemic continues to spread, there’s an ever greater need for personal protection that works best for this very infectious virus. Face masks, even N95 masks, are not great at preventing the virus from entering the nose, mouth, and the eyes. Spurred by necessity, an Israeli physician designed a protective mask that bridges the gap between N95 masks and a lot more restrictive gas masks, in the process protecting the airways and the eyes from being entry points...
Synthetic dry elastomers are polymeric materials that feature cross-linked networks that form into random and unordered shapes and textures. These materials have a host of properties that are applicable in biomedicine, but the randomness of their internal structures at different scales makes it difficult to actually use these elastomers. Now, researchers at Chalmers University of Technology in Sweden have developed a porous elastomer whose properties, including its structure down to the nanoscale,...
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Mucosal Immunology, Published online: 16 March 2020; doi:10.1038/s41385-020-0282-xMAdCAM-1 mediates retinal neuron degeneration in experimental colitis through recruiting gut-homing CD4+ T cells
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Condition: Thyroid CancerInterventions: Drug: Anlotinib; Procedure: surgery; Procedure: core needle biopsySponsor: Fudan UniversityRecruiting
Condition: Head and Neck CancerInterventions: Behavioral: Early ambulation; Behavioral: Early oral feeding; Other: Multimodal opioid-sparing analgesia; Procedure: Goal-directed fluid therapy; Procedure: CAD/CAM system for reconstructive plates; Other: Functional discharge criteria; Other: Standard/historical postoperative regimenSponsor: Rigshospitalet, DenmarkRecruiting
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Publication date: Available online 15 March 2020Source: Annals of Allergy, Asthma & ImmunologyAuthor(s): Caroline Foreman, Thanh-Thao Adriana Le, Joshua M. Inglis, William Bernard Smith
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Aircrew studies have the potential to inform on cancer risks from several occupational exposures: cosmic radiation, electromagnetic frequency radiation (in studies of cockpit crew), and circadian disruption due to night work and rapid transmeridian travel. Six years ago, a commentary1 in this journal queried whether there is more yet to learn about cancer from studies of aircrew cohorts and outlined some possible avenues for research, including the assembly of large cohorts from individual employers,...
ObjectiveTo determine the effect of prolonged exposure to a submarine environment on biomarkers of cardiometabolic risk in Royal Navy (RN) submariners.MethodsSerum lipids (cholesterol (C), triglyceride (TG), low-density lipoprotein cholesterol, high-density lipoprotein cholesterol (HDL-C), non-HDL-C), glucose, insulin and anthropometrics were compared within three RN submarine crews before and after submerged patrols of 12 or 6 weeks, and with a crew that remained ashore (SUB-HOME). Dietary intake...
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