High Altitude Medicine &Biology, Ahead of Print.
Mark above section as read
Horm Metab Res 2019; 51: 487-494DOI: 10.1055/a-0958-2441Sodium glucose cotransporter 2 (SGLT2) inhibitors are a new kind of hypoglycemic drugs that improve glucose homeostasis by inhibiting renal glucose reabsorption. Recent studies have shown that SGLT2 inhibitors can also mediate body metabolism through regulation of adipokines level, but the effects of SGLT2 inhibitors on the concentration of adipokines (leptin and adiponectin) remains controversial. This meta-analysis was set out to evaluate...
Horm Metab Res 2019; 51: 495-502DOI: 10.1055/a-0957-3256Neck circumference (NC) has been suggested as a predictor for blood pressure disorders. Therefore, we sought to conduct a systematic review and meta-analysis regarding the association between NC and blood pressure in adults. Pertinent studies were identified by searching PubMed and Scopus databases, up to March 2018. Studies which reported the correlation coefficient between NC, systolic blood pressure (SBP), and diastolic blood pressure (DBP)...
Horm Metab Res 2019; 51: 554-554DOI: 10.1055/a-0976-7010© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
Horm Metab Res 2019; 51: 503-510DOI: 10.1055/a-0955-6662Recently, obesity has become a common worldwide concern. Leptin, as an adipocytokine, plays a major role in the etiology of obesity. Prior studies have demonstrated that zinc potentially affects serum leptin levels. However, clinical trials carried out in this regard are not consistent. Therefore, current meta-analysis was conducted to ascertain the actual effect of zinc supplementation on serum leptin levels in adults. Databases of PubMed,...
Horm Metab Res 2019; 51: 522-530DOI: 10.1055/a-0923-9184The risk of thyroid autoimmunity and thyroid dysfunction among patients with gout and hyperuricemia has not been well defined. This study was undertaken to examine the impact of gout and hyperuricemia on risk of thyroid disorders including thyroid autoimmunity and thyroid dysfunction. A population-based cross-sectional study was conducted to assess the risk of thyroid autoimmunity and thyroid dysfunction related to gout and hyperuricemia, which...
Horm Metab Res 2019; 51: 511-521DOI: 10.1055/a-0963-0054We conducted this meta-analysis to evaluate effects of second-generation anti-epileptic drugs (AEDs; levetiracetam, lamotrigine) compared to first-generation AEDs (valproic acid, carbamazepine) on bone metabolism in epilepsy patients. PubMed, Web of Science, Clinical trials.gov, Wanfang, and China national knowledge infrastructure databases were searched. Ten trials were included. Results showed: (1) The overall SMD for changes of serum calcium,...
Mark above section as read
Nature, Published online: 13 August 2019; doi:10.1038/d41586-019-02455-1Canadian telescope finds eight more repeating blasts — energetic events from deep in the cosmos.
Nature, Published online: 13 August 2019; doi:10.1038/d41586-019-02448-0A Los Angeles fault could unleash significant destruction — but isn’t factored into the region’s earthquake planning.
Nature, Published online: 13 August 2019; doi:10.1038/d41586-019-02402-0How Nature reported wartime advances in underwater microphones in 1919, and predictions of overcrowding in geostationary orbits in 1969.
Nature, Published online: 13 August 2019; doi:10.1038/d41586-019-02434-6Choi Ki-young is set to take the job as tensions with Japan spill into the semiconductor industry.
Nature, Published online: 13 August 2019; doi:10.1038/d41586-019-02444-4Don’t squander sand — save it for sea-level rise
Nature, Published online: 13 August 2019; doi:10.1038/d41586-019-02415-9The World Bank’s funding scheme for disease outbreaks drained potential resources from the Democratic Republic of the Congo, says Olga Jonas.
Nature, Published online: 13 August 2019; doi:10.1038/d41586-019-02429-3Rule out conflicts of interest in psychology awards
Nature, Published online: 13 August 2019; doi:10.1038/d41586-019-02441-7Astronomy must respect rights of Indigenous peoples
Nature, Published online: 13 August 2019; doi:10.1038/d41586-019-02433-7Danger to science of no-deal Brexit
Nature, Published online: 13 August 2019; doi:10.1038/d41586-019-02412-yEric J. Topol weighs up a book on a field sprinting to keep up with biotechnology.
Nature, Published online: 13 August 2019; doi:10.1038/d41586-019-02443-5Sand particles — an overlooked occupational hazard
Mark above section as read
Analytical ChemistryDOI: 10.1021/acs.analchem.9b01750
Analytical ChemistryDOI: 10.1021/acs.analchem.9b01232
Analytical ChemistryDOI: 10.1021/acs.analchem.9b00973
Analytical ChemistryDOI: 10.1021/acs.analchem.9b01382
Analytical ChemistryDOI: 10.1021/acs.analchem.9b02149
Analytical ChemistryDOI: 10.1021/acs.analchem.9b01746
Analytical ChemistryDOI: 10.1021/acs.analchem.9b02855
Analytical ChemistryDOI: 10.1021/acs.analchem.9b01606
Mark above section as read
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b04728
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b05901
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b05065
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b05225
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b06978
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b08727
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b06896
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b06582
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b07996
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b06358
Mark above section as read
Evolutionary adaptation increases the fitness of an organism in its environment. It can occur through rewiring of gene regulatory networks, such that an organism responds appropriately to environmental changes. We investigated whether sirtuin deacetylases, which repress transcription and require NAD+ for activity, could facilitate the evolution of potentially adaptive responses by serving as transcriptional rewiring points. If so, bringing genes under the control of sirtuins could enable organisms...
Urbanization and associated environmental changes are causing global declines in vertebrate populations. In general, population declines of the magnitudes now detected should lead to reduced effective population sizes for animals living in close proximity to humans. This is cause for concern because effective population sizes set the rate of genetic diversity loss due to genetic drift, the rate of increase in inbreeding, and the efficiency with which selection can spread beneficial alleles. We predicted...
Unsampled or extinct "ghost" populations leave signatures on the genomes of individuals from extant, sampled populations, especially if they have exchanged genes with them over evolutionary time. This gene flow from "ghost" populations can introduce biases when estimating evolutionary history from genomic data, often leading to data misinterpretation and ambiguous results. To assess the extent of this bias, we perform an extensive simulation study under varying degrees of gene flow to and from "ghost"...
The RNA world hypothesis relies on the ability of ribonucleic acids to spontaneously acquire complex structures capable of supporting essential biological functions. Multiple sophisticated evolutionary models have been proposed for their emergence, but they often assume specific conditions. In this work we explore a simple and parsimonious scenario describing the emergence of complex molecular structures at the early stages of life. We show that at specific GC-content regimes, an undirected replication...
Understanding the impacts of current human activities on within-species genetic variation requires a thorough description of the historical factors that have shaped the genomic and geographical distribution of nucleotide diversity. Past and current conditions influencing effective population size have important evolutionary implications for the efficacy of selection, increased accumulation of deleterious mutations, and loss of adaptive potential under the nearly neutral theory. Here, we gather extensive...
The circum-basmati group of cultivated Asian rice (Oryza sativa) contains many iconic varieties and is widespread in the Indian subcontinent. Despite its economic and cultural importance, a high-quality reference genome is currently lacking, and the groups evolutionary history is not fully resolved. To address these gaps, we used long-read nanopore sequencing and assembled the genomes of two circum-basmati rice varieties, Basmati 334 and Dom Sufid. We generated two high-quality, chromosome-level...
Mark above section as read
Hypertensive disorders in pregnancy are a leading cause of maternal and perinatal morbidity and mortality, especially in low-resource settings. Identifying mothers and babies at greatest risk of complications ...
To assess the magnitude and associated factors of repeat induced abortion among women aged from 15 to 49 who seek abortion care services in the health institutions of Debre Berhan town, Central Ethiopia, 2019.
To determine the geographical distribution and risk stratification of dengue infection in an endemic region of Peru, and its relationship with the presence of El Niño Southern Oscillation (ENSO).
Mark above section as read
Severe Combined Immune Deficiency (SCID) is the first primary immunodeficiency amenable to population based newborn screening (NBS) and is now available in all 50 states and Puerto Rico. NBS for SCID uses real time qPCR to measure the number of copies of T cell restriction excision circles (TREC) in DNA from newborn dried blood spots (DBS) and reliably detects severe T cell lymphopenia (TCL) at birth. SCID is the primary condition detected using this assay. However, it is well known that many secondary...
It is well established that there are significant benefits of prescribing beta-lactam antibiotics for susceptible infections. Prescription of non-beta-lactam antibiotics in inpatients with penicillin allergy labels is associated with increased hospital days (1), increased cost of admission (1, 2), increased readmissions (3), increased intensive care unit admissions, increased multi-resistant organisms (MROs) (1), and increased mortality (4).
Mark above section as read
We read with great interest the article entitled “Zygomatico-orbital artery: The largest artery in the temporal area” by Dr. Choi et al.1 The paper found that zygomatico-orbital artery bifurcates from the external carotid artery, rises and crosses the zygomatic arch anterior to the porion. The zygomatico-orbital artery mean diameter was 2.52 mm. Figure 1A described by the author showed the detailed course of the zygomatico-orbital artery.1
Mark above section as read
Heterologous protein production is widely used in industrial biotechnology. However, using non-native production hosts can lead to enzymes with altered post-translational modifications, such as glycosylation. ...
Mark above section as read
The aim of the current systematic review was to compare the radiologic effects of functional appliance Class II treatment compared to no treatment on the temporomandibular joint and its components.
Mark above section as read
This protocol utilized a commercially available pressure myograph system to perform pressure myograph testing on the murine vagina and cervix. Utilizing media with and without calcium, the contributions of the smooth muscle cells (SMC) basal tone and passive extracellular matrix (ECM) were isolated for the organs under estimated physiological conditions.
Here we present a surgical protocol in rabbits with the aim to assess bone substitution materials in terms of bone regeneration capacities. By using PEEK cylinders fixed onto rabbit skulls, osteoconduction, osteoinduction, osteogenesis and vasculogenesis induced by the materials may be evaluated either on live or euthanized animals.
Clinically, estrogen deficiency in menopausal women may aggravate the incidence of lipid disruption and atherosclerosis. We established an in vivo estrogen deficiency model by bilateral ovariectomy via a double dorsal-lateral incision in apoE-/- mice. The mouse model is applicable for screening exogenous estrogen treatments of cardiovascular dysfunction after menopause.
Being comprehensively utilized, sum frequency generation (SFG) vibrational spectroscopy can help to reveal chain conformational order and secondary structural change happening at polymer and biomacromolecule interfaces.
Here, we present a protocol to build a component-level mathematical model for a variable cycle engine.
Here, we present a friction stir spot welding (FSSW) protocol on dual phase 780 steel. A tool pin with high-speed rotation generates heat from friction to soften the material, and then, the pin plunges into 2 sheet joints to create the lap joint.
Mark above section as read
Various antiepileptic drugs can potentially cause psychiatric side effects in patients with epilepsy, but the precise mechanism of these actions remains unknown. In recent years, the common polymorphism C677T ...
Mark above section as read
A molecule called tRNA is an essential component of the human genome that acts as a translator. When researchers and clinicians investigate the genome's relation to disease, they have traditionally focused on mutations in the code for proteins. But now researchers have shown that the genes encoding tRNAs can also have mutations that cause the code to be misread, and in greater numbers than previously thought.
New research has resolved a pig paradox. Archaeological evidence has shown that pigs were domesticated in the Near East and as such, modern pigs should resemble Near Eastern wild boar. They do not. Instead, the genetic signatures of modern European domestic pigs resemble European wild boar.
Mark above section as read
Nature Communications, Published online: 13 August 2019; doi:10.1038/s41467-019-11097-wTropical land ecosystems contain vast carbon reservoirs, but their influence on atmospheric CO2 is poorly understood. Here the authors use new carbon-observing satellites to reveal a large emission source over northern tropical Africa, where there are large soil carbon stores and substantial land use changes.
Nature Communications, Published online: 13 August 2019; doi:10.1038/s41467-019-11622-xThe studies showing health benefits of flavonoids and their impact on cancer mortality are incomplete. Here, the authors perform a prospective cohort study in Danish participants and demonstrate an inverse association between regular flavonoid intake and both cardiovascular and cancer related mortality.
Nature Communications, Published online: 13 August 2019; doi:10.1038/s41467-019-11639-2Antivenoms, obtained by venom immunization, have narrow species coverage due to low immunogenicity of venom neurotoxins. Here the authors immunize horses with a designed recombinant consensus neurotoxin, and the resulting antisera protect mice from envenomation by a broad spectrum of elapid snakes.
Nature Communications, Published online: 13 August 2019; doi:10.1038/s41467-019-11631-wTo enter the cells, nanomaterials often need covalent conjugation with cell-penetrating ligands such as TAT. Here, the authors show that simple mixing with TAT-coupled nanoparticles enables the cellular uptake of unfunctionalized nanoparticles, and its activity is stimulated by cysteine in the medium.
Nature Communications, Published online: 13 August 2019; doi:10.1038/s41467-019-11577-zThe glomerular filtration barrier is a complex structure in charge of renal ultrafiltration. Here the authors present a glomerulus-on-a-chip for disease modelling and high-throughput drug screening where human podocytes and human glomerular endothelial cells are separated by an extracellular matrix resembling the in vivo basement membrane.
Nature Communications, Published online: 13 August 2019; doi:10.1038/s41467-019-11636-5Little is known about the pathways that maintain mitochondrial structure and function under neuronal stress conditions. Here, authors demonstrate that the Mul1-Mfn2 pathway plays a checkpoint role in maintaining mitochondrial integrity and energy maintenance by ensuring ER-mitochondrial tethering and preventing mitophagy.
Nature Communications, Published online: 13 August 2019; doi:10.1038/s41467-019-11570-6Topoisomerases are required to release topological stress on DNA during replication and transcription. Here, Broderick et al. report genetic variants in TOP2B that cause a syndromic B cell immunodeficiency associated with reduced TOP2B function, defects in B cell development and B cell activation.
Nature Communications, Published online: 13 August 2019; doi:10.1038/s41467-019-11372-wA common feature of many transition metal materials is global symmetry breaking at low temperatures. Here the authors show that such materials are characterized by fluctuating symmetry-lowering distortions that exist pre-formed in higher temperature phases with greater average symmetry.
Nature Communications, Published online: 13 August 2019; doi:10.1038/s41467-019-11368-6Understanding the functional group distribution in a polymer chain has been difficult, but this information can be very useful. Here the authors visualize the monomer distribution in individual polymer chains by combining experimental and theoretical analysis of the construction of functionality-chain length distributions.
Mark above section as read
ObjectivesThe study aimed to investigate the relative and absolute risks of early exit from paid employment among older workers with a chronic disease, and to assess whether these risks differ across educational groups.MethodsData on chronic diseases and demographics from 9160 Dutch workers aged 45–64 years were enriched with monthly information on employment status from Statistics Netherlands. Subdistribution hazard ratios (SHR) and 7-year probabilities among workers with a chronic disease of exit...
Mark above section as read
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου