Abstract Denture impacted in the esophagus of adults has been a complex foreign body for otolaryngologists. We reviewed clinical characteristics, diagnosis, and treatment of these patients and evaluated computed tomography (CT) scans to identify a better method of dealing with such tricky situations. Twenty-nine patients who underwent rigid esophagoscopy were included in this retrospective study conducted at the University hospital. The patients underwent preoperative tests and...
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Of the $69.1 trillion global financial assets under management across mutual funds, hedge funds, real estate, and private equity, fewer than 1.3% are managed by women and people of color. Why is this powerful, elite industry so racially homogenous? We conducted an online experiment with actual asset allocators to determine...
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Ambient water properties have been shown to require heterogeneity (1). Niskanen et al. (2) apply a linear relationship between the intensity of the 4a1 excitation in an electron energy loss spectroscopy gas-phase spectrum and the preedge in water and ice from X-ray Raman scattering to extract the number of hydrogen...
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In recent years, air pollution has caused more than 1 million deaths per year in China, making it a major focus of public health efforts. However, future climate change may exacerbate such human health impacts by increasing the frequency and duration of weather conditions that enhance air pollution exposure. Here,...
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Fay et al. (1) suggest that larger populations do not enhance cumulative cultural evolution (CCE), as working memory becomes taxed while consciously processing additional social models. This decrease in working memory leads to a reduction in high-fidelity copying. Results from a large study (n = 543) are largely consistent with...
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“Ambient water properties have been shown to require heterogeneity” (1) is the imperative followed by Pettersson et al. (2) to relate X-ray spectroscopic findings to a heterogeneous or 2-phase model of ambient water. In ref. 3 we question this hypothesis based on quantitative X-ray spectroscopic evidence. We come to conclude...
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Hydrophobic base stacking is a major contributor to DNA double-helix stability. We report the discovery of specific unstacking effects in certain semihydrophobic environments. Water-miscible ethylene glycol ethers are found to modify structure, dynamics, and reactivity of DNA by mechanisms possibly related to a biologically relevant hydrophobic catalysis. Spectroscopic data and...
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How ocean eddies influence blue shark foraging Blue shark. Image courtesy of Tom Burns (photographer). Anticyclonic eddies, masses of water swirling clockwise in oceans’ pelagic zones, make up oceans’ internal weather systems and are generally considered nutrient deserts due to their low productivity. Powerful anticyclonic eddies draw warm water from...
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The peptide natural product nisin has been used as a food preservative for 6 decades with minimal development of resistance. Nisin contains the unusual amino acids dehydroalanine and dehydrobutyrine, which are posttranslationally installed by class I lanthipeptide dehydratases (LanBs) on a linear peptide substrate through an unusual glutamyl-tRNA–dependent dehydration of...
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The dentate gyrus (DG) and its primary cell type, the granule cell (GC), are thought to be critical to many cognitive functions. A major neuronal subtype of the DG is the hilar mossy cell (MC). MCs have been considered to play an important role in cognition, but in vivo studies to understand the activity of MCs during cognitive tasks are challenging because the experiments usually involve trauma to the overlying hippocampus or DG, which kills hilar neurons. In addition, restraint typically occurs,...
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Zusammenfassung Autoimmune Enzephalitiden sind seltene, schnell progrediente und potenziell schwer verlaufende, entzündliche Erkrankungen des Gehirns, meist vermittelt durch Autoantikörper. Häufig durchlaufen die betroffenen Patienten verschiedene Krankheitsphasen mit Prodromi, neuropsychologischen Auffälligkeiten, schweren neurologischen und autonomen Störungen und meist langer Rekonvaleszenz. Bei bis zu 85 % der Patienten sind intensivmedizinische Behandlungen notwendig, speziell...
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Zusammenfassung Das Rechtsherzversagen auf der Intensivstation ist ein häufiges und ernstes, aber oftmals unbemerktes Krankheitsbild. Die häufigsten Ursachen sind die akute Dekompensation einer pulmonalen Hypertension, Lungenembolie, Sepsis, „acute respiratory distress syndrome“ sowie kardiochirurgische Eingriffe. Goldstandard der bettseitigen Diagnostik ist die Kombination aus klinischer Symptomatik, Labordiagnostik (NT-proBNP) und Echokardiographie. Zum hämodynamischen Monitoring...
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Abstract Cav3.2 calcium channels play a key role in nociceptive signaling in the primary afferent pain pathway. We have previously reported the regulation of Cav3.2 calcium channels by the deubiquitinase USP5 and its importance for regulating peripheral transmission of pain signals. Here we describe the regulation of the Cav3.2-USP5 interaction by SUMOylation. We show that endogenous USP5 protein expressed in dorsal root ganglia undergoes SUMOylation, and the level of USP5 SUMOylation...
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Microbial Drug Resistance, Ahead of Print.
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Therapeutic Hypothermia and Temperature Management, Ahead of Print.
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Abstract We aimed to investigate the absorption-enhancing effect (AEE) of caproyl-modified G2 PAMAM dendrimer (G2-AC) on peptide and protein drugs via the pulmonary route. In this study, G2 PAMAM dendrimer conjugates modified with caproic acid was synthesized, the pulmonary absorption of insulin as models with or without G2-AC were evaluated. The results indicated that G2-AC6 exhibited a greatest AEE for insulin in various caproylation levels of G2-AC. G2-AC6 could significantly...
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Abstract Background The aim of this study is to use data representative of the U.S. population to determine if households (HHs) age, birth country, and marital status, are strong predictors as HHs education for dental sealants, restorations, and caries in children 5 to 19 years of age. Methods A cross sectional analysis was performed with oral...
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Abstract The text deals with Harold Garfinkels theorizing of what Karl Mannheim called ‘documentary meaning’, and established as a foundation of all historical disciplines, and what Garfinkel calls the ‘documentary method’ of lay and professional sociological reasoning. The commentary tries to establish the systematical position of the chapter in Garfinkel’s ‘Studies in Ethnomethodology’, and, indeed, in Garfinkel’s social theory at the time of publication. This position involves,...
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Abstract How do we determine where to focus our attention in real-world scenes? Image saliency theory proposes that our attention is ‘pulled’ to scene regions that differ in low-level image features. However, models that formalize image saliency theory often contain significant scene-independent spatial biases. In the present studies, three different viewing tasks were used to evaluate whether image saliency models account for variance in scene fixation density based primarily...
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Abstract Extracellular vesicles (EVs) are nanosized, membrane-bound vesicles released from eukaryotic and prokaryotic cells that can transport cargo containing DNA, RNA, lipids and proteins, between cells as a means of intercellular communication. Although EVs were initially considered to be cellular debris deprived of any essential biological functions, emerging literature highlights the critical roles of EVs in the context of intercellular signaling, maintenance of tissue homeostasis,...
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Abstract Primary brain tumors, both benign and malignant, pose a high risk of perioperative venous thromboembolism (VTE) due to the development of a prothrombotic state. Perioperative pharmacologic thromboprophylaxis with subcutaneous (SC) unfractionated heparin (UFH) has significantly reduced VTE associated morbidity. Recent reports suggest an association between prolonged activated partial thromboplastin time (aPTT) due to prophylactic SC UFH and increased bleeding risk. We present...
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Abstract Laparoscopic esophagojejunostomy is a challenging procedure because of its technical difficulty. We herein report a new method involving circular-stapled anastomosis using a hand-sewn suture with four stay-sutures and evaluate its outcomes. Esophagojejunostomy using this method was performed in 36 consecutive patients with clinical stage I gastric cancer at the authors’ institutions. The key feature of our procedure was the placement of four full-thickness stay-sutures...
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Zusammenfassung Trotz der hohen Inzidenz der Osteoporose, des hohen Folgefrakturrisikos nach einer ersten Fraktur und effektiver Therapiemöglichkeiten besteht in Deutschland und auch weltweit ein erhebliches Defizit in der Diagnostik und Therapie der an Osteoporose leidenden Patientinnen und Patienten. Die Gründe hierfür sind vielfältig und sowohl bei den Ärzten als auch bei den Patienten sowie in systemimmanenten Fehlsteuerungen zu suchen. Der vorliegende Beitrag gibt einen Überblick...
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Abstract This article focuses on partitioning a manufacturing system into machine cells. The benefit of such a conversion is improving manufacturing efficiency by eliminating waste in terms of material handling and time as well as increasing production capacity of the manufacturing system. Rank order clustering (ROC) algorithm is used in this study for the conversion. It is easy to understand and its application in obtaining machine cells with a cellular layout is straightforward....
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Toxins, Vol. 11, Pages 499: Acrylamide Reduction Strategy in Combination with Deoxynivalenol Mitigation in Industrial Biscuits Production Toxins doi: 10.3390/toxins11090499 Authors: Suman Generotti Cirlini Dall’Asta Acrylamide is formed during baking in some frequently consumed food products. It is proven to be carcinogenic in rodents and a probable human carcinogen. Thus, the food industry is working to find solutions to minimize its formation during processing. To better...
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Toxins, Vol. 11, Pages 495: Influence of Two Garlic-Derived Compounds, Propyl Propane Thiosulfonate (PTS) and Propyl Propane Thiosulfinate (PTSO), on Growth and Mycotoxin Production by Fusarium Species In Vitro and in Stored Cereals Toxins doi: 10.3390/toxins11090495 Authors: Kalliopi Mylona Esther Garcia-Cela Michael Sulyok Angel Medina Naresh Magan Two garlic-derived compounds, Propyl Propane Thiosulfonate (PTS) and Propyl Propane Thiosulfinate (PTSO), were examined for...
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Toxins, Vol. 11, Pages 497: Synthesis and Characterization of Cry2Ab–AVM Bioconjugate: Enhanced Affinity to Binding Proteins and Insecticidal Activity Toxins doi: 10.3390/toxins11090497 Authors: Zhi-Zhen Pan Lian Xu Yi-Shu Zheng Li-Yang Niu Bo Liu Nan-Yan Fu Yan Shi Qing-Xi Chen Yu-Jing Zhu Xiong Guan Bacillus thuringiensis insecticidal proteins (Bt toxins) have been widely used in crops for agricultural pest management and to reduce the use of chemical insecticides....
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Toxins, Vol. 11, Pages 496: Venomic, Transcriptomic, and Bioactivity Analyses of Pamphobeteus verdolaga Venom Reveal Complex Disulfide-Rich Peptides That Modulate Calcium Channels Toxins doi: 10.3390/toxins11090496 Authors: Sebastian Estrada-Gomez Fernanda Caldas Cardoso Leidy Johana Vargas-Muñoz Juan Carlos Quintana-Castillo Claudia Marcela Arenas Gómez Sandy Steffany Pineda Monica Maria Saldarriaga-Cordoba Pamphobeteus verdolaga is a recently described Theraphosidae...
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Toxins, Vol. 11, Pages 498: Insights into the Diversity of Secondary Metabolites of Planktothrix Using a Biphasic Approach Combining Global Genomics and Metabolomics Toxins doi: 10.3390/toxins11090498 Authors: Sandra Kim Tiam Muriel Gugger Justine Demay Séverine Le Manach Charlotte Duval Cécile Bernard Benjamin Marie Cyanobacteria are an ancient lineage of slow-growing photosynthetic bacteria and a prolific source of natural products with diverse chemical structures...
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Toxins, Vol. 11, Pages 494: The Influence of Bee Venom Melittin on the Functioning of the Immune System and the Contractile Activity of the Insect Heart—A Preliminary Study Toxins doi: 10.3390/toxins11090494 Authors: Jan Lubawy Arkadiusz Urbański Lucyna Mrówczyńska Eliza Matuszewska Agata Światły-Błaszkiewicz Jan Matysiak Grzegorz Rosiński Melittin (MEL) is a basic polypeptide originally purified from honeybee venom. MEL exhibits a broad spectrum of biological activity....
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Toxins, Vol. 11, Pages 493: A Novel Magnetic Molecular Imprinted Polymer for Selective Extraction of Zearalenone from Cereal Flours before Liquid Chromatography-Tandem Mass Spectrometry Determination Toxins doi: 10.3390/toxins11090493 Authors: Chiara Cavaliere Michela Antonelli Andrea Cerrato Giorgia La Barbera Aldo Laganà Michele Laus Susy Piovesana Anna Laura Capriotti Zearalenone (ZEN) is a nonsteroidal estrogenic mycotoxin produced by various Fusarium species...
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Future Oncology, Ahead of Print.
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Future Oncology, Ahead of Print.
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Conclusion: Elevated NLR alone and in combination with hyponatremia at time of initial RCC diagnosis and at time of RCC recurrence are associated with poor prognosis. Combining these two prognostic markers yield a stronger association than NLR considered alone. This may impact prognostic prediction and its related therapeutic strategy. PMID: 31448981 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
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Authors: Strander B PMID: 31441363 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
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Authors: Savijärvi S, Seppä K, Malila N, Pitkäniemi J, Heikkinen S Abstract Background: The aim of this study was to investigate if the incidence of colorectal cancer (CRC) is associated with education and socioeconomic status (SES) in Finland, and if there are any changes in incidence differences between the groups over the period 1976-2014. Material and methods: CRC cases (N = 77,614) were retrieved from the Finnish Cancer Registry and linked with information on the education level and...
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AbstractBackgroundIt remains unknown to what extent Consensus Molecular Subtype (CMS) groups and immune-stromal infiltration patterns improve our ability to predict outcomes over TNM staging and microsatellite instability (MSI) status in early-stage colorectal cancer (CRC).Patients And MethodsWe performed a comprehensive retrospective biomarker analysis of prognostic markers in adjuvant chemotherapy-untreated (N = 1,656) and treated (N = 980), stage II (N = 1,799) and III (N = 837) CRCs. We defined...
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AbstractBackgroundChemotherapy-induced damage of hematopoietic stem and progenitor cells (HSPC) causes multi-lineage myelosuppression. Trilaciclib is an intravenous CDK4/6 inhibitor in development to proactively preserve HSPC and immune system function during chemotherapy (myelopreservation). Preclinically, trilaciclib transiently maintains HSPC in G1 arrest and protects them from chemotherapy damage, leading to faster hematopoietic recovery and enhanced anti-tumor immunity.Patients and methodsThis...
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