We investigated the potential regulatory role of TRAPPC9 and LPL‐mediated OC cytoskeleton reorganization and actin ring formation. Abstract Trafficking protein particle complex 9 (TRAPPC9) is a major subunit of the TRAPPII complex. TRAPPC9 has been reported to bind nuclear factor κB kinase subunit β (IKKβ) and NF‐kB‐inducing kinase (NIK) where it plays a role in the canonical and noncanonical of nuclear factor‐κB (NF‐kB) signaling pathways, receptively. The role of TRAPPC9 in protein trafficking...
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Exogenous interleukin‐1β can effectively induce autophagy of mouse embryos at stages of 2 to 8 cell and blastocyst, which also help to improve blastocyst quality. Abstract Autophagy is one of the basic cellular mechanism during preimplantation development of mammalian embryos, and it plays crucial role in several physiological processes. It is induced by interleukin (IL)‐1β in mammalian cells. Our present study shows that IL‐1β is important for autophagy activation in embryo development. Our...
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AbstractBackgroundChemotherapy-induced damage of hematopoietic stem and progenitor cells (HSPC) causes multi-lineage myelosuppression. Trilaciclib is an intravenous CDK4/6 inhibitor in development to proactively preserve HSPC and immune system function during chemotherapy (myelopreservation). Preclinically, trilaciclib transiently maintains HSPC in G1 arrest and protects them from chemotherapy damage, leading to faster hematopoietic recovery and enhanced anti-tumor immunity.Patients and methodsThis...
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Dysregulation of the ubiquitin-editing enzyme A20 contributes to the development of several human inflammatory diseases. Liu et al. demonstrate that suppression of A20 enzymatic activity in alveolar macrophages promotes lung fibrosis by reducing transcriptional factor C/EBPβ degradation and enhancing targeted gene expression, which directs the profibrotic phenotype of macrophages.
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Type I IFNs, but not type III IFNs (IFNλ), promote inflammation at the site of infection. Forero et al. find that differential expression of proinflammatory genes results from selective induction of the transcription factor IRF1 by type I IFNs. Type III IFNs induce a tissue repair program, suggesting a division of labor that spans proinflammatory and tissue repair functions to promote protective immunity.
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Metabolic insufficiency is a major barrier for antitumor immunity. Rivadeneira et al. demonstrate that engineering an oncolytic virus to express a metabolic modulator, in this case the adipokine leptin, improves T cell metabolic function in the tumor microenvironment, allowing a superior antitumor response compared to a control oncolytic.
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Kawasaki disease (KD) is the leading cause of acquired heart disease among children, and the etiology is unknown. Noval Rivas et al. demonstrate that a murine model of KD vasculitis is dependent on intestinal barrier dysfunction leading to secretory IgA leakage and IgA-C3 immune complex deposition in cardiovascular lesions.
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Nature Neuroscience, Published online: 27 August 2019; doi:10.1038/s41593-019-0463-7Breen et al. map RNA editing profiles in cortical samples from individuals with schizophrenia and controls, and find links between altered RNA editing in glutamatergic and postsynaptic density genes and schizophrenia genetic risk architecture.
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Nature Neuroscience, Published online: 27 August 2019; doi:10.1038/s41593-019-0485-1A new study sheds light on how sensitivity to communication sounds is established in the brain. Juvenile finches raised with tutors of either the same or different species always learned the tutors’ songs. Cortical neurons developed selectivity for the learned song by tuning for its secondary acoustic features.
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Nature Neuroscience, Published online: 27 August 2019; doi:10.1038/s41593-019-0469-1Gehrlach et al. show how the posterior insular cortex processes and modulates diverse internally and externally generated aversive states, and they dissect the functional contribution of segregated projections mediating inhibition of ongoing behaviors.
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Nature Neuroscience, Published online: 27 August 2019; doi:10.1038/s41593-019-0499-8Chronic pain is associated with anxio-depressive comorbidities, but the neuroanatomical substrates remain unknown. A specific serotonergic pathway from the dorsal raphe nucleus to the lateral habenula via the central amygdala is now uncovered as a key neural circuit governing comorbid depressive symptoms in chronic pain.
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Abstract Purpose We report a case of successful management of complex recurrent cryptoglandular fistula-in-ano by surgery combined with autologous bone marrow–derived mesenchymal stroma cells (MSCs) and platelet-rich plasma (PRP) injection. Methods Clinical, radiological, and surgical data of the patient were reviewed, as well as the current literature on...
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Abstract In healthy participants, the strength of task-evoked network reconfigurations is associated with cognitive performance across several cognitive domains. It is, however, unclear whether the capacity for network reconfiguration also plays a role in cognitive deficits in brain tumor patients. In the current study, we examined whether the level of reconfiguration of the fronto-parietal (‘FPN’) and default mode network (‘DMN’) during task execution is correlated with cognitive...
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Future Oncology, Ahead of Print.
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Future Oncology, Ahead of Print.
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Publication date: Available online 26 August 2019Source: Journal of Surgical EducationAuthor(s): Heather Lesch, Evan Johnson, Jörg Peters, Juan C. CendánObjectiveActive learning techniques result in greater knowledge acquisition compared to passive methods. For medical students with limited hands-on operative experiences, virtual reality platforms represent active learning and may enhance procedural training. We hypothesize that virtual reality simulators like Toolkit for Illustration of Procedures...
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Publication date: Available online 26 August 2019Source: Journal of Surgical EducationAuthor(s): Teresa Ziegler, Alexander Adibfar, Aram Abbasian, Shirley Xue Jiang, James T Rutka, Nada GawadObjectiveAttrition of general surgery residents highlights a need to support well-informed specialty selection. This study evaluated preclerkship medical students’ perception of overnight call shifts in surgical career exploration.DesignA mixed-methods design was used, involving entry and postcall shift surveys...
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Publication date: Available online 26 August 2019Source: Journal of Surgical EducationAuthor(s): Claire I. Lauer, Mohsen M. Shabahang, Brian Restivo, Samantha Lane, Sarah Hayek, James Dove, Halle B. Ellison, Erin Pica, Evan J. RyerOBJECTIVESurgical graduate medical education (GME) programs add both significant cost and complexity to the mission of teaching hospitals. While expenses tied directly to surgical training programs are well tracked, overall cost-benefit accounting has not been performed....
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Abstract Objective Many studies have demonstrated the superiority of white matter (WM) reference regions (RR) in amyloid PET studies in comparison to cerebellar RR. However, the principle behind its improved measurement stability is yet to be elucidated. Our study aimed to determine the origin of WM stability; stability over cerebral blood flow and input function fluctuation or the greater statistical noise in the cerebellum due to its...
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Abstract Purpose Ventral hernia repair has become a common procedure, but the way in which it is performed still depends on surgeon’s skill, experience, and habit. The initial open approach is faced with extensive dissection and a high risk of infection and prolonged hospital stay. To tackle these problems, minimally invasive procedures are gaining interest. Several new techniques are emerging, but laparoscopic intra-peritoneal onlay mesh...
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SACRAMENTO, Calif. (August 27, 2019) - Children with neurodevelopmental disabilities and their families were invited to spend quality time with each other, have fun and make friends.
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Abstract Biliary intraepithelial neoplasia (BilIN) is a noninvasive precursor lesion which progresses to cholangiocarcinoma (CC). BilIN is often found synchronously adjacent to the tumor or at the surgical resection margin of resection CC. However, irrespective of its location, its prognostic significance on outcome after CC resection is unknown. The aim of this study was to elucidate the prevalence of BilIN in CC and to determine if the presence of BilIN has a prognostic or predictive...
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Publication date: Available online 26 August 2019Source: Archives of Physical Medicine and RehabilitationAuthor(s): Almir Resende Coelho, Rafaela Correia Fontes, Renato Moraes, Camila de Giacomo Carneiro Barros, Daniela Cristina Carvalho de AbreuAbstractObjectiveTo assess the effectiveness of the anchors in the balance rehabilitation of participants with chronic peripheral vestibulopathy who failed to respond positively to conventional rehabilitation for dynamic balance and gait.DesignAssessor-blind,...
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Publication date: Available online 26 August 2019Source: Archives of Physical Medicine and RehabilitationAuthor(s): Geetanjali Gera, Brett W. Fling, Fay B. HorakAbstractObjectiveTo assess how postural sway deficits during eyes open and closed relate to the integrity of cerebellar peduncles in people with MS.DesignCross-sectional studySettingLaboratory based settingParticipants29 MS (Expanded Disability Status Scale: 2-4) and 15 healthy adults were recruited. Inclusion criteria for all participants...
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Publication date: Available online 26 August 2019Source: Archives of Physical Medicine and RehabilitationAuthor(s): Hanieh Zarei, Soha Bervis, Soraya Piroozi, Alireza MoteallehAbstractObjectiveTo compare the effects of exercise therapy alone and exercise therapy plus gluteus medius (GM) and quadratus lumbarum (QL) dry needling on pain and function in female athletes with patellofemoral pain (PFP).DesignSingle-blind randomized controlled trial with follow-up.SettingPhysiotherapy clinicParticipantsConvenience...
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Publication date: Available online 26 August 2019Source: Archives of Physical Medicine and RehabilitationAuthor(s): Andrea Baraldi Cunha, Iryna Babik, Regina Harbourne, Nathanial J. Cochran, Jaclynn Stankus, Kimberly Szucs, Michele A. LoboAbstractObjectiveTo assess the convergent validity and reliability of joint angle measurements from a new video goniometer iPhone/iPad application (app) separately in adults, older and young children.DesignCross-sectional.SettingChildcare and university environments.ParticipantsFifty-four...
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Publication date: Available online 26 August 2019Source: Archives of Physical Medicine and RehabilitationAuthor(s): Opeyemi O. Babatunde, Amy L. Bourton, Karen Hind, Zoe Paskins, Jacky J. ForsythAbstractObjectiveTo examine the effectiveness of exercises for improving forearm bone mass.Data sourcesMEDLINE, EMBASE, CINAHL, AMED, Web of Science, and Cochrane CENTRAL were searched from their inception till December 2018.Study selectionEligibility included adults undertaking upper-limb exercise interventions...
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Publication date: Available online 26 August 2019Source: Archives of Physical Medicine and RehabilitationAuthor(s): Yun-juan Xie, Qiang Gao, Cheng-qi He, Rong BianAbstractObjectiveThe purpose of this review was to systematically assess the effectiveness of repetitive transcranial magnetic stimulation (rTMS) intervention on gait in individuals with Parkinson’s disease (PD).Data SourcesWe searched online electronic databases up to March 28, 2019, including MEDLINE, Embase, the Cochrane Library and...
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Publication date: Available online 26 August 2019Source: Archives of Physical Medicine and RehabilitationAuthor(s): Jennifer L. Maher, Carsten Bach Baunsgaard, Jan van Gerven, Anne E. Palermo, Fin Biering-Sorensen, Armando Mendez, Robert W. Irwin, Mark S. NashAbstractObjectives1) Compare energy expenditure during seated rest, standing, and prolonged bionic ambulation (BA) or bipedal ambulation in participants with SCI and non-injured controls (CON), respectively, and 2) test effects on post-BA glycemia...
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Publication date: Available online 26 August 2019Source: Archives of Physical Medicine and RehabilitationAuthor(s): Davide Sattin, Matilde Leonardi, Barbara Nelli, Placido Bramanti, Silvia Marino, Salvatore Ferro, Nino Basaglia, Davide Guido, Consortium on functioning and disability in patients with DOCAbstractObjectiveTo evaluate the effects of rehabilitation (physical and cognitive) treatments on the diagnosis severity and disability rating scale scores, adjusted for a number of potential confounders...
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Publication date: Available online 26 August 2019Source: Journal of VoiceAuthor(s): Jeff Searl, Troy Dargin, Erika BaileySummaryObjectivesThis study described voice use and lifestyle information about student actors and assessed whether different information is reported at study intake compared to data extracted from a 3-week voice Log.MethodsTwenty-five student actors estimated 14 voice and life style parameters at the start of the study. These included daily speaking time, performance time, vocal...
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Abstract Background Tricuspid annular plane systolic excursion (TAPSE) is frequently used as an objective measure of right-ventricular dysfunction. Abnormal TAPSE values are associated with poor prognosis in a number of disease states; however, the measure is not always easy to obtain in the critically ill. The purpose of this study is to assess the feasibility and accuracy of using a subcostal view and TAPSE measurement as a measure...
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In conclusion, our in vivo and in vitro studies revealed that IRX1 gene functionally acts as a true tumor suppressor, inhibiting tumor cell growth by regulating cell cycle. PMID: 31450023 [PubMed - as supplied by publisher] (Source: Neoplasia)
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We present the functional characterization of a pseudogene associated recurrent gene fusion in prostate cancer. The fusion gene KLK4-KLKP1 is formed by the fusion of the protein coding gene KLK4 with the noncoding pseudogene KLKP1. Screening of a cohort of 659 patients (380 Caucasian American; 250 African American, and 29 patients from other races) revealed that the KLK4-KLKP1 is expressed in about 32% of prostate cancer patients. Correlative analysis with other ETS gene fusions and SPINK1 revealed...
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In conclusion we show that the c-MYC-NAMPT-DBC1-SIRT1 positive feedback loop contributes to murine serrated tumor progression. Targeting the feedback loop exerted a unique, dual therapeutic effect of oncoprotein inhibition and tumor suppressor activation. It may therefore represent a promissing target for serrated colorectal cancer, and presumably for other cancer types with deregulated c-MYC. PMID: 31442917 [PubMed - as supplied by publisher] (Source: Neoplasia)
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Authors: Saenz FR, Ory V, Schmidt MO, Kallakury BV, Mueller SC, Furth PA, Wellstein A, Riegel AT Abstract The transcriptional coactivator Amplified in Breast Cancer 1 (AIB1) plays a major role in the progression of hormone and HER2-dependent breast cancers but its role in triple negative breast cancer (TNBC) is undefined. Here, we report that established TNBC cell lines, as well as cells from a TNBC patient-derived xenograft (PDX) that survive chemotherapy treatment in vitro express lower...
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