Early clinical and EEG findings associated with the outcome in childhood absence epilepsy. Epilepsy Behav. 2019 Aug 13;98(Pt A):273-278 Authors: Canafoglia L, Dettori MS, Duran D, Ragona F, Freri E, Casellato S, Granata T, Franceschetti S, Panzica F Abstract OBJECTIVES: The objective of this study was to investigate several clinical electroencephalogram (EEG) findings possibly predicting the early response to antiepileptic drugs (AEDs) and the late outcome...
Knowledge, expectations and fears of cannabis use of epilepsy patients at a tertiary epilepsy center. Epilepsy Behav. 2019 Aug 13;99:106458 Authors: von Wrede R, Moskau-Hartmann S, Amarell N, Elger CE, Helmstaedter C Abstract INTRODUCTION: Medical cannabis is increasingly discussed as an alternative treatment option in neurological diseases, e.g. epilepsy. Supporters and opponents base their propositions mostly on subjective estimates, they confuse cannabis...
Disease-modifying effects of a novel T-type calcium channel antagonist, Z944, in a model of temporal lobe epilepsy. Prog Neurobiol. 2019 Aug 13;:101677 Authors: Casillas-Espinosa PM, Shultz SR, Braine EL, Jones NC, Snutch TP, Powell KL, O'Brien TJ Abstract We evaluated whether pharmacologically targeting T-type Ca2+ channels with Z944, a potent and selective antagonist, has disease-modifying effects in a model of temporal lobe epilepsy (TLE) that exhibits...
Epigenetics and epilepsy prevention: the therapeutic potential of adenosine and metabolic therapies.
Epigenetics and epilepsy prevention: the therapeutic potential of adenosine and metabolic therapies. Neuropharmacology. 2019 Aug 13;:107741 Authors: Boison D, Rho JM Abstract Prevention of epilepsy and its progression remains the most urgent need for epilepsy research and therapy development. Novel conceptual advances are required to meaningfully address this fundamental challenge. Maladaptive epigenetic changes, which include methylation of DNA and...
Related ArticlesAmentoflavone Affects Epileptogenesis and Exerts Neuroprotective Effects by Inhibiting NLRP3 Inflammasome. Front Pharmacol. 2019;10:856 Authors: Rong S, Wan D, Fan Y, Liu S, Sun K, Huo J, Zhang P, Li X, Xie X, Wang F, Sun T Abstract Brain inflammation is one of the main causes of epileptogenesis, a chronic process triggered by various insults, including genetic or acquired factors that enhance susceptibility to seizures. Amentoflavone,...
Related ArticlesElectroencephalography and Functional Magnetic Resonance Imaging-Guided Simultaneous Transcranial Direct Current Stimulation and Repetitive Transcranial Magnetic Stimulation in a Patient With Minimally Conscious State. Front Neurosci. 2019;13:746 Authors: Lin Y, Liu T, Huang Q, Su Y, Chen W, Gao D, Tian X, Huang T, Zhen Z, Han T, Ye H, Wang Y Abstract Objective: A minimally conscious state (MCS) is characterized by discernible behavioral...
Related ArticlesCurcumin-loaded nanoparticles: a novel therapeutic strategy in treatment of central nervous system disorders. Int J Nanomedicine. 2019;14:4449-4460 Authors: Yavarpour-Bali H, Ghasemi-Kasman M, Pirzadeh M Abstract Curcumin as a hydrophobic polyphenol is extracted from the rhizome of Curcuma longa. Curcumin is widely used as a dietary spice and a topical medication for the treatment of inflammatory disorders in Asia. This compound also...
Related Articles[Chinese expert consensus on surgical treatment of tuberous sclerosis complex-related epilepsy]. Zhongguo Dang Dai Er Ke Za Zhi. 2019 Aug;21(8):735-742 Authors: Professional Committee of Tuberous Sclerosis Complex, China Anti-Epilepsy Association PMID: 31416495 [PubMed - in process]
Related ArticlesEfficacy Of Phenytoin In Prevention Of Early Posttraumatic Seizures. J Ayub Med Coll Abbottabad. 2019 Apr-Jun;31(2):237-241 Authors: Gul N, Khan SA, Khattak HA, Muhammad G, Khan AA, Khan I, Aurangzeb A Abstract BACKGROUND: The use of anti-epileptic drugs for prophylaxis of early post-traumatic seizures after traumatic brain injury has been very promising. The objective of this study was to determine the outcome of phenytoin in prevention...
Related ArticlesImmediate vs delayed treatment of first unprovoked seizure: To treat, or not to treat? Neurology. 2018 10 09;91(15):684-685 Authors: Jacobs CS, Lee JW PMID: 30209237 [PubMed - indexed for MEDLINE]
Related ArticlesEuropean trends in epilepsy surgery. Neurology. 2018 07 10;91(2):e96-e106 Authors: Baud MO, Perneger T, Rácz A, Pensel MC, Elger C, Rydenhag B, Malmgren K, Cross JH, McKenna G, Tisdall M, Lamberink HJ, Rheims S, Ryvlin P, Isnard J, Mauguière F, Arzimanoglou A, Akkol S, Deniz K, Ozkara C, Lossius M, Rektor I, Kälviäinen R, Vanhatalo LM, Dimova P, Minkin K, Staack AM, Steinhoff BJ, Kalina A, Krsek P, Marusic P, Jordan Z, Fabo D, Carrette E, Boon P, Rocka...
Related ArticlesLong-term surgical results of supplementary motor area epilepsy surgery. J Neurosurg. 2017 Nov;127(5):1153-1159 Authors: Alonso-Vanegas MA, San-Juan D, Buentello García RM, Castillo-Montoya C, Sentíes-Madrid H, Mascher EB, Bialik PS, Trenado C Abstract OBJECTIVE Supplementary motor area (SMA) epilepsy is a well-known clinical condition; however, long-term surgical outcome reports are scarce and correspond to small series or isolated case...
Related ArticlesEarly and late epilepsy surgery in focal epilepsies associated with long-term epilepsy-associated tumors. J Neurosurg. 2017 Nov;127(5):1147-1152 Authors: Pelliccia V, Deleo F, Gozzo F, Sartori I, Mai R, Cossu M, Tassi L Abstract OBJECTIVE Epilepsy surgery is an effective means of treating focal epilepsy associated with long-term epilepsy-associated tumors. This study evaluated a large population of surgically treated patients with childhood...
Related ArticlesA Representative Survey of Knowledge, Use, Perceived Benefits, Barriers, and Risks of Select Herbal Drugs Among Female Students in Gorgan City (Northeast Iran). J Evid Based Complementary Altern Med. 2017 Apr;22(2):227-231 Authors: Ghanbari MR, Lotfalinezhad E, Lotfalinezhad E, Bhalla D Abstract We conducted a representative survey among young women to determine knowledge, use, and perceptions on barriers, benefits, and risks related...
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Background Chemotherapy is the backbone of many cancer therapies; however, the terminology used to describe chemotherapy may be difficult for patients to understand, particularly in underserved populations. Studies have shown that educational videos can improve patient understanding of cancer‐related terms. The goal of this study was to identify chemotherapy terms that were difficult for an underserved population to understand and then develop and test educational videos describing these terms....
Background Cancer, its treatment, and associated adverse effects may accelerate the functional aging of cancer survivors. In the current study, the authors used geriatric assessment (GA) to compare the functional age of long‐term cancer survivors with that of similarly aged women without a cancer history, and to examine whether functional age influences all‐cause mortality differently between these 2 groups. Methods Participants included 1723 cancer survivors and 11,145 age‐matched, cancer‐free...
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Abstract Objectives The function of miR‐611 has not yet been reported. We aimed to investigate the effects of miR‐611 on tongue squamous cell carcinoma (TSCC) and the underlying mechanism. Materials and Methods The expression level of miR‐611 in TSCC tissues was measured using quantitative reverse transcriptase‐polymerase chain reaction (RT‐qPCR). Cell proliferation, migration, and invasion were examined by performing CCK‐8, IncuCyte, and Transwell assays. Bioinformatics analyses and microarrays...
Abstract Objectives This 6‐month prospective clinical study assessed the impacts of Invisalign appliances on the oral bacterial community and oral health of patients. Methods Salivary samples were obtained from twenty‐five adult patients receiving Invisalign aligner treatment before the treatment (Group B) and at a 6‐month follow‐up (Group P). The bacterial composition of each sample was determined using Illumina MiSeq sequencing of the bacterial 16S rRNA. Intra‐ and intergroup biodiversity...
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Related ArticlesAdvances in drug delivery for post-surgical cancer treatment. Biomaterials. 2019 Apr 28;219:119182 Authors: Bu LL, Yan J, Wang Z, Ruan H, Chen Q, Gunadhi V, Bell RB, Gu Z Abstract Surgery remains a primary modality of treatment for the majority of solid tumor malignancies. While advancements in surgical technique and instrumentation have improved the quality of life for cancer patients, local tumor recurrence and metastasis after surgery...
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Abstract Purpose Arterial hypotension is a major adverse effect of general anesthesia. Patients with pre-existing autonomic dysfunction are at greater risk of hypotension. This study was performed to examine whether objective measurement of the pupillary light reflex is predictive of intraoperative hypotension. Methods We studied 79 patients who underwent...
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Abstract Mild cognitive impairment (MCI) is considered an intermediate transitional stage for the development of dementia, especially Alzheimer's disease. The identification of neurophysiological biomarkers for MCI will allow improvement in detecting and tracking the progression of cognitive impairment. The primary objective of this study was to compare cortical auditory evoked potentials between older adults with and without probable MCI to identify potential neurophysiological indicators of cognitive...
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Replacing the central cobalt ion of vitamin B12 by other metals has been a long‐held aspiration within the B12‐field. Herein, we describe the synthesis from hydrogenobyric acid of zincobyric acid (Znby) and zincobalamin (Znbl), the Zn‐analogs of the natural cobalt‐corrins cobyric acid and vitamin B12, respectively. The solution structures of Znby and Znbl were studied by NMR‐spectroscopy. Single crystals of Znby were produced, providing the first X‐ray crystallographic structure of a zinc corrin....
Divergent and enantiospecific total syntheses of the indolosesquiterpenoids xiamycins A, C, F, H and oridamycin A have been accomplished. The syntheses, which commence from (R)‐carvone, employ a key photoinduced benzannulation sequence to forge the carbazole moiety characteristic of these natural products. Late‐stage diversification from a common intermediate enabled the first syntheses of xiamycins C and F, and an unexpected one‐pot oxidative decarboxylation, which may prove general, led to xiamycin...
Unveiling the Secret, Dark, and Short Life of a Vibronic State in a Boron Difluoride Formazanate Dye
Boron difluoride (BF2) formazanate dyes are contenders for molecular species that exhibit a large Stokes shift and bright red emission. Excitation of 3‐cyanoformazanate complexes with 10 μs wide pulses of specific wavelengths resulted in strong luminescence at 663 nm at both room temperature in solution and at 77 K. Analysis of the short‐lived excitation spectrum from this luminescence shows that it arises from a vibronic manifold of a higher lying excited state. This dark state relaxes to the emitting...
The photocatalytic CO2 reduction reaction (CRR) represents a promising route for the clean utilization of stranded renewable electricity, while poor selectivity resulting from the competing hydrogen evolution reaction (HER) in aqueous solution limits its practical applicability. In the present contribution we fabricate a photocatalyst with hydrophobic surfaces, facilitating an efficient three‐phase contact of CO2 (gas), H2O (liquid) and catalyst (solid). Thus, concentrated CO2 molecules in the gas...
Radiotherapy is highly effective against solid tumor with high doses of radiation. The use of gold nanoparticles as radiosensitizers is an effective way to boost the killing efficacy while drastically limiting the received dose and reducing the possible damage to normal tissues. Herein, we designed aggregation‐induced emission gold clustoluminogens (AIE‐Au) to achieve efficient low‐dose X‐ray‐induced photodynamic therapy with negligible side effects. The aggregations of glutathione‐protected gold...
A highly enantioselective dicarbofunctionalization of unactivated alkenes was implemented by Pd‐catalyzed asymmetric tandem Heck/Suzuki‐coupling reaction. This represents the first example of highly enantioselective intramolecular cyclization/cross‐coupling of olefin‐tethered aryl halides with alkyl‐, alkenyl‐ or arylboronic acids, which provides a rapid access to a number of chiral compounds such as dihydrobenzofurans, indolines, chromanes and indanes bearing a quaternary stereocenter in good yields...
The behaviour of hydroxide and hydrated protons, the auto‐ionization products of water, at surfaces is important for a wide range of applications and disciplines. However, it is unknown at which bulk concentration these ions start to become surface active at the water‐air interface. Here, we report changes in the D2O‐air interface in the presence of excess D+hyd/OD‐hyd determined using surface‐sensitive vibrational Sum Frequency Generation spectroscopy. The onset of the perturbation of the D2O surface...
The twofold hydroboration products of (Fmes)BH2·SMe2 with a series of alkynes (2‐butyne, arylethynes) react with two molar equiv. of 2,6‐dimethylphenyl isocyanide (CN‐Xyl) at 80°C to give rare examples of 1,3‐azaborinine derivatives. A mechanistic study revealed a reaction course involving insertion of one isonitrile followed by a bora‐Nazarov type ring‐closure reaction and subsequent isonitrile insertion to give the respective 1,3‐dihydro‐1,3‐azaborinines 5.
The skeletons of some classes of terpenoids are unusual, because they contain a larger number of Me groups (or their biosynthetic equivalents such as olefinic methylene groups, hydroxymethyl groups, aldehydes or carboxylic acids and their derivatives) than provided by their oligoprenyl diphosphate precursor. This is sometimes the result of an oxidative ring opening reaction at a terpene cyclase derived molecule containing the regular number of Me group equivalents, as observed for picrotoxan sesquiterpenes....
A general approach is developed to construct a precise drug‐containing DNA framework with defined drug content and architecture via drug conjugation on PS oligonucleotides and programmable DNA self‐assembly. With stimuli‐responsiveness and efficient cellular uptake, the DNA‐based drug delivery system exhibits enhanced antitumor efficacy both in vitro and in vivo. Abstract Most chemotherapeutics are hydrophobic molecules and need to be converted into hydrophilic form before administration. Based...
Covalent organic frameworks (COFs) with 2D π‐conjugation were designed and synthesized as molecular photosensitizers for efficient photodynamic therapy. Two molecules inactive to generating reactive oxygen species (ROS) were linked to form two COFs exhibiting excellent ROS production efficiency. The high permanent porosity of these COFs promoted both the diffusion of oxygen and the release of ROS in cells. Abstract Covalent organic frameworks (COFs) with 2D π‐conjugation were designed and synthesized...
Ultrathin Bi2O3 nanosheets have been successfully grown on a conductive multi‐channel carbon matrix (Bi2O3NSs@MCCM). The obtained Bi2O3NSs@MCCM electrocatalyst achieves a comparably high current density at a moderate overpotential for electrochemical CO2 reduction to HCOOH with high selectivity and good long‐term stability. Abstract Bi2O3 nanosheets were grown on a conductive multiple channel carbon matrix (MCCM) for CO2RR. The obtained electrocatalyst shows a desirable partial current density...
In the present study, we investigate the Mo and W for Cr substitution in the synthetic mineral colusite, Cu26Cr2Ge6S32. Primarily, we elucidate the origin of extremely low electrical resistivity which does not compromise the Seebeck coefficient and leads to outstanding power factors of 1.94 mW m‐1 K‐2 at 700 K in Cu26Cr2Ge6S32. We demonstrate that the abnormally long iono‐covalent T‐S bonds competing with short metallic Cu‐T interactions govern the electronic transport properties of the conductive...
The stability of pure organic room‐temperature phosphorescent (RTP) materials in air is one of the research hotspot in recent years. Without crystallization or encapsulation, a new strategy was proposed to obtain self‐stabilized organic RTP materials, based on a complete ionization of photo‐induced charge separation system. The ionization of aromatic phenol 4‐carbazolyl salicylaldehyde (CSA), formed a stable H‐bonding anion‐cation radical structure, and led to the completely amorphous CSA‐I film....
Anode oxygen evolution reaction (OER) is known to largely limit the efficiency of electrolyzers owing to its sluggish kinetics. While crystalline metal oxides have demonstrated big potential as OER catalysts, their amorphous phases also show high activities. Synthetic efforts to produce amorphous metal oxides, however, have progressed slowly, and how amorphous structure benefits the catalytic performances remain elusive. We report here the first scalable synthesis of amorphous NiFeMo oxide (up to...
Relative to other cyclic poly‐phosphorus species (i.e. cyclo‐Pn), the planar cyclo‐P4 group is unique in its requirement of two additional electrons to achieve aromaticity. In the coordination chemistry of cyclo‐P4 ligands, these additional electrons are supplied from one or more metal centers. However the degree of charge transfer to the cyclo‐P4 ligand is highly dependent on the nature of the metal fragment to which it is bound. Reported here are unique examples of dianionic mononuclear η4‐P4 complexes...
The controllable design of single‐atom electrocatalysts with high‐site‐density and enhanced mass/volume specific activity holds tremendous potential for clean energy devices involving the oxygen reduction reaction (ORR). Herein, two‐dimensional conjugated aromatic networks (CAN) with ultra‐thin conjugated layers (ca. 3.5 nm) and high single‐metal‐atom‐site density (mass content of 10.7 wt.%, and 0.73 metal atoms per nm2) are prepared via a facile pyrolysis‐free route involving a one‐step ball milling...
A cyclic hexapeptide containing three pyridyl moieties connected to its backbone forms hydrogen‐bonded dimers, which encapsulate tightly a single xenon atom, like a pearl in its shell. Supramolecular capsules self‐assemble hierarchically forming a porous supramolecular architecture whose cavities are filled by small molecules and gases. The dimers imprint their shape and symmetry to the captured xenon, as demonstrated by 129Xe NMR, X‐Ray diffraction, and computational studies.
The cyanine‐based fluorophore Alexa Fluor 647 is a widely used fluorescent probe for cell bioimaging and super‐resolution microscopy applications, with excellent fluorescence quantum yields and high brightness. Herein is reported the reversible switching of the fluorescence intensity of Alexa 647 conjugated to the protein bovine serum albumin (BSA) and adsorbed onto indium tin oxide (ITO) electrodes under electrochemical potential control at the level of single protein molecules. The modulation of...
The first chemical synthesis of tetravinylallene (3,5‐divinylhepta‐1,3,4,6‐tetraene) is reported. The final, key step of the synthesis involves a palladium‐catalyzed, Negishi‐type cross‐coupling involving 1,5‐transposition of a penta‐2‐en‐4‐yn‐1‐ol methanesulfonate. The unprecedented fundamental hydrocarbon is sufficiently stable to be purified by flash chromatography. A similar synthetic pathway grants access to the first substituted tetravinylallenes, which provide insights into the influence of...
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Current Anthropology, Volume 60, Issue 4, August 2019.
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Current Anthropology, Volume 60, Issue 4, Page 604-606, August 2019.
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Current Anthropology, Volume 60, Issue 4, Page 603-604, August 2019.
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Current Anthropology, Volume 60, Issue 4, Page 602-603, August 2019.
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Current Anthropology, Ahead of Print.
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