Introduction Knowledge of surgical markings for unilateral cleft lip (UCL) repair is critical for surgical competency. However, few appropriate models are accessible to residents and affordable and accurately reproduce this 3-dimensional (3D) deformity. We propose that cleft care units have the capability of creating affordable 3D stone models to teach UCL markings. Methods Polyvinyl siloxane and SnapStone were used to create UCL stone models. Thirteen plastic surgery residents were prospectively...
Clinical care is often directed at improving patient's quality of life, the effectiveness of which can be measured by objective or subjective outcomes. Surgical intervention, especially in plastic and reconstructive surgery, can often provide hard objective measures, for example, breast size reduction after bilateral reduction mammaplasty, or improved joint position/movement after Dupuytren's surgery. These measurements do not describe how a particular intervention affects the patient's life, from...
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Goals/Purpose Rhinoplasty is the most common procedure seen in the teenage population. Many of these patients have facial imbalance both recognized and unrecognized by the individual and family. Most often it involves chin or midface deficiency. When the discussion involves the possibility of additional surgery, such as an alloplastic chin implant or a surgical osteotomy, the conversation halts because the patient and family seek a simpler solution. Autologous fat transfer is a useful adjunct...
Current medical literature has described many variations of the palmaris longus. One variation that is rarely seen is that of the accessory palmaris longus, which is better known in literature as the “palmaris profundus.” This brief review will describe the anatomy and the developmental origins of the palmaris longus, as well as the clinical relevance of an accessory palmaris longus. We will also present a case on the accessory palmaris longus and discuss whether the accessory palmaris longus, if...
Background Anabolic-androgenic steroids (AAS) are widely implicated in gynecomastia development. Surgery is the definitive treatment for cases persisting after cessation of AAS use. Currently, the relevance of AAS use to the surgical approach of gynecomastia has not been well explored. This study aims to compare patient characteristics, surgical outcomes, and surgical management of gynecomastia correction in AAS users versus nonusers. Methods A retrospective cohort study was performed with...
Background Modern approaches to erectile dysfunction (ED) often entail the use of multimodal medical therapy and surgery; however, with recent advances in microsurgery, new options may exist for patients suffering from ED. This comprehensive review of the literature serves to reevaluate anatomical and physiological principles that mediate erection to improve understanding for reconstructive surgeons hoping to offer new interventions. Methods A search strategy for this review was agreed upon...
Background Immediate breast reconstruction in 1 stage using permanent implants is gaining popularity and can be performed with or without the use of acellular dermal matrices. This study aimed to investigate the results of breast implants placed submuscularly without acellular dermal matrix and assess the factors affecting surgical complications. Methods From November 2009 to March 2018, 138 patients underwent immediate breast reconstruction with permanent submuscular implants after concomitant...
Background The iliac crest bone graft (ICBG) is criticized for high donor site morbidity. Recent research suggests this morbidity is related to the patient population for which the ICBG is harvested. This systematic review is the first to delineate the type and incidence of ICBG donor site complications in craniofacial surgery. Methods Two independent reviewers conducted a systematic review of multiple databases (MEDLINE, EMBASE, CINAHL, PEDRO, and Cochrane Central Register of Controlled...
Background Hypertrophic scars (HSs) generally form after injury to the deep layers of the dermis and are characterized by excessive collagen deposition. An increasing amount of evidence has determined that human adipose tissue–derived mesenchymal stem cells attenuate fibrosis in various conditions. We explored the effect and possible mechanism of chyle fat–derived stem cells (CFSCs) on HS formation. Methods Hypertrophic scar–derived fibroblasts (HSFs) and CFSCs were isolated from individual...
No abstract available
Introduction Hand and wrist surgeries are often carried out under local/regional anesthesia. We describe our experience using Surgeon Administered Local/Regional Anaesthesia (SALoRA) without sedation to deliver acute and elective hand surgery anesthesia in a tertiary public hospital in Singapore. This is in comparison to wide awake local anesthesia no tourniquet, which has been increasing in popularity. Methods Retrospective analysis was conducted on all surgeries performed under SALoRA between...
Introduction Nerve repair poses a significant surgical challenge, and much research on this topic for improvement in reconstruction of segmental defects is ongoing. The aims of the study were to reconfirm the accuracy and safety of a previously described nerve decellularization method on a larger experimental population of rabbits, as well as on human nerves, and to establish in vivo the efficacy of a new-concept mixed graft, comprising autologous and acellular nerve allograft components within...
Background Distraction osteogenesis has gained popularity in the treatment of different types of craniosynostosis. We aimed to present the technique of 1-piece fronto-orbital distraction with midline splitting osteotomy but without bandeau for the treatment of metopic craniosynostosis, and the protocol of outcome evaluation using craniometric, volumetric, and morphologic parameters based on 3-dimensional computer simulation. Methods This retrospective study included 9 patients with isolated...
Background A substantial global inequality exists between surgical need and the availability of safe, affordable surgical care. Low- and middle-income countries have the greatest burden of untreated surgical disease and addressing this inequity is the goal of the Global Surgery movement. Reconstructive surgery is a fundamental component of Global Surgery as it is central to the appropriate treatment of trauma, burns, wounds, and congenital malformations. The objective of this study was to analyze...
Massive intraosseous vascular malformations, a relatively rare entity in the vascular malformation spectrum, deserves attention as involving the membranous bones of the craniofacial skeleton and may lead to severe life-threatening hemorrhages and even death. The main aim of this study was to summarize the 25 years of clinical experience with these vascular malformation osseous patients, focus on the molecular and genetic aspect of the clinical entity, and to emphasize the certain challenging conditions...
Background Cartilage tissue has a limited capacity for healing with the consequence that patients are often treated symptomatically until they become candidates for osteotomy or total joint replacement. Alternative biological therapies, for example, application of platelet-rich plasma and implantation of chondrocytes and mesenchymal stem cells, have emerged as a new treatment modality to repair articular cartilage. In addition, autologous fat transfer is performed for treatment of cartilage defects,...
Introduction Nasal reconstruction after oncologic resection often constitutes a technically demanding task. The aim of this study was to investigate our experience with nasal reconstruction after Mohs micrographic surgery using the following 3 well-established, versatile, and reliable techniques: the bilobed flap, nasolabial flap, and forehead flap. Methods A single-surgeon retrospective chart review of all patients undergone a bilobed, nasolabial, or forehead flap for nasal reconstruction...
Toxic shock syndrome is a rare but life-threatening complication after breast implant surgery. We describe a 77-year-old woman who developed toxic shock syndrome caused by methicillin-resistant Staphylococcus aureus after breast implant reconstruction. Despite a high fever and markedly increased white blood cell count, suggesting severe infection, she initially had no symptoms of local findings, such as wound swelling and redness of the breast. Soon after diagnosis of toxic shock syndrome and removal...
Purpose The use of externalized jejunal monitoring flaps for jejunum transfers could be facilitative for the direct clinical assessment. Although this monitoring method would seem to be highly reliable, we modified this method and used mesentery only as a monitor to make it easy to manage the monitor more. Methods Between 2013 and 2018, 43 patients underwent vascularized jejunum transfer for reconstruction of laryngopharyngectomy using the externalized mesentery monitor. There were 39 men...
No abstract available
Background Upper limb lymphedema is a common problem after axillary lymph node dissection. Lymphatic drainage can be improved by microvascular lymph node transfer, whereas liposuction can be used to reduce arm volume and excess of adipose tissue. We present the results of chronic lymphedema patients who have undergone lymph node transfer and liposuction simultaneously in 1 operation and compare the results with patients who have undergone lymph node transfer without liposuction. Methods During...
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The original article [1] contains an error in the title - the motif ‘pectoral assay’ should not be present and as such, the title should instead be: ‘Diagnosis of abdominal tuberculosis: lessons learned over 3...
Adhesion barriers have proven to reduce adhesion-related complications in colorectal surgery. However, barriers are seldom applied. The aim of this study was to determine the cost-effectiveness of adhesion bar...
Far reaching sub-specialization tends to become obligatory for surgeons in most Western countries. It is suggested that exposure of surgeons to emergency laparotomy after trauma is ever declining. Therefore, i...
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Hearing loss is positively associated with a risk of dementia, especially among adults 45 to 64 years old, according to a new study (JAMA Netw Open. 2019;2[7]:e198112). Researchers in Taiwan analyzed data of 16,270 patients from 2000 to 2013 from the National Health Insurance Research Database of Taiwan, comparing the incidence of dementia of those with and without hearing loss. Of the 16,270 patients included, 1868 developed dementia, and the dementia incidence rate in the hearing loss group was...
The Hearing Industries Association (HIA) argued against the Food and Drug Administration's (FDA) marketing authorization of Bose's self-fitting hearing aids. According to the HIA, the authorization relied on a flawed Phase II clinical study design that the HIA stated "does not provide enough evidence of effectiveness of the self-fitting method given the study's initial reliance on professionals for fitting." The FDA originally granted the self-fitting hear aid a 'De Novo' in 2018 based on clinical...
Medicine to treat age-related hearing loss could potentially receive FDA approval through a study being conducted at the University of South Florida (USF). Chair of the USF Medical Engineering Department and Director of the USF Global Center for Hearing and Speech Research Robert Frisina, PhD, and his team were awarded a U.S. patent for his theory on managing hearing loss. He and his team believe that you can slow hearing loss by combining supplements for the hormone aldosterone with anti-inflammatory...
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Abstract Lung cancer is among the most frequently occurring cancers and the leading cause of cancer‐related deaths worldwide. Nonsmall cell lung cancer is accountable for 85% to 90% of all lung cancer cases and develops distant metastases with high mortality. In this work, we elucidated the role of activating transcription factor 1 (ATF1) in migration and invasion of lung cancer cells. We found that the migration and invasion were inhibited with ATF1 silencing in lung cancer cells. By contrast,...
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Oncogenesis, Published online: 16 August 2019; doi:10.1038/s41389-019-0157-8DeepCC: a novel deep learning-based framework for cancer molecular subtype classification
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We aimed to elucidate the role of intraoperative clean surgical margin (iCSM) determined according to lesion size and duration to obtain appropriate histological clean surgical margin (hCSM) in high-risk basal cell carcinoma (BCC) patients evaluated according to National Comprehensive Cancer Network (NCCN) criteria considering the tumor size and/or location. The contribution of lesion area to determine iCSM was also evaluated. Patients with high-risk BCC requiring surgical management were included....
Craniomaxillofacial and plastic surgeons are often confronted with patients who present with enophthalmos caused mainly by trauma. In many patients, one-stage reconstruction repairs only the bony orbit, leaving intact the disfiguring enophthalmos. Thus, some filler is needed to restore the normal volume of the orbit. The authors describe a technique to correct such deformation safely and effectively. Data were collected from 30 enophthalmic patients (average age 36.67 ± 11.66 years) who underwent...
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Background: Contemporary description of facial fracture patterns and factors associated with early operative intervention at trauma centers is lacking. The purpose of this study was to characterize injuries and initial treatment patterns of patients suffering from facial fractures. Methods: Using the National Trauma Databank from 2007 to 2015, patients suffering from facial fractures were included. Demographics, injury characteristics, and outcomes including operative interventions were assessed. ...
Background: Underdevelopment of nose and chin in East Asians is quite common. Rhinoplasty and mentoplasty are effective procedures to solve the above-depicted defects and can achieve remarkable cosmetic effects. An autologous costal cartilage graft has become an ideal material for rhinoplasty, especially for revision surgery. However, many problems in the clinical application of costal cartilage remain unresolved. This study is to investigate application strategies of autologous costal cartilage...
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AbstractPublished evidence suggests that inherent rhythmically active or ‘bursting’ primary olfactory receptor neurons (bORNs) in crustaceans have the previously undescribed functional property of encoding olfactory information by having their rhythmicity entrained by the odor stimulus. In order to determine whether such bORN-based encoding is a fundamental feature of olfaction that extends beyond crustaceans, we patch-clamped bORN-like ORNs in mice, characterized their dynamic properties, and show...
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Journal of International Medical Research, Ahead of Print.
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Journal of Adolescent and Young Adult Oncology, Ahead of Print.
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Cancers, Vol. 11, Pages 1200: SRSF2 Mutations in Uveal Melanoma: A Preference for In-Frame Deletions? Cancers doi: 10.3390/cancers11081200 Authors: Natasha M. van Poppelen Wojtek Drabarek Kyra N. Smit Jolanda Vaarwater Tom Brands Dion Paridaens Emine Kiliç Annelies de Klein Background: Uveal melanoma (UM) is the most common primary ocular malignancy in adults in the Western world. UM with a mutation in SF3B1, a spliceosome gene, is characterized by three or more...
Cancers, Vol. 11, Pages 1198: Clinical-Scale Production of CAR-T Cells for the Treatment of Melanoma Patients by mRNA Transfection of a CSPG4-Specific CAR under Full GMP Compliance Cancers doi: 10.3390/cancers11081198 Authors: Manuel Wiesinger Johannes März Mirko Kummer Gerold Schuler Jan Dörrie Beatrice Schuler-Thurner Niels Schaft Chimeric antigen receptor (CAR)-T cells already showed impressive clinical regressions in leukemia and lymphoma. However, the development...
Cancers, Vol. 11, Pages 1194: The Multiple Roles and Therapeutic Potential of Molecular Chaperones in Prostate Cancer Cancers doi: 10.3390/cancers11081194 Authors: Hoter Rizk Naim Prostate cancer (PCa) is one of the most common cancer types in men worldwide. Heat shock proteins (HSPs) are molecular chaperones that are widely implicated in the pathogenesis, diagnosis, prognosis, and treatment of many cancers. The role of HSPs in PCa is complex and their expression has been linked...
Cancers, Vol. 11, Pages 1195: Targeting Heat Shock Protein 27 in Cancer: A Druggable Target for Cancer Treatment? Cancers doi: 10.3390/cancers11081195 Authors: Choi Kam Kim Park Lee Heat shock protein 27 (HSP27), induced by heat shock, environmental, and pathophysiological stressors, is a multi-functional protein that acts as a protein chaperone and an antioxidant. HSP27 plays a significant role in the inhibition of apoptosis and actin cytoskeletal remodeling. HSP27...
Cancers, Vol. 11, Pages 1196: Development, Implementation and Assessment of Molecular Diagnostics by Next Generation Sequencing in Personalized Treatment of Cancer: Experience of a Public Reference Healthcare Hospital Cancers doi: 10.3390/cancers11081196 Authors: Simarro Murria Pérez-Simó Llop Mancheño Ramos Juan Barragán Laiz Cases Ansótegui Gómez-Codina Aparicio Salvador Juan Palanca The establishment of precision medicine...
Cancers, Vol. 11, Pages 1197: Targeting Oncogenic BRAF: Past, Present, and Future Cancers doi: 10.3390/cancers11081197 Authors: Zaman Wu Bivona Identifying recurrent somatic genetic alterations of, and dependency on, the kinase BRAF has enabled a “precision medicine” paradigm to diagnose and treat BRAF-driven tumors. Although targeted kinase inhibitors against BRAF are effective in a subset of mutant BRAF tumors, resistance to the therapy inevitably emerges....
Cancers, Vol. 11, Pages 1199: Single-Cell Analysis of Multiple Steps of Dynamic NF-κB Regulation in Interleukin-1α-Triggered Tumor Cells Using Proximity Ligation Assays Cancers doi: 10.3390/cancers11081199 Authors: Mayr-Buro Schlereth Beuerlein Tenekeci Meier-Soelch Schmitz Kracht The frequently occurring heterogeneity of cancer cells and their functional interaction with immune cells in the tumor microenvironment raises the need to study signaling pathways at...
Cancers, Vol. 11, Pages 1193: Epigenetic Dysregulation at the Crossroad of Women’s Cancer Cancers doi: 10.3390/cancers11081193 Authors: Rakesh Kumar Aswathy Mary Paul Pranela Rameshwar M. Radhakrishna Pillai An increasingly number of women of all age groups are affected by cancer, despite substantial progress in our understanding of cancer pathobiology, the underlying genomic alterations and signaling cascades, and cellular-environmental interactions. Though our understanding...
Cancers, Vol. 11, Pages 1191: Reactive Oxygen Species in the Tumor Microenvironment: An Overview Cancers doi: 10.3390/cancers11081191 Authors: Frank Weinberg Nithya Ramnath Deepak Nagrath Reactive oxygen species (ROS) are important signaling molecules in cancer. The level of ROS will determine physiological effects. While high levels of ROS can cause damage to tissues and cell death, low levels of ROS can have a proliferative effect. ROS are produced by tumor cells but also cellular...
Cancers, Vol. 11, Pages 1192: Lambda-Carrageenan Enhances the Effects of Radiation Therapy in Cancer Treatment by Suppressing Cancer Cell Invasion and Metastasis through Racgap1 Inhibition Cancers doi: 10.3390/cancers11081192 Authors: Ping-Hsiu Wu Yasuhito Onodera Frances C. Recuenco Amato J. Giaccia Quynh-Thu Le Shinichi Shimizu Hiroki Shirato Jin-Min Nam Radiotherapy is used extensively in cancer treatment, but radioresistance and the metastatic potential of cancer...
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Tissue Engineering Part A, Ahead of Print.
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Soft Robotics, Ahead of Print.
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Future Oncology, Ahead of Print.
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