Down syndrome is one of the most common congenital genetic disorders. Generally, individuals with Down syndrome presents perceptually strained, husky, monotonous, raucous and a typically low pitched voice quality. There are very few attempts made to investigate objective voice characteristics in these individuals. Further, there is no reported data with a specific focus on laryngeal aerodynamics in these individuals. Hence the present study aimed at performing perceptual (GRBAS scale) and laryngeal...
Mark above section as read
Key PointsPGE2 induces immune exhaustion and promotes disease progression of BLV infection. Dual blockade of PGE2 and PD-L1 invigorates antiviral immune response in cattle.
Key PointsIg-TCR rearrangement expression is equivalent to canonical TCR in the nurse shark. Novel lineage of TCR-associated Ig-like V segments is found in shark TCR locus. Ig-TCR receptors are produced by intralocus and interlocus VDJ events and pair with TCR.
Myeloid-derived suppressor cells (MDSCs) are immature suppressive cells found in tumors and immunological niches. In this article, we highlight the ability of MDSCs to promote IL-17–producing T cells (Th17) and regulatory T cells in addition to suppressing cytotoxic T cells in different tumor models. These interactions between MDSCs and T cells support tumor growth because IL-17 is tumorigenic in many cancer types and regulatory T cells suppress antitumor T cells. Besides T cells, MDSCs promote regulatory...
Key PointsThe mice with constitutively activated MDA5 exhibit SMS-like bone abnormalities. Bone resorption and bone formation are attenuated in MDA5 G821S mutant mice. The pathogenesis is dependent on type I IFN induced by MDA5/MAVS signaling.
Key PointsPlatelets alter frequency, phenotype, and function of tumor-infiltrating lymphocytes. Inhibition of platelet activation improves CD8+ T cell–dependent tumor control. Pretreatment with antiplatelet therapy enhances responsiveness to PD-1 blockade.
Key PointsOur study shows that IL-21 plays a pleiotropic role in thymic T cell development. IL-21 is involved in the differentiation of DN subsets as early as the DN1 stage. Furthermore, IL-21 seems to be implicated in the emigration of SP CD4 CD8 T cells.
Key PointsThe Il9 CNS-25 is required for IL-9 production in mast cells and basophils. There is differential control of the Il9 gene between mast cells and T cells. Intestinal mast cell expansion requires Il9 CNS-25–dependent IL-9.
Key PointsViral infection downregulates GNAQ expression. GNAQ deficiency increases host antiviral immunity both in vitro and in vivo. GNAQ negatively regulates IFN-I production in a calcineurin-dependent manner.
Key PointsSP-A aids in the resolution of allergic airway inflammation. SP-A promotes eosinophil clearance through chemotaxis and apoptosis. Genetic variation alters the ability of SP-A to induce eosinophil apoptosis.
Key PointsPPM1L prevents excessive inflammation and cardiac dysfunction after MI. PPM1L binds IKKβ, inhibits its phosphorylation, and impairs NF-B activation.
Key PointsShrimp MD-2 homologue ML1 recognizes a lipid component of white spot syndrome virus. Shrimp ML1 activates NF-B signaling. ML1 induces the expression of Vago, which is a functional analogue of IFN.
Key PointsIntegrin α5β1 binds to monomeric CD40L through the trimeric interface of CD40L. CD40L mutants defective in integrin binding act as antagonists. Functional defects in HIGM1 mutations may be due to defective integrin binding.
Key PointsIL-11+CD4+ cells accumulate in the CSF and active brain RRMS lesions. IL-11 increased the numbers of CNS-infiltrating IL-17+CD4+ cells in RREAE. Passive transfer of IL-11–induced encephalitogenic CD4+ T cells induced severe RREAE.
Key PointsPLZF-deficient mice have reduced numbers of basophil progenitors and mature basophils. PLZF-deficient basophils respond poorly to the protein allergen papain. PLZF-deficient basophils are refractory to activation and produce less IL-4.
Key PointsBiliary epithelial cells secrete Th17-polarizing cytokines. Biliary epithelial cells chemoattract AhR+CCR6+CD4 T cells. Th17 cells promote local Th17 expansion and bile duct proliferation.
Key PointsSomatic mutations in close proximity exhibit high linkage disequilibrium. Pairs of somatic mutations within 8 bp are templated from IgHV gene segments. Pairs of somatic mutations in non-Ig genes at the IgH locus are similarly templated.
Key PointsOnly 14% of CD4 or CD8 T cells of young adult Malawians were naive (CCR7+CD45RA+). There is little age-associated accumulation of differentiated or senescent T cells. There are robust T cell responses to viral Ags and mitogens from early 20s to late 60s.
Key PointsPrimary EBV infection drives highly cytotoxic virus-specific CD4+ T cell responses. EBV-specific memory CD4+ T cells are polyfunctional but lack cytotoxic activity. Acute EBV-specific CD4-CTLs differ transcriptionally from classical memory CD4-CTLs.
Key PointsmTORC1 regulates teleost T cell activation, proliferation, and effector function. mTORC1 links immune signals to metabolic programs in teleost T cells. Primordial T cells in teleost have evolved sophisticated regulatory strategies
Key PointsMemory reactivation to priming Ags induces real-time immune resetting in sepsis. Sepsis response shifts from pathogen-driven to one driven by memory reactivation. Resetting in sepsis increases survival by a new hypoinflammatory T cell response.
Key PointsVitamin A negatively regulates iNKT cell population. P2X7 upregulation by retinoic acid makes iNKT cells sensitive to cell death. Tissue-resident iNKT cells are preferentially controlled by P2X7 activation.
Key PointsMDSCs were identified as CD11b+Gr1lo-int in HSV1-infected mice. In vitro–generated MDSCs controlled the severity of HSK lesions. MDSCs promoted endogenous Treg response that also included a de novo conversion.
Key PointsLPS downregulates 11β-HSD2 through inhibiting PPAR in placental trophoblasts. LPS promotes interaction between NF-B p65 and PPAR in the cytoplasm and nucleus. Pretreatment with PPAR agonist RSG partially alleviates LPS-induced fetal IUGR.
Key PointsIFNs induce RIPK3-dependent cell death in the absence of RIPK1. The IFN-stimulated gene product ZBP1 drives cell death in Ripk1–/– cells. ZBP1 and IFN signaling contribute to perinatal lethality of Ripk1–/– mice.
Key PointsCD4Cre efficiently recombines in alveolar macrophages and lung epithelial cells. Constitutively active KRas causes T cell hyperactivation and autoimmune diseases. CD4Cre-mediated KRas expression causes fatal hyperproliferative pneumonitis.
Key PointsTongue sole GSDME is cleaved mainly by CASP1 and induces pyroptosis. CASP3/7 also cleave tongue sole GSDME and switch apoptosis to secondary pyroptosis. CASP1-dependent cleavage of GSDME is preserved in a large number of teleost species.
Key PointsPPE2 protein of M. tuberculosis inhibits ROS production. PPE2 protein interact with p67phox, inhibiting NADPH oxidase complex formation. W236 in PPE2–SH3 domain is crucial for PPE2–p67phox interaction and ROS inhibition.
Key PointsPostoperative portal hypertension enhances alloimmune responses after LDLT. Immune-suppression capacity of LSECs is impaired by portal hypertension.
Mark above section as read
Head and neck squamous cell carcinoma (HNSCC) has a substantial risk of cervical lymph node metastases [1]. For small nodal metastases, it is not uncommon that they remain undetected (i.e. occult) because they fall below the detection threshold of diagnostic imaging [1,2]. In a clinically negative neck (cN0) the prevalence of occult metastases ranges between 10% and 35%, depending on the primary tumor site and T-stage [2]. To eradicate potential occult nodal disease, elective irradiation (typically...
Overall survival (OS) following radiotherapy (RT) for locally-advanced non-small cell lung cancer (LA-NSCLC) remains disappointing. While some dose-escalation trials have achieved promising results [1], outcomes have been inconsistent, with median OS in better performing studies being 25–28 months [2,3]. Surprisingly, the RTOG-0617 phase III study of concurrent chemoradiotherapy (CRT) found a sub-unity median survival ratio (MSR) of 0.71 for 74 Gy in 37 daily fractions versus 60 Gy in 30 fractions...
Non-squamous cell carcinoma (NSCC) in the head and neck region is resistant to photon therapy and chemotherapy, and therefore the standard therapy for this disease remains a subject of debate. Previous studies indicated that carbon-ion radiotherapy provides favorable local control and survival for head and neck NSCCs [1–4]. Differing from squamous cell carcinomas of the head and neck region, which are predominantly located in the oral cavity and pharynx, more than 50% of NSCCs arising in the head...
The cGAS-STING pathway can be activated by radiation induced DNA damage and because of its important role in anti-cancer immunity activation, methods to increase its activation in cancer cells could provide significant therapeutic benefits for patients. We explored the impact of hafnium oxide nanoparticles (NBTXR3) activated by radiotherapy on cell death, DNA damage, and activation of the cGAS-STING pathway. We demonstrate that NBTXR3 activated by radiotherapy enhances cell destruction, DNA double...
Mark above section as read
Abstract MHC class I-related chain A (MICA) is one of the major ligands for natural killer group 2 member D (NKG2D), which is an activating NK receptor. MICA is expressed on the surface of human epithelial tumor cells, and its shedding from tumor cells leads to immunosuppression. To activate immune response in the tumor microenvironment, we designed an anti-VEGFR2–MICA bispecific antibody (JZC01), consisting of MICA and an anti-VEGFR2 single chain antibody fragment (JZC00) and...
Mark above section as read
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b06328
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b05054
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b03680
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b03036
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b05221
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b04866
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b03484
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b06711
Mark above section as read
We provide an outline of the clinical protocol for non-invasive assessment of human egg maturity using polarized light microscopy.
Presented here is a protocol that guarantees uniform distribution of initial moisture inside of a fabric and investigates the effects of hot-air thermodynamic parameters (velocity, temperature, and direction) and thickness on the fabric's drying characteristics (e.g., temperature variation) under the condition of air impingement.
We present a fluorescence assay to demonstrate that Lucifer Yellow (LY) is a robust marker to determine the apparent paracellular permeability of hCMEC/D3 cell monolayers, an in vitro model of the human blood-brain barrier. We used this assay to determine the kinetics of a confluent monolayer formation in cultured hCMEC/D3 cells.
Mark above section as read
A hydatidiform mole with a coexisting fetus is a rare condition that commonly occurs as either a partial mole with fetus or a twin pregnancy comprising a complete mole and normal fetus. In the former case, the...
Mark above section as read
Publication date: October 2019Source: Neoplasia, Volume 21, Issue 10Author(s): FR Saenz, V Ory, MO Schmidt, BV Kallakury, SC Mueller, PA Furth, A Wellstein, AT RiegelAbstractThe transcriptional coactivator Amplified in Breast Cancer 1 (AIB1) plays a major role in the progression of hormone and HER2-dependent breast cancers but its role in triple negative breast cancer (TNBC) is undefined. Here, we report that established TNBC cell lines, as well as cells from a TNBC patient-derived xenograft (PDX)...
Mark above section as read
AbstractThe chemical senses and pharmaceuticals fundamentally depend on similar biological processes, but novel molecule discovery has classically been approached from vastly different vantagepoints. From the perspective of ingredient and flavor companies, there are countless ingredients that act via largely unknown mechanisms, whereas the pharmaceutical industry has numerous mechanisms in search of novel compounds. Mixtures of agonists can result in synergistic (super-additive) responses, which...
Chem. Senses (2019). doi: 10.1093/chemse/bjz015.
Mark above section as read
Cold plasma is an unusual gaseous substance in which only the electrons are heated to thousands of degrees, with the rest of the material remaining at room temperature. Purdue University researchers have advanced this field and have helped to make it ready for clinical applications, since cold plasma has the ability to kill target cells while sparing nearby cells. In particular, Purdue researchers created one of the first practical cold plasma generators and tested how cold plasma affects...
Researchers from TU Dresden in Germany have developed a new ultrathin lensless endoscope for biomedical applications. Their work demonstrates that the endoscope, only 200 microns in diameter, can self-calibrate and adjust its focus to perform 3D imaging. This exciting development can be used for optogenetic applications, as well as monitoring cells and tissues. Typical endoscopes use a combination of cameras, lenses, optical fibers, and light sources in order to visualize internal body...
The sweat excreted by our skin contains a number of metabolites and biomarkers that may be useful in managing disease, tracking athletic performance, and helping to identify health problems. Moreover, the amount of sweat that we produce can in itself be an important measure, but current sweat analysis techniques are very limited. Now, researchers at University of California, Berkeley have developed new sticker-like sweat sensors that can quantify the amount of sweat that is produced...
Flexible body-worn sensors that conform to the skin have great potential for monitoring patient health, conducting long-term studies, and giving consumers a way to track their exercise and overall health. Although there have been flexible sticker-like body monitors developed in the past, they have all involved rigid electronic chips and batteries. So, although they’re flexible and can be worn on the skin, they’re still rather bulky and require recharging. Now, a team at Stanford University...
Mark above section as read
Abstract “Proletarian” relations are generally understood in terms of capitalist dispossession. However, a deeper historical approach to class relations in Iceland reveals the fundamental role of monopolization and labor insecurity across capitalist and pre-capitalist political economies. During the first settlement of Iceland in the late 9th century A.D., land was freely available to colonists, but by the late 17th century, over 95% of all farming properties were owned by landlords....
Mark above section as read
Abstract Left ventricular papillary muscles are small myocardial structures that play an important role in the functioning of mitral valve and left ventricle. Typically, there are two groups of papillary muscles, namely the anterolateral and the posteromedial groups. Cardiovascular magnetic resonance (CMR) is a valuable imaging modality in the evaluation of papillary muscles, providing both morphological and functional information. There is a remarkably wide variation in the...
Mark above section as read
Abstract Coronary microvascular dysfunction combined with maladaptive cardiomyocyte morphology and energetics are major contributors to heart failure advancement. Thus, dually enhancing cardiac angiogenesis and targeting cardiomyocyte function to slow, or reverse, the development of heart failure is a logical step towards improved therapy. We present evidence for the potential to repurpose a former anti‐cancer Arg‐Gly‐Asp (RGD)‐mimetic pentapeptide, Cilengitide, here used at low doses. Cilengitide...
Mark above section as read
Children with a high genetic risk of developing type 1 diabetes have different gut microbiomes than children with a low risk, according to a new study. The results suggest that genetic risk can shape an individual's response to environmental factors in the development of autoimmune diseases.
Mark above section as read
Abstract Background The cold test is a specific test of pulp sensitivity and is part of the endodontic diagnosis. The aim of this study was to identify the diagnostic accuracy including sensitivity, specificity, accuracy, positive predictive value and negative predictive value in three sites for the cold test in teeth with a need for endodontic treatment within different age groups from both genders. ...
Abstract Background We previously showed that nasal administration of a combination of dendritic cell (DC) targeted DNA plasmid expressing Flt3 ligand and CpG oligodeoxynucleotides 1826 as a mucosal adjuvant (double adjuvant, DA) provoked protective immunity in the upper respiratory tract of young adult and aging mice. Here, we investigated whether the nasal DA system induces secretory (S)IgA antibodies (Abs) toward recombinant fimbrillin...
Mark above section as read
במשנה אנחנו נתקלים לראשונה ב"אווזים", למשל: "ואין נותנין מים [בשבת] לפני דבורים ולפני יונים שבשובך אבל נותנים לפני אווזים ותרנגלים…" (שבת כד, ג). בארמית של התלמוד הבבלי נזכר העוף בר אווזא או בר אוזא, מילולית: 'בן אווז'. צירוף זה משמש גם בספרות הרבנית. בספרות העברית של המאה ה־19 – בעיקר זו המתארת את עולם החי – אימצו את ההבחנה המקובלת בין שתי קבוצות קרובות: העופות הקרויים בגרמנית Gans כונו בעברית 'אווז', והעופות הקרויים בגרמנית Ente כונו בעברית 'בר אווזא' (על דרך הארמית) ולעיתים בגרסה 'בר אווז' (על...
ביום ראשון כ"ז בתמוז תשי"ב, 20 ביולי 1952, התפרסמה בעיתון דבר ידיעה על מסיבת עיתונאים שערך שר החוץ משה שרת לאחר שובו מביקור בארצות הברית. בצד הידיעה נכתב בתוך מסגרת דיווח קצר תחת הכותרת "בלשנות במשרד החוץ". וכך נאמר בו: בסיום המסיבה הציע שר החוץ, באופן בלתי רשמי כמובן, שני מונחים עבריים חדשים. א) אנו נוהגים לומר תחולה – החוק חל וכו'. ואיך נאמר למושג 'להפעיל את החוק שיהא חל'? על דרך רום-תרומה-תרוֹם מציע שר החוץ לקבל חול-תחולה-תחוֹל. ובכן 'אנו תוחלים את החוק הזה מעתה' וכו'. ב) אינצידנט – 'תקרית' על...
Mark above section as read
Nature Chemistry, Published online: 19 August 2019; doi:10.1038/s41557-019-0292-zThe regulation of cellular response to stimuli by genetic regulatory networks (GRNs) suggests how in vitro chemical reaction networks might be used to direct the dynamics of synthetic materials or chemical reactions. Now, multiple functional in vitro transcriptional circuit modules have been integrated to form composite regulatory networks capable of complex features analogous to those found in cellular GRNs.
Nature Chemistry, Published online: 19 August 2019; doi:10.1038/s41557-019-0311-0Interphases that form on the anode surface of lithium-ion batteries are critical for performance and lifetime, but are poorly understood. Now, a decade-old misconception regarding a main component of the interphase has been revealed, which could potentially lead to improved devices.
Nature Chemistry, Published online: 19 August 2019; doi:10.1038/s41557-019-0308-8Finding the central science
Nature Chemistry, Published online: 19 August 2019; doi:10.1038/s41557-019-0304-zThe solid–electrolyte-interphase layer is extremely important for reversible electrochemical cycling of Li-ion batteries. Now it has been observed that lithium ethylene mono-carbonate, instead of the previously reported lithium ethylene di-carbonate, is the major initial organic species in this layer and it has a high Li-ion conductivity.
Nature Chemistry, Published online: 19 August 2019; doi:10.1038/s41557-019-0306-xIn coordination and organometallic chemistry, back-bonding between an electron-rich, typically mid- or low-oxidation-state d-block metal centre and a ligand with accepting π* orbitals is widespread. Now, such an interaction has been observed between unlikely partners—high-oxidation-state uranium(v) 5f1 ion and the poor π-acceptor ligand dinitrogen—in a U(v)–bis(imido)–N2 complex stabilized by a lithium counterion.
Mark above section as read
Οι άνθρωποι που υποφέρουν από αϋπνίες είναι πιθανό να διατρέχουν μεγαλύτερο κίνδυνο για στεφανιαία νόσο, καρδιακή ανεπάρκεια και εγκεφαλικό επεισόδιο, σύμφωνα με μια νέα έρευνα που δημοσιεύθηκε στο Circulation. Προηγούμενες μελέτες έχουν δείξει ότι πράγματι υπάρχει συσχετισμός μεταξύ της αϋπνίας, που επηρεάζει έως και το 30% του γενικού πληθυσμού, και του αυξημένου κινδύνου ανάπτυξης καρδιαγγειακών παθήσεων και εγκεφαλικού επεισοδίου. «Οι μελέτες αυτές, όμως, δεν μπόρεσαν να προσδιορίσουν αν η αϋπνία...
15h
Μια νέα εξέταση αίματος που θα πραγματοποιείται στην αρχή της χορηγούμενης θεραπείας για τον καρκίνο του μαστού θα μπορεί να προβλέψει άμεσα πόσο καλά θα ανταποκριθούν οι ασθενείς και ανάλογα με τα ευρήματα θα γίνεται άμεσα τροποποίηση της αγωγής. Η νέα αυτή εξέταση αίματος, που παρουσιάστηκε στο Ετήσιο Συνέδριο ASCO που πραγματοποιήθηκε στο Σικάγο, ανίχνευσε γενετικές μεταλλάξεις στον καρκίνο του μαστού, οι οποίες έδειξαν ότι οι ασθενείς ήταν λιγότερο πιθανό να ανταποκριθούν στη θεραπεία και ότι...
21h
Συνιστώντας μία από τις μεγαλύτερες του είδους της, η μελέτη που δημοσιεύθηκε στο American Journal of Hypertension πραγματοποίησε μία μη στοχοθετημένη μεταβολομική ανάλυση σε περισσότερους από 1.200 συμμετέχοντες στη μελέτη Bogalusa Heart προκειμένου να αναγνωρίσει μεταβολίτες που συνδέονται με τη αρτηριοσκλήρυνση. Παρόλο που η αρτηριοσκλήρυνση (ή αρτηριακή δυσκαμψία) συνιστά έναν ανεξάρτητο και αρκετά σοβαρό παράγοντα κινδύνου για καρδιαγγειακές παθήσεις, ακόμα και θάνατο, οι μηχανισμοί που συμβάλλουν...
21h
Κομβική για την κατανόηση της διαδικασίας της γήρανσης ενδέχεται να είναι μία έρευνα από τη Σχολή Μηχανικών του Πανεπιστημίου Viterbi που δημοσιεύθηκε στο Journal of Biological Chemistry. Τα ευρήματα θα μπορούσαν να ανοίξουν το δρόμο για καλύτερες θεραπείες κατά του καρκίνου και επαναστατικά νέα φάρμακα για διάφορες νόσους. «Για να αξιοποιήσει κάποιος την πηγή της νεότητας πρέπει πρώτα να την ανακαλύψει και να κατανοήσει ποια είναι η ακριβής δράση της. Κάνουμε ακριβώς το αντίθετο. Προσπαθούμε να...
21h
H ατμοσφαιρική ρύπανση, συγκεκριμένα οι αυξημένες συγκεντρώσεις όζοντος που οφείλονται στην κλιματική αλλαγή, επιδεινώνει το πνευμονικό εμφύσημα σύμφωνα με μελέτη των Πανεπιστημίων Ουάσινγκτον, Κολούμπια και Μπάφαλο. Η νέα έρευνα που δημοσιεύθηκε στο JAMA παρουσιάζει μία σχέση μεταξύ της μακροχρόνιας έκθεσης τους ρύπους, ειδικά στο όζον, με την αύξηση στα περιστατικά εμφυσήματος. «Μας εκπλήσσει ότι η έντονη ατμοσφαιρική ρύπανση επιδρά στην εξέλιξη του εμφυσήματος με τον ίδιο τρόπο όπως το κάπνισμα,...
21h
Τα υψηλά επίπεδα μιας πρωτεΐνης που εκκρίνεται μετά από προπόνηση υψηλής έντασης ενδέχεται να αποτελούν δείκτη πρόβλεψης του κινδύνου εμφράγματος ή εγκεφαλικού επεισοδίου εντός των επόμενων ετών σύμφωνα με νέα έρευνα. Σε αυτό το συμπέρασμα κατέληξαν Ευρωπαίοι ερευνητές σε δημοσίευση της μελέτης τους στο Circulation. Στη μελέτη οι επιστήμονες εξέτασαν 725 ηλικιωμένους ανθρώπους που συμμετείχαν σε ένα περίπατο διάρκειας οκτώ ωρών στην Ολλανδία. Οι περιπατητές έδωσαν δείγματα αίματος πριν και αμέσως...
23h
Mark above section as read
Bipaddle Pectoralis Major Myocutaneous Flap for Single Stage Reconstruction of Oromandibular Defects
Abstract Reconstruction of full thickness defects after resection of oral cancer is a challenge. Although microvascular free flaps are considered the first choice, their use is limited in the developing regions by availability of resources and the expertise. In this study, we have presented our experience with the use of bipaddle pectoralis major myocutaneous (PMMC) flap as a single stage reconstruction option for defects of the oral cavity. After undergoing resection of oral cancer,...
Abstract The surgical approach for hypophysectomy has undergone sweeping revolution in the past three decades. With the advent of endoscopes, better instrumentation, better illumination and viewing cameras, endoscopic endo-nasal trans-sphenoidal approach to sella has now largely become the norm. The aim of this study is to present our experience, analysing the surgical outcomes of this approach in patients with pituitary adenoma, pertaining to entirety of tumor removal, alleviation...
Abstract Swallowing is a complicated, multilevel and neuromuscular physiological function. Transcutaneous neuromuscular electrical stimulation is a relatively new therapeutic intervention for the treatment of swallowing disorders. The aim was to administer and focus on pre and post therapy effects of traditional dysphagia therapy and electrical stimulation (TENS) in 2 participants with posterior stroke. Electrical current along with traditional dysphagia therapy on regular intervals...
Mark above section as read
Conditions: Nasopharyngeal Carcinoma; Neoadjuvant ChemotherapyInterventions: Drug: 4 cycles of Neoadjuvant Chemotherapy With Definitive Radiotherapy; Drug: 3 cycles of Neoadjuvant Chemotherapy With concurrent chemoradiotherapySponsor: Second Affiliated Hospital, School of Medicine, Zhejiang UniversityRecruiting
Condition: Work-Related ConditionInterventions: Other: Shoulder stabilization exercises; Other: Office exercises trainingSponsor: Eastern Mediterranean UniversityNot yet recruiting
Conditions: Pancreatic Adenocarcinoma; Esophageal Adenocarcinoma; Esophageal Squamous Cell Carcinoma; Gastric Adenocarcinoma; Gastroesophageal Junction Adenocarcinoma; Triple Negative Breast Cancer; Castration-resistant Prostate Cancer; Microsatellite Stable Colorectal CancerInterventions: Drug: GB1275; Drug: nab-paclitaxel and gemcitabine; Drug: pembrolizumabSponsor: GB006, Inc., a wholly owned subsidiary of Gossamer Bio, Inc.Recruiting
Condition: CancerIntervention: Radiation: Radical Image-Guided RadiotherapySponsors: CCTU- Cancer Theme; University of Cambridge; Microsoft ResearchNot yet recruiting
Mark above section as read
Abstract Reliable confirmation of the presence or absence of endolymphatic hydrops is essential to avoid confusing vestibular migraine with Meniere’s disease. MRI inner ear imaging is a promising new method to confirm hydrops, avoiding both unnecessary invasive or destructive inner ear treatments, but it is not universally available. Tone burst electrocochleography is an older simple, quick, safe, and sensitive test that is potentially available, with existing (or minorly upgraded)...
Mark above section as read
Objective Although it is known that the airway has bacterial contamination that seeds the surgical site during microlaryngeal surgery, literature on the use of postoperative antibiotics is lacking. We performed a retrospective analysis of open phonosurgical and phonomicrosurgical cases at a single institution to assess whether use of postoperative antibiotics impacts the incidence of surgical site infections (SSI). Methods In this retrospective cohort study, we reviewed 228 phonomicrosurgery...
Objectives/Hypothesis To determine the 10‐year incidence of hearing impairment (HI) and associated risk factors in the Beaver Dam Offspring Study (BOSS; 2004–present), a large middle‐aged cohort followed for 10 years. Study Design Prospective cohort study. Methods Hearing thresholds were measured at baseline (2005–2008) and 5‐ (2010–2013) and 10‐year (2015–2017) follow‐up examinations. HI was defined as a pure‐tone average >25 dB HL in either ear. BOSS participants free of HI at baseline...
Mark above section as read
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου