Abstract Purpose Hypothyroidism is associated with a high frequency of obstructive sleep apnea (OSA). However, the prevalence of OSA in hypothyroid patients is not different from the general population in many reports. The importance of thyroid function screening in sleep-disordered breathing is still controversial. This study aimed to explore the association between thyroid dysfunction and OSA in the adults with prediabetes or diabetes...
Abstract Introduction Severity of obstructive sleep apnea (OSA) is commonly based upon the apnea-hypopnea index (AHI). However, patients with similar AHIs may demonstrate widely varying comorbidities and risk for cardiovascular disease. These varying manifestations of disease may be related to nocturnal hypoxia and not AHI. We hypothesize that parameters of oxygenation may identify a different phenotype in OSA. ...
Abstract Purpose Velopharyngoplasty and palatine tonsillectomy are at the very heart of the surgical treatment of obstructive sleep apnea syndrome (OSAS) care. In cases of major tonsil hypertrophy, we evaluated the relevance of associating soft palate surgery with palatine tonsillectomy, independent of the soft palate length. Methods We conducted...
Abstract Purpose The aim of the current study was to further investigate the concept of previously reported high occurrence of comorbidities in obstructive sleep patients (OSA) with insomnia-like symptoms. We hypothesized that this finding at least partly is mediated by nocturnal hypoxia. Moreover, we speculated that the spectrum of the clinical OSA phenotypes differs between European geographical regions. ...
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Abstract The maintenance of obligate sex in animals is a long‐standing evolutionary paradox. To solve this puzzle, evolutionary models need to explain why obligately sexual populations consistently resist invasion by facultative strategies that combine the benefits of both sexual and asexual reproduction. Sexual antagonism and mate availability are thought to shape the occurrence of reproductive modes in facultative systems. But it is unclear how such factors interact with each other to influence...
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Publication date: Available online 19 August 2019Source: Pathology - Research and PracticeAuthor(s): Zhi Jiang, Qicheng Chen, Junhong Zhang, Lixing Cao, Zhiqiang ChenAbstractBackgroundPostoperative ileus (POI) is a temporary disturbance in gastrointestinal motility following surgery, and intestinal inflammatory response plays a critical role in the pathogenesis of POI. Wuda granule (WDG), a gastrointestinal prokinetic Chinese herbal medicine, is prescribed to promote recovery of gastrointestinal...
Publication date: Available online 19 August 2019Source: Pathology - Research and PracticeAuthor(s): Yingying Zhou, Min Wang, Ting Shuang, Yisi Liu, Yongqi Zhang, Cong ShiAbstractBackgroundExtended from our previously observation that expression of miR-1307 in chemoresistant primary ovarian cancer tissues is elevated, here we are aiming to dissect the function of miR-1307 and its predicted target gene, CIC (capicua transcriptional repressor), in ovarian cancer chemotherapy.MethodsWe evaluated the...
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Abstract Although a bipedicled deep inferior epigastric artery perforator (DIEP) flap is widely accepted for slim patients with large breasts, we suggest DIEP flap‐based breast reconstruction in which the superficial inferior epigastric artery (SIEA) is supercharged to the branch of thoracodorsal vessel as an alternative, which has not previously been well described. We report the case of a 48‐year‐old breast cancer patient who had a normal body mass index of 23.01 and relatively thin abdominal...
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A bedrock with a segregation problem On most mornings, minutes before nine o’clock, a crowd of homeless men and women—mostly men of color—congregate before the Parkway Central Library. The massive neoclassical building sits conspicuously on the southern border of the city’s Fairmount-Art Museum district. It’s the main and central branch of the free public library system of Philadelphia, PA. Eager to return to the safety, tranquility, and myriad resources unavailable to them in the City of Brotherly...
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Summary Purpose Anorexia induced by cytotoxic chemotherapy on delayed phase is a highly frequent adverse event. We aimed to determine the effects of rikkunshito (RKT) on chemotherapy-induced anorexia (CIA) in patients with lung cancer. Methods This prospective, randomized, cross-over pilot trial included 40 lung cancer patients scheduled to undergo cisplatin-based chemotherapy and randomized to either a group given RKT 7.5 g/day for 14 days (Group A, N = 20) or not (Group B, N = 20),...
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Summary Purpose Anorexia induced by cytotoxic chemotherapy on delayed phase is a highly frequent adverse event. We aimed to determine the effects of rikkunshito (RKT) on chemotherapy-induced anorexia (CIA) in patients with lung cancer. Methods This prospective, randomized, cross-over pilot trial included 40 lung cancer patients scheduled to undergo cisplatin-based chemotherapy and randomized to either a group given RKT 7.5 g/day for 14 days (Group A, N = 20) or not (Group B, N = 20),...
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Publication date: Available online 18 August 2019Source: Behavioural Brain ResearchAuthor(s): Jessica M. Hooversmith, Dionnet L. Bhatti, Philip V. HolmesAbstractThe neuropeptide galanin is a potential therapeutic target for treating stress-related disorders, such as post-traumatic stress disorder (PTSD); however, its effects on contextual fear conditioning (CFC), an accepted animal model of PTSD, are not well understood. Dysregulation of the medial prefrontal cortex (mPFC) is implicated in PTSD....
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Cancers, Vol. 11, Pages 1207: Tumor Cell Dormancy: Threat or Opportunity in the Fight against Cancer
Cancers, Vol. 11, Pages 1207: Tumor Cell Dormancy: Threat or Opportunity in the Fight against Cancer Cancers doi: 10.3390/cancers11081207 Authors: Rana Jahanban-Esfahlan Khaled Seidi Masoud H. Manjili Ali Jahanban-Esfahlan Tahereh Javaheri Peyman Zare Tumor dormancy, a clinically undetectable state of cancer, makes a major contribution to the development of multidrug resistance (MDR), minimum residual disease (MRD), tumor outgrowth, cancer relapse, and metastasis. Despite...
Cancers, Vol. 11, Pages 1206: Rapid Depletions of Subcutaneous Fat Mass and Skeletal Muscle Mass Predict Worse Survival in Patients with Hepatocellular Carcinoma Treated with Sorafenib Cancers doi: 10.3390/cancers11081206 Authors: Kenji Imai Koji Takai Takao Miwa Daisuke Taguchi Tatsunori Hanai Atsushi Suetsugu Makoto Shiraki Masahito Shimizu The aim of this study was to investigate whether rapid depletions of fat mass and skeletal muscle mass predict mortality in...
Cancers, Vol. 11, Pages 1205: The Complex Interaction between the Tumor Micro-Environment and Immune Checkpoints in Breast Cancer Cancers doi: 10.3390/cancers11081205 Authors: Vanessa Barriga Nyanbol Kuol Kulmira Nurgali Vasso Apostolopoulos The progression of breast cancer and its association with clinical outcome and treatment remain largely unexplored. Accumulating data has highlighted the interaction between cells of the immune system and the tumor microenvironment in cancer...
Cancers, Vol. 11, Pages 1204: Maintenance BEZ235 Treatment Prolongs the Therapeutic Effect of the Combination of BEZ235 and Radiotherapy for Colorectal Cancer Cancers doi: 10.3390/cancers11081204 Authors: Yu-Hsuan Chen Chun-Wei Wang Ming-Feng Wei Yi-Shin Tzeng Keng-Hsueh Lan Ann-Lii Cheng Sung-Hsin Kuo Our previous study demonstrated that administration of NVP-BEZ235 (BEZ235), a dual PI3K/mTOR inhibitor, before radiotherapy (RT) enhanced the radiotherapeutic effect...
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This paper investigates anticorrosion behaviour of the bark-extract from Rhizophora mangle L. on steel-rebar in concrete slabs in 3.5% NaCl medium of immersion (for simulating saline/marine environment). Corrosion-rate, corrosion-current, and corrosion-potential were measured from the NaCl-immersed steel-reinforced concrete cast with admixture of different plant-extract concentrations and from positive control concrete immersed in distilled water. Analyses indicate excellent mathematical-correlation...
The aim of this study was to undertake a literature review on the use of XP-endo Shaper (FKG Dentaire SA, La Chaux-de-Fonds, Switzerland) for root canal preparation evaluated using microcomputed tomography (micro-CT) technology, with emphasis on the analysis of untouched canal walls. We searched the PubMed, Science Direct, SciELO, and MEDLINE databases for articles published from 2017 to 2019 using the following keywords: micro-CT, untouched walls, XP shaper, and XP endo. Articles without an abstract...
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Publication date: Available online 19 August 2019Source: CortexAuthor(s): Mushfa Yousuf, Marcus Heldmann, Thomas F. Münte, Nuria DoñamayorAbstractDual-system accounts posit that instrumental behavior is controlled by both a goal-directed and a habitual system. In this study, we aimed to identify the electrophysiological components associated with goal-directed vs habitual performance using an outcome devaluation procedure. Datasets from 35 healthy participants were analyzed. Behaviorally, in line...
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Abstract Background Individual evidence suggests that the anti-angiogenic agent bevacizumab may control vestibular schwannoma (VS) growth and promote hearing preservation in patients with neurofibromatosis type 2 (NF2). However, such metadata has yet to be consolidated, as well as its side-effect profile yet to be fully understood. Our aim was to pool systematically-identified metadata in the literature and substantiate the clinical...
Issues with data analysis have recently been highlighted by a reader of our article. These have been addressed with changes to Tables 2&4, as shown below, and Online Resources 5-7. T2 and peritumoral signal are no longer prognostic factors on simple pooled (Online Resource 5) and IPD (Table 4) analyses respectively. In Table 5, the number of patients which informed the outcomes symptom development and intervention were 575 and 947 respectively; 69 developed symptoms (pooled proportion %8.4 [95%...
Abstract Purpose Fatigue is a common and distressing symptom in cancer patients which negatively affects patients’ daily functioning and health-related quality of life. The aim of this study was to assess multidimensional fatigue in patients with brain metastases (BM) before, and after Gamma Knife radiosurgery (GKRS). Methods Patients with BM,...
The Editor-in-Chief has retracted this article [1]. An investigation by Kurume University has not been able to establish what the appropriate authorship should be because one of the authors, Yoshihiro Sato, is now deceased. As the appropriate authorship cannot be determined the Editor-in-Chief no longer has confidence in this article. Kurume University has also stated that it has not been possible to verify the data presented as none of the research material is available for investigation. We have...
Abstract Purpose Standards for surgical decisions are unavailable, hence treatment decisions can be personalized, but also introduce variation in treatment and outcome. National registrations seek to monitor healthcare quality. The goal of the study is to measure between-hospital variation in risk-standardized survival outcome after glioblastoma surgery and to explore the association between survival and hospital characteristics...
Abstract Purpose To report outcomes of salvage re-irradiation (re-RT) in recurrent/progressive medulloblastoma (MB). Methods Medical records of patients treated with curative-intent re-RT as multi-modality management for recurrent/progressive MB between 2008 and 2018 were analyzed retrospectively. ...
Abstract Purpose Spindle cell oncocytoma (SCO) is a rare benign pituitary tumor. No patient series regarding stereotactic radiosurgery (SRS) for SCO has been published. We report the clinical outcomes of SCO treated with single-fraction SRS, as well as a systematic review of the literature. Methods Retrospective cohort series and systematic...
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Publication date: Available online 18 August 2019Source: Journal of ProteomicsAuthor(s): Carlos J. Ramírez-Flores, Rosalba Cruz-Mirón, Mónica E. Mondragón-Castelán, Sirenia González-Pozos, Emmanuel Ríos-Castro, Ricardo Mondragón-FloresAbstractAfter the cell invasion, the parasite Toxoplasma gondii locates within a parasitophorous vacuole to proliferate. It continuously modifies the composition of the parasitophorous vacuole by the secretion of GRA and ROP proteins, some of which become inserted into...
Publication date: Available online 18 August 2019Source: Journal of ProteomicsAuthor(s): Monica Losada-Barragán, Adriana Umaña-Pérez, Andrés Rodriguez-Vega, Sergio Cuervo-Escobar, Renata Azevedo, Fernanda N. Morgado, Vinicius de Frias Carvalho, Priscila Aquino, Paulo C. Carvalho, Renato Porrozzi, Myriam Sánchez-Gómez, Gabriel Padron, Patricia CuervoAbstractProtein malnutrition is a risk factor for developing visceral leishmaniasis. Because we previously demonstrated that protein malnutrition and...
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Publication date: Available online 19 August 2019Source: Seminars in OncologyAuthor(s): Marco Durante, Jay FlanzAbstractCharged particle therapy is the most advanced radiotherapy method in oncology. The favorable depth-dose distribution and the biological properties of charged particles have potentially a great benefit for reducing toxicity and increasing the local control. While the number of proton centers is exponentially growing worldwide, the therapy remains controversial due to the high cost...
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Nature Communications, Published online: 19 August 2019; doi:10.1038/s41467-019-11646-3Membrane contact sites between the ER and mitochondria are known to convey calcium signals between these two organelles via IP3 receptors, but the molecular mechanisms are currently unclear. Here, the authors show that IP3 receptors play a structural tethering role in maintaining ER-mitochondrial contacts.
Nature Communications, Published online: 19 August 2019; doi:10.1038/s41467-019-11650-7Artificial light harvesting systems in aqueous medium are challenging to realize due to quenching effects from water and oxygen. Here the authors demonstrate rod-coil amphiphiles which act as compartmentalization agent to shield platinum(II) phosphors and enable their ordered spatial organization.
Nature Communications, Published online: 19 August 2019; doi:10.1038/s41467-019-11179-9Single molecule real-time DNA sequencing allows genome-wide identification of DNA methylation patterns. Here, Jensen et al. present a high-throughput method that allows rapid coupling of DNA methylation patterns with their corresponding methyltransferase genes in bacteria.
Nature Communications, Published online: 19 August 2019; doi:10.1038/s41467-019-11612-zMolecular crystals can be bent elastically by expansion or contraction on opposite faces, or plastically by delamination into slabs that glide along slip planes. Here the authors report crystals that can be bent plastically while undergoing a mechanically induced phase transition without delamination.
Nature Communications, Published online: 19 August 2019; doi:10.1038/s41467-019-11530-0Activating oncogenic mutations in KRAS and NRAS are common in colorectal cancer, which is a heterogenous disease. Here, the authors show that the RAS mutation spectrum is markedly different between colon and rectal cancer, and also different based on age of diagnosis and microsatellite instability.
Nature Communications, Published online: 19 August 2019; doi:10.1038/s41467-019-11801-wAuthor Correction: SREBP1 drives keratin-80-dependent cytoskeletal changes and invasive behavior in endocrine-resistant ERα breast cancer
Nature Communications, Published online: 19 August 2019; doi:10.1038/s41467-019-11695-8Small non-coding RNAs (sRNA) regulate bacterial functions by finding nucleic acids and proteins. Here the authors identify PhrS sRNA in Pseudomonas as a positive regulator of CRISPR, and show PhrS acts by binding to CRISPR leader, thereby preventing Rho-mediated transcription termination and promoting anti-bacteriophage immunity.
Nature Communications, Published online: 19 August 2019; doi:10.1038/s41467-019-11493-2Pilocytic astrocytoma is a low-grade pediatric glioma, characterized by a single BRAF rearrangement. Here, Reitman and colleagues use single-cell RNA sequencing to reveal molecular hallmarks of the disease that might be targeted therapeutically.
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Abstract Objectives Primates that live in predominantly forested habitats and open, savanna mosaics should exhibit behavioral responses to differing food distributions and weather. We compared ecological constraints on red‐tailed monkey ranging behavior in forest and savanna mosaic environments. Intraspecific variation in adaptations to these conditions may reflect similar pressures faced by hominins during the Plio‐Pleistocene. Methods We followed six groups in moist evergreen forest at...
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Publication date: Available online 18 August 2019Source: Journal of Neuroscience MethodsAuthor(s): Hyuntaek Oh, Jung Hwan Kim, Jeffrey M. YauAbstractBackgroundTranscranial magnetic stimulation (TMS) can be paired with functional magnetic resonance imaging (fMRI) in concurrent TMS-fMRI experiments. These multimodal experiments enable causal probing of network architecture in the human brain which can complement alternative network mapping approaches. Critically, merely introducing the TMS coil into...
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Publication date: Available online 19 August 2019Source: Clinical Neurology and NeurosurgeryAuthor(s): Tadashi Ozawa, Ryota Tanaka, Risa Nagaoka, Yuhei Anan, Younhee Kim, Kosuke Matsuzono, Takafumi Mashiko, Reiji Koide, Haruo Shimazaki, Keisuke Ohtani, Yusuke Amano, Kensuke Kawai, Shigeru Fujimoto
Publication date: Available online 19 August 2019Source: Clinical Neurology and NeurosurgeryAuthor(s): Patricia Rodrigo-Armenteros, Solange Kapetanovic-García, Lander Antón-Méndez, Juan José Gómez-Muga, Edurne Bedia-Del Río, María Ángeles Fernández-Cuesta, Juan Carlos García-Moncó
Publication date: Available online 19 August 2019Source: Clinical Neurology and NeurosurgeryAuthor(s): HyeonJu Kim, Hyo Sung Kwak, Gyung Ho Chung, Seung Bae HwangAbstractObjectiveA lack of visualization of the proximal internal carotid artery (ICA) on computed tomography angiography (CTA) in acute ischemic stroke may be caused by an atherosclerotic occlusion or a pseudo-occlusion by a massive thrombus in the ICA. Pseudo-occlusion of the proximal ICA is caused by stagnant flow from a distal ICA occlusion....
Publication date: Available online 19 August 2019Source: Clinical Neurology and NeurosurgeryAuthor(s): Márton Balázsfi, Dávid Kis, Tamás Tóth, Tamás Zsoldos, Pál BarzóAbstractObjectivesRadiofrequency denervation of the facet joints is performed via a well-established method. Its primary, direct indication is a positive response to a nerve block injection (MBB). Our study aimed to find other, effective but indirect indication signs through the retrospective analysis of our patients treated earlier.Patients...
Publication date: Available online 18 August 2019Source: Clinical Neurology and NeurosurgeryAuthor(s): Frederico Tundo, Mauricio J. Avila, Laura Willard, Sandra Fanous, Cloe Curri, Ibrahim Hussain, Ali A. BaajAbstractCompared to the thoracolumbar spine, the literature on cervical spine alignment is scarce. While a consistent number of articles have been published, few analyze the ideal surgical approaches for each type of deformity and the optimal amount of correction to achieve. This paper provides...
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Publication date: Available online 18 August 2019Source: Magnetic Resonance ImagingAuthor(s): Christian R. Meixner, Patrick Liebig, Peter Speier, Christoph Forman, Bernhard Hensel, Manuel Schmidt, Marc Saake, Michael Uder, Arnd Doerfler, Robin M. Heidemann, Sebastian Schmitter, Armin M. NagelAbstractBackground3D Time-of-Flight (TOF) MR-angiography (MRA) substantially benefits from ultra-high magnetic field strengths (≥7 T) due to increased Signal-to-Noise ratio and improved contrast. However, high-resolution...
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Information on taxa distribution is a prerequisite for many research fields, and biological records are a major source of data contributing to biogeographic studies. The Global Biodiversity Information Facility (GBIF) and the Ocean Biogeographic Information System (OBIS) are important infrastructures facilitating free and open access to classical biological data from several sources in both temporal and spatial scales. Over the last ten years, high throughput sequencing (HTS) metabarcoding data have...
Background Dentistry has undergone an evolution in endodontics practice caused by the advancement of rotary techniques for root canal preparation and their subsequent incorporation into the teaching of dentistry undergraduates. This research aimed to evaluate the shaping ability of third-year dental students as their first experience in rotary instrumentation using ProTaper Universal (PTU) and ProTaper Next (PTN) (Dentsply Maillefer) rotary instruments in simulated curved canals....
Hepatitis A (HAV), hepatitis B (HBV), and hepatitis C (HCV) viruses are hepatotropic viruses responsible for acute/chronic hepatitis associated with liver failure, cirrhosis, and hepatocellular carcinoma. Due to the limited data on the prevalence of hepatitis in the older population in Thailand, this study aimed to evaluate the seroprevalence of these viruses in elderly Thais. Using an automated immunoassay, serum samples from individuals older than 60 years of age in Chum Phae district of Khon Kaen...
Until now, Hargeria was considered a monospecific leptocheliid genus, with the species Hargeria rapax considered a taxon with a wide distribution, from the Northwestern Atlantic to the Mexican Caribbean. Herein, after a detailed revision of type and topotype materials and specimens collected from the Mexican Caribbean, a new species H. chetumalensis sp. nov. is described, and the redescription of H. rapax is provided. Also, we found a significant genetic divergence between the two species based on...
Fallow management can improve the soil nutrients in the topsoil and upper subsoil. However, little is known about the effects of short-term (one year) fallowing with different treatments, such as vegetation and fertilization, on subsoil (20–40 cm) properties. We conducted field trials to explore the changes in subsoil properties in response to such treatments in the Yellow River Delta region in China. Different vegetation and fertilization treatments were applied, and we measured the carbon and nitrogen...
Ports have been built or expanded in a number of countries to cater to increasing maritime trade in the 21st century. Port expansion is associated with economic and environmental impacts on the local and regional scales, and these impacts can be studied using remote sensing. The present study presents new results from multi-source remote sensing monitoring of the Ajmr Port expansion. An analysis of land use and vegetation coverage at the port is used to monitor the impact of port construction on...
Heterotrophic protists play pivotal roles in aquatic ecosystems by transferring matter and energy, including lipids, from primary producers to higher trophic predators. Using Oxyrrhis marina as a model organism, changes to the non-saponifiable protist lipids were investigated under satiation and starvation conditions. During active feeding on the alga Cryptomonas sp., the O. marina hexane soluble non-saponifiable fraction lipid profile reflected its food source with the observed presence of long...
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Despite over 50 years of clinical and basic studies, acute respiratory distress syndrome (ARDS) is still a critical challenge with high mortality worldwide. The severity of neutrophil activation was associated with disease severity. However, the detailed pathophysiology of the circulating polymorphonuclear neutrophil activation in ARDS remains unclear. To identify key pathways and genes in the ARDS-specific neutrophil phenotype distinct from sepsis, the datasets of blood polymorphonuclear neutrophils...
The incidence of gastric cancer is extremely high in China, prompting the development of effective therapeutic strategies. Sodium selenite (SS) affects the proliferation and redifferentiation of gastric cancer cells and the Adriamycin prodrug Ac-Phe-Lys-PABC-ADM (PADM) reduces toxicity in gastric cancer treatment. However, the mechanisms involved therein remain unclear. In this study, nude mice were transplanted with SGC-7901 gastric cancer cells to construct a tumor xenograft model. After administration...
Little is known about the function of acid-sensing ion channels (ASICs) in bone cells or osteoporotic vertebral fractures (OVF). This study delineated ASICs expression in adult human bone marrow-mesenchymal stem cells- (BM-MSC-) derived osteoblasts and in OVF bone cells. Adult BM-MSC-derived osteoblasts were isolated and cultured in different pH values. Osteogenic markers as alkaline phosphatase (ALP), osteopontin (OPN), and osteocalcin (OC) mRNA were assessed. Western blots method was applied to...
Pulmonary embolism (PE) is one of the most common causes of cardiovascular death. The most often PE etiology is a deep vein thrombosis (DVT) of the lower extremities, but embolic material can arise in pelvic or upper extremity veins as well as in right heart chambers. There is growing number of evidences of atrial fibrillation (AF) involvement in PE. The presence of AF in patients with PE may be both the cause and the consequence of PE. The PE association with AF should be considered in patients...
In the biomedical field, there is growing interest in using human stem cell-derived neurons as in vitro models for pharmacological and toxicological screening of bioactive compounds extracted from natural products. Lignosus rhinocerus (Tiger Milk Mushroom) is used by indigenous communities in Malaysia as a traditional medicine to treat various diseases. The sclerotium of L. rhinocerus has been reported to have medicinal properties, including various bioactivities such as neuritogenic, anti-inflammatory,...
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Abstract As prairie voles (Microtus ochrogaster) display spontaneous bi‐parental care, and the ventromedial hypothalamus (VMH) has been implicated in reproductive behavior, we conducted experiments to test the hypothesis that the VMH neurochemical circuitry is involved in alloparental behaviors in male prairie voles. We compared alloparental behaviors of adult, sexually‐naïve male and female voles – both displayed licking/grooming, huddling, and retrieving behaviors toward conspecific pups. We also...
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Abstract Purpose To compare the outcomes of extraskeletal and skeletal Ewing sarcomas treated with standard chemotherapy protocol. Methods We retrospectively collected data on primary localized skeletal and extraskeletal ES patients. Demographics and disease characteristics were compared between the two groups. The influence of presentation (skeletal vs....
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Abstract Background Sport participation has many physical and psychosocial benefits, but there is also an inherent risk of injury, subsequent osteoarthritis and psychological challenges that can negatively impact quality of life (QOL). Considering the multifaceted impacts of sport participation on QOL across the lifespan, there is a need to consolidate and present the evidence on QOL in former sport participants. ...
Abstract Background Sedentary behaviour is a risk factor for type 2 diabetes and cardiovascular disease. Objectives The aims of this work were to systematically review the effects of workplace sedentary behaviour reduction interventions on cardiometabolic risk markers (primary aim) and identify the active behaviour change techniques (BCTs) by which these...
Abstract Inter-individual differences in size, maturity status, function, and behavior among youth of the same chronological age (CA) have long been a concern in grouping for sport. Bio-banding is a recent attempt to accommodate maturity-associated variation among youth in sport. The historical basis of the concept of maturity-matching and its relevance to youth sport, and bio-banding as currently applied are reviewed. Maturity matching in sport has often been noted but has not...
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IV‐OCT is a light based imaging modality with high resolution, which employs near‐infrared light to provide tomographic intracoronary images. Morbidity caused by CHD is a substantial cause of ACS and sudden cardiac death. The most common intracoronay complications caused by CAD are intimal hyperplasia, calcification, fibrosis, neovascularization, and macrophage accumulation, which require efficient prevention strategies. OCT can provide discriminative information of the intracoronary tissues, which...
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Cyclohexanone monooxygenases (CHMOs) show very high catalytic specificity for natural Baeyer−Villiger (BV) reactions, but promiscuous reduction reactions have not been reported to date. In order to reach this goal, we focused mechanistically on the flavin adenine dinucleotide (FAD) as the cofactor of CHMOs, which can switch between oxidation and reduction states. We achieved such a novel promiscuous reduction activity of CHMOs by converting CHMOAcineto into a ketoreductase. Rational structure‐guided...
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Abstract Background Patients with head and neck cancer have a higher risk of emergency department (ED) frequent attender (FA). We hypothesized that FAs present with issues different from non‐FAs. Methods A retrospective cohort study was conducted on Singapore residents with head and neck cancers using de‐identified registry merged with electronic medical record data. A competing risk regression analysis was performed to identify factors associated with FA. Aggregated primary diagnoses...
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Background Follow-up with computed tomographic angiography is recommended after endovascular aneurysm repair, exposing patients to significant levels of radiation and iodine contrast medium. Dual-energy computed tomography allows virtual noncontrast (VNC) images to be reconstructed from contrast-enhanced images using a software algorithm. If the VNC images are a good-enough approximation of true noncontrast (TNC) images, a reduction in radiation dose can be ensured through omitting a TNC scan. ...
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Hearing healthcare is evolving at a rapid rate. Origins of this evolution stem, in part, from the recent proliferation of disruptive innovations (e.g., OTCs/PSAPs, pharmaceuticals), along with changes in population dynamics. This course provides participants with evidence and hands-on tools that promote opportunities for increased audiology awareness, and increased adoption of services and technologies in this changing market landscape.
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