AbstractAlthough the E3 ubiquitin ligase Zinc and ring finger 3 (ZNRF3) negatively regulates the Wnt signaling pathway, its function in rheumatoid arthritis (RA) is elusive. Here, the effects and the mechanism of ZNRF3 on a mouse model of collagen-induced arthritis (CIA) and human fibroblast-like synoviocytes (FLS) obtained from RA patients were determined. Our results showed that ZNRF3 was highly expressed in tissues and FLSs compared to trauma patients. Lentivirus-mediated silencing of ZNRF3 induced...
Tue Mar 03, 2020 00:00
AbstractSodium butyrate (NaBu), a histone deacetylase inhibitor, has shown to exert beneficial actions attenuating inflammation in a number of intestinal and extra-intestinal diseases. However, the effects of NaBu on persistent inflammatory processes as in a response to implantation of foreign material have not been investigated. Synthetic matrix of polyether-polyurethane sponge was implanted in mice ’s subcutaneous layer of the dorsal region, and the animals were treated daily with oral administration...
Tue Mar 03, 2020 00:00
Currently recommended R-time thresholds for FFP transfusion or PCC treatment in multi-trauma are highly specific, but not sensitive. Use of these low sensitivity thresholds may result in under-treatment of many patients with procoagulant factor deficiency.
Tue Mar 03, 2020 02:00
Circumferential resection margin (CRM) status is an important predictor of outcomes following rectal cancer surgery and influenced not only by operative technique, but also by incorporation of a multi-disciplinary treatment strategy. This study sought to develop a risk-adjusted quality metric, based on CRM status to assess hospital-level performance for rectal cancer surgery.
Tue Mar 03, 2020 02:00
This is a simple index for comprehensive esophagogastric junction (EGJ) anti-reflux competency. Our proposed index showed excellent validation of EGJ barrier score in relation to previously established manometric parameters for EGJ disruption. Simple grading of EGJ may improve evaluation and clinical treatment of gastroesophageal reflux disease.
Tue Mar 03, 2020 02:00
Abstract Recently, local binary patterns (LBP) coupled with principal component analysis has been developed for feature extraction of hyperspectral imagery, which has shown success over traditional methods but is limited in physical meaning representation due to the noise bands existing in hyperspectral data. In order to preserve the intrinsic geometrical structure of original data, we propose a segmented LBP (SLBP) to group correlative bands and then extract spatial-spectral...
Tue Mar 03, 2020 02:00
Abstract This paper provides a comparative performance evaluation of local features for images from CMOS APS sensors affected by fixed pattern noise for different combinations of common detectors and descriptors. Although numerous studies report comparisons of local features designed for ordinary visual images, their performance on images with fixed pattern noise is far less assessed. The goal of this work is to develop a tool that allows to evaluate the performance of computer...
Tue Mar 03, 2020 02:00
The metaxins were originally identified as vertebrate proteins of the outer mitochondrial membrane involved in protein import into mitochondria. Metaxin proteins have also been found in diverse invertebrate phyla. The present study is concerned with examining whether metaxin-like proteins occur in plants and bacteria. Metaxin-like proteins were revealed by their homology with human metaxins and the possession of characteristic GST_Metaxin protein domains. The results demonstrate that metaxin-like...
Tue Mar 03, 2020 02:00
Through the analysis of linkage disequilibrium from genome-wide sequencing data for multiple individuals from eight populations, the general features of the recombinational landscape are revealed in the microcrustacean Daphnia pulex. The data suggest an exceptionally uniform pattern of recombination across the genome, while also confirming general patterns that are inconsistent with existing population-genetic models for the relationship between linkage disequilibrium and physical distances between...
Tue Mar 03, 2020 02:00
The origin of oxygen respiration in bacteria has long intrigued biochemists, microbiologists and evolutionary biologists. The earliest enzymes that consume oxygen to extract energy did not evolve in the same lineages of photosynthetic bacteria that released oxygen on primordial earth, leading to the great oxygenation event (GOE). A widespread type of such enzymes is proton pumping cytochrome c oxidase (COX) that contains heme A, a unique prosthetic group for these oxidases. Here we show that the...
Tue Mar 03, 2020 02:00
Divergent selection is a powerful driver of speciation and has been widely studied in relation to the physical characters of organisms. Because evolution of behavioural traits may contribute to evolutionary processes, we explored how consistent variation in behaviours may affect the process of adaptive divergence and speciation. We studied whether two sympatric morphs of Arctic charr (Salvelinus alpinus) have recently evolved genetically-based differences in personality that conform to their respective...
Tue Mar 03, 2020 02:00
The evolution of morphological allometry or scaling is a long-standing enigma in biology. Three types of allometric relationships have been defined: static, ontogenetic and evolutionary allometry. However, the theory of the interrelationship between these three types of allometry have not been tested in Orthopterans and to a lesser extent in hemimetabolous insects. Here, the ontogenetic allometry of hind femur length in the cricket Gryllus bimaculatus was observed to be slightly positive as compared...
Tue Mar 03, 2020 02:00
Synthetic gene drive technologies aim to spread transgenic constructs into wild populations even when they impose organismal fitness disadvantages. The properties of gene drive constructs are diverse and depend on their molecular construction, and differential selection pressure they impose in the varied ecological situations they encounter. The extraordinary diversity of conceivable drive mechanisms and the range of selective parameters they may encounter makes it very difficult to convey their...
Tue Mar 03, 2020 02:00
Antimicrobial therapeutic treatments are by definition applied after the onset of symptoms, which tend to correlate with infection severity. I use mathematical epidemiology models to explore how this link affects the coevolutionary dynamics between the virulence of an infection, measured via host mortality rate, and its susceptibility to chemotherapy. I show that unless resistance pre-exists in the population, drug resistant infections are initially more virulent than drug sensitive ones. As the...
Tue Mar 03, 2020 02:00
We introduce a new pattern of population genetic structure in a host-parasite system that can arise after secondary contact (SC) of previously isolated populations. Due to different generation time and therefore different tempo of molecular evolution the host and parasite populations reach different degrees of genetic differentiation during their separation (e.g. in refugia). Consequently, during the SC the host populations are able to re-establish a single panmictic population across the whole recolonized...
Tue Mar 03, 2020 02:00
Opsins are the primary light-sensing molecules in animals. Opsins have peak sensitivities to specific wavelengths which allows for color discrimination. The opsin protein family has undergone duplications and losses, dynamically expanding and contracting the number of opsins, throughout invertebrate evolution, but it is unclear what drives this diversity. Light availability, however, appears to play a significant role. Dim environments are associated with low opsin diversity in deep-sea fishes and...
Tue Mar 03, 2020 02:00
Publication date: Available online 2 March 2020Source: Journal of Cranio-Maxillofacial SurgeryAuthor(s): Koichiro Ueki, Akinori Moroi, Akihiro Takayama, Takamitsu Tsutsui, Yuki Saito, Kunio Yoshizawa (Source: Journal of Cranio Maxillofacial Surgery)
Tue Mar 03, 2020 22:09
A novel accurate volumetric analysis protocol for evaluating secondary alveolar cleft reconstruction
Publication date: Available online 2 March 2020Source: Journal of Cranio-Maxillofacial SurgeryAuthor(s): Bing Liu, Bing H. Li, Shu X. Chen, Ran Xiao, Yong Q. Wang (Source: Journal of Cranio Maxillofacial Surgery)
Tue Mar 03, 2020 22:09
Abstract Purpose Tonsillectomy is indicated in unilateral tonsillar enlargement (UTE) to rule out malignancy, which eventually is found in about 1.4% of the patients. The aim of this study was to evaluate the presenting symptoms of patients who underwent tonsillectomy for UTE and identify parameters that are associated with an increased risk for malignancy, for better assessment and refinement of current management protocols. ...
02:00
Abstract Purpose Prolonged endotracheal intubation may lead to laryngeal damage, with stridor being the most relevant clinical symptom. Our objective was to determine the incidence of post-extubation stridor and their clinical consequences in children within a tertiary referral center and to identify contributing factors. Methods 150 children, aged 0–16 years,...
02:00
Publication date: Available online 3 March 2020Source: Journal of Cranio-Maxillofacial SurgeryAuthor(s): Lenka Jaklová, Jiří Borský, Michal Jurovčík, Eva Hoffmannová, Miloš Černý, Ján Dupej, Jana Velemínská (Source: Journal of Cranio Maxillofacial Surgery)
Tue Mar 03, 2020 22:09
Publication date: Available online 2 March 2020Source: Journal of Cranio-Maxillofacial SurgeryAuthor(s): Jebrane Bouaoud, Quentin Hennocq, Giovanna Paternoster, Syril James, Eric Arnaud, Roman H. Khonsari (Source: Journal of Cranio Maxillofacial Surgery)
Tue Mar 03, 2020 22:09
Publication date: Available online 3 March 2020Source: Journal of Cranio-Maxillofacial SurgeryAuthor(s): Shaden Abu-Hammad, Shadia Elsayed, Ibrahim Nourwali, Osama Abu-Hammad, Mohammed Sghaireen, Basant Abou Zaid, Najla Dar-Odeh (Source: Journal of Cranio Maxillofacial Surgery)
Tue Mar 03, 2020 22:09
Publication date: Available online 3 March 2020Source: Journal of Cranio-Maxillofacial SurgeryAuthor(s): Vanpoecke Jasper, Verstraete Laurence, Smeets Maximiliaan, Joël Ferri, Romain Nicot, Politis Constantinus (Source: Journal of Cranio Maxillofacial Surgery)
Tue Mar 03, 2020 22:09
Abstract Sleep and opioid medications used to treat insomnia and chronic pain are associated with adverse side effects (falls and cognitive disturbance). Although behavioural treatments such as cognitive behavioral therapy for insomnia (CBT‐I) and pain (CBT‐P) improve sleep and clinical pain, their effects on sleep and opioid medication use are unclear. In this secondary analysis of published trial data, we investigated whether CBT‐I and CBT‐P reduced reliance on sleep/opioid medication in patients...
01:04
AbstractEustachian tube appears to be central to the pathogenesis of all forms of otitis media. The reported frequency of bilateral disease ranges from 27 to 55%. The affected ear may well be the end point of the pathology in the contra lateral ear (CLE). Cross sectional observational study. One hundred patients who had unilateral chronic otitis media (COM) were enrolled in the study. Diseased ear was divided into either mucosal or squamosal type. Otoendoscopy, pure tone audiometry, impedance audiometry...
Tue Mar 03, 2020 00:00
This study indicates the advantage of endoscopic approach for clival chordoma resection. This is a Retrospective case series of 7 endoscopically operated clival chordoma patients between May 2015 and April 2018 in our tertiary care hospital. 5 patients presented with primary disease and 2 were recurrent disease cases. Endoscopic endonasal transphenoidal approach with wide clearance of margins of tumor were performed in all 7 cases. High energy photon radiotherapy were delivered to all. All patients...
Mon Feb 24, 2020 16:05
AbstractTo study the prognostic significance of neutrophil –lymphocyte ratio (NLR) and platelet–lymphocyte ratio (PLR) in head and neck cancers. The study included 170 cases of histopathologically diagnosed head and neck cancer patients and 80 control subjects. NLR and PLR of patients with head and neck cancers were compared to the control group. The co rrelation between NLR and PLR values and factors such as age, gender, duration of symptoms, site of tumour, histological type, histological grading,...
Mon Feb 24, 2020 16:05
AbstractTraditionally congenital muscular torticollis is treated with a neck incision which results in a neck scar. The purpose of this study was to evaluate the effectiveness of the transaxillary subcutaneous endoscopic sternocleidomastoid muscle division for the treatment of congenital muscular torticollis. This is a prospective study of 7 children with torticollis treated surgically by the transaxillary endoscopic approach in the department of Pediatric Surgery between 2014 and 2018. The age at...
Mon Feb 24, 2020 16:05
A link between a genotoxin-producing strain of E coli and about 5% of colorectal cancer cases could offer novel clues as to how the cancer develops.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Tue Mar 03, 2020 20:28
Dr Bishal Gyawali on how reaction to a recent ovarian cancer study reveals a troubling trend among oncologists of doubting negative results.Medscape Oncology (Source: Medscape Hematology-Oncology Headlines)
Tue Mar 03, 2020 17:49
Three studies and two editorials in Journal of the American Medical Association tackle the issue of the relentless rise in prices of new drugs and ask: Is the pharma industry making too much profit?Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Tue Mar 03, 2020 17:34
Everolimus prolongs progression-free survival compared with placebo as long as patients with advanced head and neck cancer remain on it.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Tue Mar 03, 2020 06:23
Isatuximab, in combination with pomalidomide and dexamethasone, has been approved for the treatment of multiple myeloma in patients who have received two or more prior therapies.FDA Approvals (Source: Medscape Hematology-Oncology Headlines)
Mon Mar 02, 2020 22:11
All the good habits and willpower in the world may not protect against a patient's bad luck, notes Dr Mark Lewis.Medscape Oncology (Source: Medscape Hematology-Oncology Headlines)
Mon Mar 02, 2020 16:12
Generic pyrimethamine, from Cerovene Inc, is indicated for the treatment of toxoplasmosis when used with a sulfonamide.FDA Approvals (Source: Medscape Hematology-Oncology Headlines)
Mon Mar 02, 2020 12:15
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