Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Tue Sep 01, 2020 10:00
Abstract Purpose To determine performances of 2-deoxy-2-(18F)fluoro-d-glucose (18F-FDG) positron emission tomography (PET) to detect the development of permanent thyroid dysfunction (PTD), and to evaluate the prognostic value of early increased thyroid uptake in stage IV melanoma patients treated with anti-programmed death 1 (anti-PD-1) antibodies. Methods ...
Thu Sep 03, 2020 03:00
Abstract Ibrutinib might improve the efficacy of anti‐CD19 chimeric antigen receptor (CD19 CAR) T cell therapy in chronic lymphocytic leukemia (CLL). We studied the possibility and mechanism of the synergistic effect of ibrutinib and CAR‐T cells in other types of lymphoma. In this study, we selected the CD19 CAR‐T cells of a patient with lymphoma who failed in his CD19 CAR‐T cell therapy and a dose of 8 mg/kg/day ibrutinib. Subcutaneous and tail vein tumorigenic mice were established with Raji cells....
Wed Sep 02, 2020 12:14
Abstract The actin‐binding protein Girdin is a hub protein that interacts with multiple proteins to regulate motility and Akt and trimeric G protein signaling in cancer cells. Girdin expression correlates with poor outcomes in multiple human cancers. However, those findings are not universal, as they depend on study conditions. Those data suggest that multiple aspects of Girdin function and its role in tumor cell responses to anticancer therapeutics must be reconsidered. In the present study, we...
Wed Sep 02, 2020 11:13
Purpose: GEP-NENs are rare malignancies with increasing incidence. Their molecular characteristics are still undefined. We explored the underlying biology of GEP-NENs and the differences between gastrointestinal (GI) and pancreatic (PNET), high grade (HG) and low grade (LG) tumors. Experimental Design: GEP-NENs were analyzed using next-generation sequencing (NGS; MiSeq on 47 genes, NextSeq on 592 genes), immunohistochemistry, and in-situ hybridization. Tumor mutational burden (TMB) was calculated...
Thu Sep 03, 2020 15:56
Isocitrate dehydrogenase active-site mutations cause a neomorphic enzyme activity that results in the formation of supraphysiological concentrations of D-2-hydroxyglutarate (D-2HG). D-2HG is thought to be an oncometabolite that drives the formation of cancers in a variety of tissue types by altering the epigenetic state of progenitor cells by inhibiting enzymes involved in histone and DNA demethylation. This model has led to the development of pharmacological inhibitors of mutant IDH activity for...
Thu Sep 03, 2020 15:56
Publication date: October 2020Source: European Journal of Cancer, Volume 138Author(s): Katharina C. Kähler, Katerina Kosova, Ann-Sophie Bohne, Sefan Schreiber, Axel Hauschild
Thu Sep 03, 2020 18:23
Publication date: October 2020Source: European Journal of Cancer, Volume 138Author(s): M. Sinn, T. Liersch, H. Riess, K. Gellert, P. Stübs, D. Waldschmidt, F. Lammert, G. Maschmeyer, W. Bechstein, M. Bitzer, C. Denzlinger, R. Hofheinz, U. Lindig, M. Ghadimi, A. Hinke, J.K. Striefler, U. Pelzer, S. Bischoff, M. Bahra, H. Oettle
Thu Sep 03, 2020 18:23
Publication date: Available online 2 September 2020Source: European Journal of CancerAuthor(s): Kamal S. Saini, Marco Tagliamento, Matteo Lambertini, Richard McNally, Marco Romano, Manuela Leone, Giuseppe Curigliano, Evandro de Azambuja
Thu Sep 03, 2020 18:23
Publication date: Available online 3 September 2020Source: European Journal of Surgical OncologyAuthor(s): Laura Lorenzon, Andreas Brandl, Delia Cortes Guiral, Frederik Hoogwater, Dara Lundon, Luigi Marano, Giacomo Montagna, Karol Polom, Florian Primavesi, Yvonne Schrage, Santiago Gonzalez-Moreno, Tibor Kovacs, Domenico D'Ugo, Sergio Sandrucci
Thu Sep 03, 2020 21:22
Related Articles Belantamab mafodotin in the treatment of relapsed or refractory multiple myeloma. Future Oncol. 2020 Sep 02;: Authors: Sheikh S, Lebel E, Trudel S Abstract Multiple myeloma remains an incurable disease, with a large proportion of patients in the relapsed/refractory setting often unable to achieve durable responses. Novel, well-tolerated and highly effective therapies in this patient population represent an unmet need. Preclinical...
Thu Sep 03, 2020 23:03
Abstract Breast cancer incidence among Asian Americans increased at a rate of 1.8% per year from 2014 to 2018, while the general population’s incidence rate remained stable. Vietnamese-American women have been found to have the longest follow-up time after an abnormal mammogram. This study assesses the impact of a patient navigator program for Vietnamese-American women who received abnormal mammograms. Ninety-six Vietnamese-American participants with abnormal mammograms were assigned...
Thu Sep 03, 2020 03:00
Publication date: Available online 3 September 2020Source: Practical Radiation OncologyAuthor(s): Glenn S. Bauman, Ashesh B. Jani
Thu Sep 03, 2020 16:36
Abstract ObjectiveTo test the ‘buffering’ effect of Psychological Resilience upon depression in prostate cancer patients, and to also investigate any effects that past or current treatment may have had upon patients’ Psychological Resilience as a test of the ‘steeling’ hypothesis of past adversity upon future resilience.MethodsA total of 576 volunteer prostate cancer patients completed questionnaires about their demographic and treatment variables, and their Psychological Resilience and depression....
Wed Sep 02, 2020 16:44
AbstractThis article is protected by copyright. All rights reserved.
Wed Sep 02, 2020 16:34
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