This study was aimed at elucidating the potential mechanisms of quercetin in the treatment of gastric cancer (GC). A network pharmacology approach was used to analyze the targets and pathways of quercetin in treating GC. The predicted targets of quercetin against GC were obtained through database mining, and the correlation of these targets with GC was analyzed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses. Next, the protein-protein interaction...
Thu Sep 03, 2020 17:05
Background. The purpose of this study was to investigate the regulatory mechanisms of ceRNAs in breast cancer (BC) and construct a new five-mRNA prognostic signature. Methods. The ceRNA network was constructed by different RNAs screened by the edgeR package. The BC prognostic signature was built based on the Cox regression analysis. The log-rank method was used to analyse the survival rate of BC patients with different risk scores. The expression of the 5 genes was verified by the GSE81540 dataset...
Thu Sep 03, 2020 17:05
Background. Within the past decade, Africa has faced several recurrent outbreaks of Ebola virus disease (EVD), including the 2014-2016 outbreak in West Africa and the recent 2018-2020 Kivu outbreak in the Democratic Republic of Congo. The study thus aimed at quantifying and mapping the scientific output of EVD research published within 2010-2020 though a bibliometric perspective. Methods. EVD-related publications from 2010 to 2020 were retrieved from the Web of Science (WoS) and Scopus databases...
Thu Sep 03, 2020 17:05
Background. The present study was designed to verify the accuracy of the noninvasive biomarkers enolase/Cr, CA125, and CA19-9 as a clinical diagnostic tool for the detection of endometriosis. Methods. A cross-sectional study was performed at Rasool-e-Akram Hospital affiliated to Iran University of Medical Sciences, Tehran, Iran, from April 2015 to April 2018. Eighty-six women were scheduled to undergo laparoscopy due to chronic pelvic pain, infertility, pelvic mass, and abnormal uterine bleeding....
Thu Sep 03, 2020 08:35
There were no systematic researches about autophagy-related long noncoding RNA (lncRNA) signatures to predict the survival of patients with colon adenocarcinoma. It was necessary to set up corresponding autophagy-related lncRNA signatures. The expression profiles of lncRNAs which contained 480 colon adenocarcinoma samples were obtained from The Cancer Genome Atlas (TCGA) database. The coexpression network of lncRNAs and autophagy-related genes was utilized to select autophagy-related lncRNAs. The...
Thu Sep 03, 2020 07:20
Alydia Health, a company based in Menlo Park, California, has developed the Jada System, a device designed to stop postpartum hemorrhage. The condition involves heavy bleeding after delivery of a baby. Affected women can experience extended hospital stays, and, unfortunately, can sometimes die. In fact, postpartum hemorrhage is a leading cause of maternal death in the US. Current treatments for the condition are not ideal, and include medications that can be too slow to work, and an...
Thu Sep 03, 2020 23:45
Scientists at the RMIT University in Melbourne, Australia have announced the development of an artificial skin material that can sense pain, temperature, and pressure. It’s remarkable because it replicates how real skin responds to stimuli, which sends appropriate electric signals through neural pathways to the brain. The technology is slated to allow for life-like transmission of tactile sensations through prosthetic arms and legs, and may even help replace skin grafts with artificial solutions....
Thu Sep 03, 2020 19:31
Background NirS-type denitrifying bacteria and ammonia-oxidizing bacteria (AOB) play a key role in the soil nitrogen cycle, which may affect the growth and development of underground truffles. We aimed to investigate nirS-type denitrifying bacterial and AOB community structures in the rhizosphere soils of Carya illinoinensis seedlings inoculated with the black truffle (Tuber melanosporum) during the early symbiotic stage. Methods ...
Thu Sep 03, 2020 03:00
Purpose Glaucoma is the second commonest cause of blindness. We assessed the gene expression profile of astrocytes in the optic nerve head to identify possible prognostic biomarkers for glaucoma. Method A total of 20 patient and nine normal control subject samples were derived from the GSE9944 (six normal samples and 13 patient samples) and GSE2378 (three normal samples and seven patient samples) datasets, screened by...
Thu Sep 03, 2020 03:00
Background Biological invasion is one of the main threats to tropical biodiversity and ecosystem functioning. Prosopis juliflora (Sw) DC. (Fabales: Fabaceae: Caesalpinioideae) was introduced in the Caatinga dry forest of Northeast Brazil at early 1940s and successfully spread across the region. As other invasive species, it may benefit from the soils and seed dispersal by livestock. Here we examine how seed dispersal ecology and soil conditions collectively affect seed germination, early seedling...
Thu Sep 03, 2020 03:00
Background Ecological adaptations of mammals are reflected in the morphological diversity of their feeding apparatus, which includes differences in tooth crown morphologies, variation in snout size, or changes in muscles of the feeding apparatus. The adaptability of their feeding apparatus allowed them to optimize resource exploitation in a wide range of habitats. The combination of computer-assisted X-ray microtomography (µ-CT) with contrast-enhancing staining protocols has bolstered...
Thu Sep 03, 2020 03:00
The family Pseudopimelodidae is widely distributed in South America and includes 51 described species organized in seven genera. Only two of four species of the genus Pseudopimelodus have been recorded for the trans-Andean basins of Colombia, Pseudopimelodus bufonius and P. schultzi, whose similarity in external morphology make their identification difficult. We performed a phylogenetic analysis using a fragment of the Cytochrome C Oxidase subunit 1 gene (COI), and analyzed osteological and traditional...
Thu Sep 03, 2020 03:00
Background Ecological communities tend to be spatially structured due to environmental gradients and/or spatially contagious processes such as growth, dispersion and species interactions. Data transformation followed by usage of algorithms such as Redundancy Analysis (RDA) is a fairly common approach in studies searching for spatial structure in ecological communities, despite recent suggestions advocating the use of Generalized Linear Models (GLMs). Here, we compared the performance...
Thu Sep 03, 2020 03:00
Background Paraburkholderia fungorum (P. fungorum) is a Gram-negative environmental species that has been commonly used as a beneficial microorganism in agriculture as an agent for biocontrol and bioremediation. Its use in agriculture is controversial as many people believe that it could harm human health; however, there is no clear evidence to support. Methodology The pangolin P. fungorum (pangolin Pf) genome has a...
Thu Sep 03, 2020 03:00
Background A prime objective in metagenomics is to classify DNA sequence fragments into taxonomic units. It usually requires several stages: read’s quality control, de novo assembly, contig annotation, gene prediction, etc. These stages need very efficient programs because of the number of reads from the projects. Furthermore, the complexity of metagenomes requires efficient and automatic tools that orchestrate the different stages. ...
Thu Sep 03, 2020 03:00
Background Yak (Bos grunniens) is an ancient bovine species on the Qinghai-Tibetan Plateau. Due to extremely harsh condition in the plateau, the growth retardation of yaks commonly exist, which can reduce the incomes of herdsman. The gastrointestinal barrier function plays a vital role in the absorption of nutrients and healthy growth. Functional deficiencies of the gastrointestinal barrier may be one of the contributors for yaks with growth retardation. ...
Thu Sep 03, 2020 03:00
Background Serological assays that detect antibodies to SARS-CoV-2 are critical for determining past infection and investigating immune responses in the COVID-19 pandemic. We established ELISA-based immunoassays using locally produced antigens when New Zealand went into a nationwide lockdown and the supply chain of diagnostic reagents was a widely held domestic concern. The relationship between serum antibody binding measured by ELISA and neutralising capacity was investigated using a surrogate...
Thu Sep 03, 2020 03:00
Publication date: Available online 2 September 2020Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Shaheer Shahhat, Nikesh Hanumanthappa, Youn Tae Chung, James Beck, Rashmi Koul, Bashir Bashir, Andrew Cooke, Arbind Dubey, Jim Butler, Maged Nashed, William Hunter, Shrinivas Rathod, Aldrich Ong, Kim Tran, Julian O. Kim
Thu Sep 03, 2020 21:16
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου