IJMS, Vol. 21, Pages 6441: Hyperspectral Reflectance of Light-Adapted Leaves Can Predict Both Dark- and Light-Adapted Chl Fluorescence Parameters, and the Effects of Chronic Ozone Exposure on Date Palm (Phoenix dactylifera) International Journal of Molecular Sciences doi: 10.3390/ijms21176441 Authors: Lorenzo Cotrozzi Giacomo Lorenzini Cristina Nali Elisa Pellegrini Vincenzo Saponaro Yasutomo Hoshika Leila Arab Heinz Rennenberg Elena Paoletti High-throughput and...
Thu Sep 03, 2020 03:00
IJMS, Vol. 21, Pages 6438: FRUITFULL Is a Repressor of Apical Hook Opening in Arabidopsis thaliana International Journal of Molecular Sciences doi: 10.3390/ijms21176438 Authors: Miriam Führer Angelika Gaidora Peter Venhuizen Jedrzej Dobrogojski Chloé Béziat Mugurel I Feraru Jürgen Kleine-Vehn Maria Kalyna Elke Barbez Plants adjust their architecture to a constantly changing environment, requiring adaptation of differential growth. Despite their importance, molecular...
Thu Sep 03, 2020 03:00
IJMS, Vol. 21, Pages 6431: Platelets Boost Recruitment of CD133+ Bone Marrow Stem Cells to Endothelium and the Rodent Liver—The Role of P-Selectin/PSGL-1 Interactions International Journal of Molecular Sciences doi: 10.3390/ijms21176431 Authors: Nadja Lehwald Constanze Duhme Iryna Pinchuk Julian Kirchner Kristina Wieferich Moritz Schmelzle Kerstin Jurk Beatrice A. Windmöller Wolfgang Hübner Bernhard Homey Johannes Bode Ralf Kubitz Tahar Benhidjeb Martin...
Thu Sep 03, 2020 03:00
IJMS, Vol. 21, Pages 6437: Comparative Proteomic Analysis Identifies EphA2 as a Specific Cell Surface Marker for Wharton’s Jelly-Derived Mesenchymal Stem Cells International Journal of Molecular Sciences doi: 10.3390/ijms21176437 Authors: Ashraf Al Madhoun Sulaiman K. Marafie Dania Haddad Motasem Melhem Mohamed Abu-Farha Hamad Ali Sardar Sindhu Maher Atari Fahd Al-Mulla Wharton’s jelly-derived mesenchymal stem cells (WJ-MSCs) are a valuable tool in stem...
Thu Sep 03, 2020 03:00
IJMS, Vol. 21, Pages 6436: Molecular Profile of Barrett’s Esophagus and Gastroesophageal Reflux Disease in the Development of Translational Physiological and Pharmacological Studies International Journal of Molecular Sciences doi: 10.3390/ijms21176436 Authors: Edyta Korbut Vincent T Janmaat Mateusz Wierdak Jerzy Hankus Dagmara Wójcik Marcin Surmiak Katarzyna Magierowska Tomasz Brzozowski Maikel P Peppelenbosch Marcin Magierowski Barrett’s esophagus...
Thu Sep 03, 2020 03:00
IJMS, Vol. 21, Pages 6435: State of the Art Review of Cell Therapy in the Treatment of Lung Disease, and the Potential for Aerosol Delivery International Journal of Molecular Sciences doi: 10.3390/ijms21176435 Authors: Hosanna Brave Ronan MacLoughlin Respiratory and pulmonary diseases are among the leading causes of death globally. Despite tremendous advancements, there are no effective pharmacological therapies capable of curing diseases such as COPD (chronic obstructive pulmonary...
Thu Sep 03, 2020 03:00
IJMS, Vol. 21, Pages 6430: GO Nanosheets: Promising Nano Carrier for the S29, 1-(2-Chloro-2-(4-chlorophenyl-ethyl)-N-(4-fluorobenzyl)-1H-pyrazolo[3,4-d] pyrimidin-4-amine, Therapeutic Agent in Neuroblastoma International Journal of Molecular Sciences doi: 10.3390/ijms21176430 Authors: Mardente Aventaggiato Mari Francioso Tafani Mosca Zicari Malyshev Kuznetsova Valentini Graphene oxide (GO) derivatives are reported as a valid alternative to conventional...
Thu Sep 03, 2020 03:00
IJMS, Vol. 21, Pages 6433: Bordetella holmesii Lipopolysaccharide Hide and Seek Game with Pertussis: Structural Analysis of the O-Specific Polysaccharide and the Core Oligosaccharide of the Type Strain ATCC 51541 International Journal of Molecular Sciences doi: 10.3390/ijms21176433 Authors: Karolina Ucieklak Sabina Koj Tomasz Niedziela Whooping cough is a highly contagious disease caused predominantly by Bordetella pertussis, but it also comprises of a pertussis-like illness caused...
Thu Sep 03, 2020 03:00
IJMS, Vol. 21, Pages 6424: Antibiotic Treatment Prior to Injury Improves Post-Traumatic Osteoarthritis Outcomes in Mice International Journal of Molecular Sciences doi: 10.3390/ijms21176424 Authors: Melanie E. Mendez Deepa K. Murugesh Aimy Sebastian Nicholas R. Hum Summer A. McCloy Edward A. Kuhn Blaine A. Christiansen Gabriela G. Loots Osteoarthritis (OA) is a painful and debilitating disease characterized by the chronic and progressive degradation of articular...
Thu Sep 03, 2020 03:00
IJMS, Vol. 21, Pages 6419: Adiponectin: The Potential Regulator and Therapeutic Target of Obesity and Alzheimer’s Disease International Journal of Molecular Sciences doi: 10.3390/ijms21176419 Authors: Jong Youl Kim Sumit Barua Ye Jun Jeong Jong Eun Lee Animal and human mechanistic studies have consistently shown an association between obesity and Alzheimer’s disease (AD). AD, a degenerative brain disease, is the most common cause of dementia and is characterized by...
Thu Sep 03, 2020 03:00
IJMS, Vol. 21, Pages 6434: The Role of MicroRNAs in Arrhythmogenic Cardiomyopathy: Biomarkers or Innocent Bystanders of Disease Progression? International Journal of Molecular Sciences doi: 10.3390/ijms21176434 Authors: Maria Bueno Marinas Rudy Celeghin Marco Cason Gaetano Thiene Cristina Basso Kalliopi Pilichou Arrhythmogenic cardiomyopathy (AC) is an inherited cardiac disease characterized by a progressive fibro-fatty replacement of the working myocardium and by life-threatening...
Thu Sep 03, 2020 03:00
IJMS, Vol. 21, Pages 6426: Collagen/Chitosan Functionalization of Complex 3D Structures Fabricated by Laser Direct Writing via Two-Photon Polymerization for Enhanced Osteogenesis International Journal of Molecular Sciences doi: 10.3390/ijms21176426 Authors: Irina Alexandra Păun Cosmin Cătălin Mustăciosu Roxana Cristina Popescu Bogdan Ştefăniţă Călin Mona Mihăilescu The fabrication of 3D microstructures is under continuous development for engineering bone substitutes. Collagen/chitosan...
Thu Sep 03, 2020 03:00
IJMS, Vol. 21, Pages 6427: Seminal Plasma Analysis of Oxidative Stress in Different Genitourinary Topographical Regions Involved in Reproductive Tract Disorders Associated with Genital Heat Stress International Journal of Molecular Sciences doi: 10.3390/ijms21176427 Authors: Monika Fraczek Lukasz Wojnar Marzena Kamieniczna Malgorzata Piasecka Kamil Gill Michal Kups Valentina Chopyak Anna Havrylyuk Jozef Nakonechnyy Andrij Nakonechnyy Tomasz Wozniak Maciej Kurpisz...
Thu Sep 03, 2020 03:00
IJMS, Vol. 21, Pages 6425: Umbilical Cord Mesenchymal Stem Cell-Derived Nanovesicles Potentiate the Bone-Formation Efficacy of Bone Morphogenetic Protein 2 International Journal of Molecular Sciences doi: 10.3390/ijms21176425 Authors: Songhyun Lim Hao-Zhen Lyu Ju-Ro Lee Shi Huan Han Jae Hyup Lee Byung-Soo Kim Recombinant human bone morphogenetic protein 2 (rhBMP-2) is one of the most potent osteogenic factors used to treat bone loss. However, at higher doses, rhBMP-2 does...
Thu Sep 03, 2020 03:00
IJMS, Vol. 21, Pages 6428: BcMF30a and BcMF30c, Two Novel Non-Tandem CCCH Zinc-Finger Proteins, Function in Pollen Development and Pollen Germination in Brassica campestris ssp. chinensis International Journal of Molecular Sciences doi: 10.3390/ijms21176428 Authors: Liai Xu Xingpeng Xiong Weimiao Liu Tingting Liu Youjian Yu Jiashu Cao Chinese cabbage (Brassica campestris) is an economically important leaf vegetable crop worldwide. Mounting studies have shown that cysteine-cysteine-cysteine-histidine...
Thu Sep 03, 2020 03:00
IJMS, Vol. 21, Pages 6422: The Molecular Floodgates of Stress-Induced Senescence Reveal Translation, Signalling and Protein Activity Central to the Post-Mortem Proteome International Journal of Molecular Sciences doi: 10.3390/ijms21176422 Authors: Valerie C. Wasinger Darren Curnoe Ceridwen Boel Naomi Machin Hsiao Mei Goh The transitioning of cells during the systemic demise of an organism is poorly understood. Here, we present evidence that organismal death is accompanied...
Thu Sep 03, 2020 03:00
IJMS, Vol. 21, Pages 6423: Modulatory Roles of ATP and Adenosine in Cholinergic Neuromuscular Transmission International Journal of Molecular Sciences doi: 10.3390/ijms21176423 Authors: Ayrat U. Ziganshin Adel E. Khairullin Charles H. V. Hoyle Sergey N. Grishin A review of the data on the modulatory action of adenosine 5’-triphosphate (ATP), the main co-transmitter with acetylcholine, and adenosine, the final ATP metabolite in the synaptic cleft, on neuromuscular transmission...
Thu Sep 03, 2020 03:00
IJMS, Vol. 21, Pages 6421: Oxidative Stress, Kinase Activity and Inflammatory Implications in Right Ventricular Hypertrophy and Heart Failure under Hypobaric Hypoxia International Journal of Molecular Sciences doi: 10.3390/ijms21176421 Authors: Eduardo Pena Julio Brito Samia El Alam Patricia Siques High altitude (hypobaric hypoxia) triggers several mechanisms to compensate for the decrease in oxygen bioavailability. One of them is pulmonary artery vasoconstriction and its subsequent...
Thu Sep 03, 2020 03:00
IJMS, Vol. 21, Pages 6420: Targeting Nonsense: Optimization of 1,2,4-Oxadiazole TRIDs to Rescue CFTR Expression and Functionality in Cystic Fibrosis Cell Model Systems International Journal of Molecular Sciences doi: 10.3390/ijms21176420 Authors: Ivana Pibiri Raffaella Melfi Marco Tutone Aldo Di Leonardo Andrea Pace Laura Lentini Cystic fibrosis (CF) patients develop a severe form of the disease when the cystic fibrosis transmembrane conductance regulator (CFTR) gene is...
Thu Sep 03, 2020 03:00
IJMS, Vol. 21, Pages 6417: Prodigiosin Modulates the Immune Response and Could Promote a Stable Atherosclerotic Lession in C57bl/6 Ldlr-/- Mice International Journal of Molecular Sciences doi: 10.3390/ijms21176417 Authors: Alejandro Cuevas Nicolás Saavedra Luis A. Salazar Marcela F. Cavalcante Jacqueline C. Silva Dulcineia S. P. Abdalla Atherosclerosis is a chronic inflammatory disease, whose progression and stability are modulated, among other factors, by an innate and...
Thu Sep 03, 2020 03:00
IJMS, Vol. 21, Pages 6418: Immobilization of BMP-2 and VEGF within Multilayered Polydopamine-Coated Scaffolds and the Resulting Osteogenic and Angiogenic Synergy of Co-Cultured Human Mesenchymal Stem Cells and Human Endothelial Progenitor Cells International Journal of Molecular Sciences doi: 10.3390/ijms21176418 Authors: Maria Godoy-Gallardo Núria Portolés-Gil Ana M. López-Periago Concepción Domingo Leticia Hosta-Rigau We have previously reported the fabrication of a polycaprolactone...
Thu Sep 03, 2020 03:00
IJMS, Vol. 21, Pages 6416: Dual Oxidase Maturation Factor 1 Positively Regulates RANKL-Induced Osteoclastogenesis via Activating Reactive Oxygen Species and TRAF6-Mediated Signaling International Journal of Molecular Sciences doi: 10.3390/ijms21176416 Authors: Yoon-Hee Cheon Chang Hoon Lee Da Hye Jeong Sung Chul Kwak Soojin Kim Myeung Su Lee Ju-Young Kim Receptor activator of NF-κB ligand (RANKL) induces generation of intracellular reactive oxygen species...
Thu Sep 03, 2020 03:00
IJMS, Vol. 21, Pages 6415: Effect of Seminal Plasma Protein Fractions on Stallion Sperm Cryopreservation International Journal of Molecular Sciences doi: 10.3390/ijms21176415 Authors: Filipa Bubenickova Pavla Postlerova Ondrej Simonik Jitka Sirohi Jiri Sichtar Seminal plasma (SP) is the natural environment for spermatozoa and contains a number of components, especially proteins important for successful sperm maturation and fertilization. Nevertheless, in standard frozen stallion...
Thu Sep 03, 2020 03:00
IJMS, Vol. 21, Pages 6413: Alcohol Addiction, Gut Microbiota, and Alcoholism Treatment: A Review International Journal of Molecular Sciences doi: 10.3390/ijms21176413 Authors: Shao-Cheng Wang Yuan-Chuan Chen Shaw-Ji Chen Chun-Hung Lee Ching-Ming Cheng Alcohol addiction is a leading risk factor for personal death and disability. In 2016, alcohol use caused 2.2% of female deaths and 6.8% of male deaths, and disability-adjusted life years (DALYs) were 2.3% in female and 8.9%...
Thu Sep 03, 2020 03:00
IJMS, Vol. 21, Pages 6412: The HMOX1 Pathway as a Promising Target for the Treatment and Prevention of SARS-CoV-2 of 2019 (COVID-19) International Journal of Molecular Sciences doi: 10.3390/ijms21176412 Authors: Neelu Batra Cristabelle De Souza Jyoti Batra Alan G. Raetz Ai-Ming Yu The coronavirus disease of 2019 (COVID-19) or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is a global pandemic with increasing incidence and mortality rates. Recent evidence...
Thu Sep 03, 2020 03:00
IJMS, Vol. 21, Pages 6414: Mass Spectrometry Imaging as a Potential Tool to Investigate Human Osteoarthritis at the Tissue Level International Journal of Molecular Sciences doi: 10.3390/ijms21176414 Authors: Yea-Rin Lee Matthew T. Briggs Mark R. Condina Hamish Puddy Paul H. Anderson Peter Hoffmann Julia S. Kuliwaba Osteoarthritis (OA) is the most common degenerative joint disease, predicted to increase in incidence year by year due to an ageing population. Due to the...
Thu Sep 03, 2020 03:00
IJMS, Vol. 21, Pages 6410: GANT61 and Lithium Chloride Inhibit the Growth of Head and Neck Cancer Cell Lines Through the Regulation of GLI3 Processing by GSK3β International Journal of Molecular Sciences doi: 10.3390/ijms21176410 Authors: Vedran Zubčić Nikolina Rinčić Matea Kurtović Diana Trnski Vesna Musani Petar Ozretić Sonja Levanat Dinko Leović Maja Sabol Several signaling pathways are aberrantly activated in head and neck squamous cell carcinoma (HNSCC),...
Thu Sep 03, 2020 03:00
IJMS, Vol. 21, Pages 6411: Application of Various Molecular Modelling Methods in the Study of Estrogens and Xenoestrogens International Journal of Molecular Sciences doi: 10.3390/ijms21176411 Authors: Anna Helena Mazurek Łukasz Szeleszczuk Thomas Simonson Dariusz Maciej Pisklak In this review, applications of various molecular modelling methods in the study of estrogens and xenoestrogens are summarized. Selected biomolecules that are the most commonly chosen as molecular modelling...
Thu Sep 03, 2020 03:00
IJMS, Vol. 21, Pages 6409: Short-Term Mild Temperature-Stress-Induced Alterations in the C. elegans Phosphoproteome International Journal of Molecular Sciences doi: 10.3390/ijms21176409 Authors: Jichang Huang Zhen Wu Xumin Zhang Exposure to mild early-life stresses can slow down aging, and protein phosphorylation might be an essential regulator in this process. However, the mechanisms of phosphorylation-based signaling networks during mild early-life stress remain elusive. Herein,...
Thu Sep 03, 2020 03:00
IJMS, Vol. 21, Pages 6407: Immunohistological Expression of SOX-10 in Triple-Negative Breast Cancer: A Descriptive Analysis of 113 Samples International Journal of Molecular Sciences doi: 10.3390/ijms21176407 Authors: Katharina Kriegsmann Christa Flechtenmacher Jörg Heil Jörg Kriegsmann Gunhild Mechtersheimer Sebastian Aulmann Wilko Weichert Hans-Peter Sinn Mark Kriegsmann Background: SRY-related HMG-box 10 (SOX-10) is commonly expressed in triple negative breast...
Thu Sep 03, 2020 03:00
IJMS, Vol. 21, Pages 6406: Phenolic-Enriched Collagen Fibrillar Coatings on Titanium Alloy to Promote Osteogenic Differentiation and Reduce Inflammation International Journal of Molecular Sciences doi: 10.3390/ijms21176406 Authors: Anna Mieszkowska Harrison Beaumont Laurine Martocq Andrey Koptyug Maria A. Surmeneva Roman A. Surmenev Javad Naderi Timothy E.L. Douglas Katarzyna A. Gurzawska-Comis The adsorption of biomolecules on biomaterial surfaces can promote...
Thu Sep 03, 2020 03:00
IJMS, Vol. 21, Pages 6405: Proteostasis and Proteotoxicity in the Network Medicine Era International Journal of Molecular Sciences doi: 10.3390/ijms21176405 Authors: Marta Lualdi Tiziana Alberio Mauro Fasano Neurodegenerative proteinopathies are complex diseases that share some pathogenetic processes. One of these is the failure of the proteostasis network (PN), which includes all components involved in the synthesis, folding, and degradation of proteins, thus leading to the aberrant...
Thu Sep 03, 2020 03:00
IJMS, Vol. 21, Pages 6408: The Phenomenon of Clopidogrel High On-Treatment Platelet Reactivity in Ischemic Stroke Subjects: A Comprehensive Review International Journal of Molecular Sciences doi: 10.3390/ijms21176408 Authors: Adam Wiśniewski Karolina Filipska Clopidogrel is increasingly being used for the secondary prevention of ischemic stroke according to the updated guidelines on acute stroke management. Failure to achieve a drug response is referred to as clopidogrel resistance....
Thu Sep 03, 2020 03:00
IJMS, Vol. 21, Pages 6404: Epigenetic Regulations of AhR in the Aspect of Immunomodulation International Journal of Molecular Sciences doi: 10.3390/ijms21176404 Authors: Anna Wajda Joanna Łapczuk-Romańska Agnieszka Paradowska-Gorycka Environmental factors contribute to autoimmune disease manifestation, and as regarded today, AhR has become an important factor in studies of immunomodulation. Besides immunological aspects, AhR also plays a role in pharmacological, toxicological and...
Thu Sep 03, 2020 03:00
IJMS, Vol. 21, Pages 6403: Cellular and Subcellular Localisation of Kv4-Associated KChIP Proteins in the Rat Cerebellum International Journal of Molecular Sciences doi: 10.3390/ijms21176403 Authors: Rocío Alfaro-Ruíz Carolina Aguado Alejandro Martín-Belmonte Ana Esther Moreno-Martínez Rafael Luján The K+ channel interacting proteins (KChIPs) are a family of cytosolic proteins that interact with Kv4 channels, leading to higher current density, modulation of channel inactivation...
Thu Sep 03, 2020 03:00
IJMS, Vol. 21, Pages 6402: Gut Microbiota and Intestinal Trans-Epithelial Permeability International Journal of Molecular Sciences doi: 10.3390/ijms21176402 Authors: Bénédicte Allam-Ndoul Sophie Castonguay-Paradis Alain Veilleux Constant remodeling of tight junctions to regulate trans-epithelial permeability is essential in maintaining intestinal barrier functions and thus preventing diffusion of small molecules and bacteria to host systemic circulation. Gut microbiota dysbiosis...
Thu Sep 03, 2020 03:00
IJMS, Vol. 21, Pages 6400: Progression-Free Survival and Overall Survival of CDK 4/6 Inhibitors Plus Endocrine Therapy in Metastatic Breast Cancer: A Systematic Review and Meta-Analysis International Journal of Molecular Sciences doi: 10.3390/ijms21176400 Authors: Michela Piezzo Paolo Chiodini Maria Riemma Stefania Cocco Roberta Caputo Daniela Cianniello Germira Di Gioia Vincenzo Di Lauro Francesca Di Rella Giuseppina Fusco Giovanni Iodice Francesco Nuzzo Carmen...
Thu Sep 03, 2020 03:00
IJMS, Vol. 21, Pages 6401: The Role of the IL-23/IL-17 Pathway in the Pathogenesis of Spondyloarthritis International Journal of Molecular Sciences doi: 10.3390/ijms21176401 Authors: Hiroyuki Tsukazaki Takashi Kaito Spondyloarthritis (SpA) is a subset of seronegative rheumatic-related autoimmune diseases that consist of ankylosing spondylitis (AS), psoriatic spondylitis (PsA), reactive spondylitis (re-SpA), inflammatory bowel disease (IBD)-associated spondylitis, and unclassifiable...
Thu Sep 03, 2020 03:00
IJMS, Vol. 21, Pages 6399: Rocuronium Has a Suppressive Effect on Platelet Function via the P2Y12 Receptor Pathway In Vitro That Is Not Reversed by Sugammadex International Journal of Molecular Sciences doi: 10.3390/ijms21176399 Authors: Yutaka Murata Shuji Kawamoto Kazuhiko Fukuda Rocuronium is an aminosteroid nondepolarizing neuromuscular blocker that is widely used for anesthesia and intensive care. In this study, we investigated the effect of rocuronium on human platelet functions...
Thu Sep 03, 2020 03:00
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