Publication date: Available online 27 April 2020Source: Free Radical Biology and MedicineAuthor(s): Yik-Lam Cho, Hayden Weng Siong Tan, Quaiser Saquib, Yi Ren, Javed Ahmad, Rizwan Wahab, Weifeng He, Boon-Huat Bay, Han-Ming Shen
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Publication date: Available online 25 April 2020Source: Free Radical Biology and MedicineAuthor(s): Dan Wang, Yang Jiang, Dong-xiao Sun-Waterhouse, Hao Zhai, Hui Guan, Xue Rong, Feng Li, Jia-cheng Yu, Da-peng Li
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by Lavanya Visvabharathy, Samantha Genardi, Liang Cao, Ying He, Francis Alonzo III, Evgeny Berdyshev, Chyung-Ru Wang Staphylococcus aureus (SA) is the causative agent of both skin/soft tissue infections as well as invasive bloodstream infections. Though vaccines have been developed to target both humoral and T cell-mediated immune responses against SA, they have largely failed due to lack of protective efficacy. Group 1 CD1-restricted T cells recognize lipid rather than peptide antigens. Previously...
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by Luca Schifanella, Susan W. Barnett, Massimiliano Bissa, Veronica Galli, Melvin N. Doster, Monica Vaccari, Georgia D. Tomaras, Xiaoying Shen, Sanjay Phogat, Ranajit Pal, David C. Montefiori, Celia C. LaBranche, Mangala Rao, Hung V. Trinh, Robyn Washington-Parks, Namal P. M. Liyanage, Giacomo Gorini, Dallas R. Brown, Frank Liang, Karin Loré, David J. Venzon, William Magnanelli, Michelle Metrinko, Josh Kramer, Matthew Breed, Galit Alter, Ruth M. Ruprecht, Genoveffa Franchini
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by Yifan Meng, Ping Wu, Wanrong Lu, Kui Liu, Ke Ma, Liang Huang, Jiaojiao Cai, Hong Zhang, Yu Qin, Haiying Sun, Wencheng Ding, Lingli Gui, Peng Wu To confirm the relationship between sex and the progression of Coronavirus Disease-19 (COVID-19), and its potential mechanism, among severe patients. For this retrospective study, we included 168 consecutive severe patients with pathogen-confirmed COVID-19 who were hospitalized between January 16th and February 4th, 2020, at Tongji Hospital in Wuhan,...
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by Alexandre Cammarata-Mouchtouris, Xuan-Hung Nguyen, Adrian Acker, François Bonnay, Akira Goto, Amir Orian, Marie-Odile Fauvarque, Michael Boutros, Jean-Marc Reichhart, Nicolas Matt The Immune Deficiency (IMD) pathway in Drosophila melanogaster is activated upon microbial challenge with Gram-negative bacteria to trigger the innate immune response. In order to decipher this nuclear factor κB (NF-κB) signaling pathway, we undertook an in vitro RNAi screen targeting E3 ubiquitin ligases specifically...
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by Xiaoming Lyu, Jianguo Wang, Xia Guo, Gongfa Wu, Yang Jiao, Oluwasijibomi Damola Faleti, Pengfei Liu, Tielian Liu, Yufei Long, Tuotuo Chong, Xu Yang, Jing Huang, Mingliang He, Chi Man Tsang, Sai Wah Tsao, Qian Wang, Qiang Jiang, Xin Li
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by Junzhu Wang, Tianyuan Chen, Meng Han, Lichao Qian, Jinlin Li, Ming Wu, Ting Han, Jidong Cao, Ugrappa Nagalakshmi, John P. Rathjen, Yiguo Hong, Yule Liu The nucleotide-binding, leucine-rich repeat-containing (NLR) class of immune receptors of plants and animals recognize pathogen-encoded proteins and trigger host defenses. Although animal NLRs form oligomers upon pathogen recognition to activate downstream signaling, the mechanisms of plant NLR activation remain largely elusive. Tm-22 is a...
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Publication date: Available online 26 April 2020Source: Microbiological ResearchAuthor(s): A. Fernandez-San Millan, I. Farran, L. Larraya, M. Ancin, L.M. Arregui, J. Veramendi
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Publication date: Available online 27 April 2020Source: The Journal of Emergency MedicineAuthor(s): Vigil James, John Samuel, Gene Yong-Kwang Ong
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Publication date: Available online 27 April 2020Source: The Journal of Emergency MedicineAuthor(s): Katherine Selman, Sarab Sodhi, Lisa Filippone, Andrew Nyce
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Publication date: Available online 27 April 2020Source: The Journal of Emergency MedicineAuthor(s): Chia-Wen Chang, Yen-Hung Wu, Hsin-Liang Liu
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Publication date: Available online 27 April 2020Source: The Journal of Emergency MedicineAuthor(s): Vishal V. Patel, Amit Mohindroo
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Publication date: Available online 27 April 2020Source: The Journal of Emergency MedicineAuthor(s): Nicola Pagnucci, Salvatore Pagliaro, Claudia Maccheroni, Marco Sichi, Monica Scateni, Angela Tolotti
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Publication date: Available online 27 April 2020Source: The Journal of Emergency MedicineAuthor(s): Sandra Afonso, Sílvia Lopes
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Publication date: Available online 27 April 2020Source: The Journal of Emergency MedicineAuthor(s): Michael P. Doyle, James P. McCarty, Alan A. Lazzara
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Objective: Aberrant expression of cadherins is known to be associated with tumor aggression. However, their role in clear cell renal cell carcinoma (CCRCC) is not well elucidated. This study investigated the expression of epithelial cadherin (E-cadherin), neural cadherin (N-cadherin), and placental cadherin (P-cadherin) in CCRCC, and assessed their prognostic significance and clinicopathologic association. Materials and Methods: We enrolled 254 patients with CCRCC who underwent radical or...
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Metastatic triple-negative breast cancer (mTNBC) is the most aggressive breast cancer subtype. Programmed death ligand 1 (PD-L1) on immune cells (IC) using the VENTANA SP142 assay is linked to improved clinical outcome in atezolizumab plus nab—paclitaxel-treated patients with mTNBC in the IMpassion130 study. The goal of the current study was to evaluate prevalence of VENTANA SP142 PD-L1 assay by anatomic location in 670 histologically confirmed TNBC cases from subjects with metastatic disease screened...
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Publication date: Available online 28 April 2020Source: Journal of Controlled ReleaseAuthor(s): Kosuke Shimizu, Yoshihito Takeuchi, Kazuma Otsuka, Tomoya Mori, Yudai Narita, Shohei Takasugi, Yasuhiro Magata, Yasuhiro Matsumura, Naoto Oku
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Publication date: Available online 27 April 2020Source: Journal of Controlled ReleaseAuthor(s): Miguel Pereira-Silva, Ivana Jarak, Carmen Alvarez-Lorenzo, Angel Concheiro, Ana Cláudia Santos, Francisco Veiga, Ana Figueiras
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Publication date: Available online 25 April 2020Source: Journal of Controlled ReleaseAuthor(s): Xiaobao Zhao, Jingxing Si, Dongsheng Huang, Ke Li, Ying Xin, Meihua Sui
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IntroductionIncentive programmes are used in health systems worldwide to spur improvement in quality of care; these include both financial incentives (eg, pay for performance) and non-financial incentives (eg, public reporting). In the USA, the Centers for Medicare & Medicaid Services’ (CMS) Star Ratings quality incentive programme for private Medicare insurance plans, or Medicare Advantage plans, incorporates both non-financial and financial incentives. Star Ratings on a 1–5 scale are publicly...
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ObjectiveTo identify US drug brand (proprietary) names that are identical or similar to drug brand names used in other countries containing different active ingredients and name confusion medication errors associated with these drugs.MethodsWe compared a list of brand names approved by the US Food and Drug Administration from 2006 through 2018 with a list of brand names from other countries generated by Uppsala Monitoring Centre using the WHODrug Dictionary. We evaluated drug name pairs that were...
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Sperm–oocyte fusion is a critical event in mammalian fertilization, categorized by three indispensable proteins. Sperm membrane protein IZUMO1 and its counterpart oocyte membrane protein JUNO make a protein complex allowing sperm to interact with the oocyte, and subsequent sperm–oocyte fusion. Oocyte tetraspanin protein CD9 also contributes to sperm–oocyte fusion. However,...
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What can humans compute in their heads? We are thinking of a variety of cryptographic protocols, games like sudoku, crossword puzzles, speed chess, and so on. For example, can a person compute a function in his or her head so that an eavesdropper with a powerful computer—who sees the responses...
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MEDICAL SCIENCES Correction for “Regulation of PRMT5–MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma,” by Shatha AbuHammad, Carleen Cullinane, Claire Martin, Zoe Bacolas, Teresa Ward, Huiqin Chen, Alison Slater, Kerry Ardley, Laura Kirby, Keefe T. Chan, Natalie Brajanovski, Lorey K. Smith, Aparna D. Rao, Emily J....
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