The authors report a case of extremely uncommon malignancy of lacrimal gland epithelial-myoepithelial carcinoma. This carcinoma is more commonly encountered in salivary glands and comprises 1% of all salivary gland tumors. Its occurrence in the orbit is very rare with only 6 cases reported in the literature, most of which arose in a pleomorphic adenoma. Epithelial-myoepithelial carcinoma is primarily a tumor of older adults, with a peak incidence in the sixth and seventh decades of life. The present...
1d
Abstract Chronic myeloid leukemia (CML) is a hematopoietic stem cell disease caused by abnormal DNA replication of bone marrow stem cells and chemotherapy resistance is a major obstacle to the effective treatment of patients with CML. Imatinib (IM), a tyrosine kinase inhibitor (TKI), is a first-line drug clinically used for CML. Mounting evidence has indicated that the dysregulation of microRNAs (miRNAs) is associated with the chemoresistance of CML. In this study, miR-153-3p,...
1d
Abstract Purpose When performing endoscopic thoracic sympathectomy (ETS) in palmar hyperhidrosis patients, a device can be used to measure sweat volume pre- and postoperatively in order to assess indications and treatment effects. In this study, we measured changes in the dynamics of sweating in hyperhidrosis patients pre- and postoperatively and compared the values with those in healthy subjects without hyperhidrosis. ...
1d
In this introductory essay, we will present a translational medical humanities approach where the humanities are not only an auxiliary to medical science and practice, but also an interdisciplinary space where both medicine and the humanities mutually challenge and inform each other. First, we explore how medicine’s attempt to tackle the nature–culture divide is emblematically expressed in the concept and practice of knowledge translation (hereinafter KT). Second, we compare and contrast KT as an...
1d
This article analyses how World War II shifted and contained embodied experiences of waiting in relation to broader ideas of lived time in modernity. The trench warfare of World War I has often been imagined as a limit experience of anxious waiting, but World War II produced compelling accounts of experiences of suspended time in civilian populations exposed to the threat and anticipation of ‘total war’. This article analyses representations of this suspended present drawn from Elizabeth Bowen and...
1d
In 1913, eccentric French composer Erik Satie wrote a fragmentary, diary-like essay where he depicted a strikingly rigid diet consisting solely of white foods: eggs, sugar, coconuts, rice, cream cheese, fuchsia juice and so on. Satie’s brief essay has later been used as one of many puzzle pieces in attempts to retrospectively diagnose him with autism spectrum disorder. With Satie’s white meal as a starting point, this paper explores colour-based food preferences and selective eating in clinical and...
1d
Abstract There are a number of psychophysical and electrophysiological measures that are correlated with SGN density in animal models, and these same measures can be performed in humans with cochlear implants (CIs). Thus, these measures are potentially applicable in humans for estimating the condition of the neural population (so called “neural health” or “cochlear health”) at individual sites along the electrode array and possibly adjusting the stimulation strategy in the CI...
1d
Obesity has reached epidemic levels in the United Kingdom. Obesity is associated with important gastrointestinal and hepatic complications which are common and can present sooner than cardiometabolic disease but often the underlying obesity remains untreated. Given that gastroenterologists and hepatologists will be at the forefront of obesity management we present an overview encompassing obesity pathophysiology, medical and surgical treatment options as well as the role of endobariatrics and the...
1d
IntroductionThe landscape of COVID-19 is rapidly changing, with new data emerging at an unprecedented rate. Making sense of these data, and interpreting what is important and high quality information is challenging. Within this article we have summarised key data published to date concerning COVID-19 and the gastrointestinal tract. We recognise the constantly changing literature and aim to update future publications with the most contemporary data.Clinical characteristics of COVID-19 in ChinaHow...
1d
This study characterizes the prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection detected on polymerase chain reaction (PCR) screening of a large homeless shelter population in Boston prompted by an outbreak of COVID-19 cases among shelter residents.
1d
In this narrative medicine essay, an internist considers the effects of the coronavirus disease 2019 pandemic on noninfected patients whose access to care may be blocked by fear, economic loss, or an overwhelmed health care system.
1d
This Viewpoint discusses the likely effects of the COVID-19 pandemic on US health care spending and on estimates of its share of gross domestic product (GDP).
1d
In this Medical News article, Howard Markel, MD, PhD, director of the Center for the History of Medicine at the University of Michigan, speaks about nonpharmaceutical interventions during the 1918-1919 influenza pandemic and their lessons for today.
1d
Simulated Coronavirus Contamination of Health Care Workers After Endotracheal Intubation of Manikins
This study uses an atomizer and fluorescent markers to simulate contamination of uncovered skin and hair of health care workers wearing personal protective equipment after intubating patient manikins under emergency conditions.
1d
Health care personnel who care for critically ill patients with suspected or confirmed novel coronavirus disease 2019 (COVID-19) routinely participate in procedures, such as endotracheal intubation, that may create infectious aerosols. Among persons infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes COVID-19, approximately 8% will require endotracheal intubation and mechanical ventilation.
1d
In the Original Investigation titled “Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area” published online April 22, 2020, in JAMA, clarification and correction of data were required. In the Abstract, Results paragraph, the sentence reporting mortality for patients receiving mechanical ventilation should read, “As of April 4, 2020, for patients requiring mechanical ventilation (n = 1151, 20.2%), 38 (3.3%) were discharged...
1d
Abstract Background It is unclear whether generics are as safe as brand-name drugs in cardiology. For public health surveillance purposes, we evaluated if switching from the brand-name losartan, valsartan, or candesartan impacted the occurrence of the following outcomes: emergency room (ER) consultations, hospitalizations, or death. Study Design This was...
1d
Abstract Posttraumatic stress disorder (PTSD) is characterized by intrusions, avoidance, and hyperarousal while patients of the dissociative subtype (PTSD-D) experience additional dissociative symptoms. A neurobiological model proposes hyper-inhibition of limbic structures mediated by prefrontal cortices to underlie dissociation in PTSD. Here, we tested whether functional alterations in fronto-limbic circuits are underpinned by white matter network abnormalities on a network level....
1d
Publication date: Available online 25 April 2020Source: Acta Otorrinolaringológica EspañolaAuthor(s): Davide Soloperto, Andrea Sacchetto, Luca Gazzini, Daniele Marchioni
1d
Abstract 2-Amino-1-methyl-6-phenylimidazo [4,5-b]pyridine (PhIP) is a central dietary mutagen, produced when proteinaceous food is heated at very high temperatures potentially causing DNA strand breaks. This study investigates the protective potential of a well-researched flavonoid, myricetin in its bulk and nano-forms against oxidative stress induced ex vivo/in vitro by PhIP in lymphocytes from pre-cancerous monoclonal gammopathy of undetermined significance (MGUS) patients and...
1d
FLAGSTAFF, Ariz. — April 27, 2020 — The Translational Genomics Research Institute (TGen) , an affiliate of City of Hope , is looking for volunteers: individuals who have run the course of COVID-19, and whose immune system may have built up antibodies against this still mysterious disease. Participants in The COVID Immunity Study must be U.S. residents, age 18 or older, have tested positive for COVID-19, and then recovered. They may sign up at: https://covidimmunity.org/ . This is a research study,...
1d
Abstract Background and Objective Plaque formation ordinarily takes place in the acute phase of Peyronie’s disease. There is no unanimous consent regarding the management of the acute phase of Peyronie’s disease. The objective of this study was to evaluate the advantages of using a single intralesional injection of collagenase Clostridium histolyticum in patients with the active phase of Peyronie’s disease and to assess its effect on disease...
1d
By: Leanne Armstrong Flowcharts are fantastic project management tools. They can help you map out complex processes, manage your tasks systematically, and present workflows in a visual way that everyone on your team can understand. If you don’t already, you’ll soon find that working with software-based project management flowcharts is a snap. All you need to start taking advantage of the benefits they offer is this go-to guide for making the most of flowchart diagrams...
1d
Abstract Background Poly (ADP-ribose) polymerase (PARP) inhibitors are extensively studied and used as anti-cancer drugs, as single agents or in combination with other therapies. Most radiotracers developed to date have been chosen on the basis of strong PARP1–3 affinity. Herein, we propose to study AZD2461, a PARP inhibitor with lower affinity towards PARP3, and to investigate its potential for PARP targeting in vivo. ...
1d
JCDD, Vol. 7, Pages 15: Exercise Prescription Guidelines for Cardiovascular Disease Patients in the Absence of a Baseline Stress Test Journal of Cardiovascular Development and Disease doi: 10.3390/jcdd7020015 Authors: Megan Mytinger Rachael K. Nelson Micah Zuhl Aerobic exercise is a core component of cardiac rehabilitation (CR). Leading organizations recommend that the exercise prescriptions should be based on a symptom limited baseline graded exercise test (GXT). However, recent...
1d
Abstract Electroconvulsive therapy (ECT) is an effective treatment for severe psychiatric disorders. Patients referred to ECT are often taking multiple medications, many of which can potentially affect the safety and efficacy of their course of ECT. This review evaluates the impact of a variety of psychotropic medications often used in conjunction with ECT and examines strategies to optimize their management. The review encompasses mood stabilizers, antidepressants, benzodiazepines,...
1d
Publication date: Available online 27 April 2020Source: Trends in ImmunologyAuthor(s): Yuqing Feng, Noé Seija, Javier Di Noia, Alberto Martin
1d
Publication date: Available online 25 April 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchAuthor(s): Pankaj Kumar, Bharath Devaki, Jonnala Ujwal Kumar, Amere Subbarao Sreedhar
1d
Objective: Previous reports proposed prelemniscal radiations (Raprl) as a target to treat motor symptoms of Parkinson’s disease, and this was found particularly effective to control rest and postural tremor. However, tremor of other etiologies has been seldom treated with deep brain stimulation or ablation in this target. We present a series of such cases successfully treated by Raprl radiofrequency (RF) lesions. Material and Methods: Six patients with predominant unilateral tremor on the right arm:...
1d
Abstract Spinocerebellar ataxia type 14 (SCA-PRKCG, formerly SCA14) is a rare, slowly progressive disorder caused by conventional mutations in protein kinase Cγ (PKCγ). The disease usually manifests with ataxia, but previous reports suggested PRKCG variants in retinal pathology. To systematically investigate for the first time visual function and retinal morphology in patients with SCA-PRKCG. Seventeen patients with PRKCG variants and 17 healthy controls were prospectively recruited,...
1d
Prostate cancer is among the most common types of cancer in men. Early detection and proper medical intervention is crucial to ensuring successful treatment. Here we describe a patient clinically presenting with castrate-resistant prostate carcinoma. Comprehensive genomic profiling identified a PTEN inactivating mutation in the patient’s tumor. After being heavily pretreated, the patient showed stable disease on everolimus, a PI3K-Akt-mTOR pathway inhibitor. Case Rep Oncol 2020;13:456–461
1d
Summary Around 76,000 people fracture their hip annually in the UK at a considerable personal, social and financial cost. Despite longstanding debate, the optimal mode of anaesthesia (general or spinal) remains unclear. Our aim was to assess whether there is a significant difference in mortality and morbidity between patients undergoing spinal anaesthesia compared with general anaesthesia during hip fracture surgery. A secondary analysis examined whether a difference exists in mortality for patients...
1d
Summary The current international coronavirus disease 19 health crisis underlines the importance of adequate and suitable personal protective equipment for clinical staff during acute airway management. This study compares the impacts of standard air purifying respirators and powered air purifying respirators during simulated difficult airway scenarios. Twenty‐five anaesthetists carried out four different standardised difficult intubation drills, either unprotected (control), or wearing a standard,...
1d
Abstract Background and Objectives With disease‐modifying treatment strategies on the horizon, stratification of individual patients at the earliest stages of Parkinson's disease (PD) is key—ideally already at clinical disease onset. Blood levels of neurofilament light chain (NfL) provide an easily accessible fluid biomarker that might allow capturing the conversion from prodromal to manifest PD. Methods We assessed longitudinal serum NfL levels in subjects converting from prodromal...
1d
1d
Our study demonstrated a novel role played by X‐box binding protein 1 in modulating the viability of liver cancer cells via the Mst1‐JNK‐mitochondrial ROS pathways. Abstract Previous studies have found that the primary pathogenesis of liver cancer progression is linked to excessive cancer cell proliferation and rapid metastasis. Although therapeutic advances have been made for the treatment of liver cancer, the mechanism underlying the liver cancer progression has not been fully addressed. In...
1d
Abstract It is hypothesized that prenatal vitamin D deficiency may contribute to the development of childhood wheezing and asthma. Beyond its known functions in bone development and health, vitamin D is emerging as a pleiotropic hormone exerting several extraskeletal effects, some of which could reduce the risk of asthma. Experimental evidence shows that vitamin D is an important regulator of foetal and neonatal lung growth. It can also modulate innate and adaptive immune responses, enhancing antiviral...
1d
Abstract It is reported that baicalein can activate PI3K/AKT pathway, inhibit caspase activation and reduce cerebral infarct volume in middle cerebral artery occlusion (MCAO) rats. However, a caspase-independent mechanism initiated by poly (ADP-ribose) polymerase-1 (PARP-1) activation has been reported to make more contribution to cells death after ischemic stroke. In the present study, we established a cerebral ischemia/reperfusion (I/R) rat model through middle cerebral artery...
1d
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου